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Optimized stress transfer interfaces enabled wearable nano-electronics for fatigue driving monitoring. 优化的应力传递接口使可穿戴纳米电子设备能够用于疲劳驾驶监测。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-15 DOI: 10.1038/s41378-025-01107-x
Hao Lei, Lingjie Xie, Xuan Qin, Guoxuan Sun, Peihao Huang, Weinuo Wang, Bohan Lu, Jiawei Yan, Yuxi Wang, Yina Liu, Eng Gee Lim, Xin Tu, Chun Zhao, Xuhui Sun, Zhen Wen

Accurate detection of arterial pulse waves is crucial for wearable warning systems but faces challenges under non-close contact or pre-stress. Here, an interfacial engineered triboelectric sensor (IETS) has been proposed to improve the detection accuracy of pulse waves. It consists of a stress-transferring sensor-skin interface with piezo-frustums array and a gradient triboelectric interface with mountain-like microstructures. The mountain-like microstructures provide stress concentration points even under a pre-stress of 10 kPa with capturing all details of the pulse waves. Additionally, the incorporation of piezo-frustums array at the sensor-skin interface not only facilitates stress transfer but also generates piezoelectric charges. Such mechano-electric coupling effect endows IETS with a high sensitivity of 4.28 V/kPa. Integrated with machine learning, a wearable system based on IETS allows for drivers' health and fatigue assessment via pulse wave analysis, offering an effective approach to prevent road accidents caused by sudden cardiovascular diseases and fatigue driving.

动脉脉搏波的准确检测对于可穿戴预警系统至关重要,但在非近距离接触或预应力下面临挑战。本文提出了一种界面工程摩擦电传感器(IETS),以提高脉冲波的检测精度。它包括一个应力传递传感器-皮肤界面与压电晶体阵列和一个梯度摩擦电界面与山状微结构。山状微结构即使在10千帕的预应力下也能提供应力集中点,并捕获脉冲波的所有细节。此外,在传感器-蒙皮界面处加入压电晶体阵列不仅有利于应力传递,还能产生压电电荷。这种机电耦合效应使其具有4.28 V/kPa的高灵敏度。基于IETS的可穿戴系统与机器学习相结合,可以通过脉搏波分析来评估驾驶员的健康状况和疲劳程度,为预防突发心血管疾病和疲劳驾驶导致的交通事故提供了有效的方法。
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引用次数: 0
Exploring the synergic effect of thermal tuning and mode-coupling for frequency stabilization in micromechanical resonators. 探讨热调谐和模式耦合对微机械谐振器稳频的协同效应。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-12 DOI: 10.1038/s41378-026-01210-7
Yuhao Xiao, Chengliang Sun, Sheng Liu, Guoqiang Wu

This work investigates the synergic effect of thermal tuning and mode-coupling on frequency stability in a dual-mode micromechanical resonator. Under dynamic input excitation, the signal in one mode induces the frequency shift of the other mode due to the self-heating and mode-coupling effects. We propose a method to stabilize frequency of the dual-mode resonator under dynamic piezoelectric excitation. The method leverages an on-chip micro-oven to thermally tune the resonator at different temperature coefficients of frequency (TCF) points, enabling the control of self-heating and mode-coupling induced resonant frequency shifts. In our experiment, the resonator is maintained at an appropriately selected TCF point, where the frequency shift caused by mode-coupling can be compensated by the self-heating effect. These findings provide valuable insights into the thermal and nonlinear dynamics of dual-mode resonators and offer a promising strategy for designing high-performance micromechanical resonators in timing and sensing applications.

本文研究了热调谐和模式耦合对双模微机械谐振器频率稳定性的协同效应。在动态输入激励下,由于自热和模式耦合效应,一种模式的信号引起另一种模式的频移。提出了一种在动态压电激励下稳定双模谐振腔频率的方法。该方法利用片上微型烤箱在不同的温度频率系数(TCF)点对谐振器进行热调谐,从而控制自加热和模式耦合引起的谐振频移。在我们的实验中,谐振器保持在一个适当选择的TCF点,在这个点上,由模式耦合引起的频移可以通过自热效应来补偿。这些发现为双模谐振器的热动力学和非线性动力学提供了有价值的见解,并为设计用于定时和传感应用的高性能微机械谐振器提供了有前途的策略。
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引用次数: 0
A parallel-legged insect-scale robot based on actuation-structure integrated origami mechanism. 基于驱动-结构集成折纸机构的平行腿昆虫级机器人。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-12 DOI: 10.1038/s41378-026-01205-4
Qunwei Zhu, Tao Jiang, Zirong Luo, Yiming Zhu, Guanhai Huang

