Carcinosarcomas are rare, extremely aggressive malignant neoplasms, combining two cellular epithelial and sarcomatous components. Epithelial to mesenchymal transition (EMT) is a biological process that occurs in malignant tumors. Sarcomatous component in carcinosarcomas is derived from the carcinomatous component as a result of metaplasia/transdifferentiation (ЕМТ). We present the pathohistological characteristics and immunohistochemical analysis of four clinicalcarcinosarcoma cases with a different primary localization. Our main goal is to present the classic pathohistological picture of EMT and the role of intermediate filament (IF) proteins in cell and tissue structural integrity, as well as their importance for local invasion and distant hematogenous metastases in carcinosarcomas.
癌肉瘤是一种罕见的、极具侵袭性的恶性肿瘤，由两种细胞上皮和肉瘤组成。上皮向间充质转化(Epithelial to mesenchymal transition, EMT)是恶性肿瘤发生的一个生物学过程。癌肉瘤中的肉瘤成分来源于化生/转分化的癌成分(ЕМТ)。我们报告了4例不同原发部位的临床癌肉瘤的病理组织学特征和免疫组织化学分析。我们的主要目标是呈现EMT的经典病理组织学图像，中间丝(IF)蛋白在细胞和组织结构完整性中的作用，以及它们在癌肉瘤局部侵袭和远处血液转移中的重要性。
{"title":"Carcinosarcomas and epithelial to mesenchymal transition (EMT)","authors":"","doi":"10.33140/mcr.08.01.04","DOIUrl":"https://doi.org/10.33140/mcr.08.01.04","url":null,"abstract":"Carcinosarcomas are rare, extremely aggressive malignant neoplasms, combining two cellular epithelial and sarcomatous components. Epithelial to mesenchymal transition (EMT) is a biological process that occurs in malignant tumors. Sarcomatous component in carcinosarcomas is derived from the carcinomatous component as a result of metaplasia/transdifferentiation (ЕМТ). We present the pathohistological characteristics and immunohistochemical analysis of four clinicalcarcinosarcoma cases with a different primary localization. Our main goal is to present the classic pathohistological picture of EMT and the role of intermediate filament (IF) proteins in cell and tissue structural integrity, as well as their importance for local invasion and distant hematogenous metastases in carcinosarcomas.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127763729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Everyone has the right to prioritize their own health. The process of empowering individuals to take charge of their health and make positive changes to it is known as health promotion [1]. According to the World Health Organization, a healthy lifestyle is one in which one takes measures to lower one’s probability of developing a major illness or dying at an early age [2]. In developing countries, non-communicable diseases are the primary reason for hospitalization and death.
每个人都有权优先考虑自己的健康。使个人能够对自己的健康负责并作出积极改变的过程被称为健康促进[1]。根据世界卫生组织(World Health Organization)的定义，健康的生活方式是指人们采取措施降低自己在早期患上重大疾病或死亡的概率[2]。在发展中国家，非传染性疾病是住院和死亡的主要原因。
{"title":"Health promoting lifestyle profile and its determinants among faculty members of Basic Health Sciences in Services Institute of Medical Sciences, Lahore","authors":"","doi":"10.33140/mcr.08.01.02","DOIUrl":"https://doi.org/10.33140/mcr.08.01.02","url":null,"abstract":"Everyone has the right to prioritize their own health. The process of empowering individuals to take charge of their health and make positive changes to it is known as health promotion [1]. According to the World Health Organization, a healthy lifestyle is one in which one takes measures to lower one’s probability of developing a major illness or dying at an early age [2]. In developing countries, non-communicable diseases are the primary reason for hospitalization and death.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134178630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natural extracellular matrices (ECM) are currently being studied as an alternative source for organ transplantation or as new solutions to treat end-stage renal disease. As the gap between donors and patients in need of an organ transplant continues to widen, research in regenerative medicine seeks to provide different strategies for treatment Tissue and organ failure is currently one of the biggest health issues our society faces [1]. Arising from disease or trauma, complete treatment typically requires the repair or replace the affected organ However, the unavailability of adequate organs for transplantation to meet the existing demand has resulted in major organ shortage crisis. As a result, there has been a major increase in the number of patients [2]. The stem cell therapy fails because of the toxic environment in the organ, the implanted cells unable to regenerate. Afterwards researchers are trying to prepare the lab made artificial organ in the laboratory with the help of artificial scaffold and the tissue specific stem cells. Then tried for the transplantation of animal organs. To overcome this organ shortage challenge is the use of organ-derived scaffolds obtained via decellularization techniques by removing all viable cells from native tissues and retaining 3D structure of natural extracellular matrix (ECM) and vascular network for regeneration. This is the most adequate method where scaffold thoroughly decellularizes, free of endotoxin or bacterial contamination. An appropriate macro and microstructure to support physiological function, intact vascular tree, specific location cues.
