Pub Date : 2023-08-01DOI: 10.1038/s41577-023-00927-0
K. Maude Ashby, Kristin A. Hogquist
{"title":"Author Correction: A guide to thymic selection of T cells","authors":"K. Maude Ashby, Kristin A. Hogquist","doi":"10.1038/s41577-023-00927-0","DOIUrl":"10.1038/s41577-023-00927-0","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 10","pages":"697-697"},"PeriodicalIF":100.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41577-023-00927-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9922965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.1038/s41577-023-00929-y
Alexandra Flemming
{"title":"Self-reactive MAIT cells are common in healthy individuals","authors":"Alexandra Flemming","doi":"10.1038/s41577-023-00929-y","DOIUrl":"10.1038/s41577-023-00929-y","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 9","pages":"543-543"},"PeriodicalIF":100.3,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.1038/s41577-023-00924-3
Kirsty Minton
A study in Immunity reports that a high-fat diet in mice leads to the loss of PPARγ+ Treg cells in the skin, which exacerbates psoriasis mediated by IL-17-producing γδ T cells.
免疫学》（Immunity）杂志上的一项研究报告称，小鼠的高脂饮食会导致皮肤中 PPARγ+ Treg 细胞的丧失，从而加剧由产生 IL-17 的 γδ T 细胞介导的牛皮癣。
{"title":"High-fat diet depletes skin Treg cells","authors":"Kirsty Minton","doi":"10.1038/s41577-023-00924-3","DOIUrl":"10.1038/s41577-023-00924-3","url":null,"abstract":"A study in Immunity reports that a high-fat diet in mice leads to the loss of PPARγ+ Treg cells in the skin, which exacerbates psoriasis mediated by IL-17-producing γδ T cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 10","pages":"616-616"},"PeriodicalIF":100.3,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-26DOI: 10.1038/s41577-023-00923-4
Mariana Borsa, Carmen Gerlach
A preprint by Rakebrandt, Yassini et al. investigates the role of CD4+ T helper cells in heterologous immunity, identifying a population of memory cells that have pro-inflammatory function in a T cell receptor-independent manner.
Rakebrandt 和 Yassini 等人的预印本研究了 CD4+ T 辅助细胞在异源免疫中的作用，发现了一批记忆细胞，它们以一种不依赖 T 细胞受体的方式具有促炎功能。
{"title":"Heterologous immunity: innate function of memory CD4+ T cells","authors":"Mariana Borsa, Carmen Gerlach","doi":"10.1038/s41577-023-00923-4","DOIUrl":"10.1038/s41577-023-00923-4","url":null,"abstract":"A preprint by Rakebrandt, Yassini et al. investigates the role of CD4+ T helper cells in heterologous immunity, identifying a population of memory cells that have pro-inflammatory function in a T cell receptor-independent manner.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 9","pages":"544-544"},"PeriodicalIF":100.3,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10081948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25DOI: 10.1038/s41577-023-00922-5
Kyle Burrows, Arthur Mortha
A preprint by Ramanan et al. examines the roles of accessory transcription factors in regulating subsets of colonic regulatory T cells, independently of the microbiota and T cell specificity.
Ramanan 等人的预印本研究了附属转录因子在调节结肠调节性 T 细胞亚群中的作用，而不受微生物群和 T 细胞特异性的影响。
{"title":"Re-investigating the origin and fates of colonic Treg cell subsets","authors":"Kyle Burrows, Arthur Mortha","doi":"10.1038/s41577-023-00922-5","DOIUrl":"10.1038/s41577-023-00922-5","url":null,"abstract":"A preprint by Ramanan et al. examines the roles of accessory transcription factors in regulating subsets of colonic regulatory T cells, independently of the microbiota and T cell specificity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 9","pages":"544-544"},"PeriodicalIF":100.3,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10080313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25DOI: 10.1038/s41577-023-00920-7
Jasmin Ochs, Silke Häusser-Kinzel, Martin S. Weber
The transfer of surface molecules between cells by trogocytosis challenges the concept of cell type-unique surface markers and indicates that monoclonal antibodies used for therapeutic purposes may be less specific than previously thought. Furthermore, trogocytosis may transfer functional properties to new cell types. This process could be used experimentally to trace disease-relevant cell–cell interactions. This Comment article proposes that the transfer of surface molecules between interacting cells by trogocytosis might affect the cellular specificity of monoclonal antibodies, as well as the functionality of receiving cells.
