首页 > 最新文献

Nature Communications最新文献

英文 中文
Small heterodimer partner protects against osteoarthritis by inhibiting IKKβ/NF-κB-mediated matrix-degrading enzymes in chondrocytes 小异二聚体伴侣通过抑制软骨细胞中IKKβ/NF-κ b介导的基质降解酶来预防骨关节炎
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69864-5
Eun-Jung Kang, Jung-Ran Noh, Jae-Hoon Kim, Ji Ah Park, Jeong-Pin Ahn, Min-Chan Kim, Jung Hyeon Choi, Young-Keun Choi, In-Bok Lee, Dong-Hee Choi, Yun Jeong Seo, Yoon Seok Jung, Kyoung-Shim Kim, Jung Hwan Hwang, Yong-Bum Kim, Jong-Soo Lee, Bon Jeong Ku, Jin-Ok Jeong, Hueng-Sik Choi, Jinhyun Kim, Yong-Hoon Kim, Chul-Ho Lee
{"title":"Small heterodimer partner protects against osteoarthritis by inhibiting IKKβ/NF-κB-mediated matrix-degrading enzymes in chondrocytes","authors":"Eun-Jung Kang, Jung-Ran Noh, Jae-Hoon Kim, Ji Ah Park, Jeong-Pin Ahn, Min-Chan Kim, Jung Hyeon Choi, Young-Keun Choi, In-Bok Lee, Dong-Hee Choi, Yun Jeong Seo, Yoon Seok Jung, Kyoung-Shim Kim, Jung Hwan Hwang, Yong-Bum Kim, Jong-Soo Lee, Bon Jeong Ku, Jin-Ok Jeong, Hueng-Sik Choi, Jinhyun Kim, Yong-Hoon Kim, Chul-Ho Lee","doi":"10.1038/s41467-026-69864-5","DOIUrl":"https://doi.org/10.1038/s41467-026-69864-5","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"97 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRAGE-RB-PI-seq reveals transcriptional dynamics of plant-associated bacteria during root colonization crages - rb - pi -seq揭示了植物相关细菌在根定植过程中的转录动态
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69903-1
Tomoya Honda, Sora Yu, Dung Mai, Leo Baumgart, Emory M. Chan, Gyorgy Babnigg, Yasuo Yoshikuni
{"title":"CRAGE-RB-PI-seq reveals transcriptional dynamics of plant-associated bacteria during root colonization","authors":"Tomoya Honda, Sora Yu, Dung Mai, Leo Baumgart, Emory M. Chan, Gyorgy Babnigg, Yasuo Yoshikuni","doi":"10.1038/s41467-026-69903-1","DOIUrl":"https://doi.org/10.1038/s41467-026-69903-1","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"46 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming upon chitin perception 磷酸化依赖的泛素化开关在几丁质感知上协调核免疫重编程
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69627-2
Chongyang Zhang, Pavinee Suttiviriya, Ruyi Wang, Feng He, Hui Tao, Debao Wang, Jisong Wang, Liang Fang, Zeyun Hao, Xiaoman You, Wei Li, Guo-Liang Wang, Yuese Ning
{"title":"A phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming upon chitin perception","authors":"Chongyang Zhang, Pavinee Suttiviriya, Ruyi Wang, Feng He, Hui Tao, Debao Wang, Jisong Wang, Liang Fang, Zeyun Hao, Xiaoman You, Wei Li, Guo-Liang Wang, Yuese Ning","doi":"10.1038/s41467-026-69627-2","DOIUrl":"https://doi.org/10.1038/s41467-026-69627-2","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"74 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement vamp7依赖的ER和线粒体蛋白的晚期内体分泌影响肿瘤微环境和巨噬细胞的接合
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69900-4
Somya Vats, Pedro Dionisio, Quentin Lemercier, Raphael Pineau, Ludivine Therreau, Joanna Lipecka, Béatrice Cholley, Jean-Baptiste Moog, Jose Wojnacki, Céline Keime, Diana Zala, Philippe Bun, Sofia Freire, Neuza Domingues, Lydia Danglot, Ida Chiara Guerrera, Cédric Delevoye, Eric Chevet, Nuno Raimundo, Thierry Galli
