Nada D. Al-Khthami, M. Alsawat, R. Mohamed, Y. Alghamdi, Z. I. Zaki
In order to create a new design for an efficient photocatalyst, you need to decrease the obtained band gap and isolate the charge carriers photogenerated while setting up a new visible light methodology. The latter option could be accomplished via combination of catalyst in the metal oxide form over the surface of semiconductor. Hence, the current work aimed at synthesizing a new nanocomposite material from LaFeO3/g-C3N4 through the use of mesoporous silica as a template processing g-C3N4 higher surface area, which was subsequently decorated with LaFeO3. The LaFeO3 of variable content of 1∼4% was used to decorate our targeted basic material. The structure was confirmed by ordinary techniques, in addition to photocatalytic ability via splitting water reaction. g-C3N4 and LaFeO3 photocatalytic efficiencies were compared to the newly developed LaFeO3/g-C3N4 nanocomposites showing their outstanding activity. The optimum LaFeO3 content was confirmed as 3%, which gave higher photocatalytic efficiency against both g-C3N4 and LaFeO3 (34 and 21 times respectively). To enhance the catalytic system efficiency, a scavenger with a positive hole was added as glycerol. A maximum of five runs of higher efficient reuse was examined as required, as well as stable nanocomposite photocatalyst. The mesoporous structure, high surface area, and capacity of charge separation over the photocatalysis process were all investigated as main conditions which affect photocatalytic activity of LaFeO3/g-C3N4 nanocomposites.
{"title":"Extremely Effective Visible Light-Driven Generation of Hydrogen by Sol–Gel LaFeO3-Decorated g-C3N4 Photocatalyst","authors":"Nada D. Al-Khthami, M. Alsawat, R. Mohamed, Y. Alghamdi, Z. I. Zaki","doi":"10.1166/NNL.2020.3241","DOIUrl":"https://doi.org/10.1166/NNL.2020.3241","url":null,"abstract":"In order to create a new design for an efficient photocatalyst, you need to decrease the obtained band gap and isolate the charge carriers photogenerated while setting up a new visible light methodology. The latter option could be accomplished via combination of catalyst in the metal\u0000 oxide form over the surface of semiconductor. Hence, the current work aimed at synthesizing a new nanocomposite material from LaFeO3/g-C3N4 through the use of mesoporous silica as a template processing g-C3N4 higher surface area, which\u0000 was subsequently decorated with LaFeO3. The LaFeO3 of variable content of 1∼4% was used to decorate our targeted basic material. The structure was confirmed by ordinary techniques, in addition to photocatalytic ability via splitting water reaction. g-C3N4\u0000 and LaFeO3 photocatalytic efficiencies were compared to the newly developed LaFeO3/g-C3N4 nanocomposites showing their outstanding activity. The optimum LaFeO3 content was confirmed as 3%, which gave higher photocatalytic efficiency against\u0000 both g-C3N4 and LaFeO3 (34 and 21 times respectively). To enhance the catalytic system efficiency, a scavenger with a positive hole was added as glycerol. A maximum of five runs of higher efficient reuse was examined as required, as well as stable nanocomposite\u0000 photocatalyst. The mesoporous structure, high surface area, and capacity of charge separation over the photocatalysis process were all investigated as main conditions which affect photocatalytic activity of LaFeO3/g-C3N4 nanocomposites.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1255-1264"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44950364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paeonia emodi is a medicinal plant that is a vital family group of Paeoniaceae and traditionally utilized for treating cardiovascular diseases, such as hypertension, heart failure, atherosclerosis, epilepsy, and palpitations. In this work, we have constructed P. emodi (Pemodi. EA) ethyl acetate subsegment of which was exposed to gain fractions via column chromatography. These subsegments were confirmed by various electroscopic methods. Further, the subsegments were examined for their cardioprotective property on induced isoproterenol hydrochloride (ISO) myocardial infractions (MIs) in nude mice. Pemodi-EA-40 was utilized with maximum segment for synthesis of silver nanoparticles (Pemodi.EA-40@AgNPs). The extreme active segments Pe-EA-40 were examined for antihyperlipidemic, cardioprotective, and histopathological examinations. The body weights of Pemodi.EA-40 (100 mg/kg) remarkably reduced the blood levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Lactic Acid Dehydrogenase (LDH), and Creatine Phosphokinase (CPK) associated with induced ISO treated groups. Pemodi.EA-40@AgNPs also reduced the ALT, AST, LDH, and CPK connected to the Pemodi.EA-40, respectively. The biochemical parameters and histological results reduced the changes as compared to induced ISO treated groups. The outcomes of our examinations proposed that the Pemodi.EA-40@AgNPs medicinal plant improves beneficial profiles of medicinal plant extract fragments for treatments and nursing care of myocardial infractions and atherosclerosis.
