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Simulation and modeling of high-sensitive JL-TFET based biosensor for label free detection of biomolecules 基于 JL-TFET 的高灵敏度生物传感器的仿真与建模,用于无标记生物分子检测
Pub Date : 2024-05-04 DOI: 10.1007/s00542-024-05638-7
Pratikhya Raut, Deepak Kumar Panda, Umakanta Nanda, Chih-Chieh Hsu

A biosensor employing a junctionless TFET (JL-TEFT) to identify different protein molecules is modelled and investigated in this paper. The JLTFET is chosen for designing the biosensor because of its superiority over TFET and JLFET. The biomolecules can be captured in this type of devices by creating cavities across the gate. Various output parameters of label free biosensing with respect to various dielectric constants was studied using TCAD simulator. This article further portrays current and voltage sensitivity. This paper also investigates the fill factor impact of size of biomolecules and cavity positioning on the performance of biosensor. The dielectric modulation method for identifying a range of proteins and amino acids is being investigated through simulations. The sensitivity of JLTFET-based biosensors was found to be 1013. The novelties in this manuscript is that for the first time, an analytical mathematical model of a triple material gate asymmetrical hetero-dielectric JLTFET biosensor has been derived here. The developed model is not having any empirical parameter. Hence the proposed model is faster. Besides exhibiting increased sensitivity when compared to previous FET and TFET-based biosensors, this device also shows its suitability for low-power applications, hence providing a multitude of avenues for future exploration.

本文对一种采用无结 TFET(JL-TEFT)来识别不同蛋白质分子的生物传感器进行了建模和研究。之所以选择 JLTFET 设计生物传感器,是因为它优于 TFET 和 JLFET。通过在栅极上形成空腔,生物分子可以被捕捉到。使用 TCAD 模拟器研究了无标记生物传感的各种输出参数与各种介电常数的关系。本文进一步描述了电流和电压灵敏度。本文还研究了生物分子大小和空腔定位对生物传感器性能的填充因子影响。通过模拟研究了用于识别一系列蛋白质和氨基酸的介电调制方法。结果发现,基于 JLTFET 的生物传感器的灵敏度为 1013。本手稿的新颖之处在于首次推导出了三重材料栅非对称异质介电 JLTFET 生物传感器的分析数学模型。所建立的模型没有任何经验参数。因此,所提出的模型速度更快。与以前基于 FET 和 TFET 的生物传感器相比,该器件除了灵敏度更高之外,还显示出其适合低功耗应用,因此为未来的探索提供了多种途径。
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引用次数: 0
Harmonics reduction and power quality improvement in distributed power flow controller by SVPWM and MGWO technique 利用 SVPWM 和 MGWO 技术降低分布式功率流控制器中的谐波并改善电能质量
Pub Date : 2024-05-02 DOI: 10.1007/s00542-024-05647-6
Subhasis Bandopadhyay, Atanu Bandyopadhyay, Ashoke Mondal, Pradip kumar Sadhu

The Distributed power flow controller can be considered as advance power flow controller which is combination of series and shunt compensator without DC link. In this paper Space vector Pulse width Modulation employs in Distributed power flow Controller for Harmonics Reduction and power quality improvement. A new technique SVPWM adopted which reduces the harmonics and the same time improves power quality and increase transient stability. In this paper a new technique of Multi objective Grey wolf algorithm used to optimize the controller parameter of DPFC. For the design of PI controller GWO algorithm can be used for better optimistic performance of DPFC. As a result of that power quality and voltage profile improves drastically and the same time harmonics also reduced remarkable level of 4.62% of Voltage THD and 1.8% of current THD. The simulation result and hardware model Prove the feasibility of proposed Configuration.

分布式功率流控制器可视为先进的功率流控制器,它是串联和并联补偿器的组合,不带直流链路。本文将空间矢量脉宽调制应用于分布式功率流控制器,以减少谐波并改善电能质量。所采用的新技术 SVPWM 可减少谐波,同时改善电能质量并提高瞬态稳定性。本文采用多目标灰狼算法这一新技术来优化 DPFC 的控制器参数。在设计 PI 控制器时,可以使用 GWO 算法来优化 DPFC 的性能。因此,电能质量和电压曲线大幅改善,同时谐波也显著降低,电压总谐波失真(THD)为 4.62%,电流总谐波失真(THD)为 1.8%。仿真结果和硬件模型证明了拟议配置的可行性。
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引用次数: 0
Design, simulation and analog/RF performance evaluation of a hetero-stacked source dual metal T-shaped gate tunnel-FET in thermally variable environments 热变化环境下异质叠层源双金属 T 型栅隧道场效应晶体管的设计、仿真和模拟/射频性能评估
Pub Date : 2024-05-02 DOI: 10.1007/s00542-024-05677-0
Mukesh Kumar, Gautam Bhaskar, Aditya Chotalia, Chhavi Rani, Puja Ghosh, Soumak Nandi, Shashank Kumar Dubey, Kalyan Koley, Aminul Islam

