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Quantitative risk assessment of respiratory exposure to acrylonitrile vapor in petrochemical industry by U.S. Environmental Protection Agency method: a cross-sectional study. 美国环境保护署方法对石化工业中丙烯腈蒸气呼吸暴露的定量风险评估:一项横断面研究。
IF 2.9 Q1 Medicine Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.350859
Ali Asghar Sajedian, Ali Karimi, Mohsen Sadeghi Yarandi, Vahid Ahmadi Moshiran, Aysa Ghasemi Koozekonan, Farideh Golbabaei

Acrylonitrile is a potential carcinogen for humans, and exposure to this substance can cause adverse effects for workers. This study aimed to carcinogenic and health risk assessment of acrylonitrile vapor exposure in exposed personnel of a petrochemical complex. This crosssectional study was performed in 2019 in a petrochemical complex. In this study, to sample and determine acrylonitrile's respiratory exposure, the method provided by the National Institute of Occupational Safety and Health (NIOSH 1601) was used, and a total of 45 inhaled air samples were sampled from men workers, aged 39.43 ± 9.37 years. All subjects' mean exposure to acrylonitrile vapors was 71.1 ± 122.8 μg/m3. Also, the mean exposure index among all subjects was 0.02 ± 0.034. The non-carcinogenic risk assessment results showed that the mean Hazard quotient index was 4.04 ± 6.93. The mean lifetime cancer risk index was also 2.1 × 10-3 ± 3.5 × 10-3 and was in the definite risk range. Considering that both carcinogenicity and health indicators of exposure to acrylonitrile in the studied petrochemical complex are more than the recommended limits, the necessary engineering and management measures to control and manage the risk to an acceptable level are essential to improving the worker's health.

丙烯腈是一种潜在的人类致癌物,接触这种物质会对工人造成不良影响。本研究旨在对某石化企业作业人员接触丙烯腈蒸气的致癌性和健康风险进行评价。这项横断面研究于2019年在一家石化综合企业进行。本研究采用美国国家职业安全卫生研究所(NIOSH 1601)提供的方法,采集了45份男性工人吸入空气样本,年龄39.43±9.37岁。所有受试者的丙烯腈蒸气平均暴露量为71.1±122.8 μg/m3。所有受试者的平均暴露指数为0.02±0.034。非致癌风险评价结果显示,平均危害商指数为4.04±6.93。平均终生癌症危险指数为2.1 × 10-3±3.5 × 10-3,处于明确的危险范围。考虑到所研究的石化企业丙烯腈暴露的致癌性和健康指标均超过建议限值,采取必要的工程和管理措施,将风险控制和管理到可接受的水平,对改善工人的健康至关重要。
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引用次数: 0
Nitric oxide therapy is beneficial to rehabilitation in professional soccer players: clinical and experimental studies. 一氧化氮治疗对职业足球运动员康复有益:临床和实验研究。
IF 2.9 Q1 Medicine Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.344983
Victoria A Zaborova, Alexandra V Butenko, Anatoly B Shekhter, Alexey L Fayzullin, Alexander V Pekshev, Natalia B Serejnikova, Ol'ga V Chigirintseva, Kira Yu Kryuchkova, Konstantin G Gurevich

Nitric oxide can activate neutrophils and macrophages, facilitate the synthesis of collagen, which allows significantly accelerating the regeneration of traumatized tissues. We studied the effects of nitric oxide-containing gas flow generated by plasma-chemical device "Plason" in a rat model of full-thickness wounds. Histological and morphometric analyses revealed that Plason treated wounds expressed significantly fewer signs of inflammation and contained a more mature granulation tissue on day 4 after the operation. Considering the results of the experimental study, we applied the Plason device in sports medicine for the treatment of lower limb bruises of 34 professional soccer players. Athletes were asked to assess the intensity of pain with the Visual Analogue Scale. Girths of their lower limbs were measured over the course of rehabilitation. Nitric oxide therapy of full-thickness wounds inhibited inflammation and accelerated the regeneration of skin and muscle tissues. Compared with the control, we observed a significant reduction in pain syndrome on days 2-7 after injuries, edema, and hematoma, and shortened treatment duration. This pilot study indicates that the use of nitric oxide is a promising treatment method for sports injuries.