{"title":"Facile Synthesis and Nano-Silver Encapsulation of Paeonia emodi for Cardioprotective and Antihyperlipidemic Nursing Care Potentials","authors":"Baihe Wang, Ying Li, H. Luan, Zhen Zhang","doi":"10.1166/NNL.2020.3238","DOIUrl":"https://doi.org/10.1166/NNL.2020.3238","url":null,"abstract":"Paeonia emodi is a medicinal plant that is a vital family group of Paeoniaceae and traditionally utilized for treating cardiovascular diseases, such as hypertension, heart failure, atherosclerosis, epilepsy, and palpitations. In this work, we have constructed P. emodi\u0000 (Pemodi. EA) ethyl acetate subsegment of which was exposed to gain fractions via column chromatography. These subsegments were confirmed by various electroscopic methods. Further, the subsegments were examined for their cardioprotective property on induced isoproterenol hydrochloride (ISO)\u0000 myocardial infractions (MIs) in nude mice. Pemodi-EA-40 was utilized with maximum segment for synthesis of silver nanoparticles (Pemodi.EA-40@AgNPs). The extreme active segments Pe-EA-40 were examined for antihyperlipidemic, cardioprotective, and histopathological examinations. The body weights\u0000 of Pemodi.EA-40 (100 mg/kg) remarkably reduced the blood levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Lactic Acid Dehydrogenase (LDH), and Creatine Phosphokinase (CPK) associated with induced ISO treated groups. Pemodi.EA-40@AgNPs also reduced the ALT, AST, LDH,\u0000 and CPK connected to the Pemodi.EA-40, respectively. The biochemical parameters and histological results reduced the changes as compared to induced ISO treated groups. The outcomes of our examinations proposed that the Pemodi.EA-40@AgNPs medicinal plant improves beneficial profiles of medicinal\u0000 plant extract fragments for treatments and nursing care of myocardial infractions and atherosclerosis.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1284-1292"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47911046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To seek novel miRNAs for the diagnosis of Chronic Obstructive Pulmonary Disease (COPD), this study analyzed the differential expression of miRNA from blood samples of COPD patients and healthy smokers (n = 3) by human microarray analysis. Then, some miRNAs were chosen for qRTPCR validation. A total of 158 miRNAs revealed by microarray analysis have been differentially expressed between the two groups, 33 miRNAs identified to be up-regulated, whereas 125 miRNAs have been down-regulated in COPD. qRT-PCR showed the miR-548h-5p was decreased in the COPD patients compared with healthy smokers (p = 0.04). The sensitivity and specificity of miR-548h-5p to the diagnosis of COPD were 84.6% and 81.8%, respectively. In conclusion, it is recommend that miR-548h-5p as an approach to the diagnosis of COPD.
