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Potential Antihyperglycemic Effects of Adzuki (Vigna angularis) Polyphenols on Mice and Caco-2 Cells 红木(Vigna angularis)多酚对小鼠和 Caco-2 细胞的潜在降血糖作用
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241271734
Kenji Kuriya, Masahide Osumi, Mana Ishihara, Masahiro Nishio, Hirotaka Katsuzaki, Junpei Sono, Masahiro Nakamura, Hayato Umekawa
Background/PurposeSome health-beneficial foods, including adzuki beans ( Vigna angularis), can show antihyperglycemic effects. Adzuki bean-derived polyphenols, such as (+)-catechin 7- O- β-d-glucopyranoside (C7G) and (+)-epicatechin 7- O- β-d-glucopyranoside (E7G), could be potential inhibitors of α-amylase and α-glucosidase, however, few studies of the activity of adzuki polyphenols have been performed in vivo. Thus, we evaluated the antihyperglycemic effects of crude adzuki bean extract containing polyphenols (ABP), and purified C7G or E7G using mice and Caco-2 cells.MethodsSix-week-old male ICR mice were orally administered ABP (100 or 250 mg/kg), C7G or E7G (15 or 40 mg/kg), and sucrose (2 g/kg). Blood samples were taken from the lateral tail vein to measure the blood glucose levels at various times over 0–120 min. Cultured caco-2 cells, an intestinal model, were treated with ABP, C7G, or E7G. The glucose concentration in the medium was measured to examine the activity of α-glucosidase.ResultsAdministration of adzuki polyphenols decreased blood glucose levels, especially E7G administration significantly showed antihyperglycemic effects in vivo. In Caco-2 cells, α-glucosidase activity was significantly decreased by ABP, C7G, or E7G addition in a dose-dependent manner without cytotoxicity.ConclusionThese results suggest that C7G and E7G in adzuki bean extract inhibited sucrose-degrading enzymes to elicit antihyperglycemic effects in vivo, which supports the results of previous studies using adzuki beans, and may contribute to health promotion.
背景/目的包括赤小豆在内的一些有益健康的食物具有降血糖作用。从赤豆中提取的多酚类物质,如(+)-儿茶素 7- O- β-d-吡喃葡萄糖苷(C7G)和(+)-表儿茶素 7- O- β-d-吡喃葡萄糖苷(E7G),可能是α-淀粉酶和α-葡萄糖苷酶的潜在抑制剂。因此,我们使用小鼠和 Caco-2 细胞评估了含有多酚的粗赤豆提取物(ABP)和纯化的 C7G 或 E7G 的降血糖作用。方法给六周大的雄性 ICR 小鼠口服 ABP(100 或 250 毫克/千克)、C7G 或 E7G(15 或 40 毫克/千克)和蔗糖(2 克/千克)。从侧尾静脉抽取血液样本,以测量 0-120 分钟内不同时间的血糖水平。用 ABP、C7G 或 E7G 处理培养的肠道模型 caco-2 细胞。测量培养基中的葡萄糖浓度,以检查α-葡萄糖苷酶的活性。结果给药赤藓红多酚可降低血糖水平,尤其是给药 E7G 显著显示出体内抗高血糖作用。在 Caco-2 细胞中,ABP、C7G 或 E7G 的添加以剂量依赖的方式显著降低了 α-葡萄糖苷酶的活性,且无细胞毒性。结论这些结果表明,赤小豆提取物中的 C7G 和 E7G 可抑制蔗糖降解酶,从而在体内产生降血糖作用,这支持了之前使用赤小豆进行研究的结果,并可能有助于促进健康。
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引用次数: 0
Abutilon theophrasti Medic.: A Review of its Traditional Uses, Phytochemistry, Pharmacology, and Pharmacokinetics Abutilon theophrasti Medic.:传统用途、植物化学、药理学和药代动力学综述
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241257380
Lu Li, Linnuo Pang, Fei Chen, Luming Zhang, Fen Zhou, Rongrong Li, Han Yan
Abutilon theophrasti Medic.( (A. theophrasti, Malvaceae) has been recognized for its ethnopharmacological values for a long time. Various studies of A. theophrasti have demonstrated that different extracts from this species exhibit a wide range of pharmacological activities, including antioxidant, antitumor, antibacterial, and anti-inflammatory analgesia activities. Until now, more than 100 kinds of phytochemical compounds have been isolated and identified in various parts of A. theophrasti including flavonoids, fatty acid, essential oil, and others. In the present review, we have been trying to summarize an up-to-date research on the traditional uses, phytochemistry, pharmacology, and pharmacokinetics of A. theophrasti. Consequently, a significant and broad overview on the current knowledge of A. theophrasti is provided to explore its clinical therapeutic potential.
