Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-318-321
E. A. Pidodniy, A. Chuprov, V. A. Trubnikov
The most common methods for studying ocular blood flow include the method of color Doppler imaging (CDI). Purpose. To evaluate the effect of drinking coffee on the indicators of retrobulbar blood flow in healthy people using color doppler and to predict the possible impact of this factor on the results of the study of ocular blood flow in pathology of the organ of vision. Material and methods. The total number of observations is 16: 8 healthy people (8 eyes) before drinking coffee and an hour after drinking it, 8 healthy people (8 eyes) of the control group. The age of the subjects was 28 ± 2 years. As a control feature, a cup of made coffee (150 ml) was used, which was drunk one hour before the examination. The control group included persons who underwent a study of retrobulbar blood flow with an hour interval without drinking coffee. The calculations were carried out using the STATISTICA 13.0 software. Results. Analyzing the dynamics of the CDI indicators, there was an increase in the diastolic blood flow velocity and the average blood flow velocity in the ophthalmic artery one hour after drinking coffee (p < 0.05) compared with the control group. When assessing the indicators of the resistance index and the pulse index, their increase was found, but these changes turned out to be reliably insignificant, which indicates a change in blood flow in a certain period of cardiac output, but does not affect the total blood flow in the ophthalmic artery. Conclusion. Thus, the data obtained during the CDI indicate a change in ocular blood flow in the ophthalmic artery to a certain cardiac output one hour after drinking coffee, without affecting the true blood flow velocity and peripheral resistance in the ophthalmic artery. The CDI values in the central retinal artery did not change. Keywords: ophthalmic artery, central retinal artery, color Doppler imaging, drinking coffee
{"title":"Effect of coffee drinking on eye hemodynamics in color Doppler imaging","authors":"E. A. Pidodniy, A. Chuprov, V. A. Trubnikov","doi":"10.25276/2312-4911-2023-2-318-321","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-318-321","url":null,"abstract":"The most common methods for studying ocular blood flow include the method of color Doppler imaging (CDI). Purpose. To evaluate the effect of drinking coffee on the indicators of retrobulbar blood flow in healthy people using color doppler and to predict the possible impact of this factor on the results of the study of ocular blood flow in pathology of the organ of vision. Material and methods. The total number of observations is 16: 8 healthy people (8 eyes) before drinking coffee and an hour after drinking it, 8 healthy people (8 eyes) of the control group. The age of the subjects was 28 ± 2 years. As a control feature, a cup of made coffee (150 ml) was used, which was drunk one hour before the examination. The control group included persons who underwent a study of retrobulbar blood flow with an hour interval without drinking coffee. The calculations were carried out using the STATISTICA 13.0 software. Results. Analyzing the dynamics of the CDI indicators, there was an increase in the diastolic blood flow velocity and the average blood flow velocity in the ophthalmic artery one hour after drinking coffee (p < 0.05) compared with the control group. When assessing the indicators of the resistance index and the pulse index, their increase was found, but these changes turned out to be reliably insignificant, which indicates a change in blood flow in a certain period of cardiac output, but does not affect the total blood flow in the ophthalmic artery. Conclusion. Thus, the data obtained during the CDI indicate a change in ocular blood flow in the ophthalmic artery to a certain cardiac output one hour after drinking coffee, without affecting the true blood flow velocity and peripheral resistance in the ophthalmic artery. The CDI values in the central retinal artery did not change. Keywords: ophthalmic artery, central retinal artery, color Doppler imaging, drinking coffee","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80880255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-57-63
V. Skvortsov, D. Tulin, O. Mirgorodskaya