In this work, a new Hetero-Stacked Source Dual Metal T-shaped Gate Silicon-on-Insulator (SOI) TFET (HS-DMTG-TFET) is proposed, exhibiting significantly improved DC performance, and switching performance over existing TFET topologies. A low threshold voltage of less than 200 mV in the proposed device allows for its integration in a variety of low-power applications. This device has been proposed in response to an acute need for low-power devices for bio-sensing, in situ memory, and loss-minimized switching. The proposed structure incorporates an overlapped gate pocket with a dual metal molybdenum-aluminum gate. The inclusion of a source side pocket improves the tunneling of charge carriers, which enhances the ON-state current. The Band-to-Band-Tunneling (BTBT) characteristic of TG-TFET in a direction perpendicular to the channel contributes to an elevated ON-current, attributed to a comparatively larger tunneling area. The channel exhibits a vertical U-shape, making the proposed device more scalable as compared to existing TFETs. A series of dimension and material-specific optimizations have been made and showcased in this work along with physical reasoning for the observed improvements. An ION/IOFF ratio of ~ 1014 is achieved with an ION of 1.05 × 10–3 A/μm and an IOFF of 1.35 × 10–17 A/μm. A highly reduced sub-threshold slope (lower is better) of 10.7 mV/dec is observed, indicating the good transient performance of the device. Considerable improvement in RF performance of the device has been showcased. The temperature dependence on transfer and RF characteristics has been also analyzed. The exhibited device characteristics indicate the potential of using composite material gates for low-power applications over their conventional single-metal counterparts. Reduced power consumption coupled with a compact device structure results in a minimally invasive device, suitable for low-power wearable sensors and bio-integrable circuits.

本研究提出了一种新型异质堆叠源双金属 T 型栅极绝缘体上硅(SOI)TFET(HS-DMTG-TFET),与现有的 TFET 拓扑相比,其直流性能和开关性能均有显著提高。该器件的阈值电压低于 200 mV,可集成到各种低功耗应用中。该器件的提出是为了满足生物传感、原位存储器和损耗最小开关对低功耗器件的迫切需求。所提出的结构包含一个重叠栅极袋和一个双金属钼铝栅极。源侧口袋的加入改善了电荷载流子的隧道效应,从而增强了导通态电流。TG-TFET 在垂直于沟道方向上的带对带隧道(BTBT)特性有助于提高导通电流,这归功于相对较大的隧道面积。沟道呈垂直 U 形,因此与现有的 TFET 相比,所提出的器件更具可扩展性。本研究对器件的尺寸和特定材料进行了一系列优化,并展示了所观察到的改进的物理原理。在离子强度为 1.05 × 10-3 A/μm 和离子强度为 1.35 × 10-17 A/μm 的情况下,离子强度/离子强度比达到了 ~ 1014。阈下斜率(越低越好)大幅降低至 10.7 mV/dec,表明该器件具有良好的瞬态性能。该器件的射频性能也得到了显著改善。此外,还分析了温度对传输和射频特性的影响。所展示的器件特性表明,在低功耗应用中使用复合材料栅极比使用传统的单金属栅极更有潜力。功耗的降低与紧凑的器件结构相结合,造就了一种微创器件,适用于低功耗可穿戴传感器和生物集成电路。
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引用次数: 0
Design and analysis of micro inertial switch with magnetic latch and adjustable threshold 带磁锁存器和可调阈值的微型惯性开关的设计与分析
Pub Date : 2024-05-01 DOI: 10.1007/s00542-024-05652-9
Xinyue Wang, Chao Zhi, Yanjun Li, Mingshan Qu, Zhuang Xiong

In this paper, a novel microelectromechanical system (MEMS) inertial switch with self-latching mechanism and adjustable acceleration threshold is proposed. The switch consisted of a proof mass suspended by flexible springs. Permanent magnets, ferromagnets and planer coils were integrated in the device to realize the latching and threshold tuning mechanism. The centrifugal experiment and laser based position measurement have been conducted to measure the acceleration threshold and the stiffness of the spring respectively. The inertial threshold value and the spring stiffness were measured as 5.27 g and 163.12 N/m. The discrepancy between measured acceleration threshold results (5.27 g) and the analytical acceleration threshold results (5 g) is mainly due to the dimension errors during device fabrication. By applying a reverse current of 0.1 A, the switch can be unlatched from its ‘on-state’. Experiment also demonstrates that by applying a current varying from − 0.5 A to 0.5 A, the threshold value can be adjusted from 6 g to 3.75 g.

