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Quasi-anisotropic wet etching of glass creates inclined microstructures for advanced optical and MEMS devices. 准各向异性湿法蚀刻玻璃为先进的光学和MEMS器件创造了倾斜的微结构。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01047-6
Jiajia Yu, Feier Li, Hao Sun, Yike Zhu, Yukun Shi, Renxin Wang, Liqun Du, Yi Li, Mengxi Wu, Junshan Liu

Glass is one of the most widely used functional materials in various fields, thus developing high-precision, on-demand and low-cost glass microstructuring technologies is essential for both academic and industry. Although numerous technological advancements in the past, it is still a challenge to fabricate microstructures with smooth inclined sidewalls on glass substrates, posing difficulties in fulfilling the advantages of glass material for many emerging applications, including optics and MEMS. In this paper, we establish a novel quasi-anisotropic wet etching strategy that expands the ability of glass micromachining and enables tunable inclined surface fabrication with high quality and low cost. By exploring the competitive effects of the etching induced by interface between glass and the mask layer, the quasi-anisotropic wet etching mechanism is systematically investigated. Through numerical simulations and experiments, the reproducibility and tunability are verified in fabrication of varied types of microstructures such as microprism, micro-pyramids and micro-cones. Furthermore, novel devices including diffusion plates, optical waveguide, VR/AR displays are designed and manufactured, with functions successfully demonstrated. The quasi-anisotropic wet etching strategy proposed in this paper not only offers a new path for precise and high-quality glass micromachining, but also enables significant application potentials in micro-optics, opto-MEMS and other related fields.

玻璃是在各个领域应用最广泛的功能材料之一,因此开发高精度、按需、低成本的玻璃微结构技术对于学术界和工业界都是必不可少的。尽管过去的技术取得了许多进步,但在玻璃基板上制造具有光滑倾斜侧壁的微结构仍然是一个挑战,这给许多新兴应用(包括光学和MEMS)实现玻璃材料的优势带来了困难。在本文中,我们建立了一种新的准各向异性湿法蚀刻策略,扩大了玻璃微加工的能力,并实现了高质量和低成本的可调倾斜表面加工。通过探索玻璃与掩膜层界面诱导的蚀刻竞争效应,系统地研究了准各向异性湿法蚀刻机理。通过数值模拟和实验,验证了该方法在微棱柱、微金字塔和微锥等微结构加工中的可重复性和可调性。此外,还设计和制造了扩散板、光波导、VR/AR显示器等新型器件,并成功演示了其功能。本文提出的准各向异性湿法蚀刻策略不仅为玻璃的精密高质量微加工提供了新的途径,而且在微光学、光电mems等相关领域具有重要的应用潜力。
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引用次数: 0
Electrochemical vibration sensor for low frequency detection: model, design and manufacture. 低频检测用电化学振动传感器:模型、设计与制造。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01094-z
Wenlang Zhao, Guangyang Gou, Honghao Zhang, Hongmin Jiang, Lintao Hu, Maoqi Zhu, Qinghua Liu, Xiuli He, Yulan Lu, Deyong Chen, Junbo Wang

Vibration sensors play a crucial role in resource exploration, structural health monitoring, and seismic activity detection. Conventional vibration sensors, primarily including electromagnetic, capacitive, piezoelectric, and fiber optic types, have been predominantly utilized in past vibration detection applications. However, with the development of deep-sea resources, vibration detection in such extreme environments demands sensors with low-frequency response, low noise, and high environmental resilience, requirements which are challenging for conventional sensors to meet. Due to their high sensitivity and low noise in the low-frequency domain, electrochemical vibration sensors have garnered increasing attention in recent years. Concurrently, advances in MEMS technology have driven the development of electrochemical vibration sensors towards cost-effectiveness, miniaturization, and low power consumption. This review summarizes the sensing mechanism models and noise models of electrochemical vibration sensors. It highlights the trends in the development of sensing electrodes, including miniaturization and integration facilitated by MEMS technology, while also outlining representative fabrication processes. Furthermore, the review summarizes key application domains encompassing geophones, hydrophones, and angular acceleration sensing. Finally, it concludes with a discussion of current major challenges and an outlook on future research directions.

