Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-369-375
E.V. Grukhina, V. V. Podyninogina, Y. Kudryavtseva
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is more common in people of young working age. It manifests itself in the appearance of light foci on the retina, leading to a decrease in visual acuity. The presented clinical cases demonstrate an interdisciplinary approach in the diagnosis and treatment of this disease. In some cases, the disease may occur without reducing visual acuity and be undiagnosed. In the acute stage of APMPPE, the use of anti-inflammatory therapy, including systemic steroids, gives a good clinical effect. Keywords: acute posterior multifocal placoid pigment epitheliopathy, gray-white foci, diagnosis, anti-inflammatory therapy
{"title":"Acute posterior multifocal placoid pigment epitheliopathy","authors":"E.V. Grukhina, V. V. Podyninogina, Y. Kudryavtseva","doi":"10.25276/2312-4911-2023-2-369-375","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-369-375","url":null,"abstract":"Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is more common in people of young working age. It manifests itself in the appearance of light foci on the retina, leading to a decrease in visual acuity. The presented clinical cases demonstrate an interdisciplinary approach in the diagnosis and treatment of this disease. In some cases, the disease may occur without reducing visual acuity and be undiagnosed. In the acute stage of APMPPE, the use of anti-inflammatory therapy, including systemic steroids, gives a good clinical effect. Keywords: acute posterior multifocal placoid pigment epitheliopathy, gray-white foci, diagnosis, anti-inflammatory therapy","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90903439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-24-29
V. Karpovich, S. V. Churashov, V. F. Chernysh
Purpose. To investigate the transparency, mechanical properties and terms of biodegradation of certain types of synthetic polyester matrices – poly(lactide-glycolide) (PLG), poly(lactide-caprolactone) (PLC) and poly(ε-caprolactone) (PCL) as possible carriers for cultured limbal epithelial stem cells. Material and methods. In the course of the study, the transparency of all polyester matrices of various thicknesses was evaluated by the width of the scattering angle of a helium-neon laser beam with a wavelength of 632.8 nm. The mechanical properties of the matrices (only 5 microns thick) and amniotic membrane (AM) (strength, elongation at break, modulus of elasticity) were studied under their uniaxial tension on a universal installation. Biodegradation was evaluated for all matrices from PLG, PLC and PCL – on 18 rabbits (12 eyes). The matrices were transplanted and sewn onto intact corneas. The biodegradation of the matrices was evaluated on the 3rd, 10th, 21st and 30th days after surgery. Results. The optical and mechanical properties of matrices made of polylactide-glycolide (PLG), polylactide-caprolactone (PLC) and poly(ε-caprolactone) (PCL) were studied during the study. The terms of biodegradation of matrices from PLC with a thickness of 5 microns were about 30 days. Conclusion. Taking into account the optimal combination of strength, elasticity, elasticity and transparency, the most acceptable for use as a carrier for transplantation of cultured LESC in order to eliminate limbal insufficiency is a matrix of PLC with a thickness of 5 microns. Keywords: transparency, mechanical properties, biodegradation, polymer matrices
{"title":"Comparative experimental study of transparency, mechanical properties and biodegradation of synthetic polymer matrices as possible carriers for cultured limbal epithelial stem cells","authors":"V. Karpovich, S. V. Churashov, V. F. Chernysh","doi":"10.25276/2312-4911-2023-2-24-29","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-24-29","url":null,"abstract":"Purpose. To investigate the transparency, mechanical properties and terms of biodegradation of certain types of synthetic polyester matrices – poly(lactide-glycolide) (PLG), poly(lactide-caprolactone) (PLC) and poly(ε-caprolactone) (PCL) as possible carriers for cultured limbal epithelial stem cells. Material and methods. In the course of the study, the transparency of all polyester matrices of various thicknesses was evaluated by the width of the scattering angle of a helium-neon laser beam with a wavelength of 632.8 nm. The mechanical properties of the matrices (only 5 microns thick) and amniotic membrane (AM) (strength, elongation at break, modulus of elasticity) were studied under their uniaxial tension on a universal installation. Biodegradation was evaluated for all matrices from PLG, PLC and PCL – on 18 rabbits (12 eyes). The