The "Cambrian explosion" (CE) refers to a sharp increase in the number of fossils of living beings in the sediments of the Cambrian period (CP), which began 538.8 ± 0.2 million years ago and ended 485.4 ± 1.9 million years ago. It was in the CP that drastic changes took place in the biosphere: if before that almost all life was simple and unicellular, then after the CE there was a sharp increase in the number of complex multicellular organisms. However, the reason(s) for these drastic changes remains unknown. Various hypotheses were put forward: a sharp change in climate; the appearance of sexual reproduction; bilaterality or an increase in oxygen concentration that allowed the development of multicellularity. Apparently, the essence of the problem is to clarify the mechanisms and material basis of fundamental changes in the biosphere. For such an explosion, radical changes in the genome are necessary. It is suggested that the CE is associated with the evolution of the most mobile part of the eukaryotic DNA genome, rather than an increase in the number of previously existing or newly emerged genes. From our point of view, the evolution of non-coding DNAs, which make up the vast majority of DNA in the eukaryotic genome, could play an important role in the emergence of CE.
{"title":"Possible Role of Non-coding DNAs in the Cambrian Explosion","authors":"","doi":"10.33140/mcr.08.12.01","DOIUrl":"https://doi.org/10.33140/mcr.08.12.01","url":null,"abstract":"The \"Cambrian explosion\" (CE) refers to a sharp increase in the number of fossils of living beings in the sediments of the Cambrian period (CP), which began 538.8 ± 0.2 million years ago and ended 485.4 ± 1.9 million years ago. It was in the CP that drastic changes took place in the biosphere: if before that almost all life was simple and unicellular, then after the CE there was a sharp increase in the number of complex multicellular organisms. However, the reason(s) for these drastic changes remains unknown. Various hypotheses were put forward: a sharp change in climate; the appearance of sexual reproduction; bilaterality or an increase in oxygen concentration that allowed the development of multicellularity. Apparently, the essence of the problem is to clarify the mechanisms and material basis of fundamental changes in the biosphere. For such an explosion, radical changes in the genome are necessary. It is suggested that the CE is associated with the evolution of the most mobile part of the eukaryotic DNA genome, rather than an increase in the number of previously existing or newly emerged genes. From our point of view, the evolution of non-coding DNAs, which make up the vast majority of DNA in the eukaryotic genome, could play an important role in the emergence of CE.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"36 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138602709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The purpose of this study is to perform analysis through the low back pain open data set to predict the incidence of non-specific chronic low back pain (NSLBP) to obtain a more accurate and convenient sagittal spinopelvic parameter model. Methods: The logistic regression analysis and multilayer perceptron (MLP) algorithm is used to construct a NSLBP prediction model based on the parameters of the spinopelvic parameters from open data source. Results: Degree of spondylolisthesis (DS), Pelvic radius (PR), Sacral slope (SS), Pelvic tilt (PT) are four predictors screened out by regression analysis that have significant predictive power for the risk of NSLBP. The overall accuracy of the equation prediction model is 85.8%.The MLP network algorithm determines that DS is the most powerful predictor of NSLBP through more precise modeling. The model has good predictive ability of 95.2% of accuracy. Conclusions: MLP models play a more accurate role in the construction of predictive models. Computer science is playing a greater role in helping precision medicine clinical research.
