The Sanfu herbal patch (SHP) is a traditional Chinese medicine external therapy consisting of Sinapis semen, Asari Radix et Rhizoma, Kansui Radix, and Corydalis Rhizoma. The review involved searching for SHP-related keywords in various databases including Web of Science, PubMed, and China National Knowledge Infrastructure, etc Relevant literature was then selected and findings were summarized. The SHP encompasses a diverse array of bioactive constituents, such as fatty acids, thioglycosides, essential oils, terpenes, alkaloids, and additional chemical compounds. The parent constituents of the SHP that enter skin circulation mainly include sinapine thiocyanate from Sinapis semen, asarinin from Asari Radix et Rhizoma, and tetrahydropalmatine from Corydalis Rhizoma. The SHP exhibits anti-inflammatory, antitussive, analgesic, and antitumor properties, making it a valuable pharmacological agent. Moreover, the SHP is frequently employed in clinical settings to address various ailments including asthma, rhinitis, chronic bronchitis, chronic obstructive pulmonary disease, chronic degenerative joint disease, and chronic gastritis. This review focuses on the main components, skin pharmacokinetics, and pharmacological research progress of the SHP, offering valuable insights for further understanding its mechanism of action and enhancing its clinical application.
三伏贴（SHP）是一种传统中药外敷疗法，由山奈精液、麻黄、甘遂和堇菜组成。该综述涉及在各种数据库（包括 Web of Science、PubMed 和中国国家知识基础设施等）中搜索 SHP 相关关键词，然后筛选出相关文献并对结果进行总结。SHP包含多种生物活性成分，如脂肪酸、硫糖苷、精油、萜烯、生物碱和其他化合物。进入皮肤循环的 SHP 母体成分主要包括山奈精液中的硫氰酸山奈碱、芦荟中的芦荟素和堇菜中的四氢巴马汀。SHP 具有抗炎、止咳、镇痛和抗肿瘤的特性，是一种有价值的药剂。此外，临床上还经常使用 SHP 来治疗各种疾病，包括哮喘、鼻炎、慢性支气管炎、慢性阻塞性肺病、慢性退行性关节病和慢性胃炎。本综述重点介绍了 SHP 的主要成分、皮肤药代动力学和药理学研究进展，为进一步了解其作用机制和加强临床应用提供了有价值的见解。
{"title":"Composition, Skin Pharmacokinetics, and Pharmacological Effects of the Sanfu Herbal Patch","authors":"Wenqing Li, Ying Lv, Wei Liao, Haibo Jiang, Yuwei Liu, Wenfei Lu, Jiansheng Cao, Yufei Feng","doi":"10.1177/1934578x241266414","DOIUrl":"https://doi.org/10.1177/1934578x241266414","url":null,"abstract":"The Sanfu herbal patch (SHP) is a traditional Chinese medicine external therapy consisting of Sinapis semen, Asari Radix et Rhizoma, Kansui Radix, and Corydalis Rhizoma. The review involved searching for SHP-related keywords in various databases including Web of Science, PubMed, and China National Knowledge Infrastructure, etc Relevant literature was then selected and findings were summarized. The SHP encompasses a diverse array of bioactive constituents, such as fatty acids, thioglycosides, essential oils, terpenes, alkaloids, and additional chemical compounds. The parent constituents of the SHP that enter skin circulation mainly include sinapine thiocyanate from Sinapis semen, asarinin from Asari Radix et Rhizoma, and tetrahydropalmatine from Corydalis Rhizoma. The SHP exhibits anti-inflammatory, antitussive, analgesic, and antitumor properties, making it a valuable pharmacological agent. Moreover, the SHP is frequently employed in clinical settings to address various ailments including asthma, rhinitis, chronic bronchitis, chronic obstructive pulmonary disease, chronic degenerative joint disease, and chronic gastritis. This review focuses on the main components, skin pharmacokinetics, and pharmacological research progress of the SHP, offering valuable insights for further understanding its mechanism of action and enhancing its clinical application.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"85 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1177/1934578x241271623
Rong-Qian Cheng, Heyanhao Zhang, Jun Chang
Objective: This study aimed to isolate and elucidate the structure of water-soluble constituents from Nelumbo nucifera Gaertn. leaves and evaluate their anti-aging effect. Methods: The natural products were isolated from the 60% aqueous acetone extract of the leaves of N. nucifera by column chromatography on MCI gel CHP 20P, YMC-Gel ODS-AQ-HG, and TSK gel Toyopearl HW-40F. Their structures were elucidated using high-resolution-electrospray ionization-mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, and electronic circular dichroism spectroscopy. The anti-aging activity was evaluated in the Caenorhabditis elegans model. Results/Conclusion: One novel flavonoid nuciferanoid (1), together with eleven known compounds, were isolated from the extract of the leaves of N. nucifera. Among them, compound 1 could be a starting point for further development of anti-aging drugs.