matrices were transplanted and sewn onto intact corneas. The biodegradation of the matrices was evaluated on the 3rd, 10th, 21st and 30th days after surgery. Results. The optical and mechanical properties of matrices made of polylactide-glycolide (PLG), polylactide-caprolactone (PLC) and poly(ε-caprolactone) (PCL) were studied during the study. The terms of biodegradation of matrices from PLC with a thickness of 5 microns were about 30 days. Conclusion. Taking into account the optimal combination of strength, elasticity, elasticity and transparency, the most acceptable for use as a carrier for transplantation of cultured LESC in order to eliminate limbal insufficiency is a matrix of PLC with a thickness of 5 microns. Keywords: transparency, mechanical properties, biodegradation, polymer matrices","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86179062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-119-122
V.N. Papyan, P. V. Makarov, E. Chentsova, T. Simonyan
To date impossibility of keratoplasty with category IV and V corneal opacifation, keratoprosthetics is the only available option to restore useful vision. The most commonly implanted keratoprostheses nowadays are keratoprosthesis «Boston 1 and 2», osteoodontokeratoprosthesis, Fedorov-Zuev keratoprosthesis («MICOF»). This article highlights a comparative evaluation, outcomes and complications of different types keratoprosthesis listed before. Results of implantation of keratoprosthesis «Boston 1 and 2», Osteoodontokeratoprosthesis, Fedorov-Zuev keratoprosthesis «MICOF» (China) collected through literature analysis. The results of implantation of the Fedorov-Zuev keratoprosthesis at the Helmholtz National Medical Research Center for Eye Diseases gained with our own clinical data analysis. In efficacy comparison of keratoprosthesis, we got the following conclusions: when implanting the Boston type keratoprosthesis, functional results are better, fewer complication rates (such as secondary glaucoma and vitreous hemorrhage), but the anatomical outcome is not that good (high necrosis and rejection rates). With osteoodontokeratoprosthesis there are good functional outcomes, but overgrowth of the optical cylinder and vitreous hemorrhage can be seen often. When implanting the FedorovZuev keratoprosthesis using the Helmholtz National Medical Research Center for Eye Disease methods we declare good functional result comparable to osteoodontokeratoprosthesis and the best anatomical result (absence of cases of tissue necrosis over the keratoprosthesis, rejection, exposure of the keratoprosthesis). Keywords: keratoprosthesis, keratoprosthesis, implantation
迄今为止，由于IV类和V类角膜混浊不可能进行角膜移植术，角膜修复术是恢复有用视力的唯一选择。目前最常见的植入式角膜假体是角膜假体«Boston 1和2»，骨齿角膜假体，Fedorov-Zuev角膜假体(«MICOF»)。本文重点介绍了不同类型角膜假体的比较评价、结果和并发症。通过文献分析收集角膜假体«Boston 1 and 2»，Osteoodontokeratoprosthesis, Fedorov-Zuev角膜假体«MICOF»(中国)植入术结果。在Helmholtz国家眼科医学研究中心植入Fedorov-Zuev角膜假体的结果是通过我们自己的临床数据分析得出的。在角膜假体的疗效比较中，我们得出以下结论:当植入波士顿型角膜假体时，功能效果更好，并发症发生率(如继发性青光眼和玻璃体出血)较少，但解剖结果不太好(高坏死和排异率)。骨齿角膜假体具有良好的功能效果，但视筒过度生长和玻璃体出血是常见的。当使用Helmholtz国家眼病医学研究中心的方法植入FedorovZuev角膜假体时，我们宣布具有与骨齿角膜假体相当的良好功能结果和最佳解剖学结果(没有角膜假体组织坏死，排斥反应，角膜假体暴露的病例)。关键词:角膜假体，角膜假体，植入术
{"title":"Comparative efficacy evaluation of keratoprosthetics with a Boston type prosthesis, osteoodontokeratoprosthesis and a Fedorov-Zuev prosthesis","authors":"V.N. Papyan, P. V. Makarov, E. Chentsova, T. Simonyan","doi":"10.25276/2312-4911-2023-2-119-122","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-119-122","url":null,"abstract":"To date impossibility of keratoplasty with category IV and V corneal opacifation, keratoprosthetics is the only available option to restore useful vision. The most commonly implanted keratoprostheses nowadays are keratoprosthesis «Boston 1 and 2», osteoodontokeratoprosthesis, Fedorov-Zuev keratoprosthesis («MICOF»). This article highlights a comparative evaluation, outcomes and complications of different types keratoprosthesis listed before. Results of implantation of keratoprosthesis «Boston 1 and 2», Osteoodontokeratoprosthesis, Fedorov-Zuev keratoprosthesis «MICOF» (China) collected through literature analysis. The results of implantation of the Fedorov-Zuev keratoprosthesis at the Helmholtz National Medical Research Center for Eye Diseases gained with our own clinical data analysis. In efficacy comparison of keratoprosthesis, we got the following conclusions: when implanting the Boston type keratoprosthesis, functional results are better, fewer complication rates (such as secondary glaucoma and vitreous hemorrhage), but the anatomical outcome is not that good (high necrosis and rejection rates). With osteoodontokeratoprosthesis there are good functional outcomes, but overgrowth of the optical cylinder and vitreous hemorrhage can be seen often. When implanting the FedorovZuev keratoprosthesis using the Helmholtz National Medical Research Center for Eye Disease methods we declare good functional result comparable to osteoodontokeratoprosthesis and the best anatomical result (absence of cases of tissue necrosis over the keratoprosthesis, rejection, exposure of the keratoprosthesis). Keywords: keratoprosthesis, keratoprosthesis, implantation","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73552029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-337-341