{"title":"Decellularization of renal fibrosis by cyclic hydrostatic pressure to restore renal function","authors":"","doi":"10.33140/mcr.08.01.01","DOIUrl":"https://doi.org/10.33140/mcr.08.01.01","url":null,"abstract":"Natural extracellular matrices (ECM) are currently being studied as an alternative source for organ transplantation or as new solutions to treat end-stage renal disease. As the gap between donors and patients in need of an organ transplant continues to widen, research in regenerative medicine seeks to provide different strategies for treatment Tissue and organ failure is currently one of the biggest health issues our society faces [1]. Arising from disease or trauma, complete treatment typically requires the repair or replace the affected organ However, the unavailability of adequate organs for transplantation to meet the existing demand has resulted in major organ shortage crisis. As a result, there has been a major increase in the number of patients [2]. The stem cell therapy fails because of the toxic environment in the organ, the implanted cells unable to regenerate. Afterwards researchers are trying to prepare the lab made artificial organ in the laboratory with the help of artificial scaffold and the tissue specific stem cells. Then tried for the transplantation of animal organs. To overcome this organ shortage challenge is the use of organ-derived scaffolds obtained via decellularization techniques by removing all viable cells from native tissues and retaining 3D structure of natural extracellular matrix (ECM) and vascular network for regeneration. This is the most adequate method where scaffold thoroughly decellularizes, free of endotoxin or bacterial contamination. An appropriate macro and microstructure to support physiological function, intact vascular tree, specific location cues.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122488099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The aim of this study was to determine the histopathological and clinical characteristics of retinoblastoma in patients followed in Bukavu, Democratic Republic of Congo. Methods: It is a cross-sectional and analytical study that included 125 consecutives, exhaustively included subjects followed for retinoblastoma at CELPA ophthalmology clinic from January 2014 up to December 2020. Clinical and histopathological data were analyzed with Epi Info and SPSS 16.0 software. Results: A total of 7200 children aged 1-5 years old were consulted, including 125 cases of retinoblastoma, representing a frequency of 1.7%. The mean annual incidence was 13.8. The age group under 24 months predominated (54.4%), with a mean age of 24.6 months. The majority of patients had no family history of retinoblastoma (79.2%). Ocular protrusion and ocular pain were the most frequent complaints on admission (51.2%). The extraorbital form was found in 59.2% of patients. The average time period between the first symptoms and the consultation was 6 months, and the time period between the first consultation and the beginning of management was 14 days. 112 patients (89.6%) had received enucleation combined with chemotherapy. The survival rate observed after 3 years of follow-up was 40.8%. There was a signifcative association between evolution of the retiboblastoma and the delay between consultation and the management, clinical form and management, and the treatment mode both in bivariate and multivariate analysis (p<0.05, CI=95%). Extraorbital retinoblastoma (61.6%), endophytic (74.4%), with classic cytology showing Flexner-Wintersteiner rosettes (96.3%), numerous mitoses (98.4), necrosis and calcification (92%) dominated. Images of infiltration of the internal structures of the eye were observed (18.4%). Conclusion: Retinoblastoma, a highly malignant tumor of children, remains a real public health problem in Bukavu. Advanced and severe histological forms were the most frequent. Early diagnosis and treatment are essential to improve the prognosis. A survival rate of 40.8% obtained in our limited conditions is a beginning of success which could be improved with the involvement of all the disciplines concerned.
