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Molecular Medicine最新文献

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Topoisomerase inhibitors in cervical cancer: mechanistic insights and therapeutic strategies. 拓扑异构酶抑制剂在宫颈癌：机制的见解和治疗策略。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-03-04 DOI: 10.1186/s10020-026-01446-z
Yashaswini Reddy, Padmini Pai, Ipshita Das, Shruthi Nayak, Neil Viren D'Souza, Manasa Gangadhar Shetty, Babitha Kampa Sundara
{"title":"Topoisomerase inhibitors in cervical cancer: mechanistic insights and therapeutic strategies.","authors":"Yashaswini Reddy, Padmini Pai, Ipshita Das, Shruthi Nayak, Neil Viren D'Souza, Manasa Gangadhar Shetty, Babitha Kampa Sundara","doi":"10.1186/s10020-026-01446-z","DOIUrl":"https://doi.org/10.1186/s10020-026-01446-z","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: AEOL-induced NRF2 activation and DWORF overexpression mitigate myocardial I/R injury. 更正：aeol诱导的NRF2激活和DWORF过表达可减轻心肌I/R损伤。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-03-04 DOI: 10.1186/s10020-026-01437-0
Maria Del Carmen Asensio-Lopez, Miriam Ruiz-Ballester, Silvia Pascual-Oliver, Francisco Jose Bastida-Nicolas, Yassine Sassi, Jose Javier Fuster, Domingo Pascual-Figal, María Josefa Fernandez Del Palacio, Fernando Soler, Antonio Lax
{"title":"Correction: AEOL-induced NRF2 activation and DWORF overexpression mitigate myocardial I/R injury.","authors":"Maria Del Carmen Asensio-Lopez, Miriam Ruiz-Ballester, Silvia Pascual-Oliver, Francisco Jose Bastida-Nicolas, Yassine Sassi, Jose Javier Fuster, Domingo Pascual-Figal, María Josefa Fernandez Del Palacio, Fernando Soler, Antonio Lax","doi":"10.1186/s10020-026-01437-0","DOIUrl":"10.1186/s10020-026-01437-0","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":"32 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic effects following initiation of single-inhaler triple therapy in COPD: a prospective observational study. 慢性阻塞性肺病单吸入器三联治疗开始后的代谢影响：一项前瞻性观察研究。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-03-03 DOI: 10.1186/s10020-026-01449-w
Noriane A Sievi, Felix Schmidt, Diego M Baur, Kai Fricke, Jonas Herth, Dora Serényi, Maurice Roeder, Nicole Mosca, Silvan Vesenbeckh, Silvia Ulrich, Christian F Clarenbach, Malcolm Kohler
{"title":"Metabolic effects following initiation of single-inhaler triple therapy in COPD: a prospective observational study.","authors":"Noriane A Sievi, Felix Schmidt, Diego M Baur, Kai Fricke, Jonas Herth, Dora Serényi, Maurice Roeder, Nicole Mosca, Silvan Vesenbeckh, Silvia Ulrich, Christian F Clarenbach, Malcolm Kohler","doi":"10.1186/s10020-026-01449-w","DOIUrl":"https://doi.org/10.1186/s10020-026-01449-w","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2. 更正：巴伐辛通过MFN2增强线粒体β氧化和脂质代谢，改善顺铂诱导的肾毒性。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-02-28 DOI: 10.1186/s10020-026-01443-2
Shilu Luo, Ming Yang, Na Jiang, Chenrui Li, Yan Liu, Lin Sun
{"title":"Correction: Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2.","authors":"Shilu Luo, Ming Yang, Na Jiang, Chenrui Li, Yan Liu, Lin Sun","doi":"10.1186/s10020-026-01443-2","DOIUrl":"10.1186/s10020-026-01443-2","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":"32 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury. 延期给药焦谷氨酸螺旋B表面肽（pHBSP），一种新的非促红细胞生成素类似物，可减轻急性肾损伤。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-02-26 DOI: 10.1186/s10020-026-01439-y
Nimesh S A Patel, Hannah L Kerr-Peterson, Michael Brines, Massimo Collino, Mara Rogazzo, Roberto Fantozzi, Elizabeth G Wood, Florence L Johnson, Muhammad M Yaqoob, Anthony Cerami, Christoph Thiemermann
{"title":"Retraction Note: Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury.","authors":"Nimesh S A Patel, Hannah L Kerr-Peterson, Michael Brines, Massimo Collino, Mara Rogazzo, Roberto Fantozzi, Elizabeth G Wood, Florence L Johnson, Muhammad M Yaqoob, Anthony Cerami, Christoph Thiemermann","doi":"10.1186/s10020-026-01439-y","DOIUrl":"10.1186/s10020-026-01439-y","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":"32 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice. 注：靶向NLRP3炎性体减少小鼠饮食诱导的代谢异常。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-02-25 DOI: 10.1186/s10020-026-01438-z