振动传感器在资源勘探、构造健康监测、地震活动检测等方面发挥着重要作用。传统的振动传感器,主要包括电磁、电容、压电和光纤类型,主要用于过去的振动检测应用。然而,随着深海资源的开发,这种极端环境下的振动检测要求传感器具有低频响应、低噪声和高环境弹性,这是传统传感器难以满足的要求。近年来,电化学振动传感器因其在低频域的高灵敏度和低噪声而受到越来越多的关注。与此同时,MEMS技术的进步推动了电化学振动传感器朝着成本效益、小型化和低功耗的方向发展。综述了电化学振动传感器的传感机理模型和噪声模型。它强调了传感电极的发展趋势,包括由MEMS技术促进的小型化和集成化,同时也概述了代表性的制造工艺。此外,综述了地震检波器、水听器和角加速度传感等关键应用领域。最后,对当前的主要挑战进行了讨论,并对未来的研究方向进行了展望。
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引用次数: 0
Electrostatically actuated MEMS resonators for magnetic and electric field sensing: a review. 用于磁场和电场传感的静电驱动MEMS谐振器:综述。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01128-6
Daeyeon Koh, Yohan Jung, Jongbaeg Kim

Recent advances in microelectromechanical systems (MEMS) resonators have enabled the development of compact devices capable of precise magnetic and electric field sensing. This review focuses on resonant MEMS sensors that employ electrostatic actuation, offering advantages such as low power consumption, fast mechanical response, and CMOS-compatible fabrication. We classify two primary types of resonant MEMS sensors based on their sensing mechanisms, where magnetic field sensors utilize electromagnetic induction and electric field sensors rely on electrostatic induction. For each type, we analyze representative devices in terms of actuation schemes, resonator design strategies, sensitivity enhancement techniques, and directional detection capability. We also address key design considerations and fabrication constraints. The review summarizes current approaches and characteristics of MEMS resonator-based magnetic and electric field sensors with a focus on their structural principles and application contexts. Through this analysis, the review aims to provide insights that support the development of next-generation field sensors for applications in navigation, biomedical diagnostics, vehicle detection, and non-destructive evaluation of electrical systems.

微机电系统(MEMS)谐振器的最新进展使能够精确感应磁场和电场的紧凑设备的发展成为可能。本文综述了采用静电驱动的谐振MEMS传感器,具有低功耗,快速机械响应和cmos兼容制造等优点。我们根据其传感机制将谐振式MEMS传感器分为两种主要类型,其中磁场传感器利用电磁感应,电场传感器依靠静电感应。对于每种类型,我们从驱动方案、谐振器设计策略、灵敏度增强技术和方向检测能力等方面分析了具有代表性的器件。我们还解决了关键的设计考虑和制造限制。综述了目前基于MEMS谐振器的磁场和电场传感器的研究方法和特点,重点介绍了它们的结构原理和应用背景。通过这一分析,该综述旨在为支持下一代现场传感器的开发提供见解,这些传感器应用于导航、生物医学诊断、车辆检测和电气系统的非破坏性评估。
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引用次数: 0
Diffraction-limit-breaking digital projection lithography via multi-exposure strategies for high-density nanopatterning. 基于多曝光策略的衍射极限数字投影光刻技术用于高密度纳米图形。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01131-x
Zi-Xin Liang, Jing-Tao Chen, Yuan-Yuan Zhao, Wen-Hui Li, Jing Zhou, Xuan-Ming Duan

Digital micromirror device-based maskless projection lithography (DMPL) has emerged as a transformative nanopatterning platform, yet faces fundamental challenges in resolving high-density nanostructures due to optical diffraction constraints. The filtering characteristics of the pupil function and the phase modulation caused by defocus lead to pattern distortion and loss of high-frequency information, making it difficult to ensure consistency and distinguishability in dense pattern lithography. Here, we introduce multiple exposures (ME) to DMPL, developing a multiple-exposure without alignment solution to solve the problem of indistinguishable dense pattern exposure. At the same time, we also propose a novel method to maximize the spacing uniformity of the layout decomposition scheme based on the gradient descent algorithm. We further improved the depth of focus by maximizing the uniformity of spacing, achieving decoherence of sub-layouts within the laser field, thereby ensuring the printability of dense patterns. Simulations and experimental results verify that this approach significantly expands the process window and improves lithographic resolution. For one-dimensional dense lines, the minimum resolvable period decreases from 378 nm (half pitch ~ 0.5λ/NA) to 223 nm (half pitch ~ 0.3λ/NA). Furthermore, the metal layer layout of the integrated circuit chip has a minimum gap of 1 DMD pixel (75.6 nm in image plane) is achieved, demonstrating the efficacy of the proposed methods in addressing the challenges posed by dense layouts in DMPL applications. This work provides a paradigm-shifting solution to the persistent "density-fidelity trade-off" in digital nanofabrication, charting new pathways toward next-generation functional meta-devices.