一氧化氮可以激活中性粒细胞和巨噬细胞,促进胶原蛋白的合成,从而显著加速创伤组织的再生。我们研究了等离子体化学装置“等离子体”产生的含一氧化氮气体流对大鼠全层伤口模型的影响。组织学和形态计量学分析显示,等离子体治疗的伤口在手术后第4天炎症症状明显减少,肉芽组织更成熟。结合实验研究结果,我们将等离子体装置应用于运动医学,对34名职业足球运动员下肢擦伤进行治疗。运动员被要求用视觉模拟量表评估疼痛的强度。在康复过程中测量了他们的下肢周长。一氧化氮治疗全层创面能抑制炎症,促进皮肤和肌肉组织的再生。与对照组相比,我们观察到损伤后2-7天疼痛综合征、水肿和血肿明显减轻,治疗时间缩短。这项初步研究表明,使用一氧化氮是一种很有前途的治疗运动损伤的方法。
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引用次数: 1
H2-induced transient upregulation of phospholipids with suppression of energy metabolism. h2诱导的瞬时磷脂上调与能量代谢的抑制。
IF 2.9 Q1 Medicine Pub Date : 2023-07-01 DOI: 10.4103/2045-9912.344973
Masumi Iketani, Iwao Sakane, Yasunori Fujita, Masafumi Ito, Ikuroh Ohsawa

Molecular hydrogen (H2) is an antioxidant and anti-inflammatory agent; however, the molecular mechanisms underlying its biological effects are largely unknown. Similar to other gaseous molecules such as inhalation anesthetics, H2 is more soluble in lipids than in water. A recent study demonstrated that H2 reduces radical polymerization-induced cellular damage by suppressing fatty acid peroxidation and membrane permeability. Thus, we sought to examine the effects of short exposure to H2 on lipid composition and associated physiological changes in SH-SY5Y neuroblastoma cells. We analyzed cells by liquid chromatography-high-resolution mass spectrometry to define changes in lipid components. Lipid class analysis of cells exposed to H2 for 1 hour revealed transient increases in glycerophospholipids including phosphatidylethanolamine, phosphatidylinositol, and cardiolipin. Metabolomic analysis also showed that H2 exposure for 1 hour transiently suppressed overall energy metabolism accompanied by a decrease in glutathione. We further observed alterations to endosomal morphology by staining with specific antibodies. Endosomal transport of cholera toxin B to recycling endosomes localized around the Golgi body was delayed in H2-exposed cells. We speculate that H2-induced modification of lipid composition depresses energy production and endosomal transport concomitant with enhancement of oxidative stress, which transiently stimulates stress response pathways to protect cells.

分子氢(H2)是一种抗氧化剂和抗炎剂;然而,其生物学作用的分子机制在很大程度上是未知的。与其他气体分子(如吸入性麻醉剂)类似,H2在脂质中比在水中更易溶解。最近的一项研究表明,H2通过抑制脂肪酸过氧化和膜通透性来减少自由基聚合引起的细胞损伤。因此,我们试图研究短时间暴露于H2对SH-SY5Y神经母细胞瘤细胞脂质组成和相关生理变化的影响。我们通过液相色谱-高分辨率质谱分析细胞来确定脂质成分的变化。对暴露于H2 1小时的细胞进行脂质分类分析,发现甘油磷脂(包括磷脂酰乙醇胺、磷脂酰肌醇和心磷脂)瞬间升高。代谢组学分析还表明,H2暴露1小时会短暂抑制总能量代谢,并伴有谷胱甘肽的减少。我们通过特异性抗体染色进一步观察到内体形态的改变。在h2暴露的细胞中,霍乱毒素B向高尔基体周围的再循环内体的内体运输被延迟。我们推测,h2诱导的脂质成分修饰抑制了能量产生和内体运输,同时增强了氧化应激,从而短暂地刺激应激反应途径以保护细胞。
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引用次数: 1
Ozone dialysis delivers three or more times the ozone than other forms of ozone blood treatment. 臭氧透析比其他形式的臭氧血液治疗提供三倍或更多的臭氧。
IF 2.9 Q1 Medicine Pub Date : 2023-04-01 DOI: 10.4103/2045-9912.356474
Robert Jay Rowen, Sharon Grabovac, Teresa B Su

Therapeutic use of ozone is becoming increasingly prevalent worldwide. New methods of administration are emerging. One of these emerging techniques, which we refer to as ozone dialysis, uses a dialysis membrane that allows blood to flow against a countercurrent of ozone gas. We found that ozone uptake by continuous countercurrent blood flow is at least 3 times higher than any comparable form of blood ozone administration currently available. This is the first quantitative report of ozone uptake by blood using the ozone dialysis technique.