N. V. Samokhvalov, E. L. Sorokin
Purpose. To study of quantitative and qualitative morphometric characteristics of the anterior chamber (AC) depth, lens thickness (LT), corneal-iris angle in young patients with high axial hyperopia planning refractive surgery. Material and methods. The main group – 35 patients (70 eyes) with high axial hyperopia. Inclusion criteria: absence of ophthalmic and systemic somatic pathology. The best corrected visual acuity (BCVA) is from 0.7 to 1.0. The comparison group included 35 patients (70 eyes) with primary closure of the anterior chamber angle (ACA) in combination with high hyperopia. Inclusion criteria: the presence of functional block of the ACA in at least 2 quadrants, the absence of signs of glaucomatous optic neuropathy. BCVA – from 0.6 to 0.9. All patients underwent gonioscopy of the ACA in 4 quadrants, optical coherence tomography, assessment of morphometric parameters of the anterior segment of the eyes. Results. The analysis of morphometric parameters revealed statistically significant differences in patients of the main group relative to the comparison group: in the AC depth in the central zone – 2.8 ± 0.3 vs. 2.4 ± 0.25 mm; LT – 4.0 ± 0.35 vs. 4.5 ± 0.3 mm; ACA width – 19.6 ± 4.4° vs. 13.1±5.1°; AC depth in the periphery – 1.0 ± 0.21 vs. 0.5 ± 0.37 mm, respectively. Next, we determined whether anyone from the main group had ACA values similar to the average values of this indicator of the comparison group (13.1 ± 5.1°): in 6 eyes of the main group (3 men aged 40 to 45 years) the values of the ACA turned out to be minimal, not significantly differing from the comparison group. In addition, in 7 eyes of 6 patients of the main group, the index of the AC depth in the periphery was less than 0.5 mm with normal values of the AC depth in the central zone, which was comparable with similar values in the comparison group. Conclusion. Among the examined patients with hyperopia at the age of 39 to 45 years, with axial length values from 19 to 22 mm, an increased risk of developing an acute angle-closure glaucoma occurred in 9 patients (26 %). Keywords: hyperopia; refractive surgery; acute angle-closure glaucoma
{"title":"Morphometric features that characterize increased risk of acute angle-closure glaucoma in patients with high axial hyperopia planning refractive surgery","authors":"N. V. Samokhvalov, E. L. Sorokin","doi":"10.25276/2312-4911-2023-2-337-341","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-337-341","url":null,"abstract":"Purpose. To study of quantitative and qualitative morphometric characteristics of the anterior chamber (AC) depth, lens thickness (LT), corneal-iris angle in young patients with high axial hyperopia planning refractive surgery. Material and methods. The main group – 35 patients (70 eyes) with high axial hyperopia. Inclusion criteria: absence of ophthalmic and systemic somatic pathology. The best corrected visual acuity (BCVA) is from 0.7 to 1.0. The comparison group included 35 patients (70 eyes) with primary closure of the anterior chamber angle (ACA) in combination with high hyperopia. Inclusion criteria: the presence of functional block of the ACA in at least 2 quadrants, the absence of signs of glaucomatous optic neuropathy. BCVA – from 0.6 to 0.9. All patients underwent gonioscopy of the ACA in 4 quadrants, optical coherence tomography, assessment of morphometric parameters of the anterior segment of the eyes. Results. The analysis of morphometric parameters revealed statistically significant differences in patients of the main group relative to the comparison group: in the AC depth in the central zone – 2.8 ± 0.3 vs. 2.4 ± 0.25 mm; LT – 4.0 ± 0.35 vs. 4.5 ± 0.3 mm; ACA width – 19.6 ± 4.4° vs. 13.1±5.1°; AC depth in the periphery – 1.0 ± 0.21 vs. 0.5 ± 0.37 mm, respectively. Next, we determined whether anyone from the main group had ACA values similar to the average values of this indicator of the comparison group (13.1 ± 5.1°): in 6 eyes of the main group (3 men aged 40 to 45 years) the values of the ACA turned out to be minimal, not significantly differing from the comparison group. In addition, in 7 eyes of 6 patients of the main group, the index of the AC depth in the periphery was less than 0.5 mm with normal values of the AC depth in the central zone, which was comparable with similar values in the comparison group. Conclusion. Among the examined patients with hyperopia at the age of 39 to 45 years, with axial length values from 19 to 22 mm, an increased risk of developing an acute angle-closure glaucoma occurred in 9 patients (26 %). Keywords: hyperopia; refractive surgery; acute angle-closure glaucoma","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78422900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-224-228