Abutilon theophrasti Medic.(A. theophrasti,锦葵科)的民族药理学价值早已得到认可。对 Abutilon theophrasti 的各种研究表明,该物种的不同提取物具有广泛的药理活性,包括抗氧化、抗肿瘤、抗菌和抗炎镇痛活性。迄今为止,已从 A. theophrasti 的不同部位分离鉴定出 100 多种植物化学物质,包括黄酮类、脂肪酸、精油等。在本综述中,我们试图总结 A. theophrasti 的传统用途、植物化学、药理学和药代动力学方面的最新研究成果。因此,我们对 A. theophrasti 的现有知识进行了重要而广泛的概述,以探索其临床治疗潜力。
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引用次数: 0
Compositional Analysis and Network Pharmacological Strategy for the Treatment of Diabetic Kidney Disease by Shengjiang Powder Based on UHPLC-Q-TOF-MS 基于 UHPLC-Q-TOF-MS 的生姜粉成分分析及治疗糖尿病肾病的网络药理学策略
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241277543
Yongzhi Yin, Lu Yang, Ke Zhang, Silin Yu, Jinfa Liao, Jinhui Wang
Objective: Shengjiang Powder (SJP) is a traditional Chinese medicine compound formula commonly used in the treatment of diabetic kidney disease (DKD). However, its material basis and mechanism of action are still unclear. Methods: In this study, the aqueous extract of SJP was obtained by aqueous decoction method, and the in vivo and in vitro constituents of SJP were analysed by ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS), and a network pharmacological strategy was established in conjunction with molecular docking in order to investigate the mechanism of action of SJP in the treatment of DKD. Results: The results identified 162 components, of which 28 could be absorbed into the blood and exert therapeutic effects in vivo. The main active ingredients were CT-1, CT-2, CT-7, BJC-2, and BJC-5, and the main targets in vivo were related to AKT1, MAPK1, MAPK3, MAPK8, and MAPK14, which could exert their therapeutic effects through the PI3K-Akt signaling pathway, Insulin resistance, and AGE-RAGE signaling pathway in diabetic complications, etc Conclusion: The present study adopts a comprehensive analytical strategy to reveal the pharmacodynamic material basis and mechanism of action of SJP in the treatment of DKD, and to provide a scientific basis for its clinical application.
目的生姜粉(SJP)是一种传统的中药复方,常用于治疗糖尿病肾病(DKD)。然而,其物质基础和作用机制尚不清楚。研究方法采用超高效液相色谱-四极杆飞行时间质谱(UHPLC-Q-TOF-MS)分析其体内外成分,并结合分子对接建立网络药理学策略,研究其治疗糖尿病肾病的作用机制。研究结果结果发现了 162 种成分,其中 28 种可被血液吸收并在体内发挥治疗作用。主要活性成分为 CT-1、CT-2、CT-7、BJC-2 和 BJC-5,体内主要靶点与 AKT1、MAPK1、MAPK3、MAPK8 和 MAPK14 有关,可通过 PI3K-Akt 信号通路、胰岛素抵抗、糖尿病并发症中的 AGE-RAGE 信号通路等发挥治疗作用 结论:本研究采用综合分析策略,揭示了SJP治疗DKD的药效物质基础和作用机制,为其临床应用提供了科学依据。
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引用次数: 0
Cimifugin Improves Motor Function Through Suppression of the NLRP3 Inflammasome in an Animal Model of Parkinson's Disease Cimifugin 通过抑制帕金森病动物模型中的 NLRP3 炎症体改善运动功能
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241265938
Ji Yun Lee, Min Jae Kim, Byung Tae Choi, Young Ju Yun, Seo-Yeon Lee, Hwa Kyoung Shin
Objective: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons and persistent neuroinflammation in the substantia nigra (SN), triggering a dopamine deficiency that can lead to movement disorders. Neuroinflammation is a common feature of aging brains and neurodegenerative diseases. Inflammasome-related neuroinflammation is involved in the progression of PD. Methods: The effects of cimifugin was investigated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. Cimifugin is one of the main components of Saposhnikovia divaricata (Turcz.) Schischkin. Behavioral tests, such as the rotarod, pole, and traction tests, were conducted to measure the recovery effects of Parkinson-related motor deficiencies. Results: Our analyses showed that cimifugin treatment mitigates motor dysfunction in a dose-dependent manner. In addition, cimifugin conferred neuroprotection by increasing the survival of dopaminergic neurons, as measured by tyrosine hydroxylase immunostaining. Neuroinflammation was reduced by cimifugin by inhibiting NLR family pyrin domain-containing 3 (NLRP3)/caspase-1/interleukin 1β signaling in the MPTP-insulted SN. Moreover, monosodium urate crystals, an NLRP3 agonist, reversed cimifugin-induced improvement in motor function in the PD model. Conclusion: These results suggest that cimifugin administration is a potential therapeutic strategy for mitigating PD.