{"title":"Spinopelvic Anatomic Parameters Prediction Model of NSLBP based on open dataset","authors":"","doi":"10.33140/mcr.05.09.06","DOIUrl":"https://doi.org/10.33140/mcr.05.09.06","url":null,"abstract":"Objective: The purpose of this study is to perform analysis through the low back pain open data set to predict the incidence of non-specific chronic low back pain (NSLBP) to obtain a more accurate and convenient sagittal spinopelvic parameter model. Methods: The logistic regression analysis and multilayer perceptron (MLP) algorithm is used to construct a NSLBP prediction model based on the parameters of the spinopelvic parameters from open data source. Results: Degree of spondylolisthesis (DS), Pelvic radius (PR), Sacral slope (SS), Pelvic tilt (PT) are four predictors screened out by regression analysis that have significant predictive power for the risk of NSLBP. The overall accuracy of the equation prediction model is 85.8%.The MLP network algorithm determines that DS is the most powerful predictor of NSLBP through more precise modeling. The model has good predictive ability of 95.2% of accuracy. Conclusions: MLP models play a more accurate role in the construction of predictive models. Computer science is playing a greater role in helping precision medicine clinical research.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114253280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several public health interventions administer drugs and vaccines to large number of people for preemptive or reactive intervention. These vaccines and drugs were developed in very narrow conditions in clinical trials and we therefore have to continuously monitor the efficacy in the field. This paper proposes a method to evaluate the efficacy in the field using data collected from the intervention coverage survey and surveillance. The design is closely related to cohort prospective studies except that the sample size is not fixed upfront and the measure of association not affected by the population denominator. It uses two new terms: hesitancy ratio denoted β, which is the ratio of the target that does to receive the intervention to the target that received it; event ratio is denoted by α is the ratio of health event or disease being prevented absolute incidence in the intervention group to that is in control group. It further shows that risk ratio (RR) can be calculated from these two parameters by taking their products. i.e. RR = α β. This method is therefore called Hesitancy and Event Ratios (HER) Method. We can conclude that this method is scientifically sound and can be used in the evaluation of public health intervention in the field. We recommend that this method be included in routine monitoring of programs for efficacy evaluation.
{"title":"Evaluation of Public Health Mass Campaign: Hesitancy and Event Ratios Method","authors":"","doi":"10.33140/mcr.05.09.02","DOIUrl":"https://doi.org/10.33140/mcr.05.09.02","url":null,"abstract":"Several public health interventions administer drugs and vaccines to large number of people for preemptive or reactive intervention. These vaccines and drugs were developed in very narrow conditions in clinical trials and we therefore have to continuously monitor the efficacy in the field. This paper proposes a method to evaluate the efficacy in the field using data collected from the intervention coverage survey and surveillance. The design is closely related to cohort prospective studies except that the sample size is not fixed upfront and the measure of association not affected by the population denominator. It uses two new terms: hesitancy ratio denoted β, which is the ratio of the target that does to receive the intervention to the target that received it; event ratio is denoted by α is the ratio of health event or disease being prevented absolute incidence in the intervention group to that is in control group. It further shows that risk ratio (RR) can be calculated from these two parameters by taking their products. i.e. RR = α β. This method is therefore called Hesitancy and Event Ratios (HER) Method. We can conclude that this method is scientifically sound and can be used in the evaluation of public health intervention in the field. We recommend that this method be included in routine monitoring of programs for efficacy evaluation.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"383 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122480132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The 2019 coronavirus outbreak (COVID-19) fast became a global pandemic. In the United Kingdom, guidlines were introduced to help control the spread of this virus. Hospitals made significant changes to accommodate for the change in demand. Orthopaedic trauma services needed to remain, however, the management of orthopaedic trauma needed modifying to comply with government and hospital guidelines. Method: Queens’s hospital, Burton, is a level III trauma unit. The orthopaedic department manages upper and lower limb trauma as well as head and chest and spine trauma. Injured patients can be referred to the orthopaedic team from the community or from the Major and Minor Emergency Department. To accommodate new guidelines, the orthopaedic department introduced a ‘virtual clinic’ and a ‘trauma clinic’. The virtual clinic took place in the morning and discussed referrals from the day before. The ‘trauma clinic’ followed on from the virtual clinic and lasted the remainder of the day. Results: The intervention introduced to Queens’s hospital was beneficial for patients, staff and for the hospital. It improved waiting times, reduced the time patients spent in hospital, reduced the number of hospital attendees and enhanced knowledge of common orthopaedic injuries for staffing involved in reviewing and managing these injuries. Conclusion: For our department, these changes improved service provision, staff education and patient safety. These benefits could be seen in other trusts if a similar method of managing trauma patients was introduced.