Late endosomal secretion is an unconventional secretion mechanism that depends on the SNARE protein VAMP7. We previously showed that VAMP7 mediates the secretion of the ER protein Reticulon3. However, the functional relevance and molecular mechanism of this secretory pathway remain unclear. Here, we show that VAMP7 knockout cells exhibit impaired secretion of ER- and mitochondrial-derived proteins and signs of ER and mitochondrial stress. In addition, pharmacological induction of organellar stress enhances the VAMP7-dependent secretion. We assess the pathophysiological significance of this mechanism using a preclinical glioblastoma model. VAMP7 knockout glioblastoma cells implanted in male rat brain develop into more necrotic tumors with reduced macrophage infiltration compared to controls, suggesting that VAMP7-dependent late endosomal secretion contributes to the tumor microenvironment and affects macrophage infiltration. Together, our results support a model in which late endosomal secretion functions as an organelle quality-control and stress-communication mechanism, with particular relevance to cancer.
晚期内体分泌是一种非常规的分泌机制,依赖于SNARE蛋白VAMP7。我们之前发现VAMP7介导内质网蛋白Reticulon3的分泌。然而,该分泌途径的功能相关性和分子机制尚不清楚。在这里,我们发现VAMP7敲除细胞表现出内质网和线粒体来源蛋白的分泌受损以及内质网和线粒体应激的迹象。此外,药理学诱导的细胞器应激增强了vamp7依赖性分泌。我们使用临床前胶质母细胞瘤模型来评估这一机制的病理生理学意义。与对照组相比,VAMP7基因敲除的雄性大鼠脑内胶质母细胞瘤细胞发育成更多坏死肿瘤,巨噬细胞浸润减少,提示VAMP7依赖的晚期内体分泌有助于肿瘤微环境,影响巨噬细胞浸润。总之,我们的研究结果支持一个模型,其中晚期内体分泌作为细胞器质量控制和应激沟通机制,与癌症特别相关。
{"title":"VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement","authors":"Somya Vats, Pedro Dionisio, Quentin Lemercier, Raphael Pineau, Ludivine Therreau, Joanna Lipecka, Béatrice Cholley, Jean-Baptiste Moog, Jose Wojnacki, Céline Keime, Diana Zala, Philippe Bun, Sofia Freire, Neuza Domingues, Lydia Danglot, Ida Chiara Guerrera, Cédric Delevoye, Eric Chevet, Nuno Raimundo, Thierry Galli","doi":"10.1038/s41467-026-69900-4","DOIUrl":"https://doi.org/10.1038/s41467-026-69900-4","url":null,"abstract":"Late endosomal secretion is an unconventional secretion mechanism that depends on the SNARE protein VAMP7. We previously showed that VAMP7 mediates the secretion of the ER protein Reticulon3. However, the functional relevance and molecular mechanism of this secretory pathway remain unclear. Here, we show that VAMP7 knockout cells exhibit impaired secretion of ER- and mitochondrial-derived proteins and signs of ER and mitochondrial stress. In addition, pharmacological induction of organellar stress enhances the VAMP7-dependent secretion. We assess the pathophysiological significance of this mechanism using a preclinical glioblastoma model. VAMP7 knockout glioblastoma cells implanted in male rat brain develop into more necrotic tumors with reduced macrophage infiltration compared to controls, suggesting that VAMP7-dependent late endosomal secretion contributes to the tumor microenvironment and affects macrophage infiltration. Together, our results support a model in which late endosomal secretion functions as an organelle quality-control and stress-communication mechanism, with particular relevance to cancer.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"284 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Localized quasiparticles in a fluxonium with quasi-two-dimensional amorphous kinetic inductors 具有准二维非晶态动力学电感的氟鎓中的定域准粒子