N. Umarova, S. Jamalova
Purpose. Analysis of the results of treatment of primary open-angle glaucoma by the method of microimpulse laser trabeculoplasty with a power of 1000 mW and different operating cycles. Material and methods. 33 patients (36 eyes) who underwent microimpulse laser trabeculoplasty were included in the study: in the 1st month, MLT with a power of 1000 mW and a duty cycle of 15% was performed in 19 patients (21 eyes), in the 2nd month MLT s rabochim cyclom 10% 14 patients (15 glasses). Criterion of inclusion of development of patients with primary open glaucoma and pigmented angular anterior camera. Observation and measurement of VGD is carried out an hour after the laser procedure, after 10 days, and after 1; 3, 6 months. Results. In the MLT group with 15% duty cycle, at 6-month follow-up, we noted a decrease in IOP by more than 20% of baseline or more than 3 mmHg, in 78% of cases, however, in the MLT group with a 10% duty cycle, this figure was only 33%. Also, in the MLT group with 15% workers, there was a decrease in the number of antihypertensive drugs used by 32%, while in the MLT group with a 10% work cycle, this figure was 9%. Conclusions. Treatment with micropulse laser trabeculoplasty for primary open-angle glaucoma is a new method that affects pigmented cells without thermal damage. However, to achieve a hypotensive effect, the laser power should be 1000 mW, and the duty cycle is 15%, since with a duty cycle of 10%, no hypotensive effect is observed in the long-term observation period. Keywords: glaucoma, laser trabeculoplasty, pigmented anterior chamber angle
{"title":"Microimpulse laser trabeculoplasty as a treatment method for primary open-angle glaucoma","authors":"N. Umarova, S. Jamalova","doi":"10.25276/2312-4911-2023-2-224-228","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-224-228","url":null,"abstract":"Purpose. Analysis of the results of treatment of primary open-angle glaucoma by the method of microimpulse laser trabeculoplasty with a power of 1000 mW and different operating cycles. Material and methods. 33 patients (36 eyes) who underwent microimpulse laser trabeculoplasty were included in the study: in the 1st month, MLT with a power of 1000 mW and a duty cycle of 15% was performed in 19 patients (21 eyes), in the 2nd month MLT s rabochim cyclom 10% 14 patients (15 glasses). Criterion of inclusion of development of patients with primary open glaucoma and pigmented angular anterior camera. Observation and measurement of VGD is carried out an hour after the laser procedure, after 10 days, and after 1; 3, 6 months. Results. In the MLT group with 15% duty cycle, at 6-month follow-up, we noted a decrease in IOP by more than 20% of baseline or more than 3 mmHg, in 78% of cases, however, in the MLT group with a 10% duty cycle, this figure was only 33%. Also, in the MLT group with 15% workers, there was a decrease in the number of antihypertensive drugs used by 32%, while in the MLT group with a 10% work cycle, this figure was 9%. Conclusions. Treatment with micropulse laser trabeculoplasty for primary open-angle glaucoma is a new method that affects pigmented cells without thermal damage. However, to achieve a hypotensive effect, the laser power should be 1000 mW, and the duty cycle is 15%, since with a duty cycle of 10%, no hypotensive effect is observed in the long-term observation period. Keywords: glaucoma, laser trabeculoplasty, pigmented anterior chamber angle","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89264720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-44-49
A. Pobeda