{"title":"Research on Water-Soluble Constituents and Anti-Aging Effect of the Leaves of Nelumbo nucifera Gaertn","authors":"Rong-Qian Cheng, Heyanhao Zhang, Jun Chang","doi":"10.1177/1934578x241271623","DOIUrl":"https://doi.org/10.1177/1934578x241271623","url":null,"abstract":"Objective: This study aimed to isolate and elucidate the structure of water-soluble constituents from Nelumbo nucifera Gaertn. leaves and evaluate their anti-aging effect. Methods: The natural products were isolated from the 60% aqueous acetone extract of the leaves of N. nucifera by column chromatography on MCI gel CHP 20P, YMC-Gel ODS-AQ-HG, and TSK gel Toyopearl HW-40F. Their structures were elucidated using high-resolution-electrospray ionization-mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, and electronic circular dichroism spectroscopy. The anti-aging activity was evaluated in the Caenorhabditis elegans model. Results/Conclusion: One novel flavonoid nuciferanoid (1), together with eleven known compounds, were isolated from the extract of the leaves of N. nucifera. Among them, compound 1 could be a starting point for further development of anti-aging drugs.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"26 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141932956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-06DOI: 10.1177/1934578x241271658
Zhao Jingyi, Xinyu Yan, Man Wang, Jinshuai Han, Junge Wang
BackgroundXiaoqinglong Decoction (XQLD) is a traditional Chinese medicine formula used for the treatment of allergic rhinitis and asthma, including combined allergic rhinitis and asthma syndrome (CARAS), due to its anti-inflammatory and anti-seizure properties. However, the pharmacological activities and the underlying molecular mechanisms of XQLD remain to be elucidated . Hence, we investigated the effects of XQLD against inflammation in an ovalbumin (OVA)-induced CARAS model in BALB/c mice.MethodsBALB/c mice were sensitized by intraperitoneal injection and aerosol inhalation of OVA. XQLD or dexamethasone was administered by oral gavage prior to OVA challenge for 7 consecutive days. Specific airway resistance (sRAW) was evaluated 24 h after the final challenge with OVA. Enzyme-linked immunosorbent assay was used to measure the levels of serum inflammatory factors. The nasal mucosa and lung tissue were examined for general morphology and goblet hyperplasia using hematoxylin and eosin or periodic acid Schiff staining. Flow cytometry was employed to analyze the frequencies of helper T lymphocytes in peripheral blood. Immunohistochemistry was performed to determine the expression of transcription factors in helper T lymphocytes and γδ TCR.ResultsXQLD significantly ameliorated the symptoms of CARAS model mice, suppressed serum levels of interferon-γ, interleukin (IL)-2, IL-4, IL-5, IL-17, while increasing levels of IL-10, transforming growth factor-β. Epithelium impairment, cilia loss, eosinophil infiltration, and goblet cell metaplasia were significantly reduced in the nasal mucosa and lung tissue sections. XQLD restored the balance of Th1/Th2 and Th17/Treg cell frequency in peripheral blood. Furthermore, XQLD down-modulated the expression of GATA-binding protein 3 (GATA3), retinoic acid receptor-related orphan receptor γt, and γδ T cell receptor (TCR) in the nasal mucosa, along with GATA3 and γδ TCR in the lung tissue.ConclusionsXQLD alleviated OVA-induced CARAS in BALB/c mice through its anti-allergic effects and modulation of the immune system.