Insect-scale robots can access extremely confined spaces, demonstrating significant application potential in fields such as disaster relief and exploration within confined environments. Currently, the integrated fabrication and formation are still a challenge for insect-scale piezoelectric robots. In this study, we propose a 1.2 g novel parallel-legged insect-scale origami robot named PLioBot featuring an integrated origami mechanism. This integrated origami mechanism encompasses all the actuators and structures integral to the PLioBot's composition and can be readily fabricated through an improved lamination process. The PLioBot is capable of forward, backward, and turning locomotion, achieving a maximum velocity of 44.6 cm/s (17.84 body length/s) at 60 Hz. It demonstrates adaptability to traverse various surfaces and can successfully climb slopes up to 12°. The robot is able to navigate through confined spaces such as tunnels and L-shaped bends while carrying a payload of 1.4 g. Equipped with hemispherical foot mats, the PLioBot demonstrates enhanced mobility across various complex environments, including grasslands, sandy terrains, and stone surfaces. It is capable of submerged locomotion along the bottom of a fishbowl, as well as swimming on the water surface using the flipper attachment. The PLioBot, along with its integrated origami mechanism and the enhanced lamination process, offers a novel approach for the design and assembly-free fabrication of insect-scale micro robots.

昆虫级机器人可以进入极端密闭的空间,在密闭环境下的救灾和勘探等领域显示出巨大的应用潜力。目前,昆虫级压电机器人的集成制造和成型仍然是一个挑战。在这项研究中,我们提出了一个1.2 g的新型平行腿昆虫级折纸机器人,名为PLioBot,具有集成的折纸机制。这种集成的折纸机制包含了PLioBot组成的所有致动器和结构,并且可以通过改进的层压工艺轻松制造。PLioBot能够向前、向后和转弯运动,在60赫兹的频率下达到44.6厘米/秒(17.84体长/秒)的最大速度。它展示了穿越各种表面的适应性,并能成功地爬上高达12°的斜坡。该机器人能够在携带1.4克有效载荷的情况下通过隧道和l型弯道等狭窄空间。PLioBot配备了半球形脚垫,在各种复杂环境(包括草地、沙质地形和石头表面)中展示了增强的机动性。它能够沿着鱼缸底部在水下运动,也可以使用鳍状附件在水面上游泳。PLioBot连同其集成的折纸机制和增强的层压工艺,为昆虫级微型机器人的设计和无装配制造提供了一种新颖的方法。
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引用次数: 0
Complementary visual localization and tactile mapping approach for robotic perception of millimeter-sized objects with irregular surfaces. 基于互补视觉定位和触觉映射的毫米级不规则物体机器人感知方法。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-11 DOI: 10.1038/s41378-026-01190-8
Jaehwan Jang, Byeong-Sun Park, Kyeong Taek Oh, Seong-Jae Yoo, Seong-Min Im, Yasser Khan, Min-Gu Kim

Humanoid robots and human-machine interaction technologies are essential for perceiving and manipulating millimeter-scale objects with irregular surfaces in extreme environments, such as outer space, radioactive zones, and hazardous sites with explosive ordnance, where human access is restricted. A vision-based perception approach provides spatial and positional information about objects but relying solely on it for robot manipulation poses challenges due to limitations in detectable object size, as well as sensitivity to external factors such as focusing issues, occlusion, and lighting conditions. In contrast, tactile perception offers valuable information about aspects that are difficult to discern visually, including an object's shape, surface characteristics, and the forces involved during contact. This study presents a complementary visual localization and tactile mapping framework that allows robots to effectively perceive small objects with irregular surfaces in visually restricted environments. The proposed method draws inspiration from the sequential vision-tactile sensory processing observed in humans when handling small objects with irregular surfaces. It employs an RGB-Depth camera for visual perception and a soft pressure sensor array, made using inkjet printing, for tactile perception. We demonstrate the feasibility of implementing a sensory substitution to detect the size and location of objects through visual perception, as well as identify object surfaces and reconstruct their three-dimensional profiles using tactile scanning, particularly in environments where visual information is limited. This study provides a technological foundation for enhancing the autonomy and adaptability of humanoid robots in unpredictable and unstructured environments, particularly to support precise robot manipulation in such conditions.