基于数字微镜器件的无掩模投影光刻技术(DMPL)已成为一种革命性的纳米图形平台,但由于光学衍射的限制,在解决高密度纳米结构方面面临着根本性的挑战。瞳孔功能的滤波特性和离焦引起的相位调制导致图案失真和高频信息丢失,使得密纹光刻难以保证一致性和可分辨性。本文将多重曝光(ME)引入到DMPL中,开发了一种无对齐的多重曝光解决方案,以解决密集模式曝光难以区分的问题。同时,我们还提出了一种基于梯度下降算法的布局分解方案间距均匀性最大化的新方法。我们进一步提高了聚焦深度,最大限度地提高了间距的均匀性,实现了激光场内子布局的退相干,从而确保了密集图案的可打印性。仿真和实验结果表明,该方法大大扩大了处理窗口,提高了光刻分辨率。对于一维密集谱线,最小可分辨周期从378 nm(半间距~ 0.5λ/NA)减小到223 nm(半间距~ 0.3λ/NA)。此外,集成电路芯片的金属层布局具有1 DMD像素的最小间隙(图像平面75.6 nm),证明了所提出的方法在解决DMPL应用中密集布局所带来的挑战方面的有效性。这项工作为数字纳米制造中持续存在的“密度-保真度权衡”提供了一种范式转换的解决方案,为下一代功能元器件绘制了新的路径。
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引用次数: 0
Insect-scale flapping-wing MAVs with variable transmission ratio and wingspan: achieving payload adaptability, and self-stabilizing hovering. 昆虫级变传动比和变翼展扑翼飞行器:实现载荷适应性和自稳定悬停。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01049-4
Xiang Lu, Yulie Wu, Jie Chen, Yang Chen, Xuezhong Wu, Dingbang Xiao

Insect-scale flapping-wing micro aerial vehicles (FWMAVs) possess compact dimensions, exceptional terrain adaptability, and operational stealth, presenting transformative potential for reconnaissance and environmental monitoring applications. However, current insect-scale FWMAVs typically suffer from limited payload capacity, making integrating the necessary electronic components for flight and functionality challenging. This study presents an enhanced structural design for an FWMAV that increases its payload capacity. By adjusting its transmission ratio and wingspan, the size and carrying capacity of the robot can be changed according to the demand. Based on this novel design, we manufactured FWMAVs with a variable wingspan ranging from 28 mm to 45 mm, the robots achieve a lift-to-weight ratio exceeding 2. This represents the insect-scale piezoelectric-driven FWMAV capable of successful takeoff by adjusting only the transmission ratio and wingspan, without altering other components. Notably, the 28 mm configuration is the smallest functional piezoelectric-decoupled FWMAV to achieve sustained lift-off. Additionally, the combined passive damper structure has allowed the robot to maintain stable hover for more than 5 seconds, achieving sustained air stagnation at an insect scale. These advancements provide certain technical support for further promoting the practical application of insect-scale MAVs.

昆虫级扑翼微型飞行器(FWMAVs)具有紧凑的尺寸,出色的地形适应性和操作隐身性,在侦察和环境监测应用中具有变型潜力。然而,目前的昆虫级FWMAVs的有效载荷能力有限,这使得集成飞行和功能所需的电子元件具有挑战性。本研究提出了一种增强的FWMAV结构设计,以增加其有效载荷能力。通过调整其传动比和翼展,可以根据需要改变机器人的尺寸和承载能力。基于这种新颖的设计,我们制造了翼展从28毫米到45毫米不等的FWMAVs,机器人的升重比超过了2。这代表了昆虫级压电驱动的FWMAV能够通过调整传动比和翼展成功起飞,而不改变其他部件。值得注意的是,28毫米的结构是实现持续升空的最小功能压电解耦FWMAV。此外,组合的被动阻尼器结构使机器人能够保持稳定的悬停超过5秒,实现昆虫尺度的持续空气停滞。这些研究成果为进一步推进昆虫级无人机的实际应用提供了一定的技术支持。
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引用次数: 0
Functional 2D MoS2 NEMS resonator array with independent electronic tunability based on mass transfer printing. 基于传质打印的具有独立电子可调性的二维MoS2 NEMS谐振器阵列。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01132-w
Zuheng Liu, Lingyu Zhu, Shuai Yuan, Yijian Zhang, Pengcheng Zhang, Zhenggang Cai, Liwei Liu, Rui Yang