{"title":"Getting it Right First Time in Trauma Clinic: How a Pandemic Improved Service Provision for Orthopaedic Patients","authors":"","doi":"10.33140/mcr.05.09.01","DOIUrl":"https://doi.org/10.33140/mcr.05.09.01","url":null,"abstract":"Introduction: The 2019 coronavirus outbreak (COVID-19) fast became a global pandemic. In the United Kingdom, guidlines were introduced to help control the spread of this virus. Hospitals made significant changes to accommodate for the change in demand. Orthopaedic trauma services needed to remain, however, the management of orthopaedic trauma needed modifying to comply with government and hospital guidelines. Method: Queens’s hospital, Burton, is a level III trauma unit. The orthopaedic department manages upper and lower limb trauma as well as head and chest and spine trauma. Injured patients can be referred to the orthopaedic team from the community or from the Major and Minor Emergency Department. To accommodate new guidelines, the orthopaedic department introduced a ‘virtual clinic’ and a ‘trauma clinic’. The virtual clinic took place in the morning and discussed referrals from the day before. The ‘trauma clinic’ followed on from the virtual clinic and lasted the remainder of the day. Results: The intervention introduced to Queens’s hospital was beneficial for patients, staff and for the hospital. It improved waiting times, reduced the time patients spent in hospital, reduced the number of hospital attendees and enhanced knowledge of common orthopaedic injuries for staffing involved in reviewing and managing these injuries. Conclusion: For our department, these changes improved service provision, staff education and patient safety. These benefits could be seen in other trusts if a similar method of managing trauma patients was introduced.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115113787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In his Utopia, Thomas More describes a generous conception of medicine. The current reality of organ transplants, with the drama of organ shortages, waiting lists, and patient mortality, requires a conceptual review. For the success of this request, the need of parts of the human body, live or after death is essential. Without organ donation, there are no transplants. The importance of non-enrichment at any level through organ and tissue transplants has been pointed out, significantly, by monotheistic churches and the World Health Organization (WHO). The value recently given to non-cognitive factors, as well as individual behaviour in community actions, when searching for social benefits has also been discussed. This essay proposes ways to change the present critical reality. Our analysis considers education and economic aspects to be of greater significance for changing social donation behaviour.
{"title":"21st Century Transplantation: A rational utopia?","authors":"","doi":"10.33140/mcr.05.09.05","DOIUrl":"https://doi.org/10.33140/mcr.05.09.05","url":null,"abstract":"In his Utopia, Thomas More describes a generous conception of medicine. The current reality of organ transplants, with the drama of organ shortages, waiting lists, and patient mortality, requires a conceptual review. For the success of this request, the need of parts of the human body, live or after death is essential. Without organ donation, there are no transplants. The importance of non-enrichment at any level through organ and tissue transplants has been pointed out, significantly, by monotheistic churches and the World Health Organization (WHO). The value recently given to non-cognitive factors, as well as individual behaviour in community actions, when searching for social benefits has also been discussed. This essay proposes ways to change the present critical reality. Our analysis considers education and economic aspects to be of greater significance for changing social donation behaviour.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114225721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The need to develop and improve methods of diagnos is and treatment of patients with deformities of the jaws is determined primarily by the frequency of it prevalence. Dental anomalies occur in 33.7 - 49% of those examined. To improve the effectiveness of orthodontic treatment of patients with skeletal forms of sagittal anomalies of occlusion of the dentition, it is necessary to conduct additional methods of examination, computer modeling of treatment results, drawing up a comprehensive treatment plan. Clinical case. Patient 33 years old. Skeletal III class, Mesial occlusion of dental arches, Narrow upper jaw, Tooth crowding, periodontal problems, gingival loss. After additional diagnostic methods, computer simulation of treatment was performed, various treatment options were considered.
