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Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients SARS-CoV-2 蛋白 S 的伪环肽的合成及其与 COVID-19 患者具有诊断意义的抗体的相互作用
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.009
Ivan M. Ryzhov , Polina S. Obukhova , Oxana E. Galanina , Eugenia M. Rapoport , Natalia S. Egorova , Nicolai V. Bovin , Alexander B. Tuzikov

An approach to the design of pseudocyclic peptide epitopes is proposed: lipid tails are attached to both C- and N-termini of the peptide through hydrophilic spacers; thanks to two lipid anchors, the conjugate is inserted into the membrane at two sites simultaneously, and the peptide becomes conformation- constrained. Despite the presence of two long lipid regions, the high hydrophilicity of the spacer makes the entire structure water-soluble, which is crucial for integration into living cells.

本文提出了一种设计伪环状肽表位的方法:通过亲水性间隔物将脂质尾部连接到肽的 C 端和 N 端;由于有了两个脂质锚,共轭物可同时插入膜的两个部位,肽的构象也会受到限制。尽管存在两个长的脂质区域,但间隔物的高亲水性使整个结构具有水溶性,这对融入活细胞至关重要。
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引用次数: 0
NiCo-Gd0.1Ti0.1Zr0.1Ce0.7O2 catalyst for dry reforming and partial oxidation of methane: effect of NiCo applying method on the conversion of methane to synthesis gas 用于甲烷干重整和部分氧化的 NiCo-Gd0.1Ti0.1Zr0.1Ce0.7O2 催化剂:NiCo 应用方法对甲烷转化为合成气的影响
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.034
Igor V. Zagaynov , Alexey S. Loktev , Anatoly A. Konovalov , Anton A. Klimashin , Olga S. Antonova , Alexey G. Dedov

A series of catalysts based on mesoporous ceria solid solutions containing NiCo active component was synthesized via co- precipitation, impregnation, hydrothermal and core–shell (sol–gel) methods and applied to partial oxidation and dry reforming of methane. In the co-precipitated and impregnated catalysts, a better NiCo dispersion and a stronger interaction between NiCo species and the ceria- based support in comparison with other catalysts were observed, which affected activity and selectivity. Thus, simpler methods of applying the active component were more advantageous owing to the manifestation of strong metal–support interactions.

通过共沉淀、浸渍、水热和核壳(溶胶-凝胶)等方法合成了一系列含有镍钴活性组分的介孔铈固溶体催化剂,并将其应用于甲烷的部分氧化和干重整。与其他催化剂相比,共沉淀和浸渍催化剂中的镍钴分散性更好,镍钴物种与铈基载体之间的相互作用更强,从而影响了催化剂的活性和选择性。因此,由于金属与载体之间存在强烈的相互作用,应用活性组分的简单方法更具优势。
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引用次数: 0
The reaction of 1-alkyl-3-phenylpropynones with aromatic aldehydes: an update 1- 烷基-3-苯基丙炔酮与芳香醛的反应:最新进展
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.037
Sofia O. Karnakova, Dmitrii A. Shabalin

1-Alkyl-3-phenylprop-2-yn-1-ones smoothly react with aromatic aldehydes in the presence of triphenylphosphine (acetonitrile, room temperature, 24 h) to regio- and stereo- selectively afford (Z)-2-benzylideneoxacyclopentan-3-ones in yields up to 93%. The proposed mechanism for the transformation involves 1,3-H proton shift from the alkyl group at the intermediate β-phosphoniovinylide species.