{"title":"Study on the Expression Spectrum of miRNAs in Peripheral Blood from Patients and the Value of miR-548h-5p in the Diagnosis of Chronic Obstructive Pulmonary Disease","authors":"Chun-Tao Li, Jian-qing Zhang, Lu-ming Dai, Jiaqiang Zhang, Li-zhou Fang, Jia-Gang Feng","doi":"10.1166/NNL.2020.3246","DOIUrl":"https://doi.org/10.1166/NNL.2020.3246","url":null,"abstract":"To seek novel miRNAs for the diagnosis of Chronic Obstructive Pulmonary Disease (COPD), this study analyzed the differential expression of miRNA from blood samples of COPD patients and healthy smokers (n = 3) by human microarray analysis. Then, some miRNAs were chosen for qRTPCR\u0000 validation. A total of 158 miRNAs revealed by microarray analysis have been differentially expressed between the two groups, 33 miRNAs identified to be up-regulated, whereas 125 miRNAs have been down-regulated in COPD. qRT-PCR showed the miR-548h-5p was decreased in the COPD patients compared\u0000 with healthy smokers (p = 0.04). The sensitivity and specificity of miR-548h-5p to the diagnosis of COPD were 84.6% and 81.8%, respectively. In conclusion, it is recommend that miR-548h-5p as an approach to the diagnosis of COPD.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1323-1328"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44385470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhuoxin Liang, Wenqiang Zhang, Yongjiang Jiang, Ping Wu, Sen Zhang, Shaolin Xu, Jinjian Fu, E. McGrath
Community-acquired pneumonia (CAP) refers to an infection contracted outside the hospital that leads to lung parenchyma inflammation. The clinical characteristics of Mycoplasma pneumoniae (M. pneumoniae) infection in CAP patients were rarely reported. The aim of this study was to describe the clinical characteristic and the impact of co-infections of M. pneumoniae with viral and bacterial pathogens in hospitalized children with CAP in Liuzhou, China. This study retrospects children diagnosed with CAP due to M. pneumoniae infection at a tertiary maternal and child health care hospital. Data related to co-infection pathogens, demographics, clinical characteristics, and hospitalization cost were collected from the electronic medical system in this hospital. A total of 983 children were diagnosed with mycoplasmal CAP in 2017. Among them, 18.2% had a bacterial-M. pneumoniae co-infection and 11.3% had a viral-M. pneumoniae co-infection. The highest infection rate of M. pneumoniae was 19.1% in February and March, while the highest rates of bacterial-M. pneumoniae and viral-M. pneumoniae co-infections were 3.6% in December and 2.3% in January, respectively. The prevalence of coughing and wheezing had significant differences between the bacterial- or viral-M. pneumoniae co-infections and the mono-infection groups. Furthermore, the chest X-ray progression, pleural effusions, respiratory failure, and ventilation rates were higher in the respiratory viral- and bacterial-M. pneumoniae co-infection groups than in the mono-infection group. Children with a bacterial or respiratory viral co-infection had a longer hospitalization and spent more on treatment fees than those with a M. pneumoniae mono-infection (P value <0.001). We conclude that children with mycoplasmal CAP, either with a bacterial or viral co-infection, who show signs of coughing and wheezing and have a radiographic progression, will have a severe disease progression and should be specifically treated and managed.
{"title":"Clinical Impact of Combined Viral and Bacterial Infection in Pediatric Mycoplasmal Community-Acquired Pneumonia in Western China","authors":"Zhuoxin Liang, Wenqiang Zhang, Yongjiang Jiang, Ping Wu, Sen Zhang, Shaolin Xu, Jinjian Fu, E. McGrath","doi":"10.1166/NNL.2020.3237","DOIUrl":"https://doi.org/10.1166/NNL.2020.3237","url":null,"abstract":"Community-acquired pneumonia (CAP) refers to an infection contracted outside the hospital that leads to lung parenchyma inflammation. The clinical characteristics of Mycoplasma pneumoniae (M. pneumoniae) infection in CAP patients were rarely reported. The aim of this study\u0000 was to describe the clinical characteristic and the impact of co-infections of M. pneumoniae with viral and bacterial pathogens in hospitalized children with CAP in Liuzhou, China. This