臭氧的治疗用途在世界范围内日益普遍。新的管理方法正在出现。其中一种新兴技术,我们称之为臭氧透析,它使用一种透析膜,允许血液在臭氧气体逆流的情况下流动。我们发现,连续逆流血流的臭氧吸收量至少是目前可用的任何类似形式的血液臭氧管理的3倍。这是第一个使用臭氧透析技术的血液臭氧摄取的定量报告。
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引用次数: 0
Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic peripheral neuropathy rats. 氢通过抑制实验性糖尿病周围神经病变大鼠氧化应激发挥神经保护作用。
IF 2.9 Q1 Medicine Pub Date : 2023-04-01 DOI: 10.4103/2045-9912.345171
Xiao-Chen Han, Zhou-Heng Ye, Hui-Jun Hu, Qiang Sun, Dan-Feng Fan

Diabetic peripheral neuropathy (DPN) is a complex disorder caused by long-standing diabetes. Oxidative stress was considered the critical creed in this DPN pathophysiology. Hydrogen has antioxidative effects on diabetes mellitus and related complications. However, there is still no concern on the beneficial effects of hydrogen in DPN. This paper aimed to evaluate the effects of exogenous hydrogen to reduce the severity of DPN in streptozotocin-induced diabetic rats. Compared with hydrogen-rich saline treatment, hydrogen inhalation significantly reduced blood glucose levels in diabetic rats in the 4th and 8th weeks. With regard to nerve function, hydrogen administration significantly attenuated the decrease in the velocity of motor nerve conduction in diabetic animals. In addition, hydrogen significantly attenuated oxidative stress by reducing the level of malondialdehyde, reactive oxygen species, and 8-hydroxy-2-deoxyguanosine and meaningfully enhanced the antioxidant capability by partially restoring the activities of superoxide dismutase. Further studies showed that hydrogen significantly upregulated the expression of nuclear factor erythroid-2-related factor 2 and downstream proteins such as catalase and hemeoxygenase-1 in the nerves of diabetic animals. Our paper showed that hydrogen exerts significant protective effects in DPN by downregulating oxidative stress via the pathway of nuclear factor erythroid-2-related factor 2, which suggests its potential value in clinical applications.

糖尿病周围神经病变(DPN)是一种由长期糖尿病引起的复杂疾病。氧化应激被认为是DPN病理生理学的关键因素。氢对糖尿病及其相关并发症具有抗氧化作用。然而,氢在DPN中的有益作用仍然没有得到关注。本文旨在评价外源性氢对链脲佐菌素诱导的糖尿病大鼠DPN严重程度的影响。与富氢盐水治疗相比,吸入氢在第4周和第8周显著降低糖尿病大鼠的血糖水平。在神经功能方面,给氢显著减轻了糖尿病动物运动神经传导速度的下降。此外,氢通过降低丙二醛、活性氧和8-羟基-2-脱氧鸟苷的水平显著减轻氧化应激,并通过部分恢复超氧化物歧化酶的活性显著增强抗氧化能力。进一步研究表明,氢显著上调糖尿病动物神经中核因子-红细胞-2相关因子-2及下游蛋白过氧化氢酶、血红素加氧酶-1的表达。我们的研究表明,氢通过核因子-红细胞-2相关因子2通路下调氧化应激,对DPN具有显著的保护作用,提示其临床应用价值。
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引用次数: 2
Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study. 分子氢暴露改善术后早期红细胞功能状态:一项随机临床研究。
IF 2.9 Q1 Medicine Pub Date : 2023-04-01 DOI: 10.4103/2045-9912.356473
Anna Vaycheslavovna Deryugina, Darya Andreevna Danilova, Yurii Dmitrievich Brichkin, Evgenii Vladimirovich Taranov, Evgenii Ivanovich Nazarov, Vladimir Viktorovich Pichugin, Aleksandr Pavlovich Medvedev, Michail Valerevich Riazanov, Sergey Andreevich Fedorov, Yurevich Smorkalov Andrej, Evgenii Vladimirovich Makarov

Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical trial was conducted with 20 patients referring to the Specialized Cardiosurgical Clinical Hospital, Nizhny Novgorod, Russian Federation, who underwent elective surgery with CPB. Twenty-four patients were randomly assigned to two groups. First group included 12 patients (research group) who received H2 at a concentration of 1.5-2.0% through a facemask using a breathing circuit of the ventilator together with anesthesia immediately after tracheal intubation and throughout the operation. Second group (control group) included 12 patients who were not given H2. Blood samples were withdrawn from peripheral veins and radial artery at four stages: immediately after the introduction of anesthesia (stage 1), before the start of CPB (stage 2), immediately after its termination (stage 3) and 24 hours after the operation (the early postoperative period) (stage 4). An increase in electrophoretic mobility, an increase in the metabolism of red blood cells, and a decrease in the aggregation of red blood cells relative to the corresponding indicators of the control group were observed in the research group. Patients in the research group had a decrease in oxidative stress manifestations most pronounced one day after the operation. There was a statistically significant difference between the indicators of myocardial contractile function in the research and control group on the 1st and 3rd days after surgery. H2 inhalation leads to improvement of functional state of red blood cells, which is accompanied by a more favorable course of the early postoperative period. These data show the presence of protective properties of molecular hydrogen.

分子氢(H2)已被认为是预防和治疗许多疾病的医用气体。本研究旨在探讨分子氢作为麻醉成分在体外循环(CPB)手术治疗获得性瓣膜缺损中对红细胞(RBC)功能状态和心脏活动功能指标的潜在作用。这项临床试验是在俄罗斯联邦下诺夫哥罗德专门心脏外科临床医院进行的,他们接受了CPB的选择性手术。24例患者随机分为两组。第一组12例患者(研究组),气管插管后立即及手术全程麻醉,通过呼吸机呼吸回路面罩给予浓度为1.5-2.0%的H2。第二组(对照组)12例患者不给予H2治疗。分四个阶段从外周静脉和桡动脉中抽取血样:麻醉后立即(第1阶段)、CPB开始前(第2阶段)、CPB结束后立即(第3阶段)、手术后24小时(术后早期)(第4阶段)。实验组的电泳迁移率增加,红细胞代谢增加,红细胞聚集量相对于对照组相应指标有所下降。实验组患者术后1天氧化应激症状明显减轻。实验组与对照组术后第1天、第3天心肌收缩功能指标比较,差异有统计学意义。H2吸入使红细胞功能状态改善,术后早期病程较好。这些数据表明氢分子具有保护作用。
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引用次数: 3
Discovery of a hydrogen molecular target. 发现氢分子靶标。
IF 2.9 Q1 Medicine Pub Date : 2023-04-01 DOI: 10.4103/2045-9912.356472
Xuejun Sun, Shigeo Ohta, John H Zhang
Fe-porphyrin acts as a primary molecular target/biosensor of hydrogen (H2), which can catalyze H2 to reduce ∙OH and carbon dioxide (CO2) into H2O and carbon monoxide (CO), respectively, for downstream signaling.1 In 1975, Dole et al.2 found that exposure to an H2/O2 (97.5%:2.5%) mixed gas at a pressure of 8 atm (1 atm = 101.325 kPa) for 2 weeks caused the marked regression of skin tumors in a skin tumor-bearing mouse model, which was speculated due to the ∙OH and O2 – scavenging effect of H2. In 2007, Ohsawa et al. 3 found that H2 can selectively reduce ∙OH with high oxidability rather than other reactive oxygen species, but later research indicated that the probability/efficiency of the direct reduction of ∙OH by H2 is considerably low. 4 Increasing studies have suggested that H2 can regulate the respiration of mitochondria,5-10 which is hardly explained by the direct ∙OH reduction by H2, especially in terms of anticancer. It seems that H2 might play a reducer or/and CO/ nitric oxide (NO)-like gasotransmitter, which was not confirmed previously with experimental evidence. More encouragingly, Jin et al.1 experimentally identified hematin, a kind of Fe-phorphyrins, as a molecular target/biosensor of H2. They found that in both free and protein-confining states, Fe-porphyrin can self-catalyze hydrogenation by reacting with H2 to obtain high reducibility of Fe-coordinated hydrogen atoms, which subsequently can not only neutralize ∙OH into H2O but also reduce CO2 into CO in the hypoxic microenvironment. Fe-porphyrin is mainly enriched in cellular mitochondria and in red blood cells, which are the two main workplaces of H2. At cellular mitochondria, H2 can efficiently reduce ∙OH under local catalysis of Fe-porphyrin to attenuate oxidative stress for antiinflammation. Moreover, in the hypoxia microenvironment, such as solid tumor and heart ischemia, Fe-porphyrin-catalytically generated CO is locally coordinated with Fe-porphyrin to mediate the downstream CO signaling, inducing apoptosis in tumor cells and protecting myocardial cells via hypoxic alleviation. The therapeutic effects on many diseases may be related to the downstream CO signaling besides ∙OH scavenging. Since the other medical gasses, such as NO, CO, and hydrogen sulfide (H2S), target Fe-porphyrin (heme) to induce each signal transduction,11 it is interesting that H2 commonly targets Fe-porphyrin (hematin) to exhibit its function. Red blood cells containing plentiful amounts of Fe-porphyrin are a kind of natural H2 vehicle. In the ischemiahypoxia microenvironment, red blood cells can be a local capturer of H2 as well as a catalyst of hydrogenation for targeted H2 therapy. In the oxygen-rich blood circulation, oxygen molecules can impede the remote delivery of hydrogen to a certain extent by exhausting reactive hydrogen, but the sufficiently hydrided red blood cells can scavenge ∙OH in the blood circulation and even throughout the body by virtue of rapid blood flow, which implies the necess
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引用次数: 3
Conventional drug acts as a "rifle gun" while hydrogen as a "machine gun". 传统药物就像“步枪”,而氢气就像“机枪”。
IF 2.9 Q1 Medicine Pub Date : 2023-04-01 DOI: 10.4103/2045-9912.344982
Shin-Ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh

Most of the drugs used in modern medical treatments are symptomatic treatments and are far from being a cure for the diseases. The adverse effects are unavoidable in the drugs in modern medical treatments. Molecular hydrogen (H2) has a remarkable therapeutic effect on various diseases, and many clinical studies have reported that H2 has no adverse effects. Therefore, H2 is a novel medical gas that is outside the concept of modern medical treatment. H2, unlike drugs, works on the root of many diseases by scavenging the two kinds of strong reactive oxygen species, hydroxyl radical (·OH) and peroxynitrite (ONOO-). Since the H2 alleviates the root of diseases and can treat many diseases at the same time, the medical application of H2 may be called "machine gun therapy." In this review, we demonstrated that the root of many diseases is based on ·OH-induced oxidative stress in the mitochondria, and at the same time, the root of chronic inflammation is also attributed to ·OH.

现代医学治疗中使用的大多数药物都是对症治疗,远远不能治愈疾病。在现代医学治疗中,药物的不良反应是不可避免的。分子氢(H2)对多种疾病具有显著的治疗作用,许多临床研究报道H2无不良反应。因此,氢气是一种新型的医用气体,是在现代医疗概念之外的。与药物不同,H2通过清除两种强活性氧——羟基自由基(·OH)和过氧亚硝酸盐(ONOO-),对许多疾病起根治作用。由于氢气可以缓解疾病的根源,同时可以治疗多种疾病,因此氢气的医疗应用可以被称为“机枪治疗”。在这篇综述中,我们证明了许多疾病的根源都是基于·OH诱导的线粒体氧化应激,同时,慢性炎症的根源也归因于·OH。
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引用次数: 2
Guidelines for the selection of hydrogen gas inhalers based on hydrogen explosion accidents. 基于氢气爆炸事故的氢气吸入器选择指南。
IF 2.9 Q1 Medicine Pub Date : 2023-04-01 DOI: 10.4103/2045-9912.344972
Yusuke Ichikawa, Shin-Ichi Hirano, Bunpei Sato, Haru Yamamoto, Yoshiyasu Takefuji, Fumitake Satoh

Despite the fact that we have reported on the dangers of the explosion of hydrogen gas inhalers, hydrogen gas inhalers with explosive hazards are, as a matter of fact, still being sold today. In this study, we investigated past reports of hydrogen gas inhaler explosion accidents to clarify the causes of these explosion incidents. As a result of this investigation, we found that the central cause was the leakage of hydrogen gas inside the hydrogen gas inhaler. Although it is said that the explosive concentration of hydrogen is between 10% and 75%, and that the gas does not explode above 75% due to the lack of oxygen, we confirmed through a series of ignition experiments that explosions can occur even in hydrogen gas inhalers that produce 100% hydrogen gas. Some manufacturers of such highly concentrated hydrogen gas inhalers claim that the high concentration and purity of hydrogen is safe and that there is no risk of explosion. We believe that manufacturing or selling such products that pose a risk of explosion or detonation is a violation of social justice. This paper presents ideas for selecting safe hydrogen gas inhalers based on a survey of past accident cases.

