Pub Date : 2025-11-26DOI: 10.1038/s41577-025-01253-3
Mehdi Chaib, James P. Allison
A preprint by Bockman et al. reports a cDC2-CD4+ T cell axis that mediates local tumour control after ablation of intratumoral Treg cells, without eliciting autoimmunity.
{"title":"Local Treg cell loss reprogrammes systemic antitumour immunity without breaking tolerance","authors":"Mehdi Chaib, James P. Allison","doi":"10.1038/s41577-025-01253-3","DOIUrl":"10.1038/s41577-025-01253-3","url":null,"abstract":"A preprint by Bockman et al. reports a cDC2-CD4+ T cell axis that mediates local tumour control after ablation of intratumoral Treg cells, without eliciting autoimmunity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"5-5"},"PeriodicalIF":60.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41577-025-01252-4
Meredith Ramba, Dusan Bogunovic
A preprint by Liu et al. shows proof-of-concept for a treatment for autoimmune diseases such as SLE using synthetic immune receptor T cells that target 9G4 idiotope B cells.
{"title":"Targeting autoreactive B cells in SLE with anti-9G4 synthetic immune receptor T cells","authors":"Meredith Ramba, Dusan Bogunovic","doi":"10.1038/s41577-025-01252-4","DOIUrl":"10.1038/s41577-025-01252-4","url":null,"abstract":"A preprint by Liu et al. shows proof-of-concept for a treatment for autoimmune diseases such as SLE using synthetic immune receptor T cells that target 9G4 idiotope B cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"5-5"},"PeriodicalIF":60.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1038/s41577-025-01238-2
David Masopust, Amit Awasthi, Rémy Bosselut, David G. Brooks, Marcus Buggert, Kenji Chamoto, Weiguo Cui, Chen Dong, Donna L. Farber, Thomas Gebhardt, Carmen Gerlach, Ananda Goldrath, Philip D. Greenberg, J. Scott Hale, Adrian Hayday, Dirk Homann, Matteo Iannacone, Stephen C. Jameson, Marc K. Jenkins, Nikhil S. Joshi, Susan M. Kaech, Axel Kallies, Alice O. Kamphorst, Mark H. Kaplan, Paul Klenerman, Marco Künzli, Antonio Lanzavecchia, Georg M. Lauer, Enrico Lugli, Andrew D. Luster, Laura K. Mackay, M. Juliana McElrath, Scott N. Mueller, Zaza Ndhlovu, Thumbi Ndung’u, Pamela S. Ohashi, Annette Oxenius, Giuseppe Pantaleo, Marion Pepper, Louis J. Picker, Clare F. Quarnstrom, Gustavo Reyes-Terán, Mario Roederer, Pamela C. Rosato, Gonzalo Salgado-Montes de Oca, Federica Sallusto, Ton N. Schumacher, Daniella M. Schwartz, Eui-Cheol Shin, Andrew G. Soerens, Daniela S. Thommen, Vaiva Vezys, João P. B. Viola, Bruce D. Walker, Tania H. Watts, Casey T. Weaver, E. John Wherry, Hai-Hui Xue, Ben Youngblood, Rafi Ahmed
{"title":"Guidelines for T cell nomenclature","authors":"David Masopust, Amit Awasthi, Rémy Bosselut, David G. Brooks, Marcus Buggert, Kenji Chamoto, Weiguo Cui, Chen Dong, Donna L. Farber, Thomas Gebhardt, Carmen Gerlach, Ananda Goldrath, Philip D. Greenberg, J. Scott Hale, Adrian Hayday, Dirk Homann, Matteo Iannacone, Stephen C. Jameson, Marc K. Jenkins, Nikhil S. Joshi, Susan M. Kaech, Axel Kallies, Alice O. Kamphorst, Mark H. Kaplan, Paul Klenerman, Marco Künzli, Antonio Lanzavecchia, Georg M. Lauer, Enrico Lugli, Andrew D. Luster, Laura K. Mackay, M. Juliana McElrath, Scott N. Mueller, Zaza Ndhlovu, Thumbi Ndung’u, Pamela S. Ohashi, Annette Oxenius, Giuseppe Pantaleo, Marion Pepper, Louis J. Picker, Clare F. Quarnstrom, Gustavo Reyes-Terán, Mario Roederer, Pamela C. Rosato, Gonzalo Salgado-Montes de Oca, Federica Sallusto, Ton N. Schumacher, Daniella M. Schwartz, Eui-Cheol Shin, Andrew G. Soerens, Daniela S. Thommen, Vaiva Vezys, João P. B. Viola, Bruce D. Walker, Tania H. Watts, Casey T. Weaver, E. John Wherry, Hai-Hui Xue, Ben Youngblood, Rafi Ahmed","doi":"10.1038/s41577-025-01238-2","DOIUrl":"https://doi.org/10.1038/s41577-025-01238-2","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"3 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145536189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1038/s41577-025-01246-2
David Masopust, Andrew G. Soerens, Clare F. Quarnstrom, Rafi Ahmed
{"title":"T cell nomenclature: from subsets to modules","authors":"David Masopust, Andrew G. Soerens, Clare F. Quarnstrom, Rafi Ahmed","doi":"10.1038/s41577-025-01246-2","DOIUrl":"https://doi.org/10.1038/s41577-025-01246-2","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"224 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145536187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41577-025-01245-3
Yvonne Bordon
Short-chain fatty acids generated by the gut microbiota can support T cell ‘stemness’ and lead to improved cancer immunotherapy outcomes.
