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Thia-Michael addition in a Brønsted acidic deep eutectic solvent 布氏酸性深共晶溶剂中的噻-迈克尔加成法
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.030
Ya-juan Fan , Dan Wang , Liang Wang , Yongsheng Zhou

A 100% atom-efficient thia-Michael addition process between thiols and α,β -unsaturated carbonyl compounds in a Brønsted acidic deep eutectic solvent at room temperature has been developed. The medium, choline chloride/p-toluene- sulfonic acid, not only showed good catalytic activity, but also could be readily recovered and reused with slight decrease in its activity after successive five runs.

在室温下,在布氏酸性深共晶溶剂中,开发了一种硫醇与 α、β - 不饱和羰基化合物之间 100% 原子效率的噻-迈克尔加成法。氯化胆碱/对甲苯磺酸介质不仅显示出良好的催化活性,而且在连续运行五次后,其活性略有下降,但可随时回收和重复使用。
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引用次数: 0
Ultrafast photochemical processes in the complex trans,trans,trans-[Ptiv(py)2(N3)2(OH)2] 反式、反式、反式-[Ptiv(py)2(N3)2(OH)2]复合物中的超快光化学过程
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.006
Grigory I. Zhdankin , Ivan P. Pozdnyakov , Alexander V. Mikheylis , Vjacheslav P. Grivin , Danila B. Vasilchenko , Alexei A. Melnikov , Sergei V. Chekalin , Evgeni M. Glebov

Using ultrafast transient absorption spectroscopy, primary photophysical processes in aqueous and acetonitrile solutions of the trans,trans,trans-[Ptiv (N3)2(py)2(OH)2] complex, which is interesting as a potential light-activated anticancer drug, were investigated. A mechanism for early photoprocesses has been proposed, including ultrafast intersystem crossing and reductive dissociation.

利用超快瞬态吸收光谱,研究了反式、反式、反式-[Ptiv (N3)2(py)2(OH)2] 复合物在水溶液和乙腈溶液中的主要光物理过程。提出了早期光过程的机理,包括超快系统间交叉和还原解离。
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引用次数: 0
Effect of particle size of titanium oxide β-Ti3O5 on its thermal stability 氧化钛 β-Ti3O5 的粒度对其热稳定性的影响
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.043
Albina A. Valeeva , Evgeny Yu. Gerasimov , Olga G. Reznitskikh

It was established that the particle size of titanium oxide β-Ti3O5 has a great influence on the processes of phase formation and the stability of particles during heating. It was shown that at a temperature of about 456 K, β-Ti3O5 micro crystals undergo a reversible first-order phase transition, in which the low- temperature β-Ti3O5 phase is transformed into the high-temperature λ- Ti3O5 phase, and at higher temperatures the β-Ti3O5 phase is partially oxidized to form the Magnéli phase Ti4O7. It was found that β-Ti3O5 nanocrystals are unstable in an argon atmosphere and at temperatures above 400 K the β-Ti3O5 powder is oxidized.

研究证实,氧化钛 β-Ti3O5 的粒度对加热过程中的相形成过程和颗粒稳定性有很大影响。研究表明,在大约 456 K 的温度下,β-Ti3O5 微晶体会发生可逆的一阶相变,其中低温的 β-Ti3O5 相会转变为高温的 λ- Ti3O5 相,而在较高温度下,β-Ti3O5 相会被部分氧化,形成 Magnéli 相 Ti4O7。研究发现,β-Ti3O5 纳米晶体在氩气环境中不稳定,在温度高于 400 K 时,β-Ti3O5 粉末会被氧化。
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引用次数: 0
Synthesis, structure and cytotoxicity of novel tetrazolo[1’,5’-c]-fused 3-aza-A-homosteroids 新型四唑并[1',5'-c]融合 3-氮杂-A-类固醇的合成、结构和细胞毒性
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.011
Evgenii I. Rodionov , Alina A. Rodionova , Alla D. Zorina , Olesya V. Khoroshilova , Vitalii V. Suslonov , Elizaveta V. Lider , Yuliya A. Golubeva , Lyubov S. Klyushova , Yuri B. Porozov , Nikolay N. Kuzmich , Rostislav E. Trifonov

A series of new 1’H-tetrazolo[1,5-c]-fused 3-aza-A- homosteroids were synthesized by azidation of progesterone, testosterone and hydrocortisone acetate in the presence of silicon tetrachloride. According to NMR spectroscopy and X-ray analysis, two double bond positional isomers (double bond in ring A or in ring B) are formed in various ratios; according to quantum chemical calculations, their energies are close within 0.4 kcal mol-1. Only low cytotoxic activity against Hep-2, MCF-7, HepG2, and Hek293 cell lines was determined in vitro for the compounds obtained.

