Medical Gas Research最新文献

Sonodynamic therapy has emerged as a novel non-invasive treatment for cancer with limited single effects. To achieve optimal therapeutic efficacy, sonodynamic therapy frequently needs to be combined with other therapeutic strategies. By exploiting the biological properties of specific gas molecules, gas therapy is an emerging tumor treatment that exerts direct or indirect inhibitory effects on tumor cells. This review systematically examines the rationales, methodologies, and outcomes of sonodynamic therapy and gas therapy combinatorial strategies for malignant tumors. There is a synergistic effect between sonodynamic therapy and gas therapy in tumor treatment. The ultrasound-induced cavitation enhances tissue permeability for improved gas delivery, while gas molecules concurrently sensitize sonodynamic reactions and ameliorate tumor hypoxia. The interaction significantly enhances the therapeutic effect of tumors. Moreover, the combination of sonodynamic therapy with other therapeutic modalities can significantly enhance the anti-tumor efficacy, improve the therapeutic precision and safety, while improve the tumor microenvironment. This combined treatment strategy can also reduce side effects and has a broad clinical application perspective.

JOURNAL/mgres/04.03/01612956-202609000-00002/figure1/v/2026-01-06T135433Z/r/image-tiff Nitric oxide, a pivotal endogenous signaling molecule, plays crucial roles in cardiovascular regulation, immune response, and neuromodulation. The rapid advancement of artificial intelligence technologies offers novel approaches to optimize real-time nitric oxide monitoring, dosing regimens, and toxicity prediction. Current interdisciplinary research on the artificial intelligence-driven nitric oxide intersection remains fragmented, with a lack of systematic investigations into knowledge architecture, technological evolution, and translational barriers. This study addressed this critical gap by presenting the knowledge graph-based analysis of artificial intelligence-driven nitric oxide system. A total of 384 relevant articles (2005-2024) were retrieved in the Web of Science Core Collection and analyzed using CiteSpace, VOSviewer, and Bibliometrix R package. Annual publications demonstrated a biphasic growth, accelerating after 2017 in tandem with breakthroughs in artificial intelligence architectures. Although China and the United States were dominated in this field, international collaborations exhibited a core-periphery structure. Research themes predominantly focused on cardiovascular and respiratory diseases, with underdeveloped applications in neuroimmunology and infectious diseases. Highly cited literature that emphasized photodynamic therapy and disease risk assessment revealed insufficient integration between artificial intelligence algorithms and fundamental nitric oxide mechanisms. Keyword evolution analysis identified a paradigm shift from traditional mechanisms (e.g., "blood pressure," "inflammation") to technology-driven approaches (e.g., "machine learning, " "deep learning"). Clinical translation has faced challenges, including data heterogeneity, algorithm interpretability, and deficiencies in multicenter validation. This pioneering study systematically delineates the knowledge framework and translational bottlenecks in artificial intelligence-driven nitric oxide convergence. Future research should prioritize artificial intelligence modeling of nitric oxide dynamic metabolism, the development of explainable algorithms, and prospective clinical trials to bridge the laboratory-to-clinic gap.

Conventional antibiotic therapies often fail to eradicate biofilms, which can lead to persistent infections and significant clinical challenges. Gas therapy, which utilizes the unique properties of gas molecules such as nitric oxide, carbon monoxide, hydrogen, and hydrogen sulfide, is emerging as a promising and innovative strategy to address these challenges. This review first highlights gas signaling in bacterial biofilms. It then goes on to list four types of gas therapy in detail: photothermal-enhanced gas therapy, photodynamic-activated gas therapy, micro/nanobubble-mediated gas therapy, and gas-based synergistic therapy. Their potential applications and future directions are also fully discussed. Due to its unique bioactivity, low resistance, and synergy with existing treatments, gas therapy has demonstrated significant potential in the prevention and treatment of biofilm-associated infections. However, overcoming delivery challenges, validating efficacy in large-scale trials, and developing standardized protocols are essential for its clinical translation. Future efforts should prioritize the integration of nanotechnology and mechanistic studies to unlock broader therapeutic utility.

The only intra-articular injections recommended by international guidelines for the treatment of knee osteoarthritis are injections of corticosteroids and hyaluronic acid; nonetheless, other substances including ozone, dextrose and platelet-rich plasma are also used in clinical. Intra-articular injections of ozone have been reported to have anti-inflammatory mechanisms and clinical benefits similar to intra-articular injections of corticosteroids in patients with knee osteoarthritis; however, this treatment has not been evaluated in a meta-analysis. The objective of this review is to evaluate the effectiveness of intra-articular injections of ozone for reducing pain and improving function in individuals with knee osteoarthritis when compared with intra-articular injections of corticosteroids. An online search was performed using the electronic databases PubMed, EMBASE, Central Cochrane and Web of Science, for controlled clinical trials that compared intra-articular injections of ozone and intra-articular injections of corticosteroid in the treatment of knee osteoarthritis. Seven clinical trials were included in this review, gathering 409 individuals with knee osteoarthritis. In the pooled analysis, ozone injections were found to be more effective in reducing pain in the short and medium terms than corticosteroids injections. Similarly, function improvement in the medium term was observed in favor of ozone injections. Our results suggest that ozone injections represent a good alternative to corticosteroids injections for reducing pain in the short and medium terms in individuals with knee osteoarthritis. Nonetheless, definitive conclusions could not be drawn due to the limited quality of the included studies. Better quality clinical trials are needed to strengthen the evidence and confirm these results.