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69709-1
Trevyn F. Q. Larson, Sarah Garcia Jones, Tamás Kalmár, Pablo Aramburu Sanchez, Sai Pavan Chitta, Varun Verma, Kristen L. Genter, Stephen T. Gill, Katarina Cicak, Sae Woo Nam, Gergö Fülöp, Jens Koch, Raymond W. Simmonds, András Gyenis
{"title":"Localized quasiparticles in a fluxonium with quasi-two-dimensional amorphous kinetic inductors","authors":"Trevyn F. Q. Larson, Sarah Garcia Jones, Tamás Kalmár, Pablo Aramburu Sanchez, Sai Pavan Chitta, Varun Verma, Kristen L. Genter, Stephen T. Gill, Katarina Cicak, Sae Woo Nam, Gergö Fülöp, Jens Koch, Raymond W. Simmonds, András Gyenis","doi":"10.1038/s41467-026-69709-1","DOIUrl":"https://doi.org/10.1038/s41467-026-69709-1","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"31 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-throughput chemical proteomics workflow for profiling protein citrullination dynamics 分析蛋白瓜氨酸化动力学的高通量化学蛋白质组学工作流程
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69490-1
Rebecca Meelker González, Sophia Laposchan, Erik Riedel, Anna Fürst, Naomi O’Sullivan, Wassim Gabriel, Mathias Wilhelm, Percy A. Knolle, Guillaume Médard, Bernhard Kuster, Chien-Yun Lee
Citrullination is a post-translational modification implicated in autoimmune and inflammatory diseases, yet its low abundance and lack of effective enrichment tools have limited proteome-wide analysis. Here, we develop a robust chemical proteomics workflow with improved specificity and throughput. This method builds upon glyoxal-based derivatization and incorporates a cleavable biotin linker for efficient peptide enrichment, release, and identification via mass spectrometry. Benchmarking demonstrates a > 10-fold increase in the detection of citrullinated peptides at sub-0.1% abundance. Applying this workflow to primary human neutrophils, we successfully monitor dynamic regulation, quantifying dose-dependent activation and inhibition by the PAD4 inhibitor GSK484. Furthermore, stimulation with the fungal pathogen Candida albicans reveals a “core citrullinome” conserved across distinct stimuli. Notably, extensive citrullination of linker histone H1 and structural proteins like lamin B1 suggests broad remodeling of cell architecture during NET formation. This workflow enables proteome-wide mapping of citrullination sites and facilitates its study across diverse biological contexts.
瓜氨酸化是一种与自身免疫性和炎症性疾病有关的翻译后修饰,但其丰度低且缺乏有效的富集工具,限制了蛋白质组范围的分析。在这里,我们开发了一个强大的化学蛋白质组学工作流程,提高了特异性和吞吐量。该方法建立在乙二醛衍生化的基础上,并结合了可切割的生物素连接物,用于高效的肽富集、释放和质谱鉴定。基准测试显示,在低于0.1%丰度下,瓜氨酸肽的检测增加了10倍。将此工作流程应用于原代人中性粒细胞,我们成功地监测了动态调节,量化了PAD4抑制剂GSK484的剂量依赖性激活和抑制。此外,真菌病原体白色念珠菌的刺激揭示了在不同刺激下保守的“核心瓜氨酸组”。值得注意的是,连接蛋白H1和结构蛋白如层粘连蛋白B1的广泛瓜氨酸化表明在NET形成过程中细胞结构的广泛重塑。该工作流程使瓜氨酸化位点的蛋白质组范围内的映射,并促进其在不同的生物学背景下的研究。