在四氯化硅存在下,通过对黄体酮、睾酮和醋酸氢化可的松进行叠氮化反应,合成了一系列新的 1'H-四唑并[1',5'-c]-融合 3-aza-A- 同甾类化合物。根据核磁共振光谱和 X 射线分析,以不同比例形成了两种双键位置异构体(双键位于 A 环或 B 环);根据量子化学计算,它们的能量接近 0.4 kcal mol-1。所获得的化合物在体外对 Hep-2、MCF-7、HepG2 和 Hek293 细胞株的细胞毒性较低。
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引用次数: 0
6-Phenyl-1,5-diazabicyclo[3.1.0]hexane: structure variations going from gas to crystal phase 6-苯基-1,5-二氮杂双环[3.1.0]己烷:从气相到晶相的结构变化
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.024
Ilya I. Marochkin , Pavel Yu. Sharanov , Vladimir V. Kuznetsov , Igor F. Shishkov , Yulia V. Novakovskaya

Based on gas electron diffraction experiments supported by quantum chemical simulations, the molecular structure of 6-phenyl-1,5-diazabicyclo[3.1.0]hexane (PhDBH) in the gas phase was determined, which is characterized by the puckering motion of the five-membered ring typical of bicyclo[3.1.0]- hexanes. It was found that the previously determined crystal packing is accompanied by a certain torsional twisting of the molecule, requiring activation energy. Based on the simulations of PhDBH clusters, it was shown that the energy is compensated by intermolecular interactions.

基于气体电子衍射实验和量子化学模拟,确定了气相中 6-苯基-1,5-二氮杂双环[3.1.0]己烷(PhDBH)的分子结构,其特征是双环[3.1.0]-己烷典型的五元环皱褶运动。研究发现,先前确定的晶体堆积伴随着一定的分子扭转,这需要活化能。基于 PhDBH 团簇的模拟结果表明,这种能量可以通过分子间的相互作用得到补偿。
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引用次数: 0
Probing transferability of intermolecular interactions by their features: a nitro group case study 通过分子间相互作用的特征探究其转移性:硝基案例研究
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.023
Ivan V. Ananyev, Leonid L. Fershtat

Based on the processing of supramolecular environments of nitro group from Cambridge Structural Database by means of the ‘Atoms in Molecules’ analysis of promolecular electron density function, it is demonstrated that the topological stability of intermolecular bonding within one associate reflects trends in prevalence of interactions with particular geometry in real crystals.

通过对原分子电子密度函数的 "分子中的原子 "分析,对剑桥结构数据库中的硝基超分子环境进行了处理,结果表明,一个关联体内分子间键合的拓扑稳定性反映了真实晶体中特定几何形状相互作用的流行趋势。
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引用次数: 0
New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies 新吡啶二硫杂蒽醚衍生物:合成、结构表征、硅学和体外生物学研究
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.014
Van T.T. Tran , Nhung T. Dao , Thuyen T. Do , Tam T.T. Pham , Duan T. Le , Victor N. Khrustalev , Phuong T.T. Nguyen , Anh T. Le

New derivatives of dithiaazacrown ethers containing ψ-arylpyridine subunits were prepared based on the Hantzsch synthesis. The obtained compounds showed potential activities toward Hep-G2 cancer cell line, in both in silico and in vitro studies. The compounds were also good ligands for complex chemistry with metal ions due to possessing up to four heteroatoms and relatively big size of the crown ring.