{"title":"Clinical and histopathological study of retinoblastoma in bukavu from 01 january 2014 to 31th december 2020","authors":"","doi":"10.33140/mcr.07.12.09","DOIUrl":"https://doi.org/10.33140/mcr.07.12.09","url":null,"abstract":"Introduction: The aim of this study was to determine the histopathological and clinical characteristics of retinoblastoma in patients followed in Bukavu, Democratic Republic of Congo. Methods: It is a cross-sectional and analytical study that included 125 consecutives, exhaustively included subjects followed for retinoblastoma at CELPA ophthalmology clinic from January 2014 up to December 2020. Clinical and histopathological data were analyzed with Epi Info and SPSS 16.0 software. Results: A total of 7200 children aged 1-5 years old were consulted, including 125 cases of retinoblastoma, representing a frequency of 1.7%. The mean annual incidence was 13.8. The age group under 24 months predominated (54.4%), with a mean age of 24.6 months. The majority of patients had no family history of retinoblastoma (79.2%). Ocular protrusion and ocular pain were the most frequent complaints on admission (51.2%). The extraorbital form was found in 59.2% of patients. The average time period between the first symptoms and the consultation was 6 months, and the time period between the first consultation and the beginning of management was 14 days. 112 patients (89.6%) had received enucleation combined with chemotherapy. The survival rate observed after 3 years of follow-up was 40.8%. There was a signifcative association between evolution of the retiboblastoma and the delay between consultation and the management, clinical form and management, and the treatment mode both in bivariate and multivariate analysis (p<0.05, CI=95%). Extraorbital retinoblastoma (61.6%), endophytic (74.4%), with classic cytology showing Flexner-Wintersteiner rosettes (96.3%), numerous mitoses (98.4), necrosis and calcification (92%) dominated. Images of infiltration of the internal structures of the eye were observed (18.4%). Conclusion: Retinoblastoma, a highly malignant tumor of children, remains a real public health problem in Bukavu. Advanced and severe histological forms were the most frequent. Early diagnosis and treatment are essential to improve the prognosis. A survival rate of 40.8% obtained in our limited conditions is a beginning of success which could be improved with the involvement of all the disciplines concerned.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128716829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Research Question: Is single embryo transfer a reasonable option. Design: Material and methods: This is a retrospective cohort study conducted in a single IVF center. These patients consisted of 96 patients using egg donors and 92 patients using their own eggs for a total of 188 patients undergoing IVF-ICSI. Results: Among 96 patients who received donor eggs, 59 women (61%) were positive for pregnancy tests, resulting in 40 live births (68% per Pregnancy). On the other hand, of 92 patients who received their own egg, 34 patients (37%) were positive in terms of pregnancy tests, resulting in 15 live births (44% per pregnancy). Overall, of all 55 live births, 24 were multiple pregnancies. Interestingly, all multiple pregnancies occured in patients <35 years of age. All of these multiples resulted from the transfer of two blastocysts of grade A. Conclusion: These results corroborate and enhance the various reproductive society recommendations that a selective single embryo transfer at the blastocyst stage and above would be a feasible option in patients less than 38 years of age, especially in patients using egg donors younger than 33 years of age, while resulting in a reasonably high successful singleton live birth rate. This is based on the predicted calculation of a 42.5% singleton live birth per egg donor pregnancy, and a 28% singleton live birth per pregnancy for patients using their own eggs. Summary: Patients who had Blastocyst or above grade A had a 63.7% biochemical or clinical positive pregnancy test result and a 40.7% Live birth. Whilst, patients with blastocysts of other grades or lower stages of development, resulted in 30.7% positive biochemical or clinical pregnancy with 10.7% live birth.