目的:帕金森病(Parkinson's disease)是一种神经退行性疾病:帕金森病(Parkinson's disease,PD)是一种神经退行性疾病,其特征是黑质(SN)中多巴胺能神经元的丧失和持续的神经炎症,引发多巴胺缺乏,从而导致运动障碍。神经炎症是大脑衰老和神经退行性疾病的共同特征。与炎症体相关的神经炎症与帕金森病的进展有关。研究方法在1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的帕金森病小鼠模型中研究了cimifugin的作用。Cimifugin 是 Saposhnikovia divaricata (Turcz.) Schischkin 的主要成分之一。为了测量帕金森氏症相关运动缺陷的恢复效果,对小鼠进行了行为测试,如转体测试、杆测试和牵引测试。结果显示我们的分析表明,cimifugin能以剂量依赖的方式缓解运动功能障碍。此外,通过酪氨酸羟化酶免疫染色法测定,cimifugin 还能提高多巴胺能神经元的存活率,从而起到神经保护作用。cimifugin通过抑制MPTP侵袭的SN中的NLR家族含吡咯啉结构域3(NLRP3)/caspase-1/白细胞介素1β信号传导,减轻了神经炎症。此外,NLRP3激动剂尿酸单钠盐晶体逆转了cimifugin诱导的帕金森病模型运动功能改善。结论这些结果表明,服用cimifugin是缓解帕金森病的一种潜在治疗策略。
{"title":"Cimifugin Improves Motor Function Through Suppression of the NLRP3 Inflammasome in an Animal Model of Parkinson's Disease","authors":"Ji Yun Lee, Min Jae Kim, Byung Tae Choi, Young Ju Yun, Seo-Yeon Lee, Hwa Kyoung Shin","doi":"10.1177/1934578x241265938","DOIUrl":"https://doi.org/10.1177/1934578x241265938","url":null,"abstract":"Objective: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons and persistent neuroinflammation in the substantia nigra (SN), triggering a dopamine deficiency that can lead to movement disorders. Neuroinflammation is a common feature of aging brains and neurodegenerative diseases. Inflammasome-related neuroinflammation is involved in the progression of PD. Methods: The effects of cimifugin was investigated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. Cimifugin is one of the main components of Saposhnikovia divaricata (Turcz.) Schischkin. Behavioral tests, such as the rotarod, pole, and traction tests, were conducted to measure the recovery effects of Parkinson-related motor deficiencies. Results: Our analyses showed that cimifugin treatment mitigates motor dysfunction in a dose-dependent manner. In addition, cimifugin conferred neuroprotection by increasing the survival of dopaminergic neurons, as measured by tyrosine hydroxylase immunostaining. Neuroinflammation was reduced by cimifugin by inhibiting NLR family pyrin domain-containing 3 (NLRP3)/caspase-1/interleukin 1β signaling in the MPTP-insulted SN. Moreover, monosodium urate crystals, an NLRP3 agonist, reversed cimifugin-induced improvement in motor function in the PD model. Conclusion: These results suggest that cimifugin administration is a potential therapeutic strategy for mitigating PD.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"9 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Logic Gates Derived from Fluorescent Natural Products 荧光天然产物衍生的分子逻辑门
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241262897
Nicola’ Agius, David C. Magri
Fluorescent natural products have been a source of fascination for centuries. In this review, we highlight natural products and natural product derivatives as optical logic-based molecules. The early beginnings of the field of molecular logic-based computation are introduced and followed with literature examples of logic gates from fluorescent natural products. The intention is to arouse the curiosity of readers to go out and discover more fluorescent natural products with intrinsic logic properties.