{"title":"High-throughput chemical proteomics workflow for profiling protein citrullination dynamics","authors":"Rebecca Meelker González, Sophia Laposchan, Erik Riedel, Anna Fürst, Naomi O’Sullivan, Wassim Gabriel, Mathias Wilhelm, Percy A. Knolle, Guillaume Médard, Bernhard Kuster, Chien-Yun Lee","doi":"10.1038/s41467-026-69490-1","DOIUrl":"https://doi.org/10.1038/s41467-026-69490-1","url":null,"abstract":"Citrullination is a post-translational modification implicated in autoimmune and inflammatory diseases, yet its low abundance and lack of effective enrichment tools have limited proteome-wide analysis. Here, we develop a robust chemical proteomics workflow with improved specificity and throughput. This method builds upon glyoxal-based derivatization and incorporates a cleavable biotin linker for efficient peptide enrichment, release, and identification via mass spectrometry. Benchmarking demonstrates a &gt; 10-fold increase in the detection of citrullinated peptides at sub-0.1% abundance. Applying this workflow to primary human neutrophils, we successfully monitor dynamic regulation, quantifying dose-dependent activation and inhibition by the PAD4 inhibitor GSK484. Furthermore, stimulation with the fungal pathogen <jats:italic>Candida albicans</jats:italic> reveals a “core citrullinome” conserved across distinct stimuli. Notably, extensive citrullination of linker histone H1 and structural proteins like lamin B1 suggests broad remodeling of cell architecture during NET formation. This workflow enables proteome-wide mapping of citrullination sites and facilitates its study across diverse biological contexts.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"174 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carbon-halogen bond substitution enables high-utilization four-electron iodine redox in noncorrosive dilute electrolytes 碳卤素键取代使四电子碘在非腐蚀性稀电解质中高利用率氧化还原
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69743-z
Zhiheng Shi, Yongchao Tang, Yue Wei, Guigui Liu, Haolong Huang, Jintu Qi, Zhenfeng Feng, Minghui Ye, Yufei Zhang, Zhipeng Wen, Xiaoqing Liu, Qi Yang, Chunyi Zhi, Cheng Chao Li
Aqueous Zn | |I 2 batteries, involving I - /I 0 /I + redox, are promising yet usually facing low I 2 utilization dominated by I 0 /I + redox, especially under high loadings. Unlocking alternative pathway to I 0 /I + redox, preferably in noncorrosive dilute electrolytes, is a crucial solution. Here, we report a pathway towards more thermodynamically favorable I 0 /I + redox, via a unique carbon-halogen bond substitution. This pathway is realized with a low-concentrated (0.7 M), noncorrosive organohalide additive (2-bromoacetamide, BrAce), triggering a reversible Br-C···I (0) and C-I (+) -Br bond substitution. Compared with conventional interhalogen bonding (I-Br) pathway, this pathway synchronously lowers the barrier for I⁰/I⁺ redox and strengthens the anti-hydrolysis of I + species, by elaborately regulating axial δ hole activity of interhalogen bond (I (δ+) -Br). Notably, this pathway enables sustainable operation of four-electron Zn | |I 2 batteries with high I 2 loading (8.6 ~ 24.0 mg cm -2 ), featuring improved performances: (1) high I 2 utilizations (55% ~ 80%) at high rates (5.8 ~ 46.4 mA cm -2 ), (2) long lifespan ( $$ > $$ > 400 cycles) with practical areal capacity ( ~ 3.85 mA h cm -2 ) and 99.5% retention even at 47.5 mA cm -2 . This pathway opens an exciting research direction to unlock unusual halogen chemistry for scalable, high-energy, sustainable aqueous batteries.
