Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.030
Ya-juan Fan , Dan Wang , Liang Wang , Yongsheng Zhou
A 100% atom-efficient thia-Michael addition process between thiols and α,β -unsaturated carbonyl compounds in a Brønsted acidic deep eutectic solvent at room temperature has been developed. The medium, choline chloride/p-toluene- sulfonic acid, not only showed good catalytic activity, but also could be readily recovered and reused with slight decrease in its activity after successive five runs.
{"title":"Thia-Michael addition in a Brønsted acidic deep eutectic solvent","authors":"Ya-juan Fan , Dan Wang , Liang Wang , Yongsheng Zhou","doi":"10.1016/j.mencom.2024.06.030","DOIUrl":"10.1016/j.mencom.2024.06.030","url":null,"abstract":"<div><p>A 100% atom-efficient thia-Michael addition process between thiols and α,β -unsaturated carbonyl compounds in a Brønsted acidic deep eutectic solvent at room temperature has been developed. The medium, choline chloride/<em>p</em>-toluene- sulfonic acid, not only showed good catalytic activity, but also could be readily recovered and reused with slight decrease in its activity after successive five runs.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.006
Grigory I. Zhdankin , Ivan P. Pozdnyakov , Alexander V. Mikheylis , Vjacheslav P. Grivin , Danila B. Vasilchenko , Alexei A. Melnikov , Sergei V. Chekalin , Evgeni M. Glebov
Using ultrafast transient absorption spectroscopy, primary photophysical processes in aqueous and acetonitrile solutions of the trans,trans,trans-[Ptiv (N3)2(py)2(OH)2] complex, which is interesting as a potential light-activated anticancer drug, were investigated. A mechanism for early photoprocesses has been proposed, including ultrafast intersystem crossing and reductive dissociation.
{"title":"Ultrafast photochemical processes in the complex trans,trans,trans-[Ptiv(py)2(N3)2(OH)2]","authors":"Grigory I. Zhdankin , Ivan P. Pozdnyakov , Alexander V. Mikheylis , Vjacheslav P. Grivin , Danila B. Vasilchenko , Alexei A. Melnikov , Sergei V. Chekalin , Evgeni M. Glebov","doi":"10.1016/j.mencom.2024.06.006","DOIUrl":"10.1016/j.mencom.2024.06.006","url":null,"abstract":"<div><p>Using ultrafast transient absorption spectroscopy, primary photophysical processes in aqueous and acetonitrile solutions of the <em>trans</em>,<em>trans</em>,<em>trans</em>-[Pt<sup>iv</sup> (N<sub>3</sub>)<sub>2</sub>(py)<sub>2</sub>(OH)<sub>2</sub>] complex, which is interesting as a potential light-activated anticancer drug, were investigated. A mechanism for early photoprocesses has been proposed, including ultrafast intersystem crossing and reductive dissociation.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.043
Albina A. Valeeva , Evgeny Yu. Gerasimov , Olga G. Reznitskikh
It was established that the particle size of titanium oxide β-Ti3O5 has a great influence on the processes of phase formation and the stability of particles during heating. It was shown that at a temperature of about 456 K, β-Ti3O5 micro crystals undergo a reversible first-order phase transition, in which the low- temperature β-Ti3O5 phase is transformed into the high-temperature λ- Ti3O5 phase, and at higher temperatures the β-Ti3O5 phase is partially oxidized to form the Magnéli phase Ti4O7. It was found that β-Ti3O5 nanocrystals are unstable in an argon atmosphere and at temperatures above 400 K the β-Ti3O5 powder is oxidized.
