Pub Date : 2026-01-05DOI: 10.1038/s41577-025-01239-1
João Mello-Vieira, Ivan Dikic
{"title":"Ubiquitination and autophagy in host–pathogen interactions: from immune surveillance to therapeutic targeting","authors":"João Mello-Vieira, Ivan Dikic","doi":"10.1038/s41577-025-01239-1","DOIUrl":"https://doi.org/10.1038/s41577-025-01239-1","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"29 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1038/s41577-025-01263-1
Sara Lamorte, Tracy L. McGaha
A preprint by Boulat et al. reports that tumour-derived lactate blocks B cell migration from cancer-associated lymph nodes, preventing the formation of tertiary lymphoid structures in the tumour.
{"title":"Tumour lactate bars B cell entry","authors":"Sara Lamorte, Tracy L. McGaha","doi":"10.1038/s41577-025-01263-1","DOIUrl":"10.1038/s41577-025-01263-1","url":null,"abstract":"A preprint by Boulat et al. reports that tumour-derived lactate blocks B cell migration from cancer-associated lymph nodes, preventing the formation of tertiary lymphoid structures in the tumour.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 2","pages":"87-87"},"PeriodicalIF":60.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1038/s41577-025-01249-z
Mary Jo Turk, Yina H Huang
Vitiligo is an autoimmune disease of melanocyte destruction, which manifests as progressive, patchy loss of pigmentation in the skin. As one of most common autoimmune diseases, vitiligo inflicts a significant psychosocial burden. Research over the past two decades has revealed the underlying immune mechanisms of vitiligo, with key studies combining detailed analyses of patient tissue samples with mechanistic experiments in mouse models. Vitiligo has emerged as a prototypical CD8+ T cell-mediated autoimmune disease, with cooperation between innate immune cells, dendritic cells, T cells, keratinocytes and fibroblasts driving autoimmune pathology against the uniquely susceptible melanocyte target. The study of vitiligo has also revealed aspects of CD8+ T cell memory and resident memory against self-antigens. This work has drawn from, and contributed to, the study of melanoma immunology. Whereas drugs used for other autoimmune conditions have been largely ineffective in treating vitiligo, a growing base of knowledge recently led to the first successful FDA-approved immune-modulating drugs for vitiligo. This review focuses on the immunology of vitiligo: the mechanisms that drive melanocyte destruction, the biology of aberrant T cell responses against melanocytes and therapeutic means for counteracting this autoimmune condition.
{"title":"The immunology of vitiligo.","authors":"Mary Jo Turk, Yina H Huang","doi":"10.1038/s41577-025-01249-z","DOIUrl":"https://doi.org/10.1038/s41577-025-01249-z","url":null,"abstract":"<p><p>Vitiligo is an autoimmune disease of melanocyte destruction, which manifests as progressive, patchy loss of pigmentation in the skin. As one of most common autoimmune diseases, vitiligo inflicts a significant psychosocial burden. Research over the past two decades has revealed the underlying immune mechanisms of vitiligo, with key studies combining detailed analyses of patient tissue samples with mechanistic experiments in mouse models. Vitiligo has emerged as a prototypical CD8<sup>+</sup> T cell-mediated autoimmune disease, with cooperation between innate immune cells, dendritic cells, T cells, keratinocytes and fibroblasts driving autoimmune pathology against the uniquely susceptible melanocyte target. The study of vitiligo has also revealed aspects of CD8<sup>+</sup> T cell memory and resident memory against self-antigens. This work has drawn from, and contributed to, the study of melanoma immunology. Whereas drugs used for other autoimmune conditions have been largely ineffective in treating vitiligo, a growing base of knowledge recently led to the first successful FDA-approved immune-modulating drugs for vitiligo. This review focuses on the immunology of vitiligo: the mechanisms that drive melanocyte destruction, the biology of aberrant T cell responses against melanocytes and therapeutic means for counteracting this autoimmune condition.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":""},"PeriodicalIF":60.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1038/s41577-025-01261-3
Andrew C Chan,Greg D Martyn,Paul J Carter
{"title":"Publisher Correction: Fifty years of monoclonals: the past, present and future of antibody therapeutics.","authors":"Andrew C Chan,Greg D Martyn,Paul J Carter","doi":"10.1038/s41577-025-01261-3","DOIUrl":"https://doi.org/10.1038/s41577-025-01261-3","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"20 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-09DOI: 10.1038/s41577-025-01260-4
Lucy Bird
Besides killing infected or transformed cells, interferon-activated natural killer cells can kill T follicular helper cells and may contribute to poor antibody responses in some individuals infected with SARS-CoV-2.