{"title":"Selectively targeted blastocyst embryo transfer: optimizing ivf pregnancy results while minimizing risks and side effects","authors":"","doi":"10.33140/mcr.07.12.10","DOIUrl":"https://doi.org/10.33140/mcr.07.12.10","url":null,"abstract":"Research Question: Is single embryo transfer a reasonable option. Design: Material and methods: This is a retrospective cohort study conducted in a single IVF center. These patients consisted of 96 patients using egg donors and 92 patients using their own eggs for a total of 188 patients undergoing IVF-ICSI. Results: Among 96 patients who received donor eggs, 59 women (61%) were positive for pregnancy tests, resulting in 40 live births (68% per Pregnancy). On the other hand, of 92 patients who received their own egg, 34 patients (37%) were positive in terms of pregnancy tests, resulting in 15 live births (44% per pregnancy). Overall, of all 55 live births, 24 were multiple pregnancies. Interestingly, all multiple pregnancies occured in patients <35 years of age. All of these multiples resulted from the transfer of two blastocysts of grade A. Conclusion: These results corroborate and enhance the various reproductive society recommendations that a selective single embryo transfer at the blastocyst stage and above would be a feasible option in patients less than 38 years of age, especially in patients using egg donors younger than 33 years of age, while resulting in a reasonably high successful singleton live birth rate. This is based on the predicted calculation of a 42.5% singleton live birth per egg donor pregnancy, and a 28% singleton live birth per pregnancy for patients using their own eggs. Summary: Patients who had Blastocyst or above grade A had a 63.7% biochemical or clinical positive pregnancy test result and a 40.7% Live birth. Whilst, patients with blastocysts of other grades or lower stages of development, resulted in 30.7% positive biochemical or clinical pregnancy with 10.7% live birth.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126320157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I am occupied with this problem for over 20 years now, I hope the remedy is found for all that are victims of the harmful microbes, but the problem is really huge and worldwide. I am an example that in 2012 survived blood-sepsis but was treated.as a last resort, with veterinary medicine used for pigs and chicken, COLISTIN (POLYMYXIN B). Waving for 1 week from worlds (saw the Whalefish and the wild Oxen) to this world (BIBI, SURE).
{"title":"Antimicrobial peptide surrogates based on active moiety of dermasetin s4: A history in Peptide-mimetics Research","authors":"","doi":"10.33140/mcr.07.12.07","DOIUrl":"https://doi.org/10.33140/mcr.07.12.07","url":null,"abstract":"I am occupied with this problem for over 20 years now, I hope the remedy is found for all that are victims of the harmful microbes, but the problem is really huge and worldwide. I am an example that in 2012 survived blood-sepsis but was treated.as a last resort, with veterinary medicine used for pigs and chicken, COLISTIN (POLYMYXIN B). Waving for 1 week from worlds (saw the Whalefish and the wild Oxen) to this world (BIBI, SURE).","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"145 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113960553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-04DOI: 10.1101/2022.12.02.22283018
Deepak Mc, S. K, A. Asirvatham, M. Kumar, M. George, N. K, G. R, A. Kannan, S. S., R. M
Objective: To understand the associated risk factors in the progression of Diabetic Kidney Disease among the Type 2 Diabetes individuals living in the state of Tamil Nadu and Puducherry. Research design and methods: Clinical and socio-demographic data was collected, digitized, and analyzed for 482 participants diagnosed either with Diabetic Kidney Disease (DKD) or Type 2 Diabetes (T2D). The study was analyzed by using descriptive statistical analysis SAS version 9.4. Results: Out of 482 participants, 422 fulfilled the eligibility criteria. Gender, age, T2D duration, and comorbidity are the major risk factors that are found to be associated with DKD in population understudy. We also found inclination towards usage of insulin among DKD participants rather than oral diabetic medications. Metformin (Biguanides) was the most used oral diabetic medication among the T2D participants followed by DPP-4 inhibitors and Sulphonylureas. Conclusion: Together, these data describe the risk pattern among participants diagnosed with DKD at regional level that is integral in early and proper management of the disease. Keywords: Diabetic Kidney Disease, Diabetic Medications, Insulin, Risk factors, Type 2 Diabetes