{"title":"Anti-Inflammatory and Immunoregulatory Effects of Xiaoqinglong Decoction on a Murine Model of Combined Allergic Rhinitis and Asthma Syndrome","authors":"Zhao Jingyi, Xinyu Yan, Man Wang, Jinshuai Han, Junge Wang","doi":"10.1177/1934578x241271658","DOIUrl":"https://doi.org/10.1177/1934578x241271658","url":null,"abstract":"BackgroundXiaoqinglong Decoction (XQLD) is a traditional Chinese medicine formula used for the treatment of allergic rhinitis and asthma, including combined allergic rhinitis and asthma syndrome (CARAS), due to its anti-inflammatory and anti-seizure properties. However, the pharmacological activities and the underlying molecular mechanisms of XQLD remain to be elucidated . Hence, we investigated the effects of XQLD against inflammation in an ovalbumin (OVA)-induced CARAS model in BALB/c mice.MethodsBALB/c mice were sensitized by intraperitoneal injection and aerosol inhalation of OVA. XQLD or dexamethasone was administered by oral gavage prior to OVA challenge for 7 consecutive days. Specific airway resistance (sRAW) was evaluated 24 h after the final challenge with OVA. Enzyme-linked immunosorbent assay was used to measure the levels of serum inflammatory factors. The nasal mucosa and lung tissue were examined for general morphology and goblet hyperplasia using hematoxylin and eosin or periodic acid Schiff staining. Flow cytometry was employed to analyze the frequencies of helper T lymphocytes in peripheral blood. Immunohistochemistry was performed to determine the expression of transcription factors in helper T lymphocytes and γδ TCR.ResultsXQLD significantly ameliorated the symptoms of CARAS model mice, suppressed serum levels of interferon-γ, interleukin (IL)-2, IL-4, IL-5, IL-17, while increasing levels of IL-10, transforming growth factor-β. Epithelium impairment, cilia loss, eosinophil infiltration, and goblet cell metaplasia were significantly reduced in the nasal mucosa and lung tissue sections. XQLD restored the balance of Th1/Th2 and Th17/Treg cell frequency in peripheral blood. Furthermore, XQLD down-modulated the expression of GATA-binding protein 3 (GATA3), retinoic acid receptor-related orphan receptor γt, and γδ T cell receptor (TCR) in the nasal mucosa, along with GATA3 and γδ TCR in the lung tissue.ConclusionsXQLD alleviated OVA-induced CARAS in BALB/c mice through its anti-allergic effects and modulation of the immune system.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"76 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141933080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-03DOI: 10.1177/1934578x241266692
Yan Liu, Zhixu Gao, Yintao Zhao, Lingjuan Kong, Xiaoqing Ji, Jinyang Wu, Zhanhua Gao
Scutellaria baicalensis, commonly known as Chinese Skullcap, is a traditional herb with a long history of cultural use in Chinese medicines. This review focuses on a comprehensive summary of the morphological description, bioactive compounds, drug-herb interactions, and pharmacological activities of Scutellaria baicalensis, as well as its therapeutic applications. A wide-ranging search using databases such as PubMed, Scopus, Google Scholar, and advanced search on the Web was conducted for data collection from prior studies. The plant root contains major active constituents including flavonoids and flavo-glycosides such as wogonin, baicalein, baicalin, oroxylin A, scutellarein, and norwogonin. These compounds have demonstrated a variety of pharmacological activities, combating inflammation, oxidative stress, cancer, neuronal disorders, and liver disorders. Chinese Skullcap represents a promising avenue for potential pharmacotherapeutic formulation advancement, emphasizing the need for further scientific exploration and clinical trials.