人形机器人和人机交互技术对于在极端环境中感知和操纵具有不规则表面的毫米级物体至关重要,例如外层空间、放射性区域和具有爆炸性弹药的危险场所,这些环境限制了人类的进入。基于视觉的感知方法提供了物体的空间和位置信息,但由于可检测物体大小的限制,以及对焦问题、遮挡和照明条件等外部因素的敏感性,仅依靠视觉来进行机器人操作带来了挑战。相比之下,触觉感知提供了关于视觉难以辨别的方面的有价值的信息,包括物体的形状、表面特征和接触过程中涉及的力。本研究提出了一种互补的视觉定位和触觉映射框架,使机器人能够在视觉受限的环境中有效地感知具有不规则表面的小物体。该方法的灵感来自于人类在处理具有不规则表面的小物体时观察到的顺序视觉-触觉感觉处理。它采用了一个rgb深度摄像头来实现视觉感知,以及一个使用喷墨打印制造的软压力传感器阵列来实现触觉感知。我们展示了通过视觉感知来检测物体大小和位置的感官替代的可行性,以及识别物体表面并使用触觉扫描重建其三维轮廓,特别是在视觉信息有限的环境中。本研究为增强人形机器人在不可预测和非结构化环境中的自主性和适应性,特别是在这种条件下支持机器人的精确操作提供了技术基础。
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引用次数: 0
Signal-to-noise ratio enhancement for MEMS resonant sensors with potential barrier adjustable stochastic resonance. 势垒可调随机共振MEMS谐振传感器的信噪比增强。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-10 DOI: 10.1038/s41378-026-01201-8
Junhui Wu, Guangya Zhou

The signature of stochastic resonance is that additional noise surprisingly enhances the signal-to-noise ratio (SNR). A noise-adaptive system that learns to add an optimal amount of noise to trigger stochastic resonance and improve SNR is known as adaptive stochastic resonance. However, the current stochastic resonance mechanism fails when environmental noise exceeds the optimal noise level, as any additional noise merely worsens the SNR. In this case, instead of adding noise, stochastic resonance can be facilitated by adapting the potential energy landscape of the bistable system. Here, we propose a novel approach to enhance SNR in noisy environments, involving a potential adjustable microelectromechanical systems resonator. A periodic signal with an amplitude of 0.28 Vrms is buried in ambient noise, emulated by a white noise signal with amplitude ranging from 0.7 Vrms to 4 Vrms. Experimental results show that when the ambient noise exceeds 1 Vrms, adding additional noise leads to a decline in SNR. However, SNR enhancement induced by stochastic resonance is experimentally demonstrated by tuning the potential well of the resonator. This advancement highlights the feasibility of potential adjustable systems to overcome the limitations of conventional noise adjustable stochastic resonance methods in noisy environments. The proposed mechanism is further applied to detect the frequency of 2.7 nN periodic forces with various waveforms.

随机共振的特征是额外的噪声惊人地提高了信噪比(SNR)。自适应随机共振是一种学习添加最优噪声量来触发随机共振并提高信噪比的噪声自适应系统。然而,当环境噪声超过最佳噪声水平时,现有的随机共振机制失效,因为任何额外的噪声只会使信噪比恶化。在这种情况下,可以通过调整双稳态系统的势能景观来促进随机共振,而不是增加噪声。在这里,我们提出了一种新的方法来提高噪声环境中的信噪比,涉及一个潜在的可调微机电系统谐振器。将幅值为0.28 Vrms的周期信号埋在环境噪声中,用幅值为0.7 ~ 4 Vrms的白噪声信号模拟。实验结果表明,当环境噪声超过1 Vrms时,加入额外的噪声会导致信噪比下降。然而,实验证明,通过调整谐振器的势阱,随机共振引起的信噪比增强。这一进展强调了潜在可调系统克服传统噪声可调随机共振方法在噪声环境中的局限性的可行性。将所提出的机制进一步应用于各种波形的2.7 nN周期力的频率检测。
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引用次数: 0
Phase error analysis for MEMS gyroscopes operational modes based on force-to-rebalance rate measurement mode. 基于力再平衡速率测量模式的MEMS陀螺仪工作模式相位误差分析。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-10 DOI: 10.1038/s41378-025-01144-6
Jia Jia, Han Zhang, Shixuan Gao, Yang Gao, Fang Chen, Huiliang Cao