{"title":"NK cells limit antibody breadth","authors":"Lucy Bird","doi":"10.1038/s41577-025-01260-4","DOIUrl":"10.1038/s41577-025-01260-4","url":null,"abstract":"Besides killing infected or transformed cells, interferon-activated natural killer cells can kill T follicular helper cells and may contribute to poor antibody responses in some individuals infected with SARS-CoV-2.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"3-3"},"PeriodicalIF":60.9,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-09DOI: 10.1038/s41577-025-01257-z
Yvonne Bordon
Respiratory infections in early life combine with genetic and maternal factors to drive asthma development in childhood.
生命早期的呼吸道感染与遗传和母亲因素相结合，推动儿童哮喘的发展。
{"title":"Parental allergy and early life infection combine to promote asthma in childhood","authors":"Yvonne Bordon","doi":"10.1038/s41577-025-01257-z","DOIUrl":"10.1038/s41577-025-01257-z","url":null,"abstract":"Respiratory infections in early life combine with genetic and maternal factors to drive asthma development in childhood.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"2-2"},"PeriodicalIF":60.9,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41577-025-01259-x
Teresa Neuwirth, Barbara B. Maier
A preprint by Breuer et al. reports that type I IFN signalling in tumour cells promotes lymph node metastasis but suppresses metastasis to distant organs such as lung.
{"title":"Type I interferon at the crossroads of metastatic dissemination","authors":"Teresa Neuwirth, Barbara B. Maier","doi":"10.1038/s41577-025-01259-x","DOIUrl":"10.1038/s41577-025-01259-x","url":null,"abstract":"A preprint by Breuer et al. reports that type I IFN signalling in tumour cells promotes lymph node metastasis but suppresses metastasis to distant organs such as lung.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 2","pages":"87-87"},"PeriodicalIF":60.9,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145704663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1038/s41577-025-01256-0
Kirsty Minton
A study in Nature reports that heterotypic T cell clusters identifed in clinical samples of melanoma metastases are biologically relevant to tumour control and might have therapeutic potential.
{"title":"Cluster-derived, tumour-reactive T cells from clinical samples","authors":"Kirsty Minton","doi":"10.1038/s41577-025-01256-0","DOIUrl":"10.1038/s41577-025-01256-0","url":null,"abstract":"A study in Nature reports that heterotypic T cell clusters identifed in clinical samples of melanoma metastases are biologically relevant to tumour control and might have therapeutic potential.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"1-1"},"PeriodicalIF":60.9,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41577-025-01251-5
Ezekiel Olumuyide, Robert Samstein
A preprint by Zhijie et al. identifies somatic mutations in TYK2 that are enriched in tumour-infiltrating lymphocytes and associated with an increased antitumour response.
{"title":"Somatic mutations in T cells promote antitumour response","authors":"Ezekiel Olumuyide, Robert Samstein","doi":"10.1038/s41577-025-01251-5","DOIUrl":"10.1038/s41577-025-01251-5","url":null,"abstract":"A preprint by Zhijie et al. identifies somatic mutations in TYK2 that are enriched in tumour-infiltrating lymphocytes and associated with an increased antitumour response.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"4-4"},"PeriodicalIF":60.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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