目的:了解泰米尔纳德邦和普杜切里邦2型糖尿病患者糖尿病肾病进展的相关危险因素。研究设计和方法:收集、数字化并分析了482名诊断为糖尿病肾病(DKD)或2型糖尿病(T2D)的参与者的临床和社会人口学数据。采用描述性统计分析SAS version 9.4对研究进行分析。结果:在482名参与者中，422名符合资格标准。性别、年龄、T2D持续时间和合并症是研究中发现的与DKD相关的主要危险因素。我们还发现DKD参与者倾向于使用胰岛素而不是口服糖尿病药物。二甲双胍(双胍类药物)是T2D参与者中使用最多的口服糖尿病药物，其次是DPP-4抑制剂和磺脲类药物。结论:总之，这些数据描述了在区域水平上被诊断为DKD的参与者的风险模式，这是早期和适当管理疾病的组成部分。关键词:糖尿病肾病，糖尿病药物，胰岛素，危险因素，2型糖尿病
{"title":"A retrospective case - control study for assessing the risk factors for development of Diabetic Kidney Disease among people with Type 2 Diabetes in Tamil Nadu and Puducherry","authors":"Deepak Mc, S. K, A. Asirvatham, M. Kumar, M. George, N. K, G. R, A. Kannan, S. S., R. M","doi":"10.1101/2022.12.02.22283018","DOIUrl":"https://doi.org/10.1101/2022.12.02.22283018","url":null,"abstract":"Objective: To understand the associated risk factors in the progression of Diabetic Kidney Disease among the Type 2 Diabetes individuals living in the state of Tamil Nadu and Puducherry. Research design and methods: Clinical and socio-demographic data was collected, digitized, and analyzed for 482 participants diagnosed either with Diabetic Kidney Disease (DKD) or Type 2 Diabetes (T2D). The study was analyzed by using descriptive statistical analysis SAS version 9.4. Results: Out of 482 participants, 422 fulfilled the eligibility criteria. Gender, age, T2D duration, and comorbidity are the major risk factors that are found to be associated with DKD in population understudy. We also found inclination towards usage of insulin among DKD participants rather than oral diabetic medications. Metformin (Biguanides) was the most used oral diabetic medication among the T2D participants followed by DPP-4 inhibitors and Sulphonylureas. Conclusion: Together, these data describe the risk pattern among participants diagnosed with DKD at regional level that is integral in early and proper management of the disease. Keywords: Diabetic Kidney Disease, Diabetic Medications, Insulin, Risk factors, Type 2 Diabetes","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129309305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Xu, Yin Liu, Mingming Hu, B. Song, X. Kong, Zhihong Lin, Jian Zhang, H. Qiu
Background: Patients with hematologic malignancies have poor immunity, and they are more vulnerable to fungal invasion because of disease characteristics and clinical treatment such as chemotherapy. Mucor infections in hematologic malignancies are rare, but once occurred usually lead to high mortality. In this study, we report two cases of hematologic malignancies complicated with breakthrough mucormycosis (BT-MCR), which were treated with amphotericin B colloidal dispersion (ABCD) combined with or without other antifungal agents. Case Presentation: Case 1 shows a patient with natural killer cell leukemia, type 2 diabetes, and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This patient was admitted to the First Affiliated Hospital of Soochow University because of fever with cough and expectoration for a week. Next-generation sequencing (NGS) of alveolar lavage fluid revealed that the patient was infected with Rhizomucor pusillus and Enterococcus faecalis. This patient was infected with fungi although he had taken voriconazole for prevention. Considering the renal toxicity of amphotericin B deoxycholate, the patient received ABCD via intravenous drip combined with posaconazole via oral administration for Rhizomucor pusillus infection and meropenem via intravenous drip for Enterococcus faecalis infection during 45 days of treatment. The patient was free of complaints in the next 2-month follow-up. Case 2 represents a patient with acute myeloid leukemia. During induction chemotherapy, the patient presented with weakness of the left limbs, and head MRI showed multiple cerebral infarctions (MCI). In addition, he had high fever with right-face swelling and pain, and the NGS of blood revealed that he had Mucor circinelloides and Stenotrophomonas maltophilia infection. ABCD and ceftazidime/avibactam were administered to the patients via intravenous drip. The patient also achieved complete remission after later consolidation chemotherapy and successfully underwent allo-HSCT. Conclusion: ABCD shows great efficiency with or without other antifungal agents in treating hematological malignancies complicated with BT-MCR. Despite its infusion-related adverse effects and nephrotoxicity, ABCD shows great application potential for patients with hematologic malignancies, who are often more susceptible to fatal BT-MCR. Furthermore, more valid data should be collected on the combination therapy (ABCD and posaconazole).