涉及I - /I 0 /I +氧化还原的水锌| | i2电池是很有前途的,但通常面临以I 0 /I +氧化还原为主的低I 2利用率,特别是在高负荷下。解锁i0 /I +氧化还原的替代途径,最好是在无腐蚀性的稀释电解质中,是一个关键的解决方案。在这里,我们报告了一种通过独特的碳卤素键取代实现热力学上更有利的I 0 /I +氧化还原的途径。该途径通过低浓度(0.7 M)、无腐蚀性的有机卤化物添加剂(2-溴乙酰胺,BrAce)实现,引发可逆的Br-C···I(0)和C-I (+) -Br键取代。与传统的卤素间键(I-Br)途径相比,该途径通过精心调节卤素间键(I (δ+) -Br)的轴向δ孔活性,同步降低了I⁰/I⁺氧化还原的屏障,增强了I +物质的抗水解能力。值得注意的是,该途径能够实现高i2负载(8.6 24.0 mg cm -2)的四电子Zn | | i2电池的可持续运行,并具有改进的性能:(1)高i2利用率(55% ~ 80%) at high rates (5.8 ~ 46.4 mA cm -2 ), (2) long lifespan ( $$ > $$ > 400 cycles) with practical areal capacity ( ~ 3.85 mA h cm -2 ) and 99.5% retention even at 47.5 mA cm -2 . This pathway opens an exciting research direction to unlock unusual halogen chemistry for scalable, high-energy, sustainable aqueous batteries.
{"title":"Carbon-halogen bond substitution enables high-utilization four-electron iodine redox in noncorrosive dilute electrolytes","authors":"Zhiheng Shi, Yongchao Tang, Yue Wei, Guigui Liu, Haolong Huang, Jintu Qi, Zhenfeng Feng, Minghui Ye, Yufei Zhang, Zhipeng Wen, Xiaoqing Liu, Qi Yang, Chunyi Zhi, Cheng Chao Li","doi":"10.1038/s41467-026-69743-z","DOIUrl":"https://doi.org/10.1038/s41467-026-69743-z","url":null,"abstract":"Aqueous Zn | |I <jats:sub>2</jats:sub> batteries, involving I <jats:sup>-</jats:sup> /I <jats:sup>0</jats:sup> /I <jats:sup>+</jats:sup> redox, are promising yet usually facing low I <jats:sub>2</jats:sub> utilization dominated by I <jats:sup>0</jats:sup> /I <jats:sup>+</jats:sup> redox, especially under high loadings. Unlocking alternative pathway to I <jats:sup>0</jats:sup> /I <jats:sup>+</jats:sup> redox, preferably in noncorrosive dilute electrolytes, is a crucial solution. Here, we report a pathway towards more thermodynamically favorable I <jats:sup>0</jats:sup> /I <jats:sup>+</jats:sup> redox, via a unique carbon-halogen bond substitution. This pathway is realized with a low-concentrated (0.7 M), noncorrosive organohalide additive (2-bromoacetamide, BrAce), triggering a reversible Br-C···I <jats:sup>(0)</jats:sup> and C-I <jats:sup>(+)</jats:sup> -Br bond substitution. Compared with conventional interhalogen bonding (I-Br) pathway, this pathway synchronously lowers the barrier for I⁰/I⁺ redox and strengthens the anti-hydrolysis of I <jats:sup>+</jats:sup> species, by elaborately regulating axial δ hole activity of interhalogen bond (I <jats:sup>(δ+)</jats:sup> -Br). Notably, this pathway enables sustainable operation of four-electron Zn | |I <jats:sub>2</jats:sub> batteries with high I <jats:sub>2</jats:sub> loading (8.6 ~ 24.0 mg cm <jats:sup>-2</jats:sup> ), featuring improved performances: (1) high I <jats:sub>2</jats:sub> utilizations (55% ~ 80%) at high rates (5.8 ~ 46.4 mA cm <jats:sup>-2</jats:sup> ), (2) long lifespan ( <jats:inline-formula> <jats:alternatives> <jats:tex-math>$$ &gt; $$</jats:tex-math> <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"> <mml:mo>&gt;</mml:mo> </mml:math> </jats:alternatives> </jats:inline-formula> 400 cycles) with practical areal capacity ( ~ 3.85 mA h cm <jats:sup>-2</jats:sup> ) and 99.5% retention even at 47.5 mA cm <jats:sup>-2</jats:sup> . This pathway opens an exciting research direction to unlock unusual halogen chemistry for scalable, high-energy, sustainable aqueous batteries.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"49 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guest-induced porous gating of a fluorescent nonporous adaptive crystal for efficient radioactive iodine sorption 一种有效吸收放射性碘的荧光无孔自适应晶体的客体诱导多孔门控