{"title":"Exploring Bioactive Constituents and Pharmacological Effects of Scutellaria baicalensis Georgi: A Review","authors":"Yan Liu, Zhixu Gao, Yintao Zhao, Lingjuan Kong, Xiaoqing Ji, Jinyang Wu, Zhanhua Gao","doi":"10.1177/1934578x241266692","DOIUrl":"https://doi.org/10.1177/1934578x241266692","url":null,"abstract":"Scutellaria baicalensis, commonly known as Chinese Skullcap, is a traditional herb with a long history of cultural use in Chinese medicines. This review focuses on a comprehensive summary of the morphological description, bioactive compounds, drug-herb interactions, and pharmacological activities of Scutellaria baicalensis, as well as its therapeutic applications. A wide-ranging search using databases such as PubMed, Scopus, Google Scholar, and advanced search on the Web was conducted for data collection from prior studies. The plant root contains major active constituents including flavonoids and flavo-glycosides such as wogonin, baicalein, baicalin, oroxylin A, scutellarein, and norwogonin. These compounds have demonstrated a variety of pharmacological activities, combating inflammation, oxidative stress, cancer, neuronal disorders, and liver disorders. Chinese Skullcap represents a promising avenue for potential pharmacotherapeutic formulation advancement, emphasizing the need for further scientific exploration and clinical trials.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"28 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141932953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-03DOI: 10.1177/1934578x241265216
Ji Hye Kim, Sooyeon Kang, Gyu-Ri Lee, Seong-Gyu Ko
BackgroundTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is well known to selectively induce apoptotic cell death in cancer cells, not in normal cells, with death receptors (DRs)—DR4 and DR5. In consequence of this specialty, this cytokine and its receptors are considered for candidates of target therapy in clinic. SH003, a new traditional medicine-based polyherbal preparation, consists of Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes kirilowii Maximowicz (Tk). In this study, we investigated whether SH003 can induce apoptosis through DRs in non-small-cell lung cancer (NSCLC) cells.MethodsCell proliferation and cytotoxicity were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), clonogenic assay, and, trypan blue exclusion staining, protein expression by western blot analysis, and apoptosis by fluorescence-activated cell sorting analysis.ResultsWe found that SH003-induced apoptosis in NSCLC cells through several mechanisms. First of all, MTT and colony formation assay confirmed the growth-inhibitory effect of SH003 in H460 cells. Second, SH003 upregulated the expression of DR4 and DR5. Third, it activated caspase-8, caspase-7, and caspase-3 cascades, which are essential for DR-mediated extrinsic apoptosis. The effect of SH003-induced apoptosis was significantly abolished by inhibition of caspases enzymes. And also, SH003 cleaved caspse-9. Fourth, SH003 reduced AKT kinase phosphorylation, and overexpression of AKT abrogated the caspase-dependent apoptosis by SH003. Fifth, SH003 inactivated ERK, but, constitutive ERK expression did not completely reduce SH003-mediated growth inhibition and apoptosis.ConclusionsSH003 potentiates caspase-dependent apoptosis of NSCLC through the upregulation of DRs, activation of caspase cascades and downregulation of AKT cell survival pathways.