Resonant nanoelectromechanical systems (NEMS) based on two-dimensional (2D) materials exhibit excellent resonance properties such as a large tuning range, ultralow power, and large dynamic range, leading to broad potential applications in sensing and signal processing. However, scalable fabrication of high-performance 2D NEMS arrays, particularly those with individually addressable electronic control, remains challenging and underexplored. Here, we report a mass transfer printing (MTP) method for the fabrication of large-scale electronically-independent molybdenum disulfide (MoS2) NEMS resonators with regular isolation spacing. MoS2 is precisely torn at the edges of polymer protrusions by the surface tension of auxiliary liquid, followed by dry-transfer to the pre-patterned substrate with microtrenches and electrodes. The MTP technique avoids lithographic processes that could lead to collapsing or failure of suspended 2D materials while obtaining electronically independent devices. Characterization of 84 monolayer MoS2 NEMS resonators demonstrates maintained material quality after transfer, structural integrity, highly tunable resonance frequencies in very-high-frequency (VHF) band, consistent tuning trend of quality (Q) factors, and significant signal-to-noise ratios (SNRs). Independent AC voltage excitation and DC voltage sweeping on different resonators confirm individual electronic control without crosstalk even for neighboring resonators. Furthermore, we design and experimentally demonstrate a functional decimal-to-binary converter building block using adjacent, electrically isolated resonators on a single chip, using gate voltage as input and amplitude at the specific frequency as output. The MTP-fabricated array of independently-addressable MoS2 resonators advances the large-scale integration of 2D NEMS devices, offering a straightforward and promising pathway for a plethora of applications built upon such device platform.

基于二维(2D)材料的谐振纳米机电系统(NEMS)具有大调谐范围、超低功耗和大动态范围等优异的谐振特性,在传感和信号处理方面具有广阔的应用前景。然而,高性能二维NEMS阵列的可扩展制造,特别是那些具有单独寻址电子控制的阵列,仍然具有挑战性,并且尚未得到充分开发。在这里,我们报告了一种用于制造具有规则隔离间距的大型电子无关二硫化钼(MoS2) NEMS谐振器的传质印刷(MTP)方法。在辅助液体的表面张力作用下,MoS2在聚合物突起的边缘被精确地撕裂,然后通过微沟槽和电极干转移到预图案衬底上。MTP技术避免了光刻工艺可能导致悬浮二维材料的坍塌或失效,同时获得电子独立的设备。对84个单层MoS2 NEMS谐振器的表征表明,转移后材料质量保持不变,结构完整,甚高频(VHF)频段谐振频率可调,质量(Q)因子的调谐趋势一致,信噪比显著。在不同的谐振器上独立的交流电压激励和直流电压扫描,即使是相邻的谐振器也可以确认单独的电子控制而不产生串扰。此外,我们设计并实验演示了一个功能性的十进制到二进制转换器构建块,使用相邻的电隔离谐振器在单个芯片上,使用门电压作为输入,特定频率的幅度作为输出。mtp制造的独立可寻址MoS2谐振器阵列推进了2D NEMS器件的大规模集成,为建立在此类器件平台上的大量应用提供了一个简单而有前途的途径。
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引用次数: 0
Proximal sound printing: direct 3D printing of microstructures on polymers. 近端声音打印:在聚合物上直接3D打印微结构。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01035-w
Shervin Foroughi, Mohsen Habibi, Muthukumaran Packirisamy

Proximal Sound Printing (PSP) is a new class of additive manufacturing (AM) processes where on-demand polymerization occurs through ultrasound waves interacting with printing material right at the proximity of the acoustic aperture by inducing cavitation. Despite recent developments in sound-based AM techniques, inherent practical limitations still remain, such as low resolution and repeatability, as well as the inability to print multi-material structures. PSP overcomes these limitations, enhancing resolution tenfold, reducing printing power fourfold, and decreasing maximum acoustic streaming velocity 1600 times compared to common sound-based printing methods, enhancing repeatability and resolution. PSP offers greater versatility than existing methods in modulating feature size through printing aperture tuning. This capability is particularly valuable for fabricating microsystems, where high-resolution patterning and material integrity are essential. Furthermore, PSP enables the direct printing of heat-curing materials such as polydimethylsiloxane (PDMS), a widely used thermoset in microfluidics and soft lithography, without altering its native formulation. The PSP process is explored through sonochemiluminescence experiments and high-speed imaging and demonstrated by the successful printing of multi-material composite structures and functional microfluidic devices. Overall, PSP establishes a practical, high-resolution approach for sound-driven additive manufacturing.