几个世纪以来,荧光天然产物一直令人着迷。在这篇综述中,我们重点介绍了作为基于光学逻辑的分子的天然产物和天然产物衍生物。文章介绍了基于分子逻辑的计算领域的早期开端,并列举了荧光天然产物逻辑门的文献实例。目的是激发读者的好奇心,去发现更多具有内在逻辑特性的荧光天然产物。
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引用次数: 0
A Systematic Review of Medicinal Plants and Their Compounds Validated as Agents for the Management of Sickle Cell Disease 对经证实可作为镰状细胞病治疗药物的药用植物及其化合物的系统回顾
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241265889
Isaac Kingsley Amponsah, Denzel Opoku-Kwabi, Francis Ackah Armah, John Nii Addotey, Bernard Kofi Turkson, Emmanuel Quaye Kontoh
Some plants used in traditional medicine to manage sickle cell disease have been validated pharmacologically to ascertain their anti-sickling properties. However, there is no global systematic review of the evidence in support of their use for sickle cell management. This research aimed to conduct a systematic review of the pharmacological evidence to highlight species, genera, and some phytochemicals which could be primed for novel anti-sickling medications. The Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines were used. Articles in English, published from 2000 to 2022 were included in the analysis. The literature search covered 411 publications of which 82 were found to be eligible. More than half (53.65%) of the articles were published from 2016 to 2022. Anti-sickling research from Africa accounted for 86.58% of the publications, with more than half coming from Nigeria, 12.20% from Asia and only 1.22% from Europe. The Fabaceae, Euphorbiaceae, and Annonaceae were the top three plant families whereas Zanthoxylum and Terminalia were the most reported genera. Carica papaya and Terminalia catappa were the most reported species. Sickling reversal ( n = 33/82) and hemoglobin polymerization studies ( n = 29/82) were the most reported assays. Benzoic acid derivatives, butyl stearate, ellagic acid derivatives, and some pentacyclic triterpenoids were the only plant derived compounds validated for anti-sickling activities. A total of 117 plant species with anti-sickling activities were documented. Studies on secondary metabolites with anti-sickling properties to serve as scaffolds for novel drug development for sickle cell management were limited.
传统医学中用于治疗镰状细胞病的一些植物已通过药理学验证,以确定其抗镰状细胞病的特性。然而,目前还没有对支持这些植物用于镰状细胞病治疗的证据进行全球性的系统综述。本研究旨在对药理学证据进行系统综述,以突出可用于新型抗镰状细胞病药物的物种、属和一些植物化学物质。研究采用了系统综述和元分析首选报告项目(PRISMA)指南。分析纳入了 2000 年至 2022 年发表的英文文章。文献检索涵盖 411 篇出版物,其中 82 篇符合条件。一半以上(53.65%)的文章发表于 2016 年至 2022 年。来自非洲的抗酸化研究占86.58%,其中一半以上来自尼日利亚,12.20%来自亚洲,只有1.22%来自欧洲。豆科(Fabaceae)、大戟科(Euphorbiaceae)和葵科(Annonaceae)是发表论文最多的三个植物科,而 Zanthoxylum 和 Terminalia 是发表论文最多的属。木瓜(Carica papaya)和鸡冠花(Terminalia catappa)是报告最多的物种。西克令反转(n = 33/82)和血红蛋白聚合研究(n = 29/82)是报道最多的检测方法。苯甲酸衍生物、硬脂酸丁酯、鞣花酸衍生物和一些五环三萜类化合物是唯一通过抗镰刀菌活性验证的植物衍生化合物。共有 117 种植物具有抗酸洗活性。对具有抗镰状细胞病特性的次生代谢物进行的研究有限,这些次生代谢物可作为开发治疗镰状细胞病的新型药物的支架。
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引用次数: 0
Chemical Analysis and Biological Activities of Various Parts of Securidaca longipedunculata From South Africa 南非 Securidaca longipedunculata 不同部位的化学分析和生物活性
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241261018
Kamogelo Shai, Zahra Battal Hassan, Segolo Lebelo, Jones Wilfred Ng’ambi, Monnye Mabelebele, Nthabiseng Amenda Sebola