The force-to-rebalance (FTR) mode is one of the most widely employed measurement schemes in MEMS Coriolis vibratory gyroscopes due to its high precision and stability. However, phase errors distributed across multiple control loops fundamentally constrain the achievable accuracy and robustness of rate measurement. This paper systematically categorizes the phase errors in both the drive modal and sense modal control loops, distinguishing between those arising in the forward and feedback paths, while excluding feedthrough effects. The influence of these phase errors is comprehensively analyzed across three key control loops: the drive modal control loop, the FTR rate control loop, and the quadrature stiffness correction loop. To address phase errors in the drive modal control loop, a dedicated calibration procedure is proposed for both the feedback and forward paths. The effects of phase errors on amplitude regulation, frequency tracking, and FTR rate measurement are quantitatively examined. For the sense modal control loop, an FTR control architecture incorporating phase error characteristics is established, along with a corresponding calibration procedure. Furthermore, the impact of phase errors on the effectiveness of quadrature stiffness correction and FTR rate measurement is investigated in detail. Finally, a comparative analysis of the sensitivity of system performance to various phase errors is conducted, and the relative influence weights of different error sources are determined. The results provide diagnostic insight into the principal mechanisms by which phase errors affect FTR gyroscope performance and lay a foundation for targeted real-time compensation design.

再平衡力(FTR)模式由于其高精度和高稳定性,是MEMS科里奥利振动陀螺仪中应用最广泛的测量方案之一。然而,分布在多个控制回路上的相位误差从根本上限制了速率测量的可实现精度和鲁棒性。本文系统地对驱动模态和感知模态控制回路中的相位误差进行了分类,区分了前向和反馈路径中产生的相位误差,同时排除了馈通效应。通过三个关键控制环:驱动模态控制环、FTR速率控制环和正交刚度校正环,全面分析了这些相位误差的影响。为了解决驱动模态控制环路中的相位误差,提出了一种针对反馈路径和前向路径的专用校准程序。相位误差对幅度调节、频率跟踪和FTR速率测量的影响进行了定量研究。对于感测模态控制回路,建立了包含相位误差特性的FTR控制体系,并给出了相应的校准程序。此外,还详细研究了相位误差对正交刚度校正和FTR率测量有效性的影响。最后,对比分析了系统性能对不同相位误差的敏感性,确定了不同误差源的相对影响权重。研究结果对相位误差影响FTR陀螺仪性能的主要机制提供了诊断性见解,并为有针对性的实时补偿设计奠定了基础。
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引用次数: 0
Rapid-manufacturing and cost-effective single-layer microfluidic device for high-throughput three-dimensional hydrodynamic focusing. 用于高通量三维流体动力聚焦的快速制造和高性价比的单层微流控装置。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-10 DOI: 10.1038/s41378-026-01212-5
Ruopeng Yan, Shubin Wei, Yueyun Weng, Rubing Li, Yan Jin, Xun Liu, Jinxuan Hou, Yu Xu, Sheng Li, Du Wang, Haihang Ye, Sheng Liu, Cheng Lei

Microfluidic devices play a crucial role in the widespread application of single-cell analysis, where hydrodynamic focusing stands out due to its simplicity in structure and excellent adaptability to a wide range of flow rates. Owing to the extensive application of soft lithography, polydimethylsiloxane (PDMS) is widely used in the fabrication of microfluidic devices. However, challenges arise under high-throughput conditions, where the elastic deformation of PDMS can cause microchannel expansion, diminishing focusing effect. To address this challenge, this work introduces a three-dimensional (3D) hydrodynamic focusing device with simplified single-layer structure, which is fabricated by the double transfer process, specifically designed for fabricating polyurethane acrylate (PUA) microfluidic devices. Notably, this approach eliminates the time-consuming heating procedures, which significantly enhances manufacturing speed by an order of magnitude compared to the soft lithography process. To evaluate the practical focusing performance of the microfluidic device, optical time-stretch (OTS) microscopy is employed for high-throughput imaging of clinical urine samples. Experimental results demonstrate that as the flow rate increases, the focusing efficiency gradually improves in both vertical and lateral directions. At an averaged velocity of 16.7 m/s, the focusing efficiency reaches 98.4% in the vertical direction and 95.0% in the lateral direction. Thus, the amalgamation of simplicity, efficiency, and adaptability positions this technology as a promising tool in the realm of microfluidics, particularly for applications requiring precise cell focusing in high-throughput scenarios.