The study and objectification of the degree of intensity of the postoperative inflammatory response, in our opinion, is of great importance after endoscopic laser cyclodestruction (ELCD), which is the most often performed in combination with cataract surgery, when it is usually about eyes with prospects for high visual functions. Features of morphological changes and to conduct an objective analysis of the severity of the postoperative inflammatory response after ELCD, accompanied by the POP-effect and without it, was the goal of the study. The experiment carried out on rabbits in two modes (on different eyes of each animal). In the first variant, surgical intervention performed to visual response obtained in the form of coagulation of processes with a power in the diapason from 0.3 to 0.5 W. In the second variant, until the visual realization of the biological vaporization effect in the diapason from 0.9 to 1.2 W. OCT of the anterior segment with prevailing coverage of the anterior chamber in 1, 7 and 14 days. The resulting frames standardized in size. They analyzed in the programm ImageJ. Series of semithin sections were made on an Ultracut E ultramicrotome (Reicher, Austria); photos were taken on an Axio A1 light microscope (Zaiss, Germany) with an AxioCam MRc5 camera (Zaiss, Germany). During the comparison of the groups, no statistically significant differences were found between them on the corresponding days of observation (p = 0.24). Light microscopy shows extensive damage to the epithelium of the processes with the migration of pigment granules outside the tissue, however the structure of the stroma remains ordered with the preservation of vascularization. Keywords: endoscopic laser cyclodestruction, postoperative inflammation, glaucoma
{"title":"Postoperative inflammatory reaction after endoscopic laser cyclodestruction in various modes (experimental study)","authors":"V. Skvortsov, D. Tulin, O. Mirgorodskaya","doi":"10.25276/2312-4911-2023-2-57-63","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-57-63","url":null,"abstract":"The study and objectification of the degree of intensity of the postoperative inflammatory response, in our opinion, is of great importance after endoscopic laser cyclodestruction (ELCD), which is the most often performed in combination with cataract surgery, when it is usually about eyes with prospects for high visual functions. Features of morphological changes and to conduct an objective analysis of the severity of the postoperative inflammatory response after ELCD, accompanied by the POP-effect and without it, was the goal of the study. The experiment carried out on rabbits in two modes (on different eyes of each animal). In the first variant, surgical intervention performed to visual response obtained in the form of coagulation of processes with a power in the diapason from 0.3 to 0.5 W. In the second variant, until the visual realization of the biological vaporization effect in the diapason from 0.9 to 1.2 W. OCT of the anterior segment with prevailing coverage of the anterior chamber in 1, 7 and 14 days. The resulting frames standardized in size. They analyzed in the programm ImageJ. Series of semithin sections were made on an Ultracut E ultramicrotome (Reicher, Austria); photos were taken on an Axio A1 light microscope (Zaiss, Germany) with an AxioCam MRc5 camera (Zaiss, Germany). During the comparison of the groups, no statistically significant differences were found between them on the corresponding days of observation (p = 0.24). Light microscopy shows extensive damage to the epithelium of the processes with the migration of pigment granules outside the tissue, however the structure of the stroma remains ordered with the preservation of vascularization. Keywords: endoscopic laser cyclodestruction, postoperative inflammation, glaucoma","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73267329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-169-172
A. Plyukhova, O. A. Savochkina
Summary. Intravitreal administration of anti-VEGF drugs is currently the main method of treatment for all types of exudative form of age-related macular degeneration (eAMD). However, most studies did not divide patients. Currently, there are two drugs with a long clinical history of use in Russia for the treatment of neovascular AMD, these are ranibizumab and aflibercept. Data regarding the binding affinity of ranibizumab and aflibercept to VEGF have been inconsistent in in vitro studies. To analyze the effectiveness of aflibercept and ranibizumab in real clinical practice over a three-year follow-up period. Material and methods. The clinical material of the study was the data of examination and treatment of 344 patients (344 eyes) aged 50 to 87 years with a diagnosis of exudative form of age-related macular degeneration on the basis of the Federal State Budget Scientific Institution “NIIGB. Results. During the first treatment, the difference between groups in BCVA (0.51 ± 0.25 for both groups) and CRT (403.3 ± 115.9 for ranibizumab and 364.2 ± 119.6 for aflibercept) during the first year was not noted (p > 0.05). During the third year of observation and treatment in both groups, the same number of IVIs was produced – 3.5. BCVA in the aflibercept group was 0.53 ± 0.30, in the ranibizumab group it was 0.41 ± 0.30 (p < 0.05). In our opinion, the main factor in the stabilization of visual functions in the aflibercept group is more thorough “disease control», while in the ranibizumab group, with a comparable number of injections, visual acuity was lower by the end of the 3rd year of observation, which we attribute to the negative effect of persistent edema, leading to to death of retinal cells. Keywords: age related macular degeneration, anti-VEGF therapy, aflibercept, ranibizumab