{"title":"Limits and Possibilities of Orthodontic Treatment of Patients with Skeletal Forms of Sagittal Anomalies","authors":"","doi":"10.33140/mcr.05.09.04","DOIUrl":"https://doi.org/10.33140/mcr.05.09.04","url":null,"abstract":"The need to develop and improve methods of diagnos is and treatment of patients with deformities of the jaws is determined primarily by the frequency of it prevalence. Dental anomalies occur in 33.7 - 49% of those examined. To improve the effectiveness of orthodontic treatment of patients with skeletal forms of sagittal anomalies of occlusion of the dentition, it is necessary to conduct additional methods of examination, computer modeling of treatment results, drawing up a comprehensive treatment plan. Clinical case. Patient 33 years old. Skeletal III class, Mesial occlusion of dental arches, Narrow upper jaw, Tooth crowding, periodontal problems, gingival loss. After additional diagnostic methods, computer simulation of treatment was performed, various treatment options were considered.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133266648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper includes development of a sensitive, accurate and precise direct spectrophotometric approach to estimate tetracycline hydrochloride in the bulk solution and in its pharmaceutical preparations. The method was based on the reaction of tetracycline hydrochloride with zirconium (IV) in presence of acetate buffer solution at pH3.6 to form a yellow complex with a highest absorption peak at 398 nm. The resulting complex conforms Beer's law to cover the concentration in the range of 0.5 to 12.5 µg/ml with a good determination coefficient (r2 =0.9989), molar absorptivity of 2.7798×104 l/mol.cm and Sandell's sensitivity of 0.0173 μg/cm2 . The Limits of detection (LOD) and quantitation (LOQ) were equal to 0.019 and 0.063μg/ml, respectively. A relative standard deviation (precision) was evaluated to be better than 0.91% depending on the concentration levels, whereas the value of recovery percentage were in the range of 97.20% to 103.82%. The approach was useful to the analysis of tetracycline hydrochloride in capsules and skin ointment. The statistic factors t-test and F-test values have also been investigated and revealed that the experimental "t" and "F" results were less than the theoretical results at confidence level of 95%
{"title":"Colourimetric Method for Assaying Tetracycline Hydrochloride in Pharmaceutical Formulations via Zirconium Complex Formation","authors":"","doi":"10.33140/mcr.08.09.01","DOIUrl":"https://doi.org/10.33140/mcr.08.09.01","url":null,"abstract":"This paper includes development of a sensitive, accurate and precise direct spectrophotometric approach to estimate tetracycline hydrochloride in the bulk solution and in its pharmaceutical preparations. The method was based on the reaction of tetracycline hydrochloride with zirconium (IV) in presence of acetate buffer solution at pH3.6 to form a yellow complex with a highest absorption peak at 398 nm. The resulting complex conforms Beer's law to cover the concentration in the range of 0.5 to 12.5 µg/ml with a good determination coefficient (r2 =0.9989), molar absorptivity of 2.7798×104 l/mol.cm and Sandell's sensitivity of 0.0173 μg/cm2 . The Limits of detection (LOD) and quantitation (LOQ) were equal to 0.019 and 0.063μg/ml, respectively. A relative standard deviation (precision) was evaluated to be better than 0.91% depending on the concentration levels, whereas the value of recovery percentage were in the range of 97.20% to 103.82%. The approach was useful to the analysis of tetracycline hydrochloride in capsules and skin ointment. The statistic factors t-test and F-test values have also been investigated and revealed that the experimental \"t\" and \"F\" results were less than the theoretical results at confidence level of 95%","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129717893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ankle injuries lead to joint pain, limitation of movement, occasional effusion, and quality of life impairment. It is estimated that one injury occurs for every 10,000 people each day due to inversion of the ankle. 7-10% of all admissions to hospital emergency departments are a result of ankle injuries. It was found that 70% of acute ankle sprains and fractures display some osteochondral defects (OCD) of the talus. Twenty five percent of all injuries of the musculoskeletal system are related to inversion injuries. About 50% of these injuries are related to sports. Full thickness focal chondral defects in athletes have an overall prevalence of 36%. The ankle is the most injured area of the body for 24 of 70 sports that were studied. Basketball, soccer, football, volleyball, running, and dancing are the sports in which these athletic injuries are most common. Individuals under 35 years of age demonstrate majority of these ankle injuries. The most common age group is for those are between the ages of 15 and 19 years. Etiology of ankle OCDs can either be non-traumatic or traumatic. Seventy percent of acute ankle sprains and fractures occur in the OCD of talus. Potential side effects or medical complications may result from OCD surgeries. Animal and human subjects are commonly used by researchers to investigate the overall effectiveness of stem cells for OCD injuries. Mesenchymal stem cells (MSC) are often the source of preference for orthopedic procedures as they have the ability to differentiate into a variety of tissues. These tissues include bone, muscle, cartilage, and fat. Stem cell transplantation has shown improved tissue quality and rate of healing, sustained gains functionally, decreased pain, and enhanced clinical outcomes. Researchers believed the use of stem cells may offer choices for patients with orthopedic injuries including OCD to reduce recovery time and osteoarthritis as well as enhance function.