Fausto Chiazza, Aurélie Couturier-Maillard, Elisa Benetti, Raffaella Mastrocola, Debora Nigro, Juan C Cutrin, Loredana Serpe, Manuela Aragno, Roberto Fantozzi, Bernard Ryffel, Christoph Thiemermann, Massimo Collino
{"title":"Retraction Note: Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice.","authors":"Fausto Chiazza, Aurélie Couturier-Maillard, Elisa Benetti, Raffaella Mastrocola, Debora Nigro, Juan C Cutrin, Loredana Serpe, Manuela Aragno, Roberto Fantozzi, Bernard Ryffel, Christoph Thiemermann, Massimo Collino","doi":"10.1186/s10020-026-01438-z","DOIUrl":"10.1186/s10020-026-01438-z","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":"32 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12934075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TAX1BP1 protects against doxorubicin-induced cardiotoxicity via maintaining mitochondrial function in a mTORC2-SGK1-VDAC1 manner. TAX1BP1以mTORC2-SGK1-VDAC1的方式维持线粒体功能，从而防止阿霉素诱导的心脏毒性。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-02-23 DOI: 10.1186/s10020-026-01427-2
Haixia Xu, Dejian Lin, Xinqing Dai, Jian Zhang, Jiayu Shi, Qi Lu, Zhifeng Gu
{"title":"TAX1BP1 protects against doxorubicin-induced cardiotoxicity via maintaining mitochondrial function in a mTORC2-SGK1-VDAC1 manner.","authors":"Haixia Xu, Dejian Lin, Xinqing Dai, Jian Zhang, Jiayu Shi, Qi Lu, Zhifeng Gu","doi":"10.1186/s10020-026-01427-2","DOIUrl":"https://doi.org/10.1186/s10020-026-01427-2","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort. 解开结直肠癌的端粒-线粒体轴：来自前瞻性随访队列的结果。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-02-21 DOI: 10.1186/s10020-026-01423-6
Adrián Gil-Korilis, Jorge Ergui-Arbizu, Petr Hanák, Natálie Danešová, Kristýna Tomášová, Anna Valíčková, Josef Horák, Manuel Gentiluomo, Miroslav Levý, Soňa Křivonosková, Jan Král, Jiří Jungwirth, Ludmila Vodičková, Veronika Vymetálková, Amaya Azqueta, Daniele Campa, Pavel Vodička, Soňa Vodenková
{"title":"Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort.","authors":"Adrián Gil-Korilis, Jorge Ergui-Arbizu, Petr Hanák, Natálie Danešová, Kristýna Tomášová, Anna Valíčková, Josef Horák, Manuel Gentiluomo, Miroslav Levý, Soňa Křivonosková, Jan Král, Jiří Jungwirth, Ludmila Vodičková, Veronika Vymetálková, Amaya Azqueta, Daniele Campa, Pavel Vodička, Soňa Vodenková","doi":"10.1186/s10020-026-01423-6","DOIUrl":"https://doi.org/10.1186/s10020-026-01423-6","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum sCD163 indicates disease severity and prognosis in sudden sensorineural hearing loss. 血清sCD163提示突发性感音神经性听力损失的病情严重程度和预后。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-02-21 DOI: 10.1186/s10020-026-01444-1
Ting Xu, Huikai Miao, Binli Xie
{"title":"Serum sCD163 indicates disease severity and prognosis in sudden sensorineural hearing loss.","authors":"Ting Xu, Huikai Miao, Binli Xie","doi":"10.1186/s10020-026-01444-1","DOIUrl":"https://doi.org/10.1186/s10020-026-01444-1","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel polymorphism in the TERT gene is associated with lower survival in male patients with melanoma. 一种新的TERT基因多态性与男性黑色素瘤患者较低的生存率有关。
IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Molecular Medicine
Pub Date : 2026-02-20 DOI: 10.1186/s10020-026-01440-5
Maria Santa Rocca, Andrea Di Nisio, Paolo Del Fiore, Fortunato Cassalia, Clara Benna, Ilaria Cosci, Simone Mocellin, Alberto Ferlin
{"title":"A novel polymorphism in the TERT gene is associated with lower survival in male patients with melanoma.","authors":"Maria Santa Rocca, Andrea Di Nisio, Paolo Del Fiore, Fortunato Cassalia, Clara Benna, Ilaria Cosci, Simone Mocellin, Alberto Ferlin","doi":"10.1186/s10020-026-01440-5","DOIUrl":"https://doi.org/10.1186/s10020-026-01440-5","url":null,"abstract":"","PeriodicalId":18813,"journal":{"name":"Molecular Medicine","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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