Medical Gas Research最新文献

JOURNAL/mgres/04.03/01612956-202606000-00006/figure1/v/2025-08-18T154854Z/r/image-tiff Although mitochondria and related proteins are essential for mitochondrial preservation, the functions of some of these proteins remain unknown. The novel protein oxidoreductase-like domain containing 1 (OXLD1/C17orf90, UniProtKB Q5BKU9) have attracted our attention because of its correlation with mitochondria. This study revealed a decrease in OXLD1 levels in cardiomyocytes cultured in 1% oxygen for 24 hours. Suppressing OXLD1 increases mitochondrial injury under both normoxic and hypoxic conditions. This is evidenced by decreased mitochondrial membrane potential and increased reactive oxygen species production. Meanwhile, suppressing OXLD1 decreased mitochondrial oxidative phosphorylation. Overexpression of OXLD1 decreased mitochondrial injury under normoxia and hypoxia, as indicated by an increase in the mitochondrial membrane potential and a decrease in reactive oxygen species production. Moreover, overexpression of OXLD1 enhanced mitochondrial oxidative phosphorylation. Additionally, we found that OXLD1 regulates mitochondrial oxidative phosphorylation by affecting mitochondrial complexes I and V. OXLD1 plays a crucial role in protecting cardiomyocytes by improving mitochondrial function under low-oxygen conditions. OXLD1 achieves this protection through interactions with mitochondrial complexes I and V. Therefore, OXLD1 may serve as a new and important regulator of mitochondrial function.

Neuroinflammation plays a critical role in the pathogenesis of neurodegenerative diseases with microglial activation and excessive nitric oxide production contributing significantly to disease progression. Plant-derived phenolic compounds have emerged as promising neuroprotective agents due to their ability to modulate the key signaling pathways, including nuclear factor-κB, mitogen-activated protein kinases, nuclear factor erythroid 2-related factor 2, and phosphoinositide 3-kinase/protein kinase B. These bioactive molecules effectively suppress inducible nitric oxide synthase expression, reduce oxidative and nitrosative stress, and restore immune homeostasis. Additionally, these natural phenolic compounds are able to regulate mitochondrial function and autophagy, further supporting their therapeutic potential in central nervous system disorders. The presented review aimed to explain the key known mechanisms of action of plant-origin phenolics, in order to evaluate their potential in developing treatments and preventing central nervous system diseases.

Gas-induced spinal cord compression, also known as intraspinous pneumorrhachis, is a rare condition in which the presence of gas in the spinal canal generally does not result in any symptoms. However, in certain cases, gas can compress the spinal cord, leading to severe neurological dysfunction. This underscores the importance of early recognition and intervention. Herein, we conduct a comprehensive analysis of the literature on pneumorrhachis by searching databases such as PubMed, ClinicalKey, Web of Science, and CNKI. We discuss the etiology, pathophysiology, clinical manifestations, imaging features, differential diagnosis, treatment strategies, and prognosis of these patients. Our findings indicate that the occurrence of intraspinous pneumorrhachis is associated with various factors, including medical conditions, trauma, and infection. While most cases are limited in extent and resolve spontaneously, a subset of cases may signal a serious underlying condition.

Paravertebral ozone injections have been used in the treatment of lumbosacral pain with or without radicular irradiation and have been reported to be effective in reducing pain when compared with placebo, physiotherapy programs or drug treatments; nevertheless, their effectiveness in comparison with minimally invasive procedures using corticosteroids is unknown. The main objective of this review was to explore the role of paravertebral ozone injections in the treatment of lumbosacral pain with radicular irradiation in comparison with minimally invasive procedures using corticosteroids. A systematic search was performed in electronic databases including PubMed, EMBASE, Central Cochrane and Web of Science, from January 2000 to December 2024; for clinical studies that compared paravertebral ozone injections with minimally invasive procedures using corticosteroids in the treatment of lumbosacral pain with radicular irradiation and were performed using the methodology of a scoping review. Four clinical trials met the inclusion criteria and were included in this review, gathering a total of 501 individuals. In the within-group comparison of every study, statistically significant reduction in pain was observed in both interventions. No side effects or serious adverse reactions were reported in the treated patients. Paravertebral ozone injections appear to have a favorable therapeutic effect in reducing pain in the short and medium terms, in individuals with lumbosacral pain with radicular irradiation, and this effect appears to be similar to that of epidural corticosteroid injections. No definitive recommendations are possible, for more clinical trials are needed to conduct meta-analytic reviews that clarify the results of this comparison.