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69608-5
Qiaoru Zhang, Xianhu Liu, Yongxian Guo, Shuya Liu, Fayuan Ge, Yanjun Gong, Mei Zhao, Yujie Song, Yiwei Liu, Di Sun, Qiongzheng Hu
{"title":"Guest-induced porous gating of a fluorescent nonporous adaptive crystal for efficient radioactive iodine sorption","authors":"Qiaoru Zhang, Xianhu Liu, Yongxian Guo, Shuya Liu, Fayuan Ge, Yanjun Gong, Mei Zhao, Yujie Song, Yiwei Liu, Di Sun, Qiongzheng Hu","doi":"10.1038/s41467-026-69608-5","DOIUrl":"https://doi.org/10.1038/s41467-026-69608-5","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"17 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thin film lithium niobate on sapphire for integrated mid-infrared modulator 蓝宝石上铌酸锂薄膜集成中红外调制器
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69880-5
Pierre Didier, Prakhar Jain, Mathieu Bertrand, Jost Kellner, Oliver Pitz, Zhecheng Dai, Tristan Kuttner, Mattias Beck, Baile Chen, Jérôme Faist, Rachel Grange
The mid-infrared spectrum, spanning from 3 to 14 µm, holds great promise for molecular spectroscopy and free space optical communication, benefiting from strong molecular absorption and reduced atmospheric attenuation. While progress in MIR photonics has accelerated due to improved sources and detectors, integrated low-loss, high -performance modulators remain limited. In order to address this gap, we demonstrate a broadband, high speed lithium niobate on sapphire Mach Zehnder electro optic modulator operating from 3.95 to 4.5 µm. The device shows a 3 dB bandwidth above 20 GHz, 17 dB extinction ratio, and V π L = 22 V ⋅ cm, with optical output power at the half milliwatt level. We demonstrate 10 Gbit s −1 data transmission and a 70 GHz broad frequency comb, uniquely combining integration, low propagation loss, extinction ratio and high-speed operation.
中红外光谱,跨度从3到14µm,对分子光谱和自由空间光通信具有很大的前景,受益于强分子吸收和减少大气衰减。虽然由于光源和探测器的改进,MIR光子学的进展已经加速,但集成的低损耗、高性能调制器仍然有限。为了解决这一差距,我们展示了一种宽带,高速铌酸锂蓝宝石Mach Zehnder电光调制器,工作范围为3.95至4.5µm。该器件带宽在20 GHz以上为3 dB,消光比为17 dB, V π L = 22 V⋅cm,光输出功率为半毫瓦级。我们展示了10gbit / s−1数据传输和70ghz宽频梳,独特地结合了集成、低传播损耗、消光比和高速运行。
{"title":"Thin film lithium niobate on sapphire for integrated mid-infrared modulator","authors":"Pierre Didier, Prakhar Jain, Mathieu Bertrand, Jost Kellner, Oliver Pitz, Zhecheng Dai, Tristan Kuttner, Mattias Beck, Baile Chen, Jérôme Faist, Rachel Grange","doi":"10.1038/s41467-026-69880-5","DOIUrl":"https://doi.org/10.1038/s41467-026-69880-5","url":null,"abstract":"The mid-infrared spectrum, spanning from 3 to 14 µm, holds great promise for molecular spectroscopy and free space optical communication, benefiting from strong molecular absorption and reduced atmospheric attenuation. While progress in MIR photonics has accelerated due to improved sources and detectors, integrated low-loss, high -performance modulators remain limited. In order to address this gap, we demonstrate a broadband, high speed lithium niobate on sapphire Mach Zehnder electro optic modulator operating from 3.95 to 4.5 µm. The device shows a 3 dB bandwidth above 20 GHz, 17 dB extinction ratio, and <jats:italic>V</jats:italic> <jats:sub> <jats:italic>π</jats:italic> </jats:sub> <jats:italic>L</jats:italic> = 22 V ⋅ cm, with optical output power at the half milliwatt level. We demonstrate 10 Gbit s <jats:sup>−1</jats:sup> data transmission and a 70 GHz broad frequency comb, uniquely combining integration, low propagation loss, extinction ratio and high-speed operation.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"24 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells 不可水解的乙酰赖氨酸类似物在体外和细胞中研究蛋白质乙酰化