{"title":"Comparative analysis of effectiveness research of ranibizumab and aflibercept","authors":"A. Plyukhova, O. A. Savochkina","doi":"10.25276/2312-4911-2023-2-169-172","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-169-172","url":null,"abstract":"Summary. Intravitreal administration of anti-VEGF drugs is currently the main method of treatment for all types of exudative form of age-related macular degeneration (eAMD). However, most studies did not divide patients. Currently, there are two drugs with a long clinical history of use in Russia for the treatment of neovascular AMD, these are ranibizumab and aflibercept. Data regarding the binding affinity of ranibizumab and aflibercept to VEGF have been inconsistent in in vitro studies. To analyze the effectiveness of aflibercept and ranibizumab in real clinical practice over a three-year follow-up period. Material and methods. The clinical material of the study was the data of examination and treatment of 344 patients (344 eyes) aged 50 to 87 years with a diagnosis of exudative form of age-related macular degeneration on the basis of the Federal State Budget Scientific Institution “NIIGB. Results. During the first treatment, the difference between groups in BCVA (0.51 ± 0.25 for both groups) and CRT (403.3 ± 115.9 for ranibizumab and 364.2 ± 119.6 for aflibercept) during the first year was not noted (p > 0.05). During the third year of observation and treatment in both groups, the same number of IVIs was produced – 3.5. BCVA in the aflibercept group was 0.53 ± 0.30, in the ranibizumab group it was 0.41 ± 0.30 (p < 0.05). In our opinion, the main factor in the stabilization of visual functions in the aflibercept group is more thorough “disease control», while in the ranibizumab group, with a comparable number of injections, visual acuity was lower by the end of the 3rd year of observation, which we attribute to the negative effect of persistent edema, leading to to death of retinal cells. Keywords: age related macular degeneration, anti-VEGF therapy, aflibercept, ranibizumab","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76464124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-298-300
A. Kirson, N. Pomytkina
Purpose. To assess the difficulties of finding out true cause of detachment of neuroepithelium in patients with various retinal pathologies. Material and methods. 3 patients (3 eyes) aged 51 to 59 years with complaints of sensation of a “spot» in front of the eye, decreased vision and metamorphopsia. The best corrected visual acuity ranged from 0.4 to 0.5. Rounded local prominating lesion – zones of local detachment of neuroepithelium, zones of local atrophy or defects in retinal pigment epithelium (RPE) were determined in all 3 eyes in the posterior pole of the eye. Results. According to results of optical coherence tomography (OCT), all 3 eyes had local serous detachment of neuroepithelium from 250 to 270 µm, local inclusions characterized by hyperreflective and heterogeneous RPE layer, episodically located in its layers hyperreflective areas with point breach in the Bruch membrane (“hard» drusen). Irregular RPE elevations (“wavy pattern») with its local fibrovascular detachment were determined. According to the results of OCT angiography, hyperreflective zones of the presence of a neovascular network in the layer of choriocapillaries under the areas of fibrovascular detachment of RPE, coinciding with zones of hyperautofluorescence, were revealed in all 3 eyes. In paired eyes of all 3 patients, “hard» retinal drusen in the macular zone were detected. Conclusions. 1. All 3 eyes were diagnosed with the wet form agerelated macular degeneration due to: their belonging to the older age group, low corrected visual acuity, the presence of complaints of metamorphopsia, irregular elevation and local fibrovascular detachment of RPE, the presence of local hyperautofluorescence, and presence of drusen on the double eye. 2. The use of OCT angiography makes it possible to differentiate between central serous chorioretinopathy and age-related macular degeneration by detecting choroidal neovascularization. Keywords: central serous chorioretinopathy, wet AMD, detachment of neuroepithelium