Glaucoma is a neurodegenerative disease and is the leading cause of blindness worldwide. According to some authors, standard therapy does not always prevent the neurodegenerative process in the retina, which indicates processes that do not depend on intraocular pressure (IOP). The model of NMDA-induced retinal degeneration was chosen by us as one of the main ones for the experimental modeling of glaucoma, due to the fact that glutamate is the main neurotransmitter and triggers excitotoxicity leading to the death of ganglion cells. 7 days after the model the electrophysiological state of the retina was assessed and organs were taken for morphological examination. According to the results of the study, it was found that the compound under the laboratory code DMAE 10-19 had the highest activity. The introduction of the compound led to an improvement in the electrophysiological function of the retina, which consisted in an increase in the amplitude of the wave-a by 34.4 %, the amplitude of the wave-b by 38.2 % relative to the group with the pathology model and has a significant difference (p < 0.05). It also led to an increase in the number of nuclei in the ganglionic layer by 68.8 % relative to the group with the pathology model (p < 0.05). Thus, it was found that the highest neuroprotective activity among dimethylaminoethanol derivatives is observed in the compound under the laboratory code DMAE 10-19. Keywords: dimethylaminoethanol derivatives, NMDA, excitotoxicity, retina, rats, electroretinography, morphometry
{"title":"Correction of morphofunctional retinal damage with dimethylaminoethanol derivatives","authors":"A. Pobeda","doi":"10.25276/2312-4911-2023-2-44-49","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-44-49","url":null,"abstract":"Glaucoma is a neurodegenerative disease and is the leading cause of blindness worldwide. According to some authors, standard therapy does not always prevent the neurodegenerative process in the retina, which indicates processes that do not depend on intraocular pressure (IOP). The model of NMDA-induced retinal degeneration was chosen by us as one of the main ones for the experimental modeling of glaucoma, due to the fact that glutamate is the main neurotransmitter and triggers excitotoxicity leading to the death of ganglion cells. 7 days after the model the electrophysiological state of the retina was assessed and organs were taken for morphological examination. According to the results of the study, it was found that the compound under the laboratory code DMAE 10-19 had the highest activity. The introduction of the compound led to an improvement in the electrophysiological function of the retina, which consisted in an increase in the amplitude of the wave-a by 34.4 %, the amplitude of the wave-b by 38.2 % relative to the group with the pathology model and has a significant difference (p < 0.05). It also led to an increase in the number of nuclei in the ganglionic layer by 68.8 % relative to the group with the pathology model (p < 0.05). Thus, it was found that the highest neuroprotective activity among dimethylaminoethanol derivatives is observed in the compound under the laboratory code DMAE 10-19. Keywords: dimethylaminoethanol derivatives, NMDA, excitotoxicity, retina, rats, electroretinography, morphometry","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82841654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-15-17
T. A. Zhigalskaya, M. S. Denisko
Currently, secondary corneal dystrophy is a common cause of corneal blindness. In addition to a significant decrease of vision, this pathology is accompanied by a significant corneal syndrome and damage to all layers of corneal tissue. The article presents the data of light microscopy of a fragment of the surface layer of pathologically altered corneal tissue obtained during surgical treatment of secondary corneal dystrophy of traumatic genesis. It was found that in this pathology there is a expressed fibrinoid swelling of the main substance and neovascularization of the subepithelial structures of the cornea. Keywords: secondary corneal dystrophy, pathomorphology, fibrinoid swelling, neovascularization
{"title":"Features of corneal pathomorphology in secondary dystrophy of traumatic genesis","authors":"T. A. Zhigalskaya, M. S. Denisko","doi":"10.25276/2312-4911-2023-2-15-17","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-15-17","url":null,"abstract":"Currently, secondary corneal dystrophy is a common cause of corneal blindness. In addition to a significant decrease of vision, this pathology is accompanied by a significant corneal syndrome and damage to all layers of corneal tissue. The article presents the data of light microscopy of a fragment of the surface layer of pathologically altered corneal tissue obtained during surgical treatment of secondary corneal dystrophy of traumatic genesis. It was found that in this pathology there is a expressed fibrinoid swelling of the main substance and neovascularization of the subepithelial structures of the cornea. Keywords: secondary corneal dystrophy, pathomorphology, fibrinoid swelling, neovascularization","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78963110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-322-329