study retrospects children diagnosed with CAP due to M. pneumoniae infection at a tertiary\u0000 maternal and child health care hospital. Data related to co-infection pathogens, demographics, clinical characteristics, and hospitalization cost were collected from the electronic medical system in this hospital. A total of 983 children were diagnosed with mycoplasmal CAP in 2017. Among them,\u0000 18.2% had a bacterial-M. pneumoniae co-infection and 11.3% had a viral-M. pneumoniae co-infection. The highest infection rate of M. pneumoniae was 19.1% in February and March, while the highest rates of bacterial-M. pneumoniae and viral-M. pneumoniae co-infections\u0000 were 3.6% in December and 2.3% in January, respectively. The prevalence of coughing and wheezing had significant differences between the bacterial- or viral-M. pneumoniae co-infections and the mono-infection groups. Furthermore, the chest X-ray progression, pleural effusions, respiratory\u0000 failure, and ventilation rates were higher in the respiratory viral- and bacterial-M. pneumoniae co-infection groups than in the mono-infection group. Children with a bacterial or respiratory viral co-infection had a longer hospitalization and spent more on treatment fees than those\u0000 with a M. pneumoniae mono-infection (P value <0.001). We conclude that children with mycoplasmal CAP, either with a bacterial or viral co-infection, who show signs of coughing and wheezing and have a radiographic progression, will have a severe disease progression and should\u0000 be specifically treated and managed.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1315-1322"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42211165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A series of palladium doped barium-based cerium (BaCe1-xPdxO3-δ) catalysts were prepared by the sol–gel method. The catalytic properties of BaCe1-xPdxO3-δ for the oxidation of carbon monoxide were studied. The results show that Pd doping can effectively inhibit the crystal size of catalyst powder, and the specific surface area of the catalyst increases with the increase of doping ratio. Palladium doping significantly improved the catalytic activity of barium ceric acid-based catalyst for CO oxidation. BaCe0.96Pd0.04O3-δ had the best catalytic activity for CO oxidation. After calcination at high temperature, the BaCeO3 perovskite is stable.
{"title":"CO Catalytic Oxidation Performances of Pd-Doped BaCeO3","authors":"Xihan Tan, Ying Li, Peng Wu","doi":"10.1166/NNL.2020.3249","DOIUrl":"https://doi.org/10.1166/NNL.2020.3249","url":null,"abstract":"A series of palladium doped barium-based cerium (BaCe1-xPdxO3-δ) catalysts were prepared by the sol–gel method. The catalytic properties of BaCe1-xPdxO3-δ for the oxidation\u0000 of carbon monoxide were studied. The results show that Pd doping can effectively inhibit the crystal size of catalyst powder, and the specific surface area of the catalyst increases with the increase of doping ratio. Palladium doping significantly improved the catalytic activity of barium\u0000 ceric acid-based catalyst for CO oxidation. BaCe0.96Pd0.04O3-δ had the best catalytic activity for CO oxidation. After calcination at high temperature, the BaCeO3 perovskite is stable.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1293-1300"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42346667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chloroquine, initially used to treat malaria, has been discovered as a sensitizer to augment antitumor activity of other clinically used chemotherapeutics. In this work, chloroquine and doxorubicin were co-loaded into hypoxia-responsive liposomes to synergistically treat solid tumor. In vitro drug release profiles demonstrated that the liposomes were of not only good stability under normoxic condition but also high sensitivity under hypoxic condition. In vitro cell experiments demonstrated that chloroquine augmented doxorubicin cytotoxicity, and co-loaded liposomes were thus more toxic than single-loaded liposomes, especially under hypoxic condition, as a result of hypoxia-responsive drug release. These findings highlighted the potential for chloroquine and doxorubicin co-loaded hypoxia-responsive liposomes in treating solid tumors.