本文提出了一种新型微机电系统(MEMS)惯性开关,具有自锁机制和可调加速度阈值。该开关由一个由柔性弹簧悬挂的质量块组成。装置中集成了永磁体、铁磁体和刨线圈,以实现闭锁和阈值调节机制。为了测量加速度阈值和弹簧刚度,分别进行了离心实验和激光位置测量。测得的惯性阈值和弹簧刚度分别为 5.27 g 和 163.12 N/m。加速度阈值测量结果(5.27 g)与加速度阈值分析结果(5 g)之间的差异主要是由于器件制造过程中的尺寸误差造成的。通过施加 0.1 A 的反向电流,开关可以从 "导通状态 "解锁。实验还表明,通过施加 - 0.5 A 至 0.5 A 的电流,阈值可从 6 g 调整到 3.75 g。
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引用次数: 0
Numerical study of a novel electroosmotic active micromixer with twin diamond-shaped chambers and sawteeth 带有双菱形腔体和锯齿的新型电渗活性微搅拌器的数值研究
Pub Date : 2024-04-30 DOI: 10.1007/s00542-024-05671-6
Liqiang Zhang, Zhuoran Zhou, Jiakang Shi, Yuanshi Wei, Sicheng Yu, Heather Almond

Microfluidic technology is widely used in biomedicine, chemical analysis, and environmental improvement. Improvement of the mixing quality of low Reynolds number flows in micro-dimensional devices is essential. In this paper, we present a novel electroosmotic micromixer with twin diamond-shaped chambers and sawteeth, that can broaden the mixing space and boost the local velocity. The fluids are disturbed and folded due to the electroosmotic flow generated by electrodes on the chambers. The comprehensive analysis of the flow characteristics, the mixing performance and pressure drop of the micromixer of different parameters have been carried out. The findings demonstrate that each of these designs is good for efficient mixing, and numerous vortices are generated in the chambers. After optimizing the parameters, the best mixing efficiency can reach 99.9% in one second. The novel structure proposed in this paper provides a simple and effective method for mixing in the field of micro-total-analysis systems.

微流体技术广泛应用于生物医学、化学分析和环境改善等领域。提高微维装置中低雷诺数流动的混合质量至关重要。本文介绍了一种新型电渗微搅拌器,它具有双菱形腔体和锯齿,可拓宽混合空间并提高局部速度。由于腔室上的电极产生电渗流,流体受到扰动和折叠。我们对不同参数的微搅拌器的流动特性、搅拌性能和压降进行了综合分析。研究结果表明,每种设计都能很好地实现高效混合,并在腔体内产生大量涡流。优化参数后,最佳混合效率可在一秒钟内达到 99.9%。本文提出的新结构为微全分析系统领域提供了一种简单有效的混合方法。
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引用次数: 0
Design and performance analysis of charge plasma TFET for biosensor applications: a simulation study 用于生物传感器应用的电荷等离子体 TFET 的设计和性能分析:模拟研究
Pub Date : 2024-04-30 DOI: 10.1007/s00542-024-05678-z
D. Manaswi, Srinivas Rao Karumuri

The paper presents a new design of a CP JLTFET, which is a type of transistor with potential applications in various electronic devices. The proposed CP JLTFET design is aimed at improving the ON current and surface potentials of the device. These improvements are essential for enhancing the device’s functionality. The source and drain regions in the intrinsic silicon material are induced using appropriate metal work functions. This design choice is made for ease of fabrication, which is a critical consideration in semiconductor device manufacturing. The cavity length is varied between 8 and 10 nm, and different dielectric constants are used in the simulation. These variations are designed to optimize the ON state performance of the device, including ON drive current, potential, and electric field. The increase in tunneling of electrons is attributed to high carrier recombination in the channel region. Carrier recombination is a key factor in device behavior and performance. The paper describes the simulation of various electrical parameters of the proposed device. This likely includes drain current, surface potentials, electric field, and energy bands. The excellent performance parameters of the proposed device, when combined with appropriate materials and the introduction of a cavity, make it suitable for sensing applications of biomolecules. The paper suggests that the excellent performance parameters of the proposed device, when combined with appropriate materials and the introduction of a cavity in the device, make it suitable for sensing applications, particularly for detecting biomolecules.