{"title":"Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies","authors":"Jasmin Ochs, Silke Häusser-Kinzel, Martin S. Weber","doi":"10.1038/s41577-023-00920-7","DOIUrl":"10.1038/s41577-023-00920-7","url":null,"abstract":"The transfer of surface molecules between cells by trogocytosis challenges the concept of cell type-unique surface markers and indicates that monoclonal antibodies used for therapeutic purposes may be less specific than previously thought. Furthermore, trogocytosis may transfer functional properties to new cell types. This process could be used experimentally to trace disease-relevant cell–cell interactions. This Comment article proposes that the transfer of surface molecules between interacting cells by trogocytosis might affect the cellular specificity of monoclonal antibodies, as well as the functionality of receiving cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 9","pages":"539-540"},"PeriodicalIF":100.3,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10080311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25DOI: 10.1038/s41577-023-00925-2
Yvonne Bordon
Individuals with the HLA-B*15:01 allele may have pre-existing T cells derived from seasonal coronavirus infections that cross-protect against SARS-CoV-2.
{"title":"Asymptomatic SARS-CoV-2 linked to HLA-B*15:01","authors":"Yvonne Bordon","doi":"10.1038/s41577-023-00925-2","DOIUrl":"10.1038/s41577-023-00925-2","url":null,"abstract":"Individuals with the HLA-B*15:01 allele may have pre-existing T cells derived from seasonal coronavirus infections that cross-protect against SARS-CoV-2.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 9","pages":"543-543"},"PeriodicalIF":100.3,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10080312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.1038/s41577-023-00906-5
Jakub Abramson, Jan Dobeš, Mengze Lyu, Gregory F. Sonnenberg
Antigen-presenting cells (APCs) are master regulators of the immune response by directly interacting with T cells to orchestrate distinct functional outcomes. Several types of professional APC exist, including conventional dendritic cells, B cells and macrophages, and numerous other cell types have non-classical roles in antigen presentation, such as thymic epithelial cells, endothelial cells and granulocytes. Accumulating evidence indicates the presence of a new family of APCs marked by the lineage-specifying transcription factor retinoic acid receptor-related orphan receptor-γt (RORγt) and demonstrates that these APCs have key roles in shaping immunity, inflammation and tolerance, particularly in the context of host–microorganism interactions. These RORγt+ APCs include subsets of group 3 innate lymphoid cells, extrathymic autoimmune regulator-expressing cells and, potentially, other emerging populations. Here, we summarize the major findings that led to the discovery of these RORγt+ APCs and their associated functions. We discuss discordance in recent reports and identify gaps in our knowledge in this burgeoning field, which has tremendous potential to advance our understanding of fundamental immune concepts. Recent studies have revealed a family of antigen-presenting cells (APCs) marked by the transcription factor RORγt that fundamentally shape immunity, inflammation and tolerance. This article reviews heterogeneity among RORγt+ APCs, their associated functions and the future promise of this new field.
{"title":"The emerging family of RORγt+ antigen-presenting cells","authors":"Jakub Abramson, Jan Dobeš, Mengze Lyu, Gregory F. Sonnenberg","doi":"10.1038/s41577-023-00906-5","DOIUrl":"10.1038/s41577-023-00906-5","url":null,"abstract":"Antigen-presenting cells (APCs) are master regulators of the immune response by directly interacting with T cells to orchestrate distinct functional outcomes. Several types of professional APC exist, including conventional dendritic cells, B cells and macrophages, and numerous other cell types have non-classical roles in antigen presentation, such as thymic epithelial cells, endothelial cells and granulocytes. Accumulating evidence indicates the presence of a new family of APCs marked by the lineage-specifying transcription factor retinoic acid receptor-related orphan receptor-γt (RORγt) and demonstrates that these APCs have key roles in shaping immunity, inflammation and tolerance, particularly in the context of host–microorganism interactions. These RORγt+ APCs include subsets of group 3 innate lymphoid cells, extrathymic autoimmune regulator-expressing cells and, potentially, other emerging populations. Here, we summarize the major findings that led to the discovery of these RORγt+ APCs and their associated functions. We discuss discordance in recent reports and identify gaps in our knowledge in this burgeoning field, which has tremendous potential to advance our understanding of fundamental immune concepts. Recent studies have revealed a family of antigen-presenting cells (APCs) marked by the transcription factor RORγt that fundamentally shape immunity, inflammation and tolerance. This article reviews heterogeneity among RORγt+ APCs, their associated functions and the future promise of this new field.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"24 1","pages":"64-77"},"PeriodicalIF":100.3,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9854157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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