{"title":"Co-Delivery of Chloroquine and Doxorubicin by Hypoxia-Responsive Liposomes for Enhanced Synergistic Antitumor Activity in Treating Solid Tumor","authors":"Xuemeng Liu, Qian-qian Luo, Zhongping Chen","doi":"10.1166/NNL.2020.3247","DOIUrl":"https://doi.org/10.1166/NNL.2020.3247","url":null,"abstract":"Chloroquine, initially used to treat malaria, has been discovered as a sensitizer to augment antitumor activity of other clinically used chemotherapeutics. In this work, chloroquine and doxorubicin were co-loaded into hypoxia-responsive liposomes to synergistically treat solid tumor.\u0000 In vitro drug release profiles demonstrated that the liposomes were of not only good stability under normoxic condition but also high sensitivity under hypoxic condition. In vitro cell experiments demonstrated that chloroquine augmented doxorubicin cytotoxicity, and co-loaded\u0000 liposomes were thus more toxic than single-loaded liposomes, especially under hypoxic condition, as a result of hypoxia-responsive drug release. These findings highlighted the potential for chloroquine and doxorubicin co-loaded hypoxia-responsive liposomes in treating solid tumors.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1309-1314"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48837653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In order to confirm whether HSFL (the fermented liquor of mycelia of Hirsutella sinensis) still contains cordycepin, Cordyceps polysaccharide and other functional components, and has the functions of anti-oxidation, tumor inhibition and immunity enhancement, the biological activity of HSFL In Vivo and in vitro was studied in this study. The transformation ability of mouse spleen lymphocytes induced by ConA, the activity of NK cells in mouse spleen, the delayed allergic reaction induced by DNFB and the phagocytosis of chicken red cells by mouse peritoneal macrophages were studied. The results showed that when the concentration of HSFL was 0.5972 mg/kg and 1.1944 mg/kg, the transformation of lymphocytes induced by ConA and the activity of NK cells were significantly increased. HSFL also can significantly improve DNFB induced anaphylaxis in mice and phagocytosis of chicken erythrocytes by peritoneal macrophages in mice when the dose of HSFL is 50 mg/kg and 75 mg/kg, indicating that HSFL has the biological activity of enhancing immunity in vitro and In Vivo.
{"title":"Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo","authors":"Bing Liu, D. Ding, Zhao Ping, Xinguo Zhang, Zhenji Tian, Xia Xingxing, Zhang Zihao","doi":"10.1166/NNL.2020.3240","DOIUrl":"https://doi.org/10.1166/NNL.2020.3240","url":null,"abstract":"In order to confirm whether HSFL (the fermented liquor of mycelia of Hirsutella sinensis) still contains cordycepin, Cordyceps polysaccharide and other functional components, and has the functions of anti-oxidation, tumor inhibition and immunity enhancement, the biological\u0000 activity of HSFL In Vivo and in vitro was studied in this study. The transformation ability of mouse spleen lymphocytes induced by ConA, the activity of NK cells in mouse spleen, the delayed allergic reaction induced by DNFB and the phagocytosis of chicken red cells by mouse\u0000 peritoneal macrophages were studied. The results showed that when the concentration of HSFL was 0.5972 mg/kg and 1.1944 mg/kg, the transformation of lymphocytes induced by ConA and the activity of NK cells were significantly increased. HSFL also can significantly improve DNFB induced anaphylaxis\u0000 in mice and phagocytosis of chicken erythrocytes by peritoneal macrophages in mice when the dose of HSFL is 50 mg/kg and 75 mg/kg, indicating that HSFL has the biological activity of enhancing immunity in vitro and In Vivo.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1337-1343"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47355430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parkinson’s syndrome (PD) is the second-most common neurodegenerative disease in the world. The chronic disability of PD and the long-term medication required to treat it imposes a huge economic burden on patients and society. Thus, enhancing the therapeutic effect of PD drugs while reducing the side effects caused by long-term drug use has become a challenge that researchers need to overcome. In this study, a compound drug—levodopa/carboxymethyl chitosan/resveratrol nanoparticles (LDP/CMCS/RVT NPs)—with both sustained release and neuroprotective effects was constructed based on carboxymethyl chitosan. The new LDP compound nano-drug can significantly promote glutathione levels of and superoxide dismutase in the substantia nigra and striatum of mice, while increasing the expression of the brain-derived neurotrophic factor. Based on these findings, LDP/CMCS/RVT NPs is expected to provide a new therapeutic strategy for the recovery of midbrain dopamine deficiency and neuroinflammatory changes in PD patients.