近端声打印(PSP)是一种新型的增材制造(AM)工艺,通过超声波与印刷材料在声孔径附近通过诱导空化作用发生按需聚合。尽管基于声音的AM技术最近有了发展,但固有的实际限制仍然存在,例如低分辨率和可重复性,以及无法打印多材料结构。与普通的基于声音的打印方法相比,PSP克服了这些限制,将分辨率提高了10倍,将打印功率降低了4倍,将最大声流速度降低了1600倍,提高了可重复性和分辨率。PSP提供了比现有方法更大的通用性,通过打印孔径调整调制特征尺寸。这种能力对于制造高分辨率图案和材料完整性至关重要的微系统特别有价值。此外,PSP可以直接打印热固化材料,如聚二甲基硅氧烷(PDMS),一种在微流体和软光刻中广泛使用的热固性材料,而无需改变其原始配方。通过声化学发光实验和高速成像探索了PSP工艺,并通过成功打印多材料复合结构和功能微流控器件进行了验证。总的来说,PSP为声音驱动的增材制造建立了一种实用的高分辨率方法。
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引用次数: 0
Beyond binary patterning: polypropylene carbonate as a versatile thermal resist for high-fidelity grayscale Nanofabrication. 超越二元图案:聚丙烯碳酸酯作为高保真灰度纳米制造的通用热阻。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01032-z
Hongtao Li, Jixiang Li, Zeming Jin, Haonan Ma, Shijie Zhao, Ziying Hu, Mingdi Zhang, Wenke Fu, Jiakai Wang, Yunyun Dai, Yuan Huang, Xia Liu, Yeliang Wang

Thermal scanning probe lithography (t-SPL) is a high-resolution nanopatterning technique that employs a heated probe for precise, maskless patterning. Polypropylene carbonate (PPC) has emerged as a promising resist material for t-SPL due to its favorable thermal decomposition behavior. In this study, we investigate the use of PPC as a thermal resist in t-SPL, leveraging its chain unzipping and random scission mechanisms to achieve controlled material removal. The effects of various parameters on the patterning of PPC films, such as temperature, tip height, and force pulse, are systematically examined. Upon exposure to the heated tip, PPC undergoes localized sublimation at the contact area, enabling nanopatterning with the lateral resolution down to 50 nm and the vertical resolution down to sub-nanometer. This approach achieves stepped cyclic and sinusoidal grayscale patterns with controllable depth and size. Furthermore, we demonstrate grayscale pattern transfer by etching the PPC patterns into dielectric layers using optimized dry etching processes. This approach offers precise depth control and shows strong potential for applications in photonic and nano-electronic device fabrication.

热扫描探针光刻(t-SPL)是一种高分辨率的纳米图案技术,采用加热探针进行精确的无掩模图案。聚丙烯碳酸酯(PPC)由于其良好的热分解性能而成为一种很有前途的抗t-SPL材料。在这项研究中,我们研究了在t-SPL中使用PPC作为热阻剂,利用其链解压缩和随机断裂机制来实现受控的材料去除。系统地研究了温度、尖端高度、力脉冲等参数对PPC薄膜成图化的影响。暴露于加热的尖端后,PPC在接触区域进行局部升华,使纳米图案的横向分辨率低至50纳米,垂直分辨率低至亚纳米。该方法实现了深度和大小可控的阶跃循环和正弦灰度模式。此外,我们还利用优化的干蚀刻工艺将PPC图案蚀刻到介电层上,从而证明了灰度图案的转移。这种方法提供了精确的深度控制,并在光子和纳米电子器件制造中显示出强大的应用潜力。
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引用次数: 0
ZIF-8/SnO2 based high sensitivity ethylene gas sensor with Au-GO doped. 掺杂Au-GO的ZIF-8/SnO2型高灵敏度乙烯气体传感器
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01081-4
Tianye Zhou, Jianhai Sun, Zhimei Qi, Liang Zhao, Xuehui Li, Bofeng Luo, Zhengkai Li, Zhiyuan Niu