本文介绍了一种 CP JLTFET 的新设计,这是一种在各种电子设备中具有潜在应用价值的晶体管。所提出的 CP JLTFET 设计旨在改善器件的导通电流和表面电位。这些改进对于提高器件的功能至关重要。本征硅材料中的源极和漏极区域采用适当的金属功函数进行诱导。这种设计选择是为了便于制造,这也是半导体器件制造中的一个重要考虑因素。空腔长度在 8 纳米和 10 纳米之间变化,模拟中使用了不同的介电常数。这些变化旨在优化器件的导通状态性能,包括导通驱动电流、电势和电场。电子隧道效应的增加归因于沟道区的高载流子重组。载流子重组是影响器件行为和性能的关键因素。论文介绍了对所提器件各种电气参数的模拟。其中可能包括漏极电流、表面电位、电场和能带。结合适当的材料和空腔的引入,拟议器件的优异性能参数使其适合于生物分子的传感应用。该论文表明,如果结合适当的材料并在器件中引入空腔,所提出的器件具有出色的性能参数,使其适合于传感应用,特别是用于检测生物分子。
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引用次数: 0
Numerical investigation of planar microcoils integrated in microfluidic devices for biological applications 用于生物应用的微流体设备中集成平面微线圈的数值研究
Pub Date : 2024-04-29 DOI: 10.1007/s00542-024-05674-3
Abdelghani Benbrahim, Halima Benchenane, Salim Hammar, Benaoumeur Aour, Nasreddine Mekkakia-Maaza

The objective of this work is to create a finite element model of different magnetic actuator topologies using COMSOL Multiphysics software. The aim is to simulate and improve the magnetic field generated by different planar microcoil topologies while minimising energy dissipation. The magnetic field generated by square and circular spiral planar microcoils was compared with that produced by serpentine meander planar microcoils. It has been found that the trapping efficiency in a magnetic manipulation microfluidic system for biological applications is closely linked to the geometry and electrical parameters of the planar microcoils. In addition, the location of these microcoils within the microfluidic channel intended for the circulation of the paramagnetic microbeads also play a crucial role. The obtained results show that bu reducing the inter-turn spacing using a thinner conductor cross-section and injected a higher electrical intensity in the actuator, both the magnetic field strength and its gradient can be increased, and therefore cause a higher magnetic actuation force.

这项工作的目的是使用 COMSOL Multiphysics 软件创建不同磁致动器拓扑结构的有限元模型。目的是模拟和改进不同平面微线圈拓扑结构产生的磁场,同时尽量减少能量耗散。方形和圆形螺旋平面微线圈产生的磁场与蛇形蜿蜒平面微线圈产生的磁场进行了比较。研究发现,用于生物应用的磁操控微流控系统的捕获效率与平面微线圈的几何形状和电气参数密切相关。此外,这些微线圈在用于顺磁微珠循环的微流体通道中的位置也起着至关重要的作用。研究结果表明,使用较薄的导体截面减小线圈间距,并在致动器中注入较高的电强度,可以增加磁场强度及其梯度,从而产生较高的磁致动力。
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引用次数: 0
Optimizing dosage in linear accelerator based on predictive analysis of radiation induced skin toxicity using machine learning techniques 利用机器学习技术对辐射引起的皮肤毒性进行预测分析,优化直线加速器的剂量
Pub Date : 2024-04-26 DOI: 10.1007/s00542-024-05676-1
Souvik Sengupta, Biplab Sarkar, Imama Ajmi, Abhishek Das

Modern radiotherapy planning and dose delivery utilize treatment planning systems (TPS) with medical linear accelerator (LINAC). A TPS is a specialized computer system that simulates values for the parameters of LINAC for radiation therapy delivery, including gantry movement, collimator angle, and dose calculation. The rule-based approach for a treatment plan is often found inaccurate due to the diverse nature of tumors and skin sensitivity in patients. Radiation-Induced Skin Toxicity (RIST) represents a significant adverse consequence of radiotherapy, impacting the well-being of cancer patients. To optimize radiation treatment and minimize RIST, the development of effective predictive and assessment methods is essential. Recent years have witnessed a surge in the application of artificial intelligence and machine learning to various aspects of radiation therapy, particularly in the prediction and grading of RIST. This study offers a comparative evaluation of the performance of diverse machine learning models for the screening and grading of RIST severity. Furthermore, it focuses on the identification of the most influential feature set for this classification task. Our dataset comprises 2000 records, incorporating 18 clinical attributes from patients who underwent radiotherapy treatment at an Indian hospital. We conduct thorough statistical analyses of features derived from these clinical attributes, utilizing different feature subsets for model training and evaluation. Intriguingly, we find that by utilizing just five selected clinical attributes, machine learning models achieve nearly equivalent performance to using the entire attribute set. In terms of model performance, Support Vector Machine excels in the screening task, while Multi-layer Perceptron stands out in the gradation task among single models. Within the ensemble methods, Random Forest surpasses AdaBoost in both the screening and gradation tasks.