{"title":"Preparation of a Carboxymethyl Chitosan-Loaded L-Dopa Composite Nano-Pharmaceutical and Its Therapeutic Effect on Parkinson’s Syndrome","authors":"Jie Wu, Rijun Ren, Zhaoyou Qiu, N. Jiang","doi":"10.1166/NNL.2020.3227","DOIUrl":"https://doi.org/10.1166/NNL.2020.3227","url":null,"abstract":"Parkinson’s syndrome (PD) is the second-most common neurodegenerative disease in the world. The chronic disability of PD and the long-term medication required to treat it imposes a huge economic burden on patients and society. Thus, enhancing the therapeutic effect of PD drugs\u0000 while reducing the side effects caused by long-term drug use has become a challenge that researchers need to overcome. In this study, a compound drug—levodopa/carboxymethyl chitosan/resveratrol nanoparticles (LDP/CMCS/RVT NPs)—with both sustained release and neuroprotective effects\u0000 was constructed based on carboxymethyl chitosan. The new LDP compound nano-drug can significantly promote glutathione levels of and superoxide dismutase in the substantia nigra and striatum of mice, while increasing the expression of the brain-derived neurotrophic factor. Based on these findings,\u0000 LDP/CMCS/RVT NPs is expected to provide a new therapeutic strategy for the recovery of midbrain dopamine deficiency and neuroinflammatory changes in PD patients.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1171-1178"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42328745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ligusticum chuanxiong can relieve the degree of renal fibrosis. However, the specific mechanism of Ligusticum chuanxiong to improve renal fibrosis is not yet clear. A unilateral ureteral obstruction was used to construct a rat renal fibrosis model. The rats were treated with 20 mg/kg and 40 mg/kg of Ligusticum chuanxiong. Four weeks after treatment, blood was collected from the rats, and the rats were sacrificed. Blood urea nitrogen (BUN), serum creatinine (Scr), kidney tissue malondialdehyde (MDA), and superoxide dismutase (SOD) levels were detected. Hematoxylin–eosin staining was used to observe the pathological rat kidney changes. The renal tissue smooth muscle actin (α-SMA) was detected by immunohistochemistry. Nrf2 and HO-1 levels were determined by PCR using nano-magnetic beads. The results showed BUN, Scr, and MDA levels reduced, while SOD levels were elevated in Ligusticum chuanxiong-treated rats, compared to model rats (P < 0.05). These effects were more dramatic in Ligusticum chuanxiong high dose (HD) rats compared to Ligusticum chuanxiong low dose (LD) rats. Additionally, Nrf2 and HO-1 levels were elevated in Ligusticum chuanxiong-treated rats (P < 0.05). These effects were also more dramatic in HD rats compared to LD rats. These findings indicated that Ligusticum chuanxiong early administration can reduce renal fibrosis in rats by stimulating the Nrf2/HO-1 pathway.
{"title":"Ligusticum chuanxiong Effects on Oxidative Stress and Nrf2/HO-1 Signaling Using Nano-Magnetic Beads in Bleomycin-Induced Renal Fibrosis Rats","authors":"Haixia Liu, Wenwen Huang, Xinli Han, Qihang Ma","doi":"10.1166/NNL.2020.3224","DOIUrl":"https://doi.org/10.1166/NNL.2020.3224","url":null,"abstract":"Ligusticum chuanxiong can relieve the degree of renal fibrosis. However, the specific mechanism of Ligusticum chuanxiong to improve renal fibrosis is not yet clear. A unilateral ureteral obstruction was used to construct a rat renal fibrosis model. The rats were treated\u0000 with 20 mg/kg and 40 mg/kg of Ligusticum chuanxiong. Four weeks after treatment, blood was collected from the rats, and the rats were sacrificed. Blood urea nitrogen (BUN), serum creatinine (Scr), kidney tissue malondialdehyde (MDA), and superoxide dismutase (SOD) levels were detected.\u0000 Hematoxylin–eosin staining was used to observe the pathological rat kidney changes. The renal tissue smooth muscle actin (α-SMA) was detected by immunohistochemistry. Nrf2 and HO-1 levels were determined by PCR using nano-magnetic beads. The results showed BUN, Scr, and MDA levels\u0000 reduced, while SOD levels were elevated in Ligusticum chuanxiong-treated rats, compared to model rats (P < 0.05). These effects were more dramatic in Ligusticum chuanxiong high dose (HD) rats compared to Ligusticum chuanxiong low dose (LD) rats. Additionally,\u0000 Nrf2 and HO-1 levels were elevated in Ligusticum chuanxiong-treated rats (P < 0.05). These effects were also more dramatic in HD rats compared to LD rats. These findings indicated that Ligusticum chuanxiong early administration can reduce renal fibrosis in rats by stimulating\u0000 the Nrf2/HO-1 pathway.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1185-1191"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49247156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yenling Cho, Xue Chen, Lishan Huang, Xue Yang, Yuhua Wang