{"title":"SH003 Induces DR5-Mediated Caspase-Dependent Apoptosis of NSCLC Through Inhibition of AKT Survival Pathway","authors":"Ji Hye Kim, Sooyeon Kang, Gyu-Ri Lee, Seong-Gyu Ko","doi":"10.1177/1934578x241265216","DOIUrl":"https://doi.org/10.1177/1934578x241265216","url":null,"abstract":"BackgroundTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is well known to selectively induce apoptotic cell death in cancer cells, not in normal cells, with death receptors (DRs)—DR4 and DR5. In consequence of this specialty, this cytokine and its receptors are considered for candidates of target therapy in clinic. SH003, a new traditional medicine-based polyherbal preparation, consists of Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes kirilowii Maximowicz (Tk). In this study, we investigated whether SH003 can induce apoptosis through DRs in non-small-cell lung cancer (NSCLC) cells.MethodsCell proliferation and cytotoxicity were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), clonogenic assay, and, trypan blue exclusion staining, protein expression by western blot analysis, and apoptosis by fluorescence-activated cell sorting analysis.ResultsWe found that SH003-induced apoptosis in NSCLC cells through several mechanisms. First of all, MTT and colony formation assay confirmed the growth-inhibitory effect of SH003 in H460 cells. Second, SH003 upregulated the expression of DR4 and DR5. Third, it activated caspase-8, caspase-7, and caspase-3 cascades, which are essential for DR-mediated extrinsic apoptosis. The effect of SH003-induced apoptosis was significantly abolished by inhibition of caspases enzymes. And also, SH003 cleaved caspse-9. Fourth, SH003 reduced AKT kinase phosphorylation, and overexpression of AKT abrogated the caspase-dependent apoptosis by SH003. Fifth, SH003 inactivated ERK, but, constitutive ERK expression did not completely reduce SH003-mediated growth inhibition and apoptosis.ConclusionsSH003 potentiates caspase-dependent apoptosis of NSCLC through the upregulation of DRs, activation of caspase cascades and downregulation of AKT cell survival pathways.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"2 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141932952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selected compounds from Centella asiatica with proven neuroprotective potential and analyzed strong binding affinity with molecular docking can be considered as potential inhibitors for alpha-1-antichymotrypsin in Alzheimer's disease.
{"title":"Asiatic Acid, Quercetin, and Kaempferol From Centella asiatica as Potential Inhibitors of Alpha-1-Antichymotrypsin in Alzheimer's Disease","authors":"Jhinuk Chatterjee, Apoorva Atmuri, Eshaana Janardhan Raichur, Gouri Anil","doi":"10.1177/1934578x241264637","DOIUrl":"https://doi.org/10.1177/1934578x241264637","url":null,"abstract":"Selected compounds from Centella asiatica with proven neuroprotective potential and analyzed strong binding affinity with molecular docking can be considered as potential inhibitors for alpha-1-antichymotrypsin in Alzheimer's disease.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"57 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141932955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-02DOI: 10.1177/1934578x241264468
Ali Aberoumand, Najmeh Ahmadi Nooradinvand, Rania Kouti, Fatemeh Hyderi
Objective/background: Different processing methods can maintain quality and ensure access to fish throughout year. In Iran, fish can be major source of affordable dietary protein for human nutrition. Fish ( Carangoides armatus) locally known as Gish, is most preferred and highest value commercial food fish species obtained from southern Iran. Methods: This article examined impact of different processes on the physicochemical properties of fresh fish. Results: Highest and lowest values for crude protein reported in fish processed using high temperature short time (HTST) in autoclave (17.51%) and salting (8.47%), respectively ( P < .05), compared to (16.69%) for fresh fish (control). Fish processed with 20% salt concluded significantly higher crude fat content (69.45%) ( P < .05) followed by samples prepared using 10% salt (68.88%), while lowest value (9.12%) found for fish marinated T1. The results suggested that fish processed with HTST found higher nutritional quality principally due to relatively high content of most needed nutrient—protein. Adopting and encouraging use of autoclave could also be a way of saving energy. Fish components that affected by processes are proximate composition and energy. Conclusions: Changes in the physicochemical and nutritional factors of processed fish affect its final quality. Gish fish ( C armatus) caught from the southern regions of Iran had a high percentage of protein and fat, which has a good potential for the growth of children and to prevent stunting.