微流控装置在单细胞分析的广泛应用中起着至关重要的作用,其中流体动力学聚焦因其结构简单和对大范围流速的良好适应性而脱颖而出。由于软光刻技术的广泛应用,聚二甲基硅氧烷(PDMS)在微流体器件的制造中得到了广泛的应用。然而,在高通量条件下,PDMS的弹性变形会导致微通道膨胀,降低聚焦效果。为了解决这一挑战,本工作介绍了一种简化单层结构的三维(3D)流体动力聚焦装置,该装置采用双转移工艺制造,专门用于制造聚氨酯丙烯酸酯(PUA)微流体装置。值得注意的是,这种方法消除了耗时的加热过程,与软光刻工艺相比,显著提高了制造速度。为了评估微流控装置的实际聚焦性能,采用光学时间拉伸(OTS)显微镜对临床尿液样本进行高通量成像。实验结果表明,随着流量的增大,在垂直方向和横向方向上聚焦效率都逐渐提高。在平均速度为16.7 m/s时,垂直聚焦效率达到98.4%,横向聚焦效率达到95.0%。因此,简单,高效和适应性的融合使该技术成为微流体领域的一个有前途的工具,特别是在高通量场景中需要精确细胞聚焦的应用。
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引用次数: 0
Electrohydrodynamic printing technology: mechanisms, control, and applications. 电流体动力印刷技术:机理、控制与应用。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-10 DOI: 10.1038/s41378-026-01195-3
Yidong Tian, Jiajun Zhou, Hengjia Zhu, Kaiwen Huo, Xianli Xie, Wei Zhang, Huai Zheng

Electrohydrodynamic (EHD) printing is an advanced micro/nanoscale additive manufacturing technique. Owing to its high-resolution capability, broad material compatibility, diverse printing modes, and low cost, it has attracted widespread attention. Nevertheless, significant challenges remain in transitioning EHD printing from the laboratory to large-scale industrial production. This paper elucidates the mechanisms of EHD printing and details control methods for high-resolution, controllable micro/nanopattern fabrication, including process-parameter optimization, rheological design of functional inks, and innovations in system architecture. We summarize recent applications in electronic devices, biomedicine, and optical components, and discuss development directions and prospects for industrial adoption.

电流体动力(EHD)打印是一种先进的微/纳米级增材制造技术。由于其高分辨率、材料兼容性广、打印方式多样、成本低等特点,受到了广泛的关注。然而,在将EHD打印从实验室过渡到大规模工业生产方面仍然存在重大挑战。本文阐述了EHD打印的机理,并详细介绍了高分辨率、可控微/纳米图案制造的控制方法,包括工艺参数优化、功能油墨的流变设计和系统架构的创新。总结了近年来在电子器件、生物医学和光学元件等领域的应用,并讨论了工业应用的发展方向和前景。
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引用次数: 0
A laminated magnetic flux concentrator with low coercivity and high relative permeability for efficient flux modulation in MEMS magnetoresistive sensors. 一种用于MEMS磁阻传感器磁通调制的低矫顽力高相对磁导率层压磁通集中器。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-10 DOI: 10.1038/s41378-026-01202-7
Qifeng Jiao, Guoshuo Peng, Zhenhu Jin, Chenglong Zhang, Jiamin Chen

The detectivity of magnetic tunnel junction (MTJ) sensors cannot be improved further because of the existence of 1/f noise. Micro - electromechanical systems (MEMS) integrated with magnetic flux concentrators (MFCs) can be an effective approach to suppressing 1/f noise for modulating low-frequency magnetic fields. The challenge in fabricating small-sized and low-noise MTJ-MEMS hybrid magnetic sensors is associated with the production of high-performance MFCs. For the preparation of MFCs applicable to MTJ-MEMS hybrid magnetic sensors, in this research, a novel Ta/Ni77Fe14Cu5Mo4 laminated structure was adopted to decrease the coercivity of the magnetic film dozens of times. Also, through optimizing the sputtering power, a relative permeability of 3246 was attained. The simulation outcomes demonstrated that the MTJ-MEMS hybrid magnetic sensor which utilized this magnetic film had a modulation efficiency of 65.4%, and it retained a competitive edge among similar magnetic sensors. A sensor prototype was successfully developed with 400-nm- thick MFCs by optimizing the fabrication process, and the MTJ's sensitivity was increased by 2.2 times. In comparison to low-frequency noise, the high-frequency noise of the MTJ showed a reduction in noise power spectral density by a factor of 686. MTJ sensors will be highly competitive candidates in the field of ultra-weak magnetic field detection because of these results.