{"title":"The Effect of Stem Cells on Ankle Injuries","authors":"","doi":"10.33140/mcr.08.09.02","DOIUrl":"https://doi.org/10.33140/mcr.08.09.02","url":null,"abstract":"Ankle injuries lead to joint pain, limitation of movement, occasional effusion, and quality of life impairment. It is estimated that one injury occurs for every 10,000 people each day due to inversion of the ankle. 7-10% of all admissions to hospital emergency departments are a result of ankle injuries. It was found that 70% of acute ankle sprains and fractures display some osteochondral defects (OCD) of the talus. Twenty five percent of all injuries of the musculoskeletal system are related to inversion injuries. About 50% of these injuries are related to sports. Full thickness focal chondral defects in athletes have an overall prevalence of 36%. The ankle is the most injured area of the body for 24 of 70 sports that were studied. Basketball, soccer, football, volleyball, running, and dancing are the sports in which these athletic injuries are most common. Individuals under 35 years of age demonstrate majority of these ankle injuries. The most common age group is for those are between the ages of 15 and 19 years. Etiology of ankle OCDs can either be non-traumatic or traumatic. Seventy percent of acute ankle sprains and fractures occur in the OCD of talus. Potential side effects or medical complications may result from OCD surgeries. Animal and human subjects are commonly used by researchers to investigate the overall effectiveness of stem cells for OCD injuries. Mesenchymal stem cells (MSC) are often the source of preference for orthopedic procedures as they have the ability to differentiate into a variety of tissues. These tissues include bone, muscle, cartilage, and fat. Stem cell transplantation has shown improved tissue quality and rate of healing, sustained gains functionally, decreased pain, and enhanced clinical outcomes. Researchers believed the use of stem cells may offer choices for patients with orthopedic injuries including OCD to reduce recovery time and osteoarthritis as well as enhance function.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130672342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kienböck’s disease is characterized by avascular necrosis of the lunate bone. There are four stages due to the severity of the disease. A 52-year-old woman was referred to the Tehran Healthcare Clinic to treat the stage II Kienböck’s disease according to the clinical finding and MRI report. Her main complaint was a painful feeling in the dorsal wrist, decreased range of motion of the wrist, and reduced grip strength for one year. The treatment was achieved after completion of our conservative course by special vibration therapy in less than two months. Even though the conservative approaches are generally not recommended in treatment of Kienböck’s disease and in many cases surgeon’s preference (radial shortening osteotomy for early disease and PRC in later stages), our theory is that the aggressive procedure should be the second choice of treatment, especially in the early stages (I and II).
{"title":"Treatment of Kienbock’s Disease by an Experimental Conservative Approach: Case report","authors":"Mohammad Kamali Kakhki, Reza Kamali Kakhki","doi":"10.33140/mcr.08.08.06","DOIUrl":"https://doi.org/10.33140/mcr.08.08.06","url":null,"abstract":"Kienböck’s disease is characterized by avascular necrosis of the lunate bone. There are four stages due to the severity of the disease. A 52-year-old woman was referred to the Tehran Healthcare Clinic to treat the stage II Kienböck’s disease according to the clinical finding and MRI report. Her main complaint was a painful feeling in the dorsal wrist, decreased range of motion of the wrist, and reduced grip strength for one year. The treatment was achieved after completion of our conservative course by special vibration therapy in less than two months. Even though the conservative approaches are generally not recommended in treatment of Kienböck’s disease and in many cases surgeon’s preference (radial shortening osteotomy for early disease and PRC in later stages), our theory is that the aggressive procedure should be the second choice of treatment, especially in the early stages (I and II).","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122890062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patient P.S. (male, born 1948) presented in April 2022 with a diagnosis of right lung carcinoma with multiple metastases to the brain. The biopsy had revealed a non-small cell lung carcinoma. He refused a usual chemotherapy because he had read on the Internet that the probability of cure with this diagnosis was only 1-2%. This was certainly right.
{"title":"Increased Incidence of Unexpected Death due to Spike Proteins: Case Report","authors":"","doi":"10.33140/mcr.08.08.07","DOIUrl":"https://doi.org/10.33140/mcr.08.08.07","url":null,"abstract":"Patient P.S. (male, born 1948) presented in April 2022 with a diagnosis of right lung carcinoma with multiple metastases to the brain. The biopsy had revealed a non-small cell lung carcinoma. He refused a usual chemotherapy because he had read on the Internet that the probability of cure with this diagnosis was only 1-2%. This was certainly right.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128807936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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