{"title":"Effect of Different Processes to Nutrient Profile of Dead Fresh Fish Carangoides armatus as Potential Protein-Rich Seafood","authors":"Ali Aberoumand, Najmeh Ahmadi Nooradinvand, Rania Kouti, Fatemeh Hyderi","doi":"10.1177/1934578x241264468","DOIUrl":"https://doi.org/10.1177/1934578x241264468","url":null,"abstract":"Objective/background: Different processing methods can maintain quality and ensure access to fish throughout year. In Iran, fish can be major source of affordable dietary protein for human nutrition. Fish ( Carangoides armatus) locally known as Gish, is most preferred and highest value commercial food fish species obtained from southern Iran. Methods: This article examined impact of different processes on the physicochemical properties of fresh fish. Results: Highest and lowest values for crude protein reported in fish processed using high temperature short time (HTST) in autoclave (17.51%) and salting (8.47%), respectively ( P < .05), compared to (16.69%) for fresh fish (control). Fish processed with 20% salt concluded significantly higher crude fat content (69.45%) ( P < .05) followed by samples prepared using 10% salt (68.88%), while lowest value (9.12%) found for fish marinated T1. The results suggested that fish processed with HTST found higher nutritional quality principally due to relatively high content of most needed nutrient—protein. Adopting and encouraging use of autoclave could also be a way of saving energy. Fish components that affected by processes are proximate composition and energy. Conclusions: Changes in the physicochemical and nutritional factors of processed fish affect its final quality. Gish fish ( C armatus) caught from the southern regions of Iran had a high percentage of protein and fat, which has a good potential for the growth of children and to prevent stunting.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"75 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-02DOI: 10.1177/1934578x241266706
Sungmin Hwang, Ji Soo Kim, Go Kyoung Na, Hyeon Jeong Lee, Bohyun Yun, Ji-Won Park, Seahee Han, Min-Ju Park, WonWoo Lee, Kyung-Min Choi, Jung Up Park
ObjectiveThe rich botanical biodiversity resulting from diverse climates and geographical distinctiveness offers a plethora of biological resources that can be pivotal in developing innovative biomaterials. This investigation sought to evaluate the functional properties of indigenous Korean plant species.MethodsForty-six indigenous plants during a year-long expedition across inhabited and uninhabited Korean islands were collected. The plant specimens were divided into 5 parts (flower, fruit, stem, leaf, and whole body) and subjected to extraction using water, 30% ethanol, and 70% ethanol, followed by characterizations of anti-inflammatory, immune response, and anti-bacterial activity.ResultsThirty-eight percent of the extracts (59 extracts from 31 species) exhibited statistically significant anti-inflammatory effects. Concurrently, 22% of the extracts (35 extracts from 24 species) demonstrated notable immune boosting effects. Additionally, 17 extracts exhibited significant inhibitory effects against the growth of pathogenic bacteria.ConclusionThis study highlights the potential utility of extracts of plants from Korean islands as natural agents for next-generation pharmaceutical and medical applications by emphasizing their effectiveness in combating inflammation, enhancing immune responses, and conferring anti-bacterial benefits.
{"title":"Characterization of the Anti-Inflammatory, Immune Response, and Anti-Bacterial Properties of the Polar Extracts of Indigenous Korean Plants","authors":"Sungmin Hwang, Ji Soo Kim, Go Kyoung Na, Hyeon Jeong Lee, Bohyun Yun, Ji-Won Park, Seahee Han, Min-Ju Park, WonWoo Lee, Kyung-Min Choi, Jung Up Park","doi":"10.1177/1934578x241266706","DOIUrl":"https://doi.org/10.1177/1934578x241266706","url":null,"abstract":"ObjectiveThe rich botanical biodiversity resulting from diverse climates and geographical distinctiveness offers a plethora of biological resources that can be pivotal in developing innovative biomaterials. This investigation sought to evaluate the functional properties of indigenous Korean plant species.MethodsForty-six indigenous plants during a year-long expedition across inhabited and uninhabited Korean islands were collected. The plant specimens were divided into 5 parts (flower, fruit, stem, leaf, and whole body) and subjected to extraction using water, 30% ethanol, and 70% ethanol, followed by characterizations of anti-inflammatory, immune response, and anti-bacterial activity.ResultsThirty-eight percent of the extracts (59 extracts from 31 species) exhibited statistically significant anti-inflammatory effects. Concurrently, 22% of the extracts (35 extracts from 24 species) demonstrated notable immune boosting effects. Additionally, 17 extracts exhibited significant inhibitory effects against the growth of pathogenic bacteria.ConclusionThis study highlights the potential utility of extracts of plants from Korean islands as natural agents for next-generation pharmaceutical and medical applications by emphasizing their effectiveness in combating inflammation, enhancing immune responses, and conferring anti-bacterial benefits.