根据汉茨合成法制备了含有ψ-芳基吡啶亚基的二噻唑冠醚新衍生物。所获得的化合物在硅学和体外研究中均显示出对 Hep-G2 癌细胞系的潜在活性。由于这些化合物具有多达四个杂原子和相对较大的冠环尺寸,因此也是与金属离子进行络合化学反应的良好配体。
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引用次数: 0
Synthesis, structure, and photoluminescent properties of a mixed carboxylate pentafluorobenzoate–phenylacetate complex of terbium 五氟苯甲酸-苯乙酸混合羧基铽络合物的合成、结构和光致发光特性
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.005
Natalia V. Gogoleva , Maxim A. Shmelev , Aleksandr S. Chistyakov , Galina A. Razgonyaeva , Vladislav M. Korshunov , Alisia V. Tsorieva , Ilya V. Taydakov , Alexey A. Sidorov , Igor L. Eremenko

A complex of mixed carboxylate pentafluorobenzoate (pfb) and phenylacetate (PhAc), viz. [Tb2(phen)2(pfb)2(PhAc)4] (phen is 1,10-phenanthroline), where each rare earth element (REE) ion is simultaneously coordinated to pentafluorobenzoic and phenylacetic acid anions, was for the first time synthesized and structurally characterized. To evaluate the influence of the second type of anion on the structure and photoluminescent properties, compounds with phenylacetic acid anions [Tb2(phen)2(PhAc)6] and pentafluorobenzoic acid anions [Tb2(EtOH)2(phen)2(pfb)6] were obtained. A change in the composition of the compounds from the phenylacetic acid anion to pentafluorobenzoate led to a change in the geometry of the metal scaffold and the REE polyhedron, a rearrangement of the system of non-covalent interactions according to the Hirshfeld surface analysis, and enhanced luminescence.

首次合成了五氟苯甲酸(pfb)和苯乙酸(PhAc)的混合羧酸根配合物,即[Tb2(phen)2(pfb)2(PhAc)4](phen 为 1,10-菲罗啉),其中每个稀土元素(REE)离子同时与五氟苯甲酸和苯乙酸阴离子配位,并对其进行了结构表征。为了评估第二类阴离子对结构和光致发光特性的影响,我们得到了带有苯乙酸阴离子[Tb2(phen)2(PhAc)6]和五氟苯甲酸阴离子[Tb2(EtOH)2(phen)2(pfb)6]的化合物。将化合物的组成从苯乙酸阴离子改为五氟苯甲酸阴离子,导致金属支架和 REE 多面体的几何形状发生变化,根据 Hirshfeld 表面分析重新排列了非共价相互作用体系,并增强了发光能力。
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引用次数: 0
Cyclization of adiponitrile in the reaction with diphenylzirconocene 己二腈与二苯基锆烯的环化反应
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.026
Maxim V. Andreev , Iuliia A. Akishkina , Vyacheslav S. Bogdanov , Alexander F. Smol’yakov , Vladimir V. Burlakov

Intramolecular cyclization of adiponitrile with the formation of an amidinate functional group in zirconium coordination sphere was found. The obtained complex can be protolyzed with HCl in dioxane to afford a new representative of amidines, namely, 7-phenyl-1,3,4,5-tetrahydro-2H-azepin-2- imine in hydrochloride form.

发现己二腈分子内环化,在锆配位球中形成一个脒基官能团。得到的复合物可在二噁烷中用盐酸进行原解,得到一种新的脒类化合物代表,即盐酸盐形式的 7-苯基-1,3,4,5-四氢-2H-氮杂卓-2-亚胺。
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引用次数: 0
The homodimer approach to the design of a new long-acting depot prodrug of abiraterone 设计阿比特龙新型长效去势原药的同源二聚体方法
IF 1.8 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-07-01 DOI: 10.1016/j.mencom.2024.06.010
Evgeniya V. Nurieva , Oxana Yu. Kravtsova , Anna V. Sydoriuk , Elena V. Britikova , Vladimir V. Britikov , Nikolay A. Zefirov , Elena R. Milaeva , Olga N. Zefirova

The synthesis of homodimeric bis-esters of abiraterone (an inhibitor of androgens synthesis used for treatment of prostate cancer) as a novel depot form of the drug intended for parenteral administration has been undertaken. The conjugate with succinic linker has been synthesized, while only mono-esters of malic and citric acid were obtained. The target ‘twin’ demonstrated excellent characteristics in preliminary biotests, proving the concept of long-lasting depot-prodrug.

我们合成了阿比特龙(一种用于治疗前列腺癌的雄激素合成抑制剂)的同二聚体双酯,作为一种新型的肠外给药形式。我们合成了带有琥珀酸连接剂的共轭物,但只得到了苹果酸和柠檬酸的单酯。目标 "孪生 "在初步生物试验中表现出优异的特性,证明了长效去势药物的概念。
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引用次数: 0
期刊
Mendeleev Communications
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