E. M. Popov, A. Kulikov
Aim. To study the relationship of the characteristics of the preservation of the sensorineural retina and retinal pigment epithelium (RPE) obtained by optical coherence tomography (OCT) with functional recovery in the surgical treatment of full thickness macular hole (FTHM). Materials and methods. This study included 89 patients (95 eyes) with an average age of 67.2 ± 9.6 years, having complete postoperative anatomical closure of the FTMH. All patients underwent standard ophthalmological examination and OCT before surgical treatment. On cross-sectional and en face images, the area and reflexivity of the neurosensory retina tissue at the edges of the gap and the reflexivity of the RPE in the projection of the gap were evaluated. 12 months after surgical treatment, the correlation between the initial indicators of retinal tissue preservation and functional recovery was evaluated. Results. The final best-corrected visual acuity showed a statistically significant correlation with baseline best-corrected visual acuity (r = 0.75, p < 0.001), reflectivity of RPE (r = 0.91, p < 0.001), reflectivity of neurosensory retina (r = – 0.85, p < 0.001), and its area (r = 0.83, p < 0.001). Conclusion. Indicators of retinal tissue preservation, such as the area and reflexivity of the neurosensory retina tissue and the reflexivity of the RPE, correlate with functional recovery after FTMH surgery. Keywords: full-thickness macular hole, optical coherence tomography, optical coherence tomography angiography
的目标。目的探讨光学相干断层扫描(OCT)获得的感觉神经视网膜和视网膜色素上皮(RPE)保存特征与全层黄斑孔(FTHM)手术治疗中功能恢复的关系。材料和方法。本研究纳入89例患者(95只眼)，平均年龄67.2±9.6岁，术后FTMH解剖完全闭合。所有患者术前均行标准眼科检查和OCT检查。在横断面和正面图像上，评估间隙边缘神经感觉视网膜组织的面积和反射率以及RPE在间隙投影中的反射率。术后12个月，评估视网膜组织保存的初始指标与功能恢复的相关性。结果。最终最佳矫正视力与基线最佳矫正视力(r = 0.75, p < 0.001)、RPE反射率(r = 0.91, p < 0.001)、神经感觉视网膜反射率(r = - 0.85, p < 0.001)及其面积(r = 0.83, p < 0.001)有统计学意义。结论。视网膜组织保存的指标，如神经感觉视网膜组织的面积和反身性以及RPE的反身性，与FTMH手术后的功能恢复相关。关键词:全层黄斑孔，光学相干断层扫描，光学相干断层扫描血管造影
{"title":"A new approach in predicting the functional outcome in the treatment of patients with a full-thickness macular hole","authors":"E. M. Popov, A. Kulikov","doi":"10.25276/2312-4911-2023-2-322-329","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-322-329","url":null,"abstract":"Aim. To study the relationship of the characteristics of the preservation of the sensorineural retina and retinal pigment epithelium (RPE) obtained by optical coherence tomography (OCT) with functional recovery in the surgical treatment of full thickness macular hole (FTHM). Materials and methods. This study included 89 patients (95 eyes) with an average age of 67.2 ± 9.6 years, having complete postoperative anatomical closure of the FTMH. All patients underwent standard ophthalmological examination and OCT before surgical treatment. On cross-sectional and en face images, the area and reflexivity of the neurosensory retina tissue at the edges of the gap and the reflexivity of the RPE in the projection of the gap were evaluated. 12 months after surgical treatment, the correlation between the initial indicators of retinal tissue preservation and functional recovery was evaluated. Results. The final best-corrected visual acuity showed a statistically significant correlation with baseline best-corrected visual acuity (r = 0.75, p < 0.001), reflectivity of RPE (r = 0.91, p < 0.001), reflectivity of neurosensory retina (r = – 0.85, p < 0.001), and its area (r = 0.83, p < 0.001). Conclusion. Indicators of retinal tissue preservation, such as the area and reflexivity of the neurosensory retina tissue and the reflexivity of the RPE, correlate with functional recovery after FTMH surgery. Keywords: full-thickness macular hole, optical coherence tomography, optical coherence tomography angiography","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79710246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-123-128
D. Petrachkov, L. Alkharki, K. Shabalina
Internal limiting membrane (ILM) peeling is a technically complex manipulation that is performed during macular surgery. Experts'opinions vary on its necessity. Visual inspection during surgery does not always make it possible to assess the degree of ILM adhesion to the retina. The aimof the study was to evaluate the morphofunctional parameters of the macular zone after ILM peeling with different degree of adhesion in the long-term postoperative period. Material and methods. A study was conducted that included 119 patients with type 1 (65 (55%) and type 2 (54 (45%) diabetes mellitus with proliferative stage of diabetic retinopathy (PDR) and tractional diabetic macular edema (tDME). All patients underwent a standard three-port 25G vitrectomy with the use of an additional endo-luminaire «chandelier» and bimanual membrane peeling technique. During ILM peeling, all patients underwent intraoperative optical coherence tomography (I-OCT) in order to assess the degree of ILM adhesion to the retina. Before, 1 and 12 months after the operation, the determination of the maximum corrected visual acuity (MCVA), OCT of the macular zone with the measurement of the central retinal thickness (CRT) was performed. Results and discussion. 