{"title":"Search causes of detachment of neuroepithelium in order to make correct diagnosis in patients with pathology of macular area","authors":"A. Kirson, N. Pomytkina","doi":"10.25276/2312-4911-2023-2-298-300","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-298-300","url":null,"abstract":"Purpose. To assess the difficulties of finding out true cause of detachment of neuroepithelium in patients with various retinal pathologies. Material and methods. 3 patients (3 eyes) aged 51 to 59 years with complaints of sensation of a “spot» in front of the eye, decreased vision and metamorphopsia. The best corrected visual acuity ranged from 0.4 to 0.5. Rounded local prominating lesion – zones of local detachment of neuroepithelium, zones of local atrophy or defects in retinal pigment epithelium (RPE) were determined in all 3 eyes in the posterior pole of the eye. Results. According to results of optical coherence tomography (OCT), all 3 eyes had local serous detachment of neuroepithelium from 250 to 270 µm, local inclusions characterized by hyperreflective and heterogeneous RPE layer, episodically located in its layers hyperreflective areas with point breach in the Bruch membrane (“hard» drusen). Irregular RPE elevations (“wavy pattern») with its local fibrovascular detachment were determined. According to the results of OCT angiography, hyperreflective zones of the presence of a neovascular network in the layer of choriocapillaries under the areas of fibrovascular detachment of RPE, coinciding with zones of hyperautofluorescence, were revealed in all 3 eyes. In paired eyes of all 3 patients, “hard» retinal drusen in the macular zone were detected. Conclusions. 1. All 3 eyes were diagnosed with the wet form agerelated macular degeneration due to: their belonging to the older age group, low corrected visual acuity, the presence of complaints of metamorphopsia, irregular elevation and local fibrovascular detachment of RPE, the presence of local hyperautofluorescence, and presence of drusen on the double eye. 2. The use of OCT angiography makes it possible to differentiate between central serous chorioretinopathy and age-related macular degeneration by detecting choroidal neovascularization. Keywords: central serous chorioretinopathy, wet AMD, detachment of neuroepithelium","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76279974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-115-118
E. N. Korobov, D. Petrachkov, L. Alkharky
Purpose. To evaluate the effectiveness of various options for anti-angiogenic therapy in patients with subretinal hemorrhage (SRH) by of age-related macular degeneration (AMD). Material and methods. A total of 15 patients (15 eyes) with SRH by of AMD were treated. The mean duration of a hemorrhage from its onset to the start of treatment was 18.8 ± 10.0 days. The size of the SRH varied from 0.5 to 5 DD. The best corrected visual acuity (BCVA) before treatment varied from hand movement near the face to 0.1. Patients underwent the following treatment options for SRH: 1) anti-VEGF intravitreal injection (IVI) – 8 (53.3%); 2) IVI anti-VEGF + IVI prourokinase + IVI ophthalmic gas (SF6, C2F6) – 7 (46.7%). The average follow-up period for patients after treatment was 10.8 ± 6.3 months. Results and discussion. With the maximum follow-up period after the treatment in 2nd group it was possible to achieve hemorrhage displacement: partial – in 2 (58%) patients, complete – in 5 (71.5%) patients. At the maximum follow-up period, an improvement in BCVA in comparison with the preoperative one was observed in 8 (53.3%) cases, no dynamics – in 4 (26.7%) cases, and negative dynamics – in 3 (20%) cases. All patients underwent anti-VEGF therapy after the start of SRH treatment. Conclusions. The data obtained indicate that the use of antiangiogenic therapy of SRH by of AMD has positive results in improving BCVA and reducing the volume of hemorrhage. The choice of treatment method is determined by the size and duration of the existence of the SRH. It is necessary to continue anti-VEGF therapy in all patients after the start of treatment with SRH by of AMD. Keywords: submacular hemorrhage, age-related macular degeneration, pneumodislocation, anti-VEGF inhibitors, tissue plasminogen activator