{"title":"Breakthrough Mucormycosis In Two Cases Of Hematological Malignancies Successfully Treated With Amphotericin B Colloidal Dispersion","authors":"Yang Xu, Yin Liu, Mingming Hu, B. Song, X. Kong, Zhihong Lin, Jian Zhang, H. Qiu","doi":"10.33140/mcr.07.12.08","DOIUrl":"https://doi.org/10.33140/mcr.07.12.08","url":null,"abstract":"Background: Patients with hematologic malignancies have poor immunity, and they are more vulnerable to fungal invasion because of disease characteristics and clinical treatment such as chemotherapy. Mucor infections in hematologic malignancies are rare, but once occurred usually lead to high mortality. In this study, we report two cases of hematologic malignancies complicated with breakthrough mucormycosis (BT-MCR), which were treated with amphotericin B colloidal dispersion (ABCD) combined with or without other antifungal agents. Case Presentation: Case 1 shows a patient with natural killer cell leukemia, type 2 diabetes, and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This patient was admitted to the First Affiliated Hospital of Soochow University because of fever with cough and expectoration for a week. Next-generation sequencing (NGS) of alveolar lavage fluid revealed that the patient was infected with Rhizomucor pusillus and Enterococcus faecalis. This patient was infected with fungi although he had taken voriconazole for prevention. Considering the renal toxicity of amphotericin B deoxycholate, the patient received ABCD via intravenous drip combined with posaconazole via oral administration for Rhizomucor pusillus infection and meropenem via intravenous drip for Enterococcus faecalis infection during 45 days of treatment. The patient was free of complaints in the next 2-month follow-up. Case 2 represents a patient with acute myeloid leukemia. During induction chemotherapy, the patient presented with weakness of the left limbs, and head MRI showed multiple cerebral infarctions (MCI). In addition, he had high fever with right-face swelling and pain, and the NGS of blood revealed that he had Mucor circinelloides and Stenotrophomonas maltophilia infection. ABCD and ceftazidime/avibactam were administered to the patients via intravenous drip. The patient also achieved complete remission after later consolidation chemotherapy and successfully underwent allo-HSCT. Conclusion: ABCD shows great efficiency with or without other antifungal agents in treating hematological malignancies complicated with BT-MCR. Despite its infusion-related adverse effects and nephrotoxicity, ABCD shows great application potential for patients with hematologic malignancies, who are often more susceptible to fatal BT-MCR. Furthermore, more valid data should be collected on the combination therapy (ABCD and posaconazole).","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134023398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: There is paucity of information on cause of Small-for- Gestational Age (weight below the 10th percentile of a sex- and gestational age) (SGA). Beside, Low birth weight (birth weight less than 2500 g) and SGA have not been examined together in the region; while, both have a worst outcome at birth and late in life. Moreover studies regarding nutrition status of infants and mother in earlier post-partum are scarce in South-Kivu. However, the country is facing a double burden of malnutrition in both mother and infant. Furthermore, if breastfeeding initiation is well-timed, the rate of exclusive breastfeeding will increase and the mortality rate of less than five years infants may diminish. Methods: We conducted a cross sectional study in rural area in Bukavu. One hundred forty three mother-infant pairs were randomly selected from February 2018 to October 2018. The data base was entered in Excel and analyzed by SPSS (Statistical Analysis Software) version 26.0. A WHO Anthropometrics measurement helped to calculate Z score. The descriptive statistic was performed to determine the prevalence of independents variables. In addition, a