由于1/f噪声的存在,磁隧道结(MTJ)传感器的探测能力无法进一步提高。集成磁通集中器(mfc)的微机电系统(MEMS)是抑制低频磁场1/f噪声的有效方法。制造小尺寸和低噪声MTJ-MEMS混合磁传感器的挑战与高性能mfc的生产有关。为了制备适用于MTJ-MEMS混合磁传感器的mfc,本研究采用了一种新型的Ta/Ni77Fe14Cu5Mo4层压结构,使磁膜的矫顽力降低了数十倍。通过优化溅射功率,获得了相对磁导率为3246。仿真结果表明,利用该磁膜制备的MTJ-MEMS混合磁传感器调制效率高达65.4%,在同类磁传感器中具有一定的竞争优势。通过优化制作工艺,成功研制出400 nm厚度的mfc传感器原型,MTJ的灵敏度提高了2.2倍。与低频噪声相比,MTJ的高频噪声显示噪声功率谱密度降低了686倍。由于这些结果,MTJ传感器将成为极具竞争力的超弱磁场探测领域的候选者。
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引用次数: 0
Boron-doped diamond solution-gate field-effect transistor (BDD-SGFET) biosensor for gene mutation detection. 用于基因突变检测的掺硼金刚石溶液门场效应晶体管(BDD-SGFET)生物传感器。
IF 9.9 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Pub Date : 2026-03-10 DOI: 10.1038/s41378-026-01184-6
Zelong Lin, Yun Zheng, Yisen Chen, Chengyong Wang, Zhishan Yuan

Gene mutation is one of the core pathogenic factors in numerous major diseases, making the detection of base mismatches resulting from these mutations critically important in both biological and clinical contexts. This study presents a high-performance boron-doped diamond solution-gated field-effect transistor (BDD-SGFET) biosensor, designed with a diamond microwire structure, for the label-free detection of base mismatches associated with EGFR gene mutations. The simulations examining the impact of variations in diamond microwire dimensions on the electrical properties of BDD-SGFET reveal that increasing the microwire width while reducing its length enhances the electrical performance of the device. Utilizing microwave plasma chemical vapor deposition (MPCVD), photolithography, and plasma etching, we successfully fabricated high-performance BDD-SGFETs featuring microwire structures that demonstrate outstanding transconductance, a reduced threshold voltage, and a limit of detection of 10 pM. Notably, the enhanced performance of the fabricated BDD-SGFET enables the successful identification of DNA molecules with two base-pair mismatches. Furthermore, the device exhibits impressive anti-interference capabilities and exceptional stability in complex environments. These findings highlight the significant potential of microscale BDD-SGFETs as rapid, label-free, and robust platforms for point-of-care testing in genetic mutation analysis pertinent to cancer diagnosis.

基因突变是许多重大疾病的核心致病因素之一,因此检测由这些突变引起的碱基错配在生物学和临床中都至关重要。本研究提出了一种高性能掺硼金刚石溶液门控场效应晶体管(BDD-SGFET)生物传感器,采用金刚石微丝结构设计,用于无标记检测与EGFR基因突变相关的碱基错配。模拟研究了金刚石微线尺寸变化对BDD-SGFET电性能的影响,结果表明,增加微线宽度同时减小微线长度可以提高器件的电性能。利用微波等离子体化学气相沉积(MPCVD)、光刻技术和等离子体蚀刻技术,我们成功地制造出了高性能的bdd - sgfet,其微细线结构具有出色的跨导性、较低的阈值电压和10 pM的检测极限。值得注意的是,制备的BDD-SGFET的性能得到了增强,能够成功识别两个碱基对不匹配的DNA分子。此外,该器件在复杂环境中表现出令人印象深刻的抗干扰能力和卓越的稳定性。这些发现突出了微型bdd - sgfet作为快速、无标签和强大的平台,在与癌症诊断相关的基因突变分析中进行即时检测的巨大潜力。
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引用次数: 0
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Microsystems & Nanoengineering
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