{"title":"Options for antiangiogenic therapy of subretinal hemorrhages by of age-related macular degeneration","authors":"E. N. Korobov, D. Petrachkov, L. Alkharky","doi":"10.25276/2312-4911-2023-2-115-118","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-115-118","url":null,"abstract":"Purpose. To evaluate the effectiveness of various options for anti-angiogenic therapy in patients with subretinal hemorrhage (SRH) by of age-related macular degeneration (AMD). Material and methods. A total of 15 patients (15 eyes) with SRH by of AMD were treated. The mean duration of a hemorrhage from its onset to the start of treatment was 18.8 ± 10.0 days. The size of the SRH varied from 0.5 to 5 DD. The best corrected visual acuity (BCVA) before treatment varied from hand movement near the face to 0.1. Patients underwent the following treatment options for SRH: 1) anti-VEGF intravitreal injection (IVI) – 8 (53.3%); 2) IVI anti-VEGF + IVI prourokinase + IVI ophthalmic gas (SF6, C2F6) – 7 (46.7%). The average follow-up period for patients after treatment was 10.8 ± 6.3 months. Results and discussion. With the maximum follow-up period after the treatment in 2nd group it was possible to achieve hemorrhage displacement: partial – in 2 (58%) patients, complete – in 5 (71.5%) patients. At the maximum follow-up period, an improvement in BCVA in comparison with the preoperative one was observed in 8 (53.3%) cases, no dynamics – in 4 (26.7%) cases, and negative dynamics – in 3 (20%) cases. All patients underwent anti-VEGF therapy after the start of SRH treatment. Conclusions. The data obtained indicate that the use of antiangiogenic therapy of SRH by of AMD has positive results in improving BCVA and reducing the volume of hemorrhage. The choice of treatment method is determined by the size and duration of the existence of the SRH. It is necessary to continue anti-VEGF therapy in all patients after the start of treatment with SRH by of AMD. Keywords: submacular hemorrhage, age-related macular degeneration, pneumodislocation, anti-VEGF inhibitors, tissue plasminogen activator","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77857331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-259-265
N.V. Babaeva, E. V. Bobykin, O. Morozova, V. Krokhalev
Changes in choroidal thickness (CT) may indicate the presence of macular diseases and be used to monitor their course and treatment. Automatic segmentation of the choroid is not currently available, and semi-automatic segmentation is laborious and time-consuming. Purpose. To evaluate the reproducibility of CT manual measurement results using spectraldomain optical coherence tomography (SD-OCT) in patients with pathological myopia. Material and methods. A retrospective analysis of SD-OCT (Optovue RTVue-100) data from the macula of patients with myopic choroidal neovascularization treated with anti-VEGF therapy (ranibizumab, aflibercept) was performed. The study group consisted of 37 patients (43 eyes), incl. 31 women, mean age 53.4 years, mean length of the anterior-posterior axis of the eye – 28.42 mm. Three researchers performed independent measurements of CT in manual mode at five points (subfoveolar, nasal, temporal, upper and lower, located 3 mm from the center of the foveola) before the start of antiangiogenic therapy and in dynamics after 1 year of treatment. Results. CT values before treatment were minimal at the nasal point (mean – 35.5 µm) and increased in the following sequence: lower point (60.9 µm), subfoveolar (74.1 µm), temporal (85.7 µm), upper (91.0 µm). The same ratio of indicators persisted at 12 months after the treatment initiation, however, the absolute values decreased, amounting to 35.1, 56.5, 66.3, 83.7 and 85.8 µm, respectively. Statistical analysis performed using the Kruskal – Wallis test showed a statistically significant (p < 0.05) difference in the data obtained between researchers 1 and 2 in one case, between researchers 2 and 3 in 5 series of measurements; the difference between the results obtained by researchers 1 and 3 did not find statistical confirmation. Conclusion. Our results correspond to the literature data and confirm the importance of CT assessment in patients with degenerative myopia, and manual measurement of the parameter using SD-OCT, due to its simplicity and accessibility, can be used by ophthalmologists to solve daily clinical issues. For a more accurate quantitative assessment of CT in scientific research, it is advisable to use more sensitive and reproducible methods. Keywords: choroidal thickness, spectral-domain optical coherence tomography, manual mode, pathological myopia, myopic choroidal neovascularization
{"title":"Reproducibility of choroidal thickness manual measurement results using spectral-domain optical coherence tomography in patients with pathological myopia","authors":"N.V. Babaeva, E. V. Bobykin, O. Morozova, V. Krokhalev","doi":"10.25276/2312-4911-2023-2-259-265","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-259-265","url":null,"abstract":"Changes in choroidal thickness (CT) may indicate the presence of macular diseases and be used to monitor their course and treatment. Automatic segmentation of the choroid is not currently available, and semi-automatic segmentation is laborious and time-consuming. Purpose. To evaluate the reproducibility of CT manual measurement results using spectraldomain optical coherence tomography (SD-OCT) in patients with pathological myopia. Material and methods. A retrospective analysis of SD-OCT (Optovue RTVue-100) data from the