{"title":"Effect of particle size of titanium oxide β-Ti3O5 on its thermal stability","authors":"Albina A. Valeeva , Evgeny Yu. Gerasimov , Olga G. Reznitskikh","doi":"10.1016/j.mencom.2024.06.043","DOIUrl":"10.1016/j.mencom.2024.06.043","url":null,"abstract":"<div><p>It was established that the particle size of titanium oxide β-Ti<sub>3</sub>O<sub>5</sub> has a great influence on the processes of phase formation and the stability of particles during heating. It was shown that at a temperature of about 456 K, β-Ti<sub>3</sub>O<sub>5</sub> micro crystals undergo a reversible first-order phase transition, in which the low- temperature β-Ti<sub>3</sub>O<sub>5</sub> phase is transformed into the high-temperature λ- Ti<sub>3</sub>O<sub>5</sub> phase, and at higher temperatures the β-Ti<sub>3</sub>O<sub>5</sub> phase is partially oxidized to form the Magnéli phase Ti<sub>4</sub>O<sub>7</sub>. It was found that β-Ti<sub>3</sub>O<sub>5</sub> nanocrystals are unstable in an argon atmosphere and at temperatures above 400 K the β-Ti<sub>3</sub>O<sub>5</sub> powder is oxidized.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.011
Evgenii I. Rodionov , Alina A. Rodionova , Alla D. Zorina , Olesya V. Khoroshilova , Vitalii V. Suslonov , Elizaveta V. Lider , Yuliya A. Golubeva , Lyubov S. Klyushova , Yuri B. Porozov , Nikolay N. Kuzmich , Rostislav E. Trifonov
A series of new 1’H-tetrazolo[1’,5’-c]-fused 3-aza-A- homosteroids were synthesized by azidation of progesterone, testosterone and hydrocortisone acetate in the presence of silicon tetrachloride. According to NMR spectroscopy and X-ray analysis, two double bond positional isomers (double bond in ring A or in ring B) are formed in various ratios; according to quantum chemical calculations, their energies are close within 0.4 kcal mol-1. Only low cytotoxic activity against Hep-2, MCF-7, HepG2, and Hek293 cell lines was determined in vitro for the compounds obtained.
在四氯化硅存在下,通过对黄体酮、睾酮和醋酸氢化可的松进行叠氮化反应,合成了一系列新的 1'H-四唑并[1',5'-c]-融合 3-aza-A- 同甾类化合物。根据核磁共振光谱和 X 射线分析,以不同比例形成了两种双键位置异构体(双键位于 A 环或 B 环);根据量子化学计算,它们的能量接近 0.4 kcal mol-1。所获得的化合物在体外对 Hep-2、MCF-7、HepG2 和 Hek293 细胞株的细胞毒性较低。
{"title":"Synthesis, structure and cytotoxicity of novel tetrazolo[1’,5’-c]-fused 3-aza-A-homosteroids","authors":"Evgenii I. Rodionov , Alina A. Rodionova , Alla D. Zorina , Olesya V. Khoroshilova , Vitalii V. Suslonov , Elizaveta V. Lider , Yuliya A. Golubeva , Lyubov S. Klyushova , Yuri B. Porozov , Nikolay N. Kuzmich , Rostislav E. Trifonov","doi":"10.1016/j.mencom.2024.06.011","DOIUrl":"10.1016/j.mencom.2024.06.011","url":null,"abstract":"<div><p>A series of new 1<em>’H</em>-tetrazolo[1<em>’</em>,5<em>’</em>-<em>c</em>]-fused 3-aza-A- homosteroids were synthesized by azidation of progesterone, testosterone and hydrocortisone acetate in the presence of silicon tetrachloride. According to NMR spectroscopy and X-ray analysis, two double bond positional isomers (double bond in ring A or in ring B) are formed in various ratios; according to quantum chemical calculations, their energies are close within 0.4 kcal mol<sup>-1</sup>. Only low cytotoxic activity against Hep-2, MCF-7, HepG2, and Hek293 cell lines was determined <em>in vitro</em> for the compounds obtained.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.024
Ilya I. Marochkin , Pavel Yu. Sharanov , Vladimir V. Kuznetsov , Igor F. Shishkov , Yulia V. Novakovskaya
Based on gas electron diffraction experiments supported by quantum chemical simulations, the molecular structure of 6-phenyl-1,5-diazabicyclo[3.1.0]hexane (PhDBH) in the gas phase was determined, which is characterized by the puckering motion of the five-membered ring typical of bicyclo[3.1.0]- hexanes. It was found that the previously determined crystal packing is accompanied by a certain torsional twisting of the molecule, requiring activation energy. Based on the simulations of PhDBH clusters, it was shown that the energy is compensated by intermolecular interactions.