3 degrees of adhesion of ILM to the retina were identified with I-OCT during ILM peeling. The degree of ILM adhesion in fovea significantly correlated with the development of a retinal defect in its central area. The development of retinal central zone atrophy showed a significant correlation with a decrease in MCVA 12 months after surgery and with the degree of ILM adhesion to the retina in patients with both types of DM. Conclusions. According to the results of this study, a significant correlation was shown between the degree of ILM adhesion to the retina determined by I-OCT and the risk of macular atrophy, which in turn is associated with low visual functions of patients after tDME surgery with ILM peeling. The resulting principle can be used in surgery of other vitreomacular interface pathologies. Keywords: vitreomacular interface, epiretinal membrane, diabetic macular edema, tractional diabetic macular edema, intraoperative optical coherence tomography, vitreoretinal surgery, proliferative diabetic retinopathy
{"title":"The effect of innternal limiting membrane adhesion rate on the results of tractional diabetic macular edema surgery","authors":"D. Petrachkov, L. Alkharki, K. Shabalina","doi":"10.25276/2312-4911-2023-2-123-128","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-123-128","url":null,"abstract":"Internal limiting membrane (ILM) peeling is a technically complex manipulation that is performed during macular surgery. Experts'opinions vary on its necessity. Visual inspection during surgery does not always make it possible to assess the degree of ILM adhesion to the retina. The aimof the study was to evaluate the morphofunctional parameters of the macular zone after ILM peeling with different degree of adhesion in the long-term postoperative period. Material and methods. A study was conducted that included 119 patients with type 1 (65 (55%) and type 2 (54 (45%) diabetes mellitus with proliferative stage of diabetic retinopathy (PDR) and tractional diabetic macular edema (tDME). All patients underwent a standard three-port 25G vitrectomy with the use of an additional endo-luminaire «chandelier» and bimanual membrane peeling technique. During ILM peeling, all patients underwent intraoperative optical coherence tomography (I-OCT) in order to assess the degree of ILM adhesion to the retina. Before, 1 and 12 months after the operation, the determination of the maximum corrected visual acuity (MCVA), OCT of the macular zone with the measurement of the central retinal thickness (CRT) was performed. Results and discussion. 3 degrees of adhesion of ILM to the retina were identified with I-OCT during ILM peeling. The degree of ILM adhesion in fovea significantly correlated with the development of a retinal defect in its central area. The development of retinal central zone atrophy showed a significant correlation with a decrease in MCVA 12 months after surgery and with the degree of ILM adhesion to the retina in patients with both types of DM. Conclusions. According to the results of this study, a significant correlation was shown between the degree of ILM adhesion to the retina determined by I-OCT and the risk of macular atrophy, which in turn is associated with low visual functions of patients after tDME surgery with ILM peeling. The resulting principle can be used in surgery of other vitreomacular interface pathologies. Keywords: vitreomacular interface, epiretinal membrane, diabetic macular edema, tractional diabetic macular edema, intraoperative optical coherence tomography, vitreoretinal surgery, proliferative diabetic retinopathy","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80107039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-29DOI: 10.25276/2312-4911-2023-2-186-190
A. Shulga, O. V. Kolenko, L. Danilova, E. L. Sorokin