IF 16.6 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-21 DOI: 10.1038/s41467-026-69782-6
Simon Maria Kienle, Matthias Sigg, Tobias Schneider, Katrin Stuber, Jan Lehmann, Jasmin Jansen, Florian Stengel, Andreas Marx, Michael Kovermann, Martin Scheffner
Lysine acetylation plays a prominent regulatory role in eukaryotic cells. Yet, determining the functional consequences of acetylation for a given protein represents a considerable challenge. For instance, lysine residues are subject to various posttranslational modifications, rendering interpretation of mutational studies difficult. The genetic code expansion technology enables site-specific incorporation of acetyllysine (AcK) into proteins, but the applicability of AcK is limited, as within cells, the acetyl group is removed by deacetylases. Here, we show that site-specific incorporation of the non-hydrolyzable AcK analog ketolysine (KeK) into ubiquitin closely resembles the structural and functional effects of AcK incorporation. Furthermore, AcK and KeK can be efficiently incorporated into the tumor suppressor p53 in cells. However, whereas AcK becomes deacetylated, KeK remains stable. Accordingly, incorporation of KeK, but not AcK, affects p53-mediated transcription. Thus, we propose that KeK is a well-suited AcK surrogate for studying acetylation of a given protein in cells.
赖氨酸乙酰化在真核细胞中起着重要的调节作用。然而,确定乙酰化对特定蛋白质的功能后果是一个相当大的挑战。例如,赖氨酸残基受到各种翻译后修饰的影响,使得突变研究的解释变得困难。遗传密码扩展技术可以将乙酰赖氨酸(AcK)特异位点整合到蛋白质中,但AcK的适用性是有限的,因为在细胞内,乙酰基被去乙酰化酶去除。在这里,我们发现非水解AcK类似物KeK在泛素中的特异性结合与AcK结合的结构和功能效应非常相似。此外,AcK和KeK可以有效地结合到细胞中的肿瘤抑制因子p53中。然而,当AcK去乙酰化时,KeK保持稳定。因此,结合KeK而不是AcK会影响p53介导的转录。因此,我们认为KeK是研究细胞中特定蛋白乙酰化的一种非常适合的AcK替代物。
{"title":"Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells","authors":"Simon Maria Kienle, Matthias Sigg, Tobias Schneider, Katrin Stuber, Jan Lehmann, Jasmin Jansen, Florian Stengel, Andreas Marx, Michael Kovermann, Martin Scheffner","doi":"10.1038/s41467-026-69782-6","DOIUrl":"https://doi.org/10.1038/s41467-026-69782-6","url":null,"abstract":"Lysine acetylation plays a prominent regulatory role in eukaryotic cells. Yet, determining the functional consequences of acetylation for a given protein represents a considerable challenge. For instance, lysine residues are subject to various posttranslational modifications, rendering interpretation of mutational studies difficult. The genetic code expansion technology enables site-specific incorporation of acetyllysine (AcK) into proteins, but the applicability of AcK is limited, as within cells, the acetyl group is removed by deacetylases. Here, we show that site-specific incorporation of the non-hydrolyzable AcK analog ketolysine (KeK) into ubiquitin closely resembles the structural and functional effects of AcK incorporation. Furthermore, AcK and KeK can be efficiently incorporated into the tumor suppressor p53 in cells. However, whereas AcK becomes deacetylated, KeK remains stable. Accordingly, incorporation of KeK, but not AcK, affects p53-mediated transcription. Thus, we propose that KeK is a well-suited AcK surrogate for studying acetylation of a given protein in cells.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Nature Communications
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1