ObjectiveThe objective of our study was to investigate the chemical composition and the biological activities of different parts of Securidaca longipedunculata from South Africa.MethodologiesThe chemical analysis methods, including chromatography and spectroscopy, were employed to identify the diverse array of compounds present in the roots, leaves, and stems of S longipedunculata.ResultsThe proximate analysis revealed that the leaf extracts had higher ( P < .05) crude protein, gross energy, and ether extract contents when compared to the stem bark and the root bark. A similar trend was observed with the mineral analysis where copper, iron, magnesium, and zinc were in abundance in the leaves. Concurrently, bioassays reveal significant biological activities, such as antioxidant, antimicrobial, and anti-inflammatory properties, associated with these plant parts. The extracts demonstrated high lipid peroxidation inhibitory activity at the concentration of 250 μg/mL, with the highest percentage inhibition of 94% recorded in the dark leaf extract, followed by 92% and 73% at the concentrations of 125 and 62.5 μg/mL, respectively. The antimicrobial analysis revealed that the root bark extract was active against Escherichia coli, Pseudomonas aeruginosa, and Enterococcus faecalis with the average minimum inhibitory concentration of 1.67 mg/mL (dark type) and 0.63 mg/mL (light type).ConclusionOur findings emphasize the medicinal potential of S longipedunculata and underscore the importance of understanding its chemical makeup in explaining its therapeutic effects. This research provides valuable insights into the pharmacological properties of S longipedunculata, offering a foundation for further exploration in drug development and natural product discovery.
研究结果近似分析表明,与茎皮和根皮相比较,叶提取物的粗蛋白、总能和醚提取物含量更高(P < .05)。矿物质分析也发现了类似的趋势,叶片中含有大量的铜、铁、镁和锌。同时,生物测定显示这些植物部分具有显著的生物活性,如抗氧化、抗菌和抗炎特性。提取物在 250 μg/mL 的浓度下具有很高的脂质过氧化抑制活性,其中深色叶提取物的抑制率最高,达到 94%,其次是 125 μg/mL 和 62.5 μg/mL 浓度下的 92% 和 73%。抗菌分析表明,根皮提取物对大肠杆菌、铜绿假单胞菌和粪肠球菌具有活性,平均最小抑菌浓度为 1.67 毫克/毫升(深色型)和 0.63 毫克/毫升(浅色型)。这项研究为了解龙脑香的药理特性提供了宝贵的见解,为进一步探索药物开发和天然产品发现奠定了基础。
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引用次数: 0
Inhibitory Mechanism of the Oregano Essential Oil on the Growth and Biofilm Formation of Streptococcus mutans 牛至精油对变异链球菌生长和生物膜形成的抑制机制
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241266699
Kegang Wu, Yuqiang Huang, Tong Zhang, Xianghua Chai, Xuejuan Duan
Objective: The objective was to determine the in vitro antibacterial effect of the Oregano essential oil (OEO) on Streptococcus mutans ( S mutans) and to explore the anti-biofilm effect and mechanism of OEO. Methods: The in vitro antibacterial susceptibility of OEO was detected by the growth curve and colony-forming unit (CFU) counting method. Confocal laser scanning microscope (CLSM) and crystal violet assay were used to explore the anti-biofilm activity of OEO, and the anti-biofilm mechanism was explored from the aspects of extracellular polysaccharides (EPS) synthesis, acidoid, and extracellular DNA changes. OEO was characterized using a gas chromatography-mass spectrometer and cytotoxicity was tested using a cell counting Kit-8 assay. Results: The minimum inhibitory concentration of OEO was 0.25 mg/mL, and the CFU showed the ability of OEO to kill planktonic bacteria. Scanning electron microscopy and CLSM showed that OEO could hinder the development of biofilms, harm bacteria, and eliminate mature biofilms by changing EPS synthesis and pH value. Carvacrol in OEO played a major role in biological antibacterial activity. OEO had low cytotoxicity and good biocompatibility. Conclusions: OEO had excellent antibacterial and anti-biofilm effects on the key virulence traits of S mutans, indicating potential prospects in preventing dental caries.