尽管我们已经报道了氢气吸入器爆炸的危险,但事实上,具有爆炸危险的氢气吸入器今天仍在销售。在本研究中,我们调查了过去报道的氢气吸入器爆炸事故,以澄清这些爆炸事件的原因。经过调查,我们发现主要原因是氢气吸入器内氢气泄漏。虽然据说氢气的爆炸浓度在10% - 75%之间,并且由于缺氧,气体不会在75%以上爆炸,但我们通过一系列点火实验证实,即使在产生100%氢气的氢气吸入器中也会发生爆炸。这种高浓度氢气吸入器的一些制造商声称,高浓度和纯度的氢气是安全的,没有爆炸的危险。我们认为,制造或销售这种有爆炸或引爆危险的产品是违反社会正义的。本文通过对以往事故案例的调查,提出了选择安全氢气吸入器的思路。
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引用次数: 1
Influence of positive end-expiratory pressure on arterial blood pressure in mechanically ventilated trauma patients in the field: a retrospective cohort study. 现场机械通气创伤患者呼气末正压对动脉血压的影响:一项回顾性队列研究
IF 2.9 Q1 Medicine Pub Date : 2023-04-01 DOI: 10.4103/2045-9912.344979
Holger Herff, Dietmar Krappinger, Peter Paal, Wolfgang G Voelckel, Volker Wenzel, Helmut Trimmel

Ventilation with positive end-expiratory pressure (PEEP) may result in decreased venous return to the heart and therefore decrease cardiac output. We evaluated the influence of PEEP ventilation on arterial blood pressure in the field in 296 posttraumatic intubated patients being treated by a helicopter emergency medical service in a retrospective cohort study. Initial systolic blood pressure on the scene, upon hospital admission and their mean difference were compared between patients being ventilated with no/low PEEP (0-0.3 kPa) and moderate PEEP (0.3-1 kPa). In a subgroup analysis of initially hemodynamic unstable patients (systolic blood pressure < 80 mmHg), systolic blood pressure was compared between patients being ventilated with no/low or moderate PEEP Further, the mean difference between initial systolic blood pressure and upon hospital admission was correlated with the chosen PEEP. Systolic arterial blood pressure of patients being ventilated with no/low PEEP improved from 105 ± 36 mmHg to 112 ± 38 mmHg, and that of patients being ventilated with moderate PEEP improved from 105 ± 38 mmHg to 119 ± 27 mmHg. In initially unstable patients being ventilated with no/low PEEP systolic blood pressure improved from initially 55 ± 36 mmHg to 78 ± 30 mmHg upon hospital admission, and in those being ventilated with moderate PEEP, the systolic blood pressure improved from 43 ± 38 mmHg to 91 ± 27 mmHg. There was no significant correlation between the chosen PEEP and the mean difference of systolic blood pressure (Pearson's correlation, r = 0.07, P = 0.17). Ventilation with moderate PEEP has no adverse effect on arterial systolic blood pressure in this cohort of trauma patients requiring mechanical ventilation. Initially unstable patients being ventilated with moderate PEEP tend to be hemodynamically more stable.

呼气末正压通气可导致静脉回流心脏减少,从而减少心输出量。在一项回顾性队列研究中,我们评估了296名接受直升机急救医疗服务的创伤后插管患者正压通气对现场动脉血压的影响。比较无/低PEEP (0-0.3 kPa)与中度PEEP (0.3-1 kPa)通气患者入院时现场初始收缩压及其平均差值。在初始血流动力学不稳定患者(收缩压< 80 mmHg)的亚组分析中,比较无/低或中度PEEP通气患者的收缩压。此外,初始收缩压与入院时的平均差值与所选择的PEEP相关。无/低PEEP通气患者的收缩压由105±36 mmHg改善至112±38 mmHg,中度PEEP通气患者的收缩压由105±38 mmHg改善至119±27 mmHg。在最初不稳定且无或低PEEP通气的患者中,收缩压从最初的55±36 mmHg改善到入院时的78±30 mmHg,在中度PEEP通气的患者中,收缩压从43±38 mmHg改善到91±27 mmHg。所选PEEP与收缩压平均差值无显著相关(Pearson相关,r = 0.07, P = 0.17)。在这组需要机械通气的创伤患者中,适度PEEP通气对动脉收缩压无不良影响。最初不稳定的患者在适度正压通气时血流动力学更稳定。
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Medical Gas Research
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