{"title":"6-Phenyl-1,5-diazabicyclo[3.1.0]hexane: structure variations going from gas to crystal phase","authors":"Ilya I. Marochkin , Pavel Yu. Sharanov , Vladimir V. Kuznetsov , Igor F. Shishkov , Yulia V. Novakovskaya","doi":"10.1016/j.mencom.2024.06.024","DOIUrl":"10.1016/j.mencom.2024.06.024","url":null,"abstract":"<div><p>Based on gas electron diffraction experiments supported by quantum chemical simulations, the molecular structure of 6-phenyl-1,5-diazabicyclo[3.1.0]hexane (PhDBH) in the gas phase was determined, which is characterized by the puckering motion of the five-membered ring typical of bicyclo[3.1.0]- hexanes. It was found that the previously determined crystal packing is accompanied by a certain torsional twisting of the molecule, requiring activation energy. Based on the simulations of PhDBH clusters, it was shown that the energy is compensated by intermolecular interactions.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.023
Ivan V. Ananyev, Leonid L. Fershtat
Based on the processing of supramolecular environments of nitro group from Cambridge Structural Database by means of the ‘Atoms in Molecules’ analysis of promolecular electron density function, it is demonstrated that the topological stability of intermolecular bonding within one associate reflects trends in prevalence of interactions with particular geometry in real crystals.
{"title":"Probing transferability of intermolecular interactions by their features: a nitro group case study","authors":"Ivan V. Ananyev, Leonid L. Fershtat","doi":"10.1016/j.mencom.2024.06.023","DOIUrl":"10.1016/j.mencom.2024.06.023","url":null,"abstract":"<div><p>Based on the processing of supramolecular environments of nitro group from Cambridge Structural Database by means of the ‘Atoms in Molecules’ analysis of promolecular electron density function, it is demonstrated that the topological stability of intermolecular bonding within one associate reflects trends in prevalence of interactions with particular geometry in real crystals.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.014
Van T.T. Tran , Nhung T. Dao , Thuyen T. Do , Tam T.T. Pham , Duan T. Le , Victor N. Khrustalev , Phuong T.T. Nguyen , Anh T. Le
New derivatives of dithiaazacrown ethers containing ψ-arylpyridine subunits were prepared based on the Hantzsch synthesis. The obtained compounds showed potential activities toward Hep-G2 cancer cell line, in both in silico and in vitro studies. The compounds were also good ligands for complex chemistry with metal ions due to possessing up to four heteroatoms and relatively big size of the crown ring.
{"title":"New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies","authors":"Van T.T. Tran , Nhung T. Dao , Thuyen T. Do , Tam T.T. Pham , Duan T. Le , Victor N. Khrustalev , Phuong T.T. Nguyen , Anh T. Le","doi":"10.1016/j.mencom.2024.06.014","DOIUrl":"10.1016/j.mencom.2024.06.014","url":null,"abstract":"<div><p>New derivatives of dithiaazacrown ethers containing ψ-arylpyridine subunits were prepared based on the Hantzsch synthesis. The obtained compounds showed potential activities toward Hep-G2 cancer cell line, in both <em>in silico</em> and <em>in vitro</em> studies. The compounds were also good ligands for complex chemistry with metal ions due to possessing up to four heteroatoms and relatively big size of the crown ring.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.005
Natalia V. Gogoleva , Maxim A. Shmelev , Aleksandr S. Chistyakov , Galina A. Razgonyaeva , Vladislav M. Korshunov , Alisia V. Tsorieva , Ilya V. Taydakov , Alexey A. Sidorov , Igor L. Eremenko
A complex of mixed carboxylate pentafluorobenzoate (pfb) and phenylacetate (PhAc), viz. [Tb2(phen)2(pfb)2(PhAc)4] (phen is 1,10-phenanthroline), where each rare earth element (REE) ion is simultaneously coordinated to pentafluorobenzoic and phenylacetic acid anions, was for the first time synthesized and structurally characterized. To evaluate the influence of the second type of anion on the structure and photoluminescent properties, compounds with phenylacetic acid anions [Tb2(phen)2(PhAc)6] and pentafluorobenzoic acid anions [Tb2(EtOH)2(phen)2(pfb)6] were obtained. A change in the composition of the compounds from the phenylacetic acid anion to pentafluorobenzoate led to a change in the geometry of the metal scaffold and the REE polyhedron, a rearrangement of the system of non-covalent interactions according to the Hirshfeld surface analysis, and enhanced luminescence.