研究目的目的:测定牛至精油(OEO)对变异链球菌(S mutans)的体外抗菌效果,并探索 OEO 的抗生物膜效果和机制。研究方法通过生长曲线和菌落形成单位(CFU)计数法检测 OEO 的体外抗菌敏感性。采用共聚焦激光扫描显微镜(CLSM)和水晶紫检测法探讨OEO的抗生物膜活性,并从胞外多糖(EPS)合成、类酸和胞外DNA变化等方面探讨其抗生物膜机制。使用气相色谱-质谱仪对 OEO 进行了表征,并使用细胞计数 Kit-8 检测了细胞毒性。结果显示OEO 的最小抑菌浓度为 0.25 mg/mL,CFU 表明 OEO 能够杀死浮游细菌。扫描电镜和CLSM显示,OEO可通过改变EPS的合成和pH值来阻碍生物膜的发展、伤害细菌并消除成熟的生物膜。OEO 中的香芹酚在生物抗菌活性中发挥了重要作用。OEO 的细胞毒性低,生物相容性好。结论OEO 对变形杆菌的主要毒力特征有很好的抗菌和抗生物膜作用,在预防龋齿方面具有潜在的前景。
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引用次数: 0
Protective Effect of Corilagin on Alcoholic Liver Injury 柯里拉京对酒精性肝损伤的保护作用
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241257089
Xudan Li, Xuan Li, Yuan Deng, Lianghua Chen, Zhizhong Zheng, Yanlin Ming
ObjectivesThe herbal product corilagin is renowned for its liver-protecting benefits and antioxidant properties. However, the protective role of corilagin in alcoholic liver injury remains unexplored. The objective of this study is to delve into the protective effects of corilagin on alcoholic liver injury, both in HepG2 cells and a mouse model.MethodsTo assess the antioxidant capacity of corilagin in vitro, DPPH and ABTS assays were conducted. HepG2 cells were pretreated with 800 mM ethanol for 24 hours, followed by corilagin treatment for another 24 hours, to evaluate its liver-protecting activity. For in vivo studies, ICR mice, with and without corilagin treatment, were given ethanol for 4 weeks to induce alcoholic liver injury. At the end of the study, serum and liver tissue samples were collected to analyze liver function, enzymatic antioxidants, reactive oxygen species (ROS) levels, alcohol dehydrogenase, and liver tissue histology.ResultsThe findings reveal that corilagin exhibits remarkable free radical scavenging ability and alleviates alcohol-induced cell damage in vitro. In vivo, corilagin significantly reduced liver index and serum levels of aminotransferase aspartate, alanine transaminase, total cholesterol, and triglyceride in mice with alcoholic liver injury. Additionally, corilagin decreased ROS levels in liver tissue and increased the activities of antioxidant enzymes CAT, SOD, and GSH-Px. GSH content increased, while lipid peroxide MDA decreased in liver tissue.ConclusionOur data strongly suggests that corilagin possesses protective effects on alcoholic liver injury, both in vitro and in vivo, which is likely attributed to its exceptional antioxidant capacity. In summary, corilagin holds promise as a potential preventive or therapeutic agent for alcoholic liver injury.