macula of patients with myopic choroidal neovascularization treated with anti-VEGF therapy (ranibizumab, aflibercept) was performed. The study group consisted of 37 patients (43 eyes), incl. 31 women, mean age 53.4 years, mean length of the anterior-posterior axis of the eye – 28.42 mm. Three researchers performed independent measurements of CT in manual mode at five points (subfoveolar, nasal, temporal, upper and lower, located 3 mm from the center of the foveola) before the start of antiangiogenic therapy and in dynamics after 1 year of treatment. Results. CT values before treatment were minimal at the nasal point (mean – 35.5 µm) and increased in the following sequence: lower point (60.9 µm), subfoveolar (74.1 µm), temporal (85.7 µm), upper (91.0 µm). The same ratio of indicators persisted at 12 months after the treatment initiation, however, the absolute values decreased, amounting to 35.1, 56.5, 66.3, 83.7 and 85.8 µm, respectively. Statistical analysis performed using the Kruskal – Wallis test showed a statistically significant (p < 0.05) difference in the data obtained between researchers 1 and 2 in one case, between researchers 2 and 3 in 5 series of measurements; the difference between the results obtained by researchers 1 and 3 did not find statistical confirmation. Conclusion. Our results correspond to the literature data and confirm the importance of CT assessment in patients with degenerative myopia, and manual measurement of the parameter using SD-OCT, due to its simplicity and accessibility, can be used by ophthalmologists to solve daily clinical issues. For a more accurate quantitative assessment of CT in scientific research, it is advisable to use more sensitive and reproducible methods. Keywords: choroidal thickness, spectral-domain optical coherence tomography, manual mode, pathological myopia, myopic choroidal neovascularization","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90922481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-286-292
R. A. Burya, Y. V. Belonozhenko, E. L. Sorokin, O. V. Kolenko
Purpose. Study of state of the Zonule of Zinn in patients with combination senile cataract with systemic involutional connective tissue dysplasia. Material and methods. 97 patients (97 eyes) – combination senile cataract with involutional pathology in connective tissue (the main group). 1st subgroup: 31 patients with kyphoscoliotic deformity of the 3d and 4th degree (classification by V.D. Chaklin (1973)); 2nd subgroup – 66 patients with chronic venous insufficiency 2nd and 3d degree (the CEAP classification) against the background of varicose veins of the lower extremity. Patients of both subgroups were comparable in terms of cataract stages and nuclear cataract lens density in Buratto classification. The control group – 55 patients (55 eyes) similar sex and age with senile cataracts without involutional connective tissue pathology. We estimated the symmetry of distance «lens equator – ciliary processes» in 2 meridians: at 6 and 12 hours. The presence of asymmetry of 0.3 mm or more was sign of weak zonular support (according to ultrasonic biomicroscopy). Results. In the control group, the distance was 0.3 mm in 3 eyes (5%), with intraoperative formation of folds in the anterior capsule. In 10 eyes of the 1st subgroup of the main group (32%), the presence of distance asymmetry was revealed: intraoperative, signs of subluxation of the lens of the 1st degree were detected in 7 eyes. In the 2nd subgroup of the main group, distance asymmetry was detected in 24 eyes (37%). Folded anterior lens capsule was determined intraoperative in 14 eyes (21%) during anterior capsulorhexis and lens mobility during nucleus emulsification. Conclusion. A statistically significant difference in frequency of asymmetries of distances «lens equator – ciliary processes» in 2 opposite meridians was revealed between groups of patients with senile cataract against the background of systemic somatic involutional pathology of connective tissue and without it (35% vs. 5%; p < 0.01). Keywords: senile cataract, Zonule of Zinn, involutional changes in connective tissue, ultrasound biomicroscopy
目的。老年性白内障合并全身性结缔组织发育不良患者锌带状态的研究。材料和方法。97例(97眼)结缔组织病变合并老年性白内障(主要组)。第一亚组:31例3、4度脊柱后凸畸形(V.D. Chaklin(1973)分类);第二亚组:以下肢静脉曲张为背景的慢性2度和3度静脉功能不全(CEAP分类)患者66例。两个亚组患者在Buratto分级的白内障分期和核性白内障晶状体密度方面具有可比性。对照组55例(55眼)，性别、年龄相近，无结缔组织病变的老年性白内障。我们估计了2个子午线上“晶状体赤道-睫状体突”距离的对称性:在6和12小时。存在0.3 mm或更多的不对称是弱带状支撑的迹象(根据超声生物显微镜)。结果。对照组3眼(5%)眼距0.3 mm，术中前囊内形成褶皱。主组1亚组10眼(32%)出现距离不对称，术中7眼出现1度晶状体半脱位。在主组的第二亚组中，有24只眼(37%)出现距离不对称。术中发现晶状体前囊折叠14眼(21%)，晶状体前囊剥脱术中晶状体移动。结论。老年性白内障患者有结缔组织的系统性体细胞病变和无结缔组织病变的两组之间，“晶状体赤道-睫状体突”距离不对称的频率有统计学上的显著差异(35% vs. 5%;P < 0.01)。关键词:老年性白内障，锌带，结缔组织变化，超声生物显微镜