1 烷基-3-苯基丙-2-炔-1-酮在三苯基膦存在下(乙腈,室温,24 小时)与芳香醛顺利发生反应,从而以区域和立体选择性方式得到 (Z)-2-亚苄基氧杂环戊烷-3-酮,收率高达 93%。所提出的转化机理涉及中间体 β-磷酰乙烯基烷基的 1,3-H 质子转移。
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引用次数: 0
4-Phenyldiazenyl-substituted 3,6-di-tert-butylcatechol: synthesis and azo–hydrazone equilibrium 4-苯基二氮基取代的 3,6-二叔丁基邻苯二酚:合成与偶氮腙平衡
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.038
Konstantin A. Martyanov, Arina A. Tsybushkina, Anton V. Cherkasov, Alexey A. Belikov, Viacheslav A. Kuropatov

Reaction of 3-hydroxy-2,5-di-tert-butyl-1,4-benzoquinone with phenylhydrazine hydrochloride mainly leads to the corresponding hydrazone at the position 1 existing in tautomeric equilibrium with 3,6-di-tert-butyl-4-(phenyl- diazenyl)catechol. Thermodynamic parameters of the tautomerization were evaluated by NMR spectroscopy. The hydrazone structure was confirmed by XRD study.

3- 羟基-2,5-二叔丁基-1,4-苯醌与苯肼盐酸盐的反应主要导致位置 1 上相应的腙与 3,6-二叔丁基-4-(苯基-偶氮基)邻苯二酚发生同分异构。核磁共振光谱评估了同分异构的热力学参数。通过 XRD 研究确认了腙结构。
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引用次数: 0
Synthesis of new heterylmethylidene derivatives of isomeric imidazo[4,5-e]thiazolo-fused [1,2,4]triazines 异构咪唑并[4,5-e]噻唑并[1,2,4]三嗪新杂环亚甲基衍生物的合成
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.029
Maksim E. Lugovoi , Alexei N. Izmest’ev , Natalya G. Kolotyrkina , Ekaterina S. Izmalkova , Angelina N. Kravchenko , Galina A. Gazieva

Novel 6-heterylmethylidene-3a,9a-diphenylimidazo[4,5-e]-thiazolo[3,2-b][1,2,4]triazines were synthesized by the three-component condensation of imidazo[4,5-e][1,2,4]triazine-3-thione derivative with bromoacetic acid and hetero-aromatic aldehydes. The following MeONa-induced skeletal rearrangement gave the recyclized isomeric products, viz. 7-heterylmethylidene-3a,9a-diphenylimidazo-[4,5-e]thi azolo[2,3-c][1,2,4]triazines.

通过咪唑并[4,5-e][1,2,4]三嗪-3-硫酮衍生物与溴乙酸和杂芳香族醛的三组分缩合,合成了新型 6-杂基亚甲基-3a,9a-二苯基咪唑并[4,5-e]噻唑并[3,2-b][1,2,4]三嗪。随后由 MeONa 诱导的骨架重排得到了再造异构产物,即 7-heterylmethylidene-3a,9a-diphenylimidazo-[4,5-e]thi azolo[2,3-c][1,2,4]triazines。
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引用次数: 0
Adsorption phenomena in solutions of cucurbit[6]uril in the presence of magnesium sulfate 硫酸镁存在下葫芦[6]脲溶液中的吸附现象
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.040
Elena V. Stenina, Liana N. Sviridova

The behavior of cucurbit[6]uril at the electrode/solution interface in the presence of magnesium sulfate was investigated and quantified. It has been established that at the highest positive potential available for the adsorption of organic compounds, a structure is formed that consists entirely of neutral cavitand molecules.

在硫酸镁存在的情况下,对葫芦[6]脲在电极/溶液界面上的行为进行了研究和量化。结果表明,在有机化合物吸附所能达到的最高正电位下,会形成一种完全由中性空穴素分子组成的结构。
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引用次数: 0
Electrochemical C–H arylation of heteroarenes with in situ diazotizated anilines 原位重氮化苯胺与杂环烯的电化学 C-H 芳基化反应
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.036
Zhen-Xiang Liu, Hui Mao, Hang-Cheng Ni, Tai-Jin Chen

A simple and efficient electrochemical C–H arylation of five- membered active heteroarenes involves the application of arenediazonium salts generated in situ from anilines and tert- butyl nitrite. A cathodic reduction-induced radical chain mechanism is proposed.