{"title":"Synthesis, structure, and photoluminescent properties of a mixed carboxylate pentafluorobenzoate–phenylacetate complex of terbium","authors":"Natalia V. Gogoleva , Maxim A. Shmelev , Aleksandr S. Chistyakov , Galina A. Razgonyaeva , Vladislav M. Korshunov , Alisia V. Tsorieva , Ilya V. Taydakov , Alexey A. Sidorov , Igor L. Eremenko","doi":"10.1016/j.mencom.2024.06.005","DOIUrl":"10.1016/j.mencom.2024.06.005","url":null,"abstract":"<div><p>A complex of mixed carboxylate pentafluorobenzoate (pfb) and phenylacetate (PhAc), <em>viz</em>. [Tb<sub>2</sub>(phen)<sub>2</sub>(pfb)<sub>2</sub>(PhAc)<sub>4</sub>] (phen is 1,10-phenanthroline), where each rare earth element (REE) ion is simultaneously coordinated to pentafluorobenzoic and phenylacetic acid anions, was for the first time synthesized and structurally characterized. To evaluate the influence of the second type of anion on the structure and photoluminescent properties, compounds with phenylacetic acid anions [Tb<sub>2</sub>(phen)<sub>2</sub>(PhAc)<sub>6</sub>] and pentafluorobenzoic acid anions [Tb<sub>2</sub>(EtOH)<sub>2</sub>(phen)<sub>2</sub>(pfb)<sub>6</sub>] were obtained. A change in the composition of the compounds from the phenylacetic acid anion to pentafluorobenzoate led to a change in the geometry of the metal scaffold and the REE polyhedron, a rearrangement of the system of non-covalent interactions according to the Hirshfeld surface analysis, and enhanced luminescence.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.026
Maxim V. Andreev , Iuliia A. Akishkina , Vyacheslav S. Bogdanov , Alexander F. Smol’yakov , Vladimir V. Burlakov
Intramolecular cyclization of adiponitrile with the formation of an amidinate functional group in zirconium coordination sphere was found. The obtained complex can be protolyzed with HCl in dioxane to afford a new representative of amidines, namely, 7-phenyl-1,3,4,5-tetrahydro-2H-azepin-2- imine in hydrochloride form.
{"title":"Cyclization of adiponitrile in the reaction with diphenylzirconocene","authors":"Maxim V. Andreev , Iuliia A. Akishkina , Vyacheslav S. Bogdanov , Alexander F. Smol’yakov , Vladimir V. Burlakov","doi":"10.1016/j.mencom.2024.06.026","DOIUrl":"10.1016/j.mencom.2024.06.026","url":null,"abstract":"<div><p>Intramolecular cyclization of adiponitrile with the formation of an amidinate functional group in zirconium coordination sphere was found. The obtained complex can be protolyzed with HCl in dioxane to afford a new representative of amidines, namely, 7-phenyl-1,3,4,5-tetrahydro-2<em>H</em>-azepin-2- imine in hydrochloride form.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.mencom.2024.06.010
Evgeniya V. Nurieva , Oxana Yu. Kravtsova , Anna V. Sydoriuk , Elena V. Britikova , Vladimir V. Britikov , Nikolay A. Zefirov , Elena R. Milaeva , Olga N. Zefirova
The synthesis of homodimeric bis-esters of abiraterone (an inhibitor of androgens synthesis used for treatment of prostate cancer) as a novel depot form of the drug intended for parenteral administration has been undertaken. The conjugate with succinic linker has been synthesized, while only mono-esters of malic and citric acid were obtained. The target ‘twin’ demonstrated excellent characteristics in preliminary biotests, proving the concept of long-lasting depot-prodrug.
{"title":"The homodimer approach to the design of a new long-acting depot prodrug of abiraterone","authors":"Evgeniya V. Nurieva , Oxana Yu. Kravtsova , Anna V. Sydoriuk , Elena V. Britikova , Vladimir V. Britikov , Nikolay A. Zefirov , Elena R. Milaeva , Olga N. Zefirova","doi":"10.1016/j.mencom.2024.06.010","DOIUrl":"10.1016/j.mencom.2024.06.010","url":null,"abstract":"<div><p>The synthesis of homodimeric bis<em>-</em>esters of abiraterone (an inhibitor of androgens synthesis used for treatment of prostate cancer) as a novel depot form of the drug intended for parenteral administration has been undertaken. The conjugate with succinic linker has been synthesized, while only mono-esters of malic and citric acid were obtained. The target ‘twin’ demonstrated excellent characteristics in preliminary biotests, proving the concept of long-lasting depot-prodrug.</p></div>","PeriodicalId":18542,"journal":{"name":"Mendeleev Communications","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}