Purpose. Evaluation of the volume of intravitreal injections in the treatment of neovascular form of age-related macular degeneration (nAMD) in an ophthalmological clinic. Material and methods. An analysis was made for 2021–2022. Aflibercept was used in all cases. The course began with 3 monthly loading injections with a further transition to the T&E treatment regimen. Results. A total of 467 nAMD patients received treatment in 2021. In their structure, 87 patients were primary, 380 people were repeated. The average number of injections was 6 during the first year in primary patients and 3 injections in repeat patients. Treatment was denied to 8 primary and 32 repeat patients for various reasons. In total, 522 injections were performed for primary patients and 1140 for repeated ones in 2021. The duration of therapy in all 380 repeat patients ranged from 2 to 9 years. 584 patients received nAMD treatment in 2022. One eye was treated in 492 people, both eyes were treated in 92 people. In their structure, 102 patients were primary, 482 people were repeated. The average number of injections was 6 during the first year in primary patients and 3 injections in repeat patients. Further treatment was denied to 4 primary and 42 repeat patients for various reasons in 2022. In total, 612 injections were performed in primary patients and 1,446 injections in repeat patients in 2022. In total, during the study period (two years), 1134 injections were performed in primary patients and 2586 injections in repeat patients. The number of «discharged» repeat patients was only 8.4 % in 2021 and 8.7 % in 2022. These figures objectively characterize the progressive increase in the total number of patients requiring anti-VEGF therapy for nAMD. It should also be noted that this analysis did not include patients with other pathologies requiring anti-VEGF therapy (diabetic macular edema, post-thrombotic retinopathy with macular edema, subretinal neovascular membrane). Conclusion. The obtained facts point to the need of search for more effective methods of treatment, what will probably allow to develop criteria for increasing the interval or stopping this type of therapy. Keywords: anti-VEGF therapy, intravitreal injections, aflibercept, age-related macular degeneration, volume of therapy
{"title":"Evaluation of the volume of intraocular injections for patients with neovascular form of age-related macular degeneration in an ophthalmic surgery clinic","authors":"A. Shulga, O. V. Kolenko, L. Danilova, E. L. Sorokin","doi":"10.25276/2312-4911-2023-2-186-190","DOIUrl":"https://doi.org/10.25276/2312-4911-2023-2-186-190","url":null,"abstract":"Purpose. Evaluation of the volume of intravitreal injections in the treatment of neovascular form of age-related macular degeneration (nAMD) in an ophthalmological clinic. Material and methods. An analysis was made for 2021–2022. Aflibercept was used in all cases. The course began with 3 monthly loading injections with a further transition to the T&E treatment regimen. Results. A total of 467 nAMD patients received treatment in 2021. In their structure, 87 patients were primary, 380 people were repeated. The average number of injections was 6 during the first year in primary patients and 3 injections in repeat patients. Treatment was denied to 8 primary and 32 repeat patients for various reasons. In total, 522 injections were performed for primary patients and 1140 for repeated ones in 2021. The duration of therapy in all 380 repeat patients ranged from 2 to 9 years. 584 patients received nAMD treatment in 2022. One eye was treated in 492 people, both eyes were treated in 92 people. In their structure, 102 patients were primary, 482 people were repeated. The average number of injections was 6 during the first year in primary patients and 3 injections in repeat patients. Further treatment was denied to 4 primary and 42 repeat patients for various reasons in 2022. In total, 612 injections were performed in primary patients and 1,446 injections in repeat patients in 2022. In total, during the study period (two years), 1134 injections were performed in primary patients and 2586 injections in repeat patients. The number of «discharged» repeat patients was only 8.4 % in 2021 and 8.7 % in 2022. These figures objectively characterize the progressive increase in the total number of patients requiring anti-VEGF therapy for nAMD. It should also be noted that this analysis did not include patients with other pathologies requiring anti-VEGF therapy (diabetic macular edema, post-thrombotic retinopathy with macular edema, subretinal neovascular membrane). Conclusion. The obtained facts point to the need of search for more effective methods of treatment, what will probably allow to develop criteria for increasing the interval or stopping this type of therapy. Keywords: anti-VEGF therapy, intravitreal injections, aflibercept, age-related macular degeneration, volume of therapy","PeriodicalId":18609,"journal":{"name":"Modern technologies in ophtalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89899928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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