五元活性杂环戊烯的一种简单高效的 C-H 芳基化电化学方法涉及到苯胺和亚硝酸叔丁酯原位生成的戊二氮盐的应用。提出了一种阴极还原诱导的自由基链机制。
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引用次数: 0
Iodocyclization of olefinic amides with acetoxybenziodoxolone and NaI toward 4-iodomethylated benzoxazines 烯烃酰胺与乙酰氧基苯并碘酮和 NaI 的碘环化反应,生成 4-碘甲基化苯并噁嗪
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.032
Yong Zhang , Junxue Bai , Song Sun

Iodocyclization of N-(2-alkenylphenyl)carboxamides with acetoxybenziodoxolone/NaI system gives 4-iodomethyl- 4H-3,1-benzoxazines with high efficiency. The process is triggered by the oxidation of NaI with acetoxybenziodo- xolone to afford iodine cation which is added to alkene moiety to form iodonium species, and the ultimate intra- molecular nucleophilic addition generates the final products.

N-(2- 烷基苯基)羧酰胺与乙酰氧基苯并二氧杂环戊酮/NaI 系统的碘环化反应可高效生成 4-iodomethyl- 4H-3,1-benzoxazines。该过程是由 NaI 与乙酰氧基苯并二碘-xolone 氧化生成碘阳离子而引发的,碘阳离子加入烯基形成碘鎓物种,最终分子内亲核加成生成最终产物。
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引用次数: 0
Simple and effective synthesis of functionalized (hydroxymethylene)bis(phosphonic) acids 简单有效地合成功能化(羟基亚甲基)双膦酸
IF 1.9 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-05-01 DOI: 10.1016/j.mencom.2024.04.029
Anastasia M. Zhirkova, Kirill V. Zaitsev, Andrey A. Prishchenko, Mikhail V. Vasiliev, Marina V. Kotova, Karina A. Uschakova, Laura A. Martirosyan, Irina V. Perminova

‘Technical’ tris(trimethylsilyl) phosphite, (Me3SiO)3P, as a mixture with (Me3SiO)2P(O)H and (Me3SiO)3P(O) (71 : 20 : 9) was obtained upon the action of (Me Si) NH on phosphorous acid H3PO3 in the presence of catalytic amount of Me3SiCl. The action of this material on acid chlorides RC(O)Cl affords (hydroxymethylene)bis(phosphonic) acids RC(OH)[P(O)(OH)2]2 in preparative yields.

在催化剂 Me3SiCl 的存在下,(Me Si) NH 与磷酸 H3PO3 发生作用,得到 "工业 "三(三甲基硅基)亚磷酸酯 (Me3SiO)3P,即 (Me3SiO)2P(O)H 和 (Me3SiO)3P(O) 的混合物 (71 : 20 : 9)。这种物质与酸性氯化物 RC(O)Cl 作用后,可以制备得到(羟基亚甲基)双(膦酸)RC(OH)[P(O)(OH)2]2。
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引用次数: 0
Synthesis of 1-adamantyl-4-alkyl-1H-1,2,3-triazoles under thermal and microwave conditions 在热和微波条件下合成 1-金刚烷基-4-烷基-1H-1,2,3-三唑
IF 1.9 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-05-01 DOI: 10.1016/j.mencom.2024.04.030
Rishat I. Aminov

Aluminate ionic liquid [Et3NH]+[Al2Cl7] was found to be an effective catalyst for the reactions of haloadamantanes with trimethylsilyl azide to produce the corresponding azido- adamantanes in 92–98% yields. Using ‘click chemistry’, the thus obtained azidoadamantanes were reacted with terminal alkynes under thermal or microwave conditions to cleanly afford the expected 1,4-disubstituted 1,2,3-triazoles some of which were new.

研究发现,铝酸离子液体 [Et3NH]+[Al2Cl7]- 是卤代金刚烷与三甲基硅叠氮化物反应生成相应叠氮金刚烷的有效催化剂,产率为 92-98%。利用 "点击化学",在热或微波条件下,将由此获得的叠氮金刚烷与末端炔烃反应,可干净利落地得到预期的 1,4 二甲基二取代 1,2,3 三唑,其中一些是新的。
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引用次数: 0
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Mendeleev Communications
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