It remains unclear whether positive relative accommodation (PRA), negative relative accommodation (NRA), or binocular cross cylinder (BCC) values present differently when manifest refraction (MR) is performed before or after drug-induced mydriasis. This study aimed to compare visual functions in children as measured by refraction and MR after the administration of mydriatics. A total of 483 children (4–18 years old) were categorized into three groups based on MR performed at three visit points: initial MR, refraction after rapid pupil dilation (RRP), and refraction after slow pupil dilation (RSP). The investigated subjects included PRA, NRA, and BCC values. No significant differences in the PRA (P = 0.120), NRA (P = 0.492), and BCC (P = 0.240) values were detected among the MR, RRP, and RSP groups. When the PRA values among different groups were stratified by age, no significant differences were detected. Although there were no statistically significant differences in the NRA values among groups for children aged 4–6 years (P = 0.077) and 7–11 years (P = 0.865), there was a significant difference in the NRA values among groups for children aged 12–18 years (P =0.044). In addition, the BCC values among groups for children aged 7–11 years (P = 0.044) also showed significant differences. Meanwhile, the differences between PRA (P <0.001) and NRA (P = 0.016) among emmetropes, pseudomyopes, myopes, and hyperopes were statistically significant, while the refractive error was not affected by MR assessed with BCC (P = 0.380). Performing MR after pupil dilation could replace MR before mydriasis in children aged 4–6 years, while MR before mydriasis could be omitted for children aged 4–6 years.
{"title":"Evaluation of Visual Functions in Children Using Manifest Refraction: Effect of Age and Refractive Error","authors":"Yenling Cho, Xue Chen, Lishan Huang, Xue Yang, Yuhua Wang","doi":"10.1166/NNL.2020.3232","DOIUrl":"https://doi.org/10.1166/NNL.2020.3232","url":null,"abstract":"It remains unclear whether positive relative accommodation (PRA), negative relative accommodation (NRA), or binocular cross cylinder (BCC) values present differently when manifest refraction (MR) is performed before or after drug-induced mydriasis. This study aimed to compare visual\u0000 functions in children as measured by refraction and MR after the administration of mydriatics. A total of 483 children (4–18 years old) were categorized into three groups based on MR performed at three visit points: initial MR, refraction after rapid pupil dilation (RRP), and refraction\u0000 after slow pupil dilation (RSP). The investigated subjects included PRA, NRA, and BCC values. No significant differences in the PRA (P = 0.120), NRA (P = 0.492), and BCC (P = 0.240) values were detected among the MR, RRP, and RSP groups. When the PRA values among different\u0000 groups were stratified by age, no significant differences were detected. Although there were no statistically significant differences in the NRA values among groups for children aged 4–6 years (P = 0.077) and 7–11 years (P = 0.865), there was a significant difference\u0000 in the NRA values among groups for children aged 12–18 years (P =0.044). In addition, the BCC values among groups for children aged 7–11 years (P = 0.044) also showed significant differences. Meanwhile, the differences between PRA (P <0.001) and NRA (P =\u0000 0.016) among emmetropes, pseudomyopes, myopes, and hyperopes were statistically significant, while the refractive error was not affected by MR assessed with BCC (P = 0.380). Performing MR after pupil dilation could replace MR before mydriasis in children aged 4–6 years, while\u0000 MR before mydriasis could be omitted for children aged 4–6 years.","PeriodicalId":18871,"journal":{"name":"Nanoscience and Nanotechnology Letters","volume":"12 1","pages":"1179-1184"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42052058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：