{"title":"Study of preoperative symmetry of distance «lens equator – ciliary processes» in patients with combination of senile cataract with clinical manifestations of involutional connective tissue dysplasia","authors":"R. A. Burya, Y. V. Belonozhenko, E. L. Sorokin, O. V. Kolenko","doi":"10.25276/2312-4911-2023-2-286-292","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-286-292","url":null,"abstract":"Purpose. Study of state of the Zonule of Zinn in patients with combination senile cataract with systemic involutional connective tissue dysplasia. Material and methods. 97 patients (97 eyes) – combination senile cataract with involutional pathology in connective tissue (the main group). 1st subgroup: 31 patients with kyphoscoliotic deformity of the 3d and 4th degree (classification by V.D. Chaklin (1973)); 2nd subgroup – 66 patients with chronic venous insufficiency 2nd and 3d degree (the CEAP classification) against the background of varicose veins of the lower extremity. Patients of both subgroups were comparable in terms of cataract stages and nuclear cataract lens density in Buratto classification. The control group – 55 patients (55 eyes) similar sex and age with senile cataracts without involutional connective tissue pathology. We estimated the symmetry of distance «lens equator – ciliary processes» in 2 meridians: at 6 and 12 hours. The presence of asymmetry of 0.3 mm or more was sign of weak zonular support (according to ultrasonic biomicroscopy). Results. In the control group, the distance was 0.3 mm in 3 eyes (5%), with intraoperative formation of folds in the anterior capsule. In 10 eyes of the 1st subgroup of the main group (32%), the presence of distance asymmetry was revealed: intraoperative, signs of subluxation of the lens of the 1st degree were detected in 7 eyes. In the 2nd subgroup of the main group, distance asymmetry was detected in 24 eyes (37%). Folded anterior lens capsule was determined intraoperative in 14 eyes (21%) during anterior capsulorhexis and lens mobility during nucleus emulsification. Conclusion. A statistically significant difference in frequency of asymmetries of distances «lens equator – ciliary processes» in 2 opposite meridians was revealed between groups of patients with senile cataract against the background of systemic somatic involutional pathology of connective tissue and without it (35% vs. 5%; p < 0.01). Keywords: senile cataract, Zonule of Zinn, involutional changes in connective tissue, ultrasound biomicroscopy","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75813035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-136-139
R. Fayzrakhmanov, M. Kalinin, O. Pavlovskiy, G. Karpov, E. D. Bosov
At present, with the likelihood of vitreoretinal surgery, a factor of increased intraocular pressure has emerged in the postoperative period and has become widespread as a potential risk factor for damage to the optic nerve. Sequelae of secondary glaucoma leading to loss of visual fields often occur. An analysis was made of the surgical treatment of 21 patients (21 eyes) with secondary glaucoma after vitreoretinal surgery using anterior anterior chamber plasty in order to assess efficacy and safety. Keywords: glaucoma, secondary glaucoma, minimally invasive glaucoma surgery, surgical treatment of glaucoma, silicone oil
{"title":"Anterior chamber angle plasty in patients with secondary glaucoma after vitreoretinal surgery","authors":"R. Fayzrakhmanov, M. Kalinin, O. Pavlovskiy, G. Karpov, E. D. Bosov","doi":"10.25276/2312-4911-2023-2-136-139","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-136-139","url":null,"abstract":"At present, with the likelihood of vitreoretinal surgery, a factor of increased intraocular pressure has emerged in the postoperative period and has become widespread as a potential risk factor for damage to the optic nerve. Sequelae of secondary glaucoma leading to loss of visual fields often occur. An analysis was made of the surgical treatment of 21 patients (21 eyes) with secondary glaucoma after vitreoretinal surgery using anterior anterior chamber plasty in order to assess efficacy and safety. Keywords: glaucoma, secondary glaucoma, minimally invasive glaucoma surgery, surgical treatment of glaucoma, silicone oil","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78707399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-40-43
G.В. Mamutova
