Pub Date : 2025-12-08DOI: 10.1038/s41577-025-01259-x
Teresa Neuwirth, Barbara B. Maier
A preprint by Breuer et al. reports that type I IFN signalling in tumour cells promotes lymph node metastasis but suppresses metastasis to distant organs such as lung.
{"title":"Type I interferon at the crossroads of metastatic dissemination","authors":"Teresa Neuwirth, Barbara B. Maier","doi":"10.1038/s41577-025-01259-x","DOIUrl":"10.1038/s41577-025-01259-x","url":null,"abstract":"A preprint by Breuer et al. reports that type I IFN signalling in tumour cells promotes lymph node metastasis but suppresses metastasis to distant organs such as lung.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 2","pages":"87-87"},"PeriodicalIF":60.9,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145704663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1038/s41577-025-01256-0
Kirsty Minton
A study in Nature reports that heterotypic T cell clusters identifed in clinical samples of melanoma metastases are biologically relevant to tumour control and might have therapeutic potential.
{"title":"Cluster-derived, tumour-reactive T cells from clinical samples","authors":"Kirsty Minton","doi":"10.1038/s41577-025-01256-0","DOIUrl":"10.1038/s41577-025-01256-0","url":null,"abstract":"A study in Nature reports that heterotypic T cell clusters identifed in clinical samples of melanoma metastases are biologically relevant to tumour control and might have therapeutic potential.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"1-1"},"PeriodicalIF":60.9,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41577-025-01251-5
Ezekiel Olumuyide, Robert Samstein
A preprint by Zhijie et al. identifies somatic mutations in TYK2 that are enriched in tumour-infiltrating lymphocytes and associated with an increased antitumour response.
{"title":"Somatic mutations in T cells promote antitumour response","authors":"Ezekiel Olumuyide, Robert Samstein","doi":"10.1038/s41577-025-01251-5","DOIUrl":"10.1038/s41577-025-01251-5","url":null,"abstract":"A preprint by Zhijie et al. identifies somatic mutations in TYK2 that are enriched in tumour-infiltrating lymphocytes and associated with an increased antitumour response.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"4-4"},"PeriodicalIF":60.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41577-025-01253-3
Mehdi Chaib, James P. Allison
A preprint by Bockman et al. reports a cDC2-CD4+ T cell axis that mediates local tumour control after ablation of intratumoral Treg cells, without eliciting autoimmunity.
{"title":"Local Treg cell loss reprogrammes systemic antitumour immunity without breaking tolerance","authors":"Mehdi Chaib, James P. Allison","doi":"10.1038/s41577-025-01253-3","DOIUrl":"10.1038/s41577-025-01253-3","url":null,"abstract":"A preprint by Bockman et al. reports a cDC2-CD4+ T cell axis that mediates local tumour control after ablation of intratumoral Treg cells, without eliciting autoimmunity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"5-5"},"PeriodicalIF":60.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41577-025-01252-4
Meredith Ramba, Dusan Bogunovic
A preprint by Liu et al. shows proof-of-concept for a treatment for autoimmune diseases such as SLE using synthetic immune receptor T cells that target 9G4 idiotope B cells.
{"title":"Targeting autoreactive B cells in SLE with anti-9G4 synthetic immune receptor T cells","authors":"Meredith Ramba, Dusan Bogunovic","doi":"10.1038/s41577-025-01252-4","DOIUrl":"10.1038/s41577-025-01252-4","url":null,"abstract":"A preprint by Liu et al. shows proof-of-concept for a treatment for autoimmune diseases such as SLE using synthetic immune receptor T cells that target 9G4 idiotope B cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"5-5"},"PeriodicalIF":60.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1038/s41577-025-01238-2