JOURNAL/mgres/04.03/01612956-202606000-00002/figure1/v/2025-08-18T154854Z/r/image-tiff Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear. This single-blind, randomized controlled clinical trial from September 2022 to July 2023 at the Second Medical Center of the PLA General Hospital and the Affiliated Hospital of Chengde Medical College examined the effect of hydrogen-oxygen on sleep disorders. Sixty-six participants with sleep disorders were randomly divided into a control group and a hydrogen-oxygen group that received nasal gas inhalation for seven days. Sleep quality and mood were assessed using the Pittsburgh Sleep Quality Index, Self-Rating Depression Scale, and Self-Rating Anxiety Scale. An Actiwatch helped evaluate the effects of two kinds of gas inhalation on total sleep time, sleep efficiency, and the wake time of patients with sleep disorders. The control group showed no significant changes in sleep parameters during treatment, whereas the hydrogen-oxygen group showed significant improvements in total sleep time and sleep efficiency on days 3, 5, and 7 and significant reductions in wake time on days 3 and 7. Compared with those in the control group, the total sleep time was greater and the wake time was lower in the hydrogen-oxygen group. After 7 days, the scores of the Pittsburgh Sleep Quality Index and Self-Rating Depression Scale in the hydrogen-oxygen group were lower than those in the control group, whereas the Self-Rating Anxiety Scale scores did not differ significantly. Hydrogen-oxygen therapy effectively improved sleep disorders by reducing wake time, relieving psychological stress, and enhancing sleep quality. The study was registered in the Chinese Clinical Trial Registry (registration No. ChiCTR2400084103).

JOURNAL/mgres/04.03/01612956-202606000-00004/figure1/v/2025-08-18T154854Z/r/image-tiff Hydrogen sulfide (H2S) holds significant potential for clinical applications in the alleviation of fibrosis. This study aimed to verify the role of H2S in combating peritoneal fibrosis and elucidate its molecular mechanisms. A peritoneal fibrosis model was established through the intraperitoneal injection of 0.1% chlorhexidine gluconate. Subsequently, the mice were administered an intraperitoneal injection of the H2S donor GYY4137. The experimental data indicate that H2S mitigates the progression of peritoneal fibrosis, potentially by inhibiting the expression of high mobility group box-1 and consequently blocking the activation of the (TGF-β)/Smad3 signaling pathway. This study provides a scientific basis for the future clinical application of H2S in the treatment of peritoneal fibrosis.

Acute kidney injury and chronic kidney disease impose substantial burdens on healthcare systems worldwide. Molecular hydrogen (H2) has emerged as a potential therapy due to its selective antioxidant, anti-inflammatory, and antiapoptotic properties. The present study reviews evidence on H₂-based renal interventions, examining therapeutic mechanisms, bibliometric trends, and existing research gaps based on data analytics. This scoping review integrates quantitative bibliometric analysis with qualitative thematic synthesis. This integration, uncommon in conventional scoping reviews, reveals important gaps. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, 69 publications were identified through Scopus and Web of Science. These publications mostly originated from Asia, particularly China and Japan, with clear peaks of activity in 2019 and 2024, but international collaboration remains limited. H₂ consistently demonstrated protective effects against apoptosis, fibrosis, inflammation, and oxidative stress across acute kidney injury, nephrotoxicity, transplantation, and early chronic kidney disease models. Our findings suggest that hydrogen therapy holds promise for renoprotection in both acute kidney injury and chronic kidney disease. Nonetheless, more robust clinical trials and standardized research methodologies are imperative to facilitate its broader adoption into clinical nephrology practice.