A prospective randomized clinical trial included 30 patients (60 eyes) with traumatic cataract after open eye injury. Patients were divided into 2 groups depending on the time of the operation. The first (n = 15, 30 eyes) was an early operation (1–3 days after the injury). The second (n = 15, 30 eyes) is a late operation (6 or more days after the injury). Research methods – measurement of visual acuity, intraocular pressure (IOP), assessment of inflammation of the anterior chamber, position of the intraocular lens (IOL), etc. The study period was 1, 3, and 6 weeks after surgical treatment. It was revealed that visual acuity with the best correction was noted 6 weeks after the early operation. Also in the group of early cataract surgery, the frequency of postoperative complications (rupture of the posterior capsule, increased IOP, inflammation of the anterior chamber, IOL opacity, posterior synechia, IOL subluxation and pigment deposition on the IOL) was significantly lower than in the late surgery group (p < 0.05). It is recommended to perform cataract surgery and IOL implantation after open eye injuries at an early stage. Keywords: surgery, traumatic cataract, vision, intraocular lens implantation
{"title":"Intraocular lens implantation in traumatic cataract: terms and prospects","authors":"G.В. Mamutova","doi":"10.25276/2312-4911-2023-2-40-43","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-40-43","url":null,"abstract":"A prospective randomized clinical trial included 30 patients (60 eyes) with traumatic cataract after open eye injury. Patients were divided into 2 groups depending on the time of the operation. The first (n = 15, 30 eyes) was an early operation (1–3 days after the injury). The second (n = 15, 30 eyes) is a late operation (6 or more days after the injury). Research methods – measurement of visual acuity, intraocular pressure (IOP), assessment of inflammation of the anterior chamber, position of the intraocular lens (IOL), etc. The study period was 1, 3, and 6 weeks after surgical treatment. It was revealed that visual acuity with the best correction was noted 6 weeks after the early operation. Also in the group of early cataract surgery, the frequency of postoperative complications (rupture of the posterior capsule, increased IOP, inflammation of the anterior chamber, IOL opacity, posterior synechia, IOL subluxation and pigment deposition on the IOL) was significantly lower than in the late surgery group (p < 0.05). It is recommended to perform cataract surgery and IOL implantation after open eye injuries at an early stage. Keywords: surgery, traumatic cataract, vision, intraocular lens implantation","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75994298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-71-77
L. Takhauova, O. I. Krivosheina, A. Takhauov
Perpose. A retrospective analysis of the morbidity rates of the organ of vision in the personnel of the facility using ionizing radiation of energy under long-term technogenic external exposure was carried out. Material and method. The medical records of 3,795 employees were analyzed. The personnel in the framework of this study was divided into 2 groups: the main one – 2,546 employees of the main production; comparison – 1,249 employees of auxiliary production. Results. As the age of the staff increases, there is an increase in the incidence of ophthalmopathology in both groups. The level of morbidity with pathology of the organ of vision in the main group aged 30 to 70 years at the time of diagnosis is statistically significantly higher than that in the comparison group. At the same time, a high prevalence of diseases of the ocular surface was noted: in the main group, conjunctivitis is most common, in the comparison group – diseases of the eyelids. Keywords: ionizing radiation, long-term technogenic external exposure, ocular surface, morbidity
{"title":"The prevalence of radiation-induced ophthalmopathology personnel use of nuclear energy","authors":"L. Takhauova, O. I. Krivosheina, A. Takhauov","doi":"10.25276/2312-4911-2023-2-71-77","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-71-77","url":null,"abstract":"Perpose. A retrospective analysis of the morbidity rates of the organ of vision in the personnel of the facility using ionizing radiation of energy under long-term technogenic external exposure was carried out. Material and method. The medical records of 3,795 employees were analyzed. The personnel in the framework of this study was divided into 2 groups: the main one – 2,546 employees of the main production; comparison – 1,249 employees of auxiliary production. Results. As the age of the staff increases, there is an increase in the incidence of ophthalmopathology in both groups. The level of morbidity with pathology of the organ of vision in the main group aged 30 to 70 years at the time of diagnosis is statistically significantly higher than that in the comparison group. At the same time, a high prevalence of diseases of the ocular surface was noted: in the main group, conjunctivitis is most common, in the comparison group – diseases of the eyelids. Keywords: ionizing radiation, long-term technogenic external exposure, ocular surface, morbidity","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87550104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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