Metal oxide semiconductor gas sensors exhibit significant advantages in gas detection due to their high sensitivity and low cost. However, challenges such as poor selectivity and insufficient stability remain critical scientific issues. In this study, tin dioxide nanomaterials with a unique structure were successfully synthesized using ZIF-8 as a template. Further modification with gold-decorated reduced graphene oxide yielded a nanocomposite that demonstrated rapid response, high sensitivity, and excellent selectivity for low-concentration ethylene detection. The crystal structure, morphology, elemental composition, and pore size distribution of the materials were systematically characterized using XRD, FESEM, EDS, UV-Vis spectroscopy, and N2 adsorption-desorption analysis. Gas sensing tests revealed that the sensor exhibited a response value of 5.35 to 20 ppm C2H4 at an optimal operating temperature of 280 °C, with response and recovery times of 14 s and 17 s, respectively. The selectivity ratio for ethylene over the second most sensitive gas was 3.26, highlighting its superior specificity. Additionally, the sensor demonstrated good stability and repeatability, providing a cost-effective solution for real-time ethylene monitoring in humid environments.

金属氧化物半导体气体传感器具有灵敏度高、成本低的特点,在气体检测中具有显著的优势。然而,选择性差和稳定性不足等挑战仍然是关键的科学问题。本研究以ZIF-8为模板,成功合成了具有独特结构的二氧化锡纳米材料。用金修饰的还原氧化石墨烯进一步改性得到的纳米复合材料对低浓度乙烯检测具有快速响应、高灵敏度和出色的选择性。采用XRD、FESEM、EDS、UV-Vis光谱、N2吸附-脱附分析等方法对材料的晶体结构、形貌、元素组成和孔径分布进行了系统表征。气体传感测试表明,在280℃的最佳工作温度下,该传感器的响应值为5.35 ~ 20 ppm C2H4,响应时间和恢复时间分别为14 s和17 s。乙烯对第二敏感气体的选择性比为3.26,突出了其优越的特异性。此外,该传感器表现出良好的稳定性和可重复性,为潮湿环境下的实时乙烯监测提供了一种经济高效的解决方案。
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引用次数: 0
A flexible wireless skin patch for synchronized glucose monitoring and regulation. 一种灵活的无线皮肤贴片,用于同步血糖监测和调节。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-01-08 DOI: 10.1038/s41378-025-01138-4
Rui Lin, Zhixian Jiang, Yanzhi Chi, Lili Xing, Zhihe Long, Xinyu Xue, Meihua Chen

Conventional diabetes management requires frequent invasive procedures such as finger-prick blood sampling and subcutaneous injections to coordinate glucose monitoring and medication. Here, we propose a novel, flexible, wearable, battery-free skin patch that synchronizes painless glucose monitoring and regulation capabilities with smartphone-mediated wireless control. This patch integrates bendable fluorescent hydrogel microneedles for minimally invasive glucose monitoring (50 to 450 mg/dL range) and thermoresponsive microneedles for metformin delivery. In diabetic mouse models, it accurately tracked interstitial glucose levels and, upon hyperglycemia detection, reduced blood glucose within 1 h (effects lasting 5-6 h). This system provides glucose monitoring with wireless data transmission and precise drug administration while eliminating pain, infection risk, and high costs. Its lightweight, disposable design offers a practical solution for improved diabetes care.

传统的糖尿病管理需要频繁的侵入性手术,如手指穿刺采血和皮下注射,以协调血糖监测和药物治疗。在这里,我们提出了一种新颖的、灵活的、可穿戴的、无电池的皮肤贴片,它将无痛血糖监测和调节功能与智能手机介导的无线控制同步。该贴片集成了可弯曲的荧光水凝胶微针,用于微创血糖监测(50至450 mg/dL范围)和热响应微针,用于二甲双胍输送。在糖尿病小鼠模型中,它准确地跟踪间质葡萄糖水平,并在高血糖检测后,在1小时内降低血糖(效果持续5-6小时)。该系统通过无线数据传输和精确给药提供血糖监测,同时消除疼痛、感染风险和高成本。其轻便的一次性设计为改善糖尿病护理提供了实用的解决方案。
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引用次数: 0
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Microsystems & Nanoengineering
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