chi-square analysis was performed to establish the association between possible incriminate factors of LBW, SGA, and DIB (Initiation of Breastfeeding) as well, and a logistic regression was performed to determine the key factors of LBW and SGA. Results: Findings showed that (8/143, 5.6%) and (7/143, 4.9%) of infant was weighted low at birth and Smaller for gestational age, respectively. Besides, almost the totality of lactating mothers (139/143, 97.2%) initiated their children in breastfeeding within the first hour of life. More than half (73.8%, 96/130) planned to exclusively breastfeed their children at 6 months. In fact, 14.3%, 20/140, of lactating mothers, planned of giving (foods or drinks or milk) besides breast milk. Of 143, 3(2.1%) mothers were malnourished in the first week after delivery. At birth and at baseline assessments, there was a mere prevalence of underweight (1/141, 2.1%; Vs 6/143, 4.2%), stunting (9/141, 6.5%; Vs 13/139, 9.5%) and wasted (12/142, 8.5%; Vs 12/140, 8.6%), as well. Unmarried women had a delay in initiation of breastfeeding (p=0.043). Mothers with vision problem at twilight during pregnancy was 6.4 times more likely to deliver a LBW baby (OR: 6.400; 95% CI: 1.183-34.630; p<0.031) and mothers who ruled the HH was 20.789 times more likely to deliver a LBW baby (OR: 20.798; 95% CI: 2.144-201.741; p<0.009). Likewise, lactating mothers with vision problem at twilight during pregnancy was 5.333 times more likely to deliver a Small-for-gestational-age baby (OR: 5.333; 95% CI: 1.391-20.449; p<0.015). Also, the mother who was a head of household was 26.796 times more likely to deliver a SGA baby than the mother who was not the head (OR: 26.796; 95% CI: (2.531-283.717; p<0.006). Conclusion: A Vitamin A supplementation and an adequate food intake during pregnancy and in early post partum pe
{"title":"Rate and risk factors of term low birth weight and small-for-gestational-age and planned behavior of breast feeding of lactating mother in rural maternity of lwiro in bukavu, eastern of the democratic republic of the congo","authors":"","doi":"10.33140/mcr.07.12.05","DOIUrl":"https://doi.org/10.33140/mcr.07.12.05","url":null,"abstract":"Background: There is paucity of information on cause of Small-for- Gestational Age (weight below the 10th percentile of a sex- and gestational age) (SGA). Beside, Low birth weight (birth weight less than 2500 g) and SGA have not been examined together in the region; while, both have a worst outcome at birth and late in life. Moreover studies regarding nutrition status of infants and mother in earlier post-partum are scarce in South-Kivu. However, the country is facing a double burden of malnutrition in both mother and infant. Furthermore, if breastfeeding initiation is well-timed, the rate of exclusive breastfeeding will increase and the mortality rate of less than five years infants may diminish. Methods: We conducted a cross sectional study in rural area in Bukavu. One hundred forty three mother-infant pairs were randomly selected from February 2018 to October 2018. The data base was entered in Excel and analyzed by SPSS (Statistical Analysis Software) version 26.0. A WHO Anthropometrics measurement helped to calculate Z score. The descriptive statistic was performed to determine the prevalence of independents variables. In addition, a chi-square analysis was performed to establish the association between possible incriminate factors of LBW, SGA, and DIB (Initiation of Breastfeeding) as well, and a logistic regression was performed to determine the key factors of LBW and SGA. Results: Findings showed that (8/143, 5.6%) and (7/143, 4.9%) of infant was weighted low at birth and Smaller for gestational age, respectively. Besides, almost the totality of lactating mothers (139/143, 97.2%) initiated their children in breastfeeding within the first hour of life. More than half (73.8%, 96/130) planned to exclusively breastfeed their children at 6 months. In fact, 14.3%, 20/140, of lactating mothers, planned of giving (foods or drinks or milk) besides breast milk. Of 143, 3(2.1%) mothers were malnourished in the first week after delivery. At birth and at baseline assessments, there was a mere prevalence of underweight (1/141, 2.1%; Vs 6/143, 4.2%), stunting (9/141, 6.5%; Vs 13/139, 9.5%) and wasted (12/142, 8.5%; Vs 12/140, 8.6%), as well. Unmarried women had a delay in initiation of breastfeeding (p=0.043). Mothers with vision problem at twilight during pregnancy was 6.4 times more likely to deliver a LBW baby (OR: 6.400; 95% CI: 1.183-34.630; p<0.031) and mothers who ruled the HH was 20.789 times more likely to deliver a LBW baby (OR: 20.798; 95% CI: 2.144-201.741; p<0.009). Likewise, lactating mothers with vision problem at twilight during pregnancy was 5.333 times more likely to deliver a Small-for-gestational-age baby (OR: 5.333; 95% CI: 1.391-20.449; p<0.015). Also, the mother who was a head of household was 26.796 times more likely to deliver a SGA baby than the mother who was not the head (OR: 26.796; 95% CI: (2.531-283.717; p<0.006). Conclusion: A Vitamin A supplementation and an adequate food intake during pregnancy and in early post partum pe","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127219892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Decades ago, an issue concerning the association between schizophrenia and glioblastoma multiforme was raised. Despite some conflicting evidence, there seemed to be a reduced propensity for glioblastoma incidence in schizophrenic patients. Moreover, the widespread use of antipsychotic medications in these patients appears to have affected the course of glioblastoma. In any case, the psychiatric medical treatment may have precedence over a putative molecular mechanism concerning the effect on glioblastoma. Independently, isolated Parkinson’s patients, notably, those affected by hemi-Parkinson’s disease, when they displayed a meningioma on top of their basic neurological disorder, and had the tumor removed surgically, they may tend to witness a remission in the neurologic disease. The causes of the aberrant interactions between psychiatric or neurodegenerative diseases and the associated tumors will be explored. The analysis may reveal unexpected and significant associations. Evidence of these atypical features and associations in primary brain tumors appear to have been ignored so far by most physicians concerned.
{"title":"Atypical facets of brain tumors: glioblastoma in schizophrenia and state after ablation of meningiomas in Parkinson’s disease","authors":"D. Benharroch, Darya Appel","doi":"10.33140/mcr.07.12.02","DOIUrl":"https://doi.org/10.33140/mcr.07.12.02","url":null,"abstract":"Decades ago, an issue concerning the association between schizophrenia and glioblastoma multiforme was raised. Despite some conflicting evidence, there seemed to be a reduced propensity for glioblastoma incidence in schizophrenic patients. Moreover, the widespread use of antipsychotic medications in these patients appears to have affected the course of glioblastoma. In any case, the psychiatric medical treatment may have precedence over a putative molecular mechanism concerning the effect on glioblastoma. Independently, isolated Parkinson’s patients, notably, those affected by hemi-Parkinson’s disease, when they displayed a meningioma on top of their basic neurological disorder, and had the tumor removed surgically, they may tend to witness a remission in the neurologic disease. The causes of the aberrant interactions between psychiatric or neurodegenerative diseases and the associated tumors will be explored. The analysis may reveal unexpected and significant associations. Evidence of these atypical features and associations in primary brain tumors appear to have been ignored so far by most physicians concerned.","PeriodicalId":186238,"journal":{"name":"Medical & Clinical Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121125532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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