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"53 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141881986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The Zuo Jin pill (ZJP), a classic formula for treating gastrointestinal diseases, has demonstrated good efficacy in the treatment of ulcerative colitis (UC). In this study, we aimed to elucidate the mechanism of action of ZJP in UC through network pharmacology and experimental validation. Methods: Bioactive compounds and targets of ZJP, along with UC-related targets, were retrieved from public databases. The intersecting targets of ZJP and UC were visualized using a Venn diagram. Protein–protein interactions and complex target networks were established using Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to enrich the biological functions and pathways of potential targets and to establish a biological process-target-pathway network. Relevant pathways were screened based on literature review and node size, and the interactions between ZJP and UC as well as hub target proteins were verified through animal experiments. Results: The findings suggested that STAT3, AKT1, EGFR, PIK3R1, and various cancer pathways exhibited potential as pivotal targets and biological processes contributing to the therapeutic efficacy of ZJP in UC. These targets were intricately associated with molecular functions, drug response, protein autophosphorylation, and protein kinase binding. Subsequent experimental intervention using ZJP on dextran sulfate sodium-induced UC mice revealed that its mode of action may involve inhibiting the PI3K/AKT/mTOR signaling pathway, mitigating intestinal mucosal inflammation, and modulating apoptosis in intestinal epithelial cells. Conclusions: The findings suggested that STAT3, AKT1, EGFR, PIK3R1, and various cancer pathways exhibited potential as pivotal targets and biological processes contributing to the therapeutic efficacy of ZJP in UC. These targets were associated with drug response, protein autophosphorylation, and protein kinase binding. Further experiments revealed that its mode of action may involve inhibiting the PI3K/AKT/mTOR signaling pathway, mitigating intestinal mucosal inflammation, and modulating apoptosis in intestinal epithelial cells.
{"title":"Investigating Molecular Mechanisms Underlying the Therapeutic Effects of Zuo Jin Pill in Ulcerative Colitis: A Combined Approach of Network Pharmacology and Experimental Validation","authors":"Xiao Xiao, Lihong Wu, Chuanyu Zhan, Zenghua Xiao, Wei Ge, Wu Liao, Leichang Zhang","doi":"10.1177/1934578x241264999","DOIUrl":"https://doi.org/10.1177/1934578x241264999","url":null,"abstract":"Objective: The Zuo Jin pill (ZJP), a classic formula for treating gastrointestinal diseases, has demonstrated good efficacy in the treatment of ulcerative colitis (UC). In this study, we aimed to elucidate the mechanism of action of ZJP in UC through network pharmacology and experimental validation. Methods: Bioactive compounds and targets of ZJP, along with UC-related targets, were retrieved from public databases. The intersecting targets of ZJP and UC were visualized using a Venn diagram. Protein–protein interactions and complex target networks were established using Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to enrich the biological functions and pathways of potential targets and to establish a biological process-target-pathway network. Relevant pathways were screened based on literature review and node size, and the interactions between ZJP and UC as well as hub target proteins were verified through animal experiments. Results: The findings suggested that STAT3, AKT1, EGFR, PIK3R1, and various cancer pathways exhibited potential as pivotal targets and biological processes contributing to the therapeutic efficacy of ZJP in UC. These targets were intricately associated with molecular functions, drug response, protein autophosphorylation, and protein kinase binding. Subsequent experimental intervention