目的草药产品柯里拉京因其保护肝脏的功效和抗氧化特性而闻名。然而,柯里拉京在酒精性肝损伤中的保护作用仍有待探索。本研究旨在探讨柯里拉京在 HepG2 细胞和小鼠模型中对酒精性肝损伤的保护作用。用 800 mM 乙醇预处理 HepG2 细胞 24 小时,然后再用柯里拉京处理 24 小时,以评估其护肝活性。在体内研究中,给接受或未接受柯里拉京治疗的 ICR 小鼠注射乙醇 4 周,以诱导酒精性肝损伤。研究结果表明,柯里拉京具有显著的清除自由基的能力,并能减轻酒精诱导的体外细胞损伤。在体内,柯里拉京能显著降低酒精性肝损伤小鼠的肝指数和血清中天门冬氨酸氨基转移酶、丙氨酸转氨酶、总胆固醇和甘油三酯的水平。此外,柯里拉京还能降低肝组织中的 ROS 水平,提高抗氧化酶 CAT、SOD 和 GSH-Px 的活性。结论我们的数据有力地表明,柯里拉京在体外和体内对酒精性肝损伤都具有保护作用,这很可能归功于其卓越的抗氧化能力。总之,柯里拉京有望成为预防或治疗酒精性肝损伤的潜在药物。
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引用次数: 0
Glochidion Species: A Review on Phytochemistry and Pharmacology Glochidion Species:植物化学和药理学综述
IF 1.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pub Date : 2024-09-10 DOI: 10.1177/1934578x241276962
Nguyen Ngoc Linh, Nguyen Quang Hop, Phi Thi Tuyet Nhung, Pham Thi Bich Dao, Vu Quoc Manh, Ty Viet Pham, Ninh The Son
ObjectivesThe genus Glochidion (the family Phyllanthaceae) is used for various medicinal purposes, such as dysentery, diarrhea, cough, and skin protection. A review of phytochemical and pharmacological aspects for this remains unavailable. The current study tends to sum up a detailed list of phytochemicals, and their role in biological examinations.MethodsReferences in English were obtained by an extensive search across various electronic data sources, encompassing Web of Science, PubMed, Google Scholar, and Science Direct. The “Sci-Finder” was also utilized to find references and revise chemical structures. Referenced documents have been gathered from the 1960s to date. It also noted that Glochidion, phytochemistry, and pharmacology are likely the keywords to seek for references.ResultsOver 240 naturally occurring phytochemicals were isolated and identified from various Glochidion tissues, including terpenoids, sterols, saponins, lignans, flavonoids, mono-phenols, megastigmanes, butenolides, glycosides, alkaloids, cyanogens, tocopherols, fatty acids, and others. Three naturally occurring triterpenoids glochidonol, glochidiol, and glochidone are the likely characteristic metabolites, being isolated frequently. Glochidion crude extracts and their isolated compounds have been demonstrated as potential agents in various pharmacological targets, such as cytotoxicity, antioxidant, antiinflammation, and neuron and liver protection.ConclusionSeveral isolates acted as promising agents in pharmacological assays. The anticancer mechanisms of various triterpenoids and saponins, especially new and potential compounds, are expected. Pharmacological advancements to enhance the efficacies of Glochidion constituents, such as synergistic combinations and nano-drug formulations, are encouraged.
目的Glochidion属(Phyllanthaceae)被用于多种药用目的,如痢疾、腹泻、咳嗽和皮肤保护。有关其植物化学和药理方面的综述仍然缺乏。本研究旨在总结植物化学物质的详细清单及其在生物检查中的作用。方法通过广泛搜索各种电子数据源,包括 Web of Science、PubMed、Google Scholar 和 Science Direct,获得英文参考文献。此外,还利用 "Sci-Finder "查找参考文献并修改化学结构。从 20 世纪 60 年代至今,我们一直在收集参考文献。结果从 Glochidion 的各种组织中分离并鉴定出 240 多种天然植物化学物质,包括萜类、甾醇类、皂苷类、木脂素类、黄酮类、单酚类、巨石榴烯类、丁烯内酯类、苷类、生物碱类、氰基类、生育酚类、脂肪酸类等。三种天然三萜类化合物钩吻醇、钩吻二醇和钩吻酮是可能的特征代谢物,经常被分离出来。钩吻粗萃取物及其分离出的化合物已被证明具有多种药理作用,如细胞毒性、抗氧化、抗炎、神经元和肝脏保护等。各种三萜类化合物和皂苷的抗癌机制,尤其是新的和潜在的化合物,值得期待。鼓励通过药理研究提高 Glochidion 成分的功效,如协同组合和纳米药物制剂。
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Natural Product Communications
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