David Masopust, Amit Awasthi, Rémy Bosselut, David G. Brooks, Marcus Buggert, Kenji Chamoto, Weiguo Cui, Chen Dong, Donna L. Farber, Thomas Gebhardt, Carmen Gerlach, Ananda Goldrath, Philip D. Greenberg, J. Scott Hale, Adrian Hayday, Dirk Homann, Matteo Iannacone, Stephen C. Jameson, Marc K. Jenkins, Nikhil S. Joshi, Susan M. Kaech, Axel Kallies, Alice O. Kamphorst, Mark H. Kaplan, Paul Klenerman, Marco Künzli, Antonio Lanzavecchia, Georg M. Lauer, Enrico Lugli, Andrew D. Luster, Laura K. Mackay, M. Juliana McElrath, Scott N. Mueller, Zaza Ndhlovu, Thumbi Ndung’u, Pamela S. Ohashi, Annette Oxenius, Giuseppe Pantaleo, Marion Pepper, Louis J. Picker, Clare F. Quarnstrom, Gustavo Reyes-Terán, Mario Roederer, Pamela C. Rosato, Gonzalo Salgado-Montes de Oca, Federica Sallusto, Ton N. Schumacher, Daniella M. Schwartz, Eui-Cheol Shin, Andrew G. Soerens, Daniela S. Thommen, Vaiva Vezys, João P. B. Viola, Bruce D. Walker, Tania H. Watts, Casey T. Weaver, E. John Wherry, Hai-Hui Xue, Ben Youngblood, Rafi Ahmed
{"title":"Guidelines for T cell nomenclature","authors":"David Masopust, Amit Awasthi, Rémy Bosselut, David G. Brooks, Marcus Buggert, Kenji Chamoto, Weiguo Cui, Chen Dong, Donna L. Farber, Thomas Gebhardt, Carmen Gerlach, Ananda Goldrath, Philip D. Greenberg, J. Scott Hale, Adrian Hayday, Dirk Homann, Matteo Iannacone, Stephen C. Jameson, Marc K. Jenkins, Nikhil S. Joshi, Susan M. Kaech, Axel Kallies, Alice O. Kamphorst, Mark H. Kaplan, Paul Klenerman, Marco Künzli, Antonio Lanzavecchia, Georg M. Lauer, Enrico Lugli, Andrew D. Luster, Laura K. Mackay, M. Juliana McElrath, Scott N. Mueller, Zaza Ndhlovu, Thumbi Ndung’u, Pamela S. Ohashi, Annette Oxenius, Giuseppe Pantaleo, Marion Pepper, Louis J. Picker, Clare F. Quarnstrom, Gustavo Reyes-Terán, Mario Roederer, Pamela C. Rosato, Gonzalo Salgado-Montes de Oca, Federica Sallusto, Ton N. Schumacher, Daniella M. Schwartz, Eui-Cheol Shin, Andrew G. Soerens, Daniela S. Thommen, Vaiva Vezys, João P. B. Viola, Bruce D. Walker, Tania H. Watts, Casey T. Weaver, E. John Wherry, Hai-Hui Xue, Ben Youngblood, Rafi Ahmed","doi":"10.1038/s41577-025-01238-2","DOIUrl":"https://doi.org/10.1038/s41577-025-01238-2","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"3 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145536189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1038/s41577-025-01246-2
David Masopust, Andrew G. Soerens, Clare F. Quarnstrom, Rafi Ahmed
{"title":"T cell nomenclature: from subsets to modules","authors":"David Masopust, Andrew G. Soerens, Clare F. Quarnstrom, Rafi Ahmed","doi":"10.1038/s41577-025-01246-2","DOIUrl":"https://doi.org/10.1038/s41577-025-01246-2","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"224 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145536187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41577-025-01245-3
Yvonne Bordon
Short-chain fatty acids generated by the gut microbiota can support T cell ‘stemness’ and lead to improved cancer immunotherapy outcomes.
肠道菌群产生的短链脂肪酸可以支持T细胞的“干性”，从而改善癌症免疫治疗的效果。
{"title":"Butyrate promotes T cell ‘stemness’ to support immunity to melanoma","authors":"Yvonne Bordon","doi":"10.1038/s41577-025-01245-3","DOIUrl":"10.1038/s41577-025-01245-3","url":null,"abstract":"Short-chain fatty acids generated by the gut microbiota can support T cell ‘stemness’ and lead to improved cancer immunotherapy outcomes.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 12","pages":"865-865"},"PeriodicalIF":60.9,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1038/s41577-025-01237-3
Erinke van Grinsven, Ananda Kishore Mukherjee, Irina A. Udalova
{"title":"Shaping neutrophil morphology and function: the importance of a segmented nucleus","authors":"Erinke van Grinsven, Ananda Kishore Mukherjee, Irina A. Udalova","doi":"10.1038/s41577-025-01237-3","DOIUrl":"https://doi.org/10.1038/s41577-025-01237-3","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"180 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1038/s41577-025-01247-1
Alisa Iakupova, Arthur Mortha
A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory region OCR369.
{"title":"The OCR369 cis-regulatory element controls gut peacekeeping cells","authors":"Alisa Iakupova, Arthur Mortha","doi":"10.1038/s41577-025-01247-1","DOIUrl":"10.1038/s41577-025-01247-1","url":null,"abstract":"A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory region OCR369.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"4-4"},"PeriodicalIF":60.9,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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