肠道菌群产生的短链脂肪酸可以支持T细胞的“干性”，从而改善癌症免疫治疗的效果。
{"title":"Butyrate promotes T cell ‘stemness’ to support immunity to melanoma","authors":"Yvonne Bordon","doi":"10.1038/s41577-025-01245-3","DOIUrl":"10.1038/s41577-025-01245-3","url":null,"abstract":"Short-chain fatty acids generated by the gut microbiota can support T cell ‘stemness’ and lead to improved cancer immunotherapy outcomes.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 12","pages":"865-865"},"PeriodicalIF":60.9,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1038/s41577-025-01237-3
Erinke van Grinsven, Ananda Kishore Mukherjee, Irina A. Udalova
{"title":"Shaping neutrophil morphology and function: the importance of a segmented nucleus","authors":"Erinke van Grinsven, Ananda Kishore Mukherjee, Irina A. Udalova","doi":"10.1038/s41577-025-01237-3","DOIUrl":"https://doi.org/10.1038/s41577-025-01237-3","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"180 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1038/s41577-025-01247-1
Alisa Iakupova, Arthur Mortha
A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory region OCR369.
{"title":"The OCR369 cis-regulatory element controls gut peacekeeping cells","authors":"Alisa Iakupova, Arthur Mortha","doi":"10.1038/s41577-025-01247-1","DOIUrl":"10.1038/s41577-025-01247-1","url":null,"abstract":"A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory region OCR369.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 1","pages":"4-4"},"PeriodicalIF":60.9,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Single-cell proteomics sheds light on neutrophil diversity in glioblastoma","authors":"Aglaia Skolariki, Eileen E. Parkes","doi":"10.1038/s41577-025-01241-7","DOIUrl":"10.1038/s41577-025-01241-7","url":null,"abstract":"A preprint by Sadiku et al. characterizes neutrophil diversity in glioblastoma using a new workflow for single-cell proteomic profiling.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 12","pages":"866-866"},"PeriodicalIF":60.9,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1038/s41577-025-01240-8
Shelley Herbrich, Padmanee Sharma
A preprint by Srinivasan et al. describes the role of the gut microbiota and serum amyloid A in regulating retinoid flux that is important for myeloid cell migration and T cell priming.
{"title":"Microbiota and vitamin A flux shape intestinal T cells","authors":"Shelley Herbrich, Padmanee Sharma","doi":"10.1038/s41577-025-01240-8","DOIUrl":"10.1038/s41577-025-01240-8","url":null,"abstract":"A preprint by Srinivasan et al. describes the role of the gut microbiota and serum amyloid A in regulating retinoid flux that is important for myeloid cell migration and T cell priming.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 12","pages":"866-866"},"PeriodicalIF":60.9,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1038/s41577-025-01243-5
Laura Rosenberg, Nicolas Vabret
A preprint by Rivera et al. explores how retroelement expression establishes a tolerogenic environment towards food antigens in the gut, shedding new insights into the immune regulatory role of retroelements.
{"title":"Retroelements orchestrate gut tolerance","authors":"Laura Rosenberg, Nicolas Vabret","doi":"10.1038/s41577-025-01243-5","DOIUrl":"10.1038/s41577-025-01243-5","url":null,"abstract":"A preprint by Rivera et al. explores how retroelement expression establishes a tolerogenic environment towards food antigens in the gut, shedding new insights into the immune regulatory role of retroelements.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 12","pages":"867-867"},"PeriodicalIF":60.9,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145492639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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