using ZJP on dextran sulfate sodium-induced UC mice revealed that its mode of action may involve inhibiting the PI3K/AKT/mTOR signaling pathway, mitigating intestinal mucosal inflammation, and modulating apoptosis in intestinal epithelial cells. Conclusions: The findings suggested that STAT3, AKT1, EGFR, PIK3R1, and various cancer pathways exhibited potential as pivotal targets and biological processes contributing to the therapeutic efficacy of ZJP in UC. These targets were associated with drug response, protein autophosphorylation, and protein kinase binding. Further experiments revealed that its mode of action may involve inhibiting the PI3K/AKT/mTOR signaling pathway, mitigating intestinal mucosal inflammation, and modulating apoptosis in intestinal epithelial cells.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"41 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.1177/1934578x241250204
Van Cuong Pham, Thi Hue Nguyen, Thuy Linh Nguyen, Mai Anh Nguyen, Thi Quyen Vu, Thi Thu Huyen Vu, Thi Hong Minh Le, Thi Mai Huong Doan
ObjectivesThis study focused on the isolation, structural elucidation, and antimicrobial activities of compounds from the culture broth of the strain Penicillium sp. OM01 (isolated from the marine mollusk sample Spondylus squamosus (Schreibers, 1793)).MethodsVarious chromatographic methods were used to isolate compounds from the ethyl acetate and MeOH extracts of the strain Penicillium sp. OM01. Their structures were elucidated using HR-ESI-MS and NMR data. The compounds were evaluated for antimicrobial effects using the dilution turbidimetric broth method.ResultsOne new alkaloid, penicritin (1), together with seven known compounds, including phenol A acid (2), topsentisteron D3 (3), ergostanol (4), (22 E,24 R)-24-methylcholesta-5,22-diene-3 β, 7 β-diol (5), 5 α,6 α-epoxy-(22 E,24 R)-ergosta-8,22-diene-3 β,7 α-diol (6), staphylopeptide A (7), and 4-hydroxybenzoic acid (8) were isolated from the culture broth of the marine-derived fungus Penicillium sp. OM01. Compounds 2-4 and 6 exhibited antibacterial activity against Gram-(+) bacteria, Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, and yeast Candida albicans with MIC values ranging from 32 to 256 µg/mL.ConclusionsThis is the first report of the strain Penicillium sp. OM01 from the marine mollusk sample S. squamosus (Schreibers, 1793). One new and seven known compounds were isolated from the strain Penicillium sp. OM01 (isolated from the marine mollusk sample S. squamosus (Schreibers, 1793). Compound 4 is a potential antibacterial agent.
{"title":"Antimicrobial Activities of a New Alkaloid from Marine-Derived Fungus, Penicillium sp. OM01","authors":"Van Cuong Pham, Thi Hue Nguyen, Thuy Linh Nguyen, Mai Anh Nguyen, Thi Quyen Vu, Thi Thu Huyen Vu, Thi Hong Minh Le, Thi Mai Huong Doan","doi":"10.1177/1934578x241250204","DOIUrl":"https://doi.org/10.1177/1934578x241250204","url":null,"abstract":"ObjectivesThis study focused on the isolation, structural elucidation, and antimicrobial activities of compounds from the culture broth of the strain Penicillium sp. OM01 (isolated from the marine mollusk sample Spondylus squamosus (Schreibers, 1793)).MethodsVarious chromatographic methods were used to isolate compounds from the ethyl acetate and MeOH extracts of the strain Penicillium sp. OM01. Their structures were elucidated using HR-ESI-MS and NMR data. The compounds were evaluated for antimicrobial effects using the dilution turbidimetric broth method.ResultsOne new alkaloid, penicritin (1), together with seven known compounds, including phenol A acid (2), topsentisteron D<jats:sub>3</jats:sub> (3), ergostanol (4), (22 E,24 R)-24-methylcholesta-5,22-diene-3 β, 7 β-diol (5), 5 α,6 α-epoxy-(22 E,24 R)-ergosta-8,22-diene-3 β,7 α-diol (6), staphylopeptide A (7), and 4-hydroxybenzoic acid (8) were isolated from the culture broth of the marine-derived fungus Penicillium sp. OM01. Compounds 2-4 and 6 exhibited antibacterial activity against Gram-(+) bacteria, Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, and yeast Candida albicans with MIC values ranging from 32 to 256 µg/mL.ConclusionsThis is the first report of the strain Penicillium sp. OM01 from the marine mollusk sample S. squamosus (Schreibers, 1793). One new and seven known compounds were isolated from the strain Penicillium sp. OM01 (isolated from the marine mollusk sample S. squamosus (Schreibers, 1793). Compound 4 is a potential antibacterial agent.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"8 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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