现代放射治疗计划和剂量输送利用医用直线加速器(LINAC)治疗计划系统(TPS)。TPS 是一种专门的计算机系统,可模拟用于放射治疗的 LINAC 参数值,包括龙门移动、准直器角度和剂量计算。由于肿瘤和患者皮肤敏感性的不同,基于规则的治疗方案往往不准确。辐射引起的皮肤毒性(RIST)是放疗的一个重要不良后果,影响着癌症患者的健康。为了优化放射治疗并最大限度地减少 RIST,开发有效的预测和评估方法至关重要。近年来,人工智能和机器学习在放射治疗各个方面的应用激增,尤其是在 RIST 的预测和分级方面。本研究比较评估了各种机器学习模型在筛选和分级 RIST 严重程度方面的性能。此外,本研究还侧重于确定对该分类任务最具影响力的特征集。我们的数据集由 2000 条记录组成,包含在一家印度医院接受放疗的患者的 18 个临床属性。我们利用不同的特征子集进行模型训练和评估,对从这些临床属性中得出的特征进行了全面的统计分析。有趣的是,我们发现仅利用五个选定的临床属性,机器学习模型就能达到与使用整个属性集几乎相当的性能。就模型性能而言,支持向量机在筛选任务中表现出色,而多层感知器则在单一模型的分级任务中脱颖而出。在集合方法中,随机森林在筛选和分级任务中都超过了 AdaBoost。
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引用次数: 0
Design, modeling, and analysis of a new XYθ piezoelectric microstage featuring high amplification ratios and multiple actuation modes 新型 XYθ 压电微型平台的设计、建模和分析,具有高放大比和多种驱动模式
Pub Date : 2024-04-26 DOI: 10.1007/s00542-024-05670-7
Gaohua Wu, Guoping Li, Yiling Yang, Yanding Wei

This paper presents the design, modeling, and analysis of a new XYθ piezoelectric microstage with high amplification ratios and fully symmetrical structures. Through the reconfigurable assembly positions of piezoelectric actuators, the proposed microstage can provide multiple actuation modes and low translational parasitic motion. The microstage is devised using improved four-bar amplification mechanisms and parallelogram guiding mechanisms. Based on the matrix-based compliance modeling, static and dynamic models are obtained. The theoretical models are analyzed by finite element analysis (FEA). Finally, a prototype of the proposed microstage is manufactured, an experimental system is set up, and the performance of the microstage is tested. The experimental results show that the microstage has amplification ratios of 8.40 (x-axis) and 8.52 (y-axis). The displacement coupling ratios in the x- and y-axis directions are 0.83% and 0.94%, respectively. Moreover, the maximum rotation angle is ± 2379.18 μrad when the microstage uses the actuation mode of the pure center rotation. The XYθ microstage is capable of multiscale micromanipulation.

本文介绍了具有高放大比和完全对称结构的新型 XYθ 压电微平台的设计、建模和分析。通过可重新配置压电致动器的装配位置,所提出的微平台可提供多种致动模式和低平移寄生运动。该微型平台采用改进的四杆放大机构和平行四边形导向机构。在基于矩阵的顺应性建模基础上,获得了静态和动态模型。通过有限元分析(FEA)对理论模型进行了分析。最后,制造了拟议微舞台的原型,建立了实验系统,并测试了微舞台的性能。实验结果表明,微舞台的放大比率为 8.40(x 轴)和 8.52(y 轴)。x 轴和 y 轴方向的位移耦合比分别为 0.83% 和 0.94%。此外,当微动平台使用纯中心旋转的驱动模式时,最大旋转角度为 ± 2379.18 μrad。XYθ 微型平台能够进行多尺度微操作。
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引用次数: 0
The effect of the surface passivation on polymerase chain reaction inside a continuous flow microfluidic chip 表面钝化对连续流微流体芯片内聚合酶链反应的影响
Pub Date : 2024-04-24 DOI: 10.1007/s00542-024-05675-2
Jyh Jian Chen, Xian Cheng Qiu
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引用次数: 0
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Microsystem Technologies
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