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Earth system simulations suggest that the Proterozoic ocean was greener but less productive 地球系统模拟表明，元古代的海洋更绿，但生产力更低

IF 16.6 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69654-z

Peng Liu, Yonggang Liu, Lin Dong, Jian Zhang, Sanzhong Li, Yihui Chen

引用次数: 0

Human-induced climate change amplification on storm dynamics in Valencia's 2024 catastrophic flash flood. 人为引起的气候变化对2024年瓦伦西亚灾难性山洪风暴动力学的影响。

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-68929-9

Carlos Calvo-Sancho, Javier Díaz-Fernández, Juan Jesús González-Alemán, Amar Halifa-Marín, Mario Marcello Miglietta, Cesar Azorin-Molina, Andreas F Prein, Ana Montoro-Mendoza, Pedro Bolgiani, Ana Morata, María Luisa Martín

Global warming alters the hydrological cycle, increasing heavy rainfall events worldwide. In October 2024, Valencia (Spain) experienced rainfall accumulations in a few hours surpassing annual averages (771.8 mm in 16 h in the official weather station at Turís) and breaking the record for one hour rainfall accumulation in Spain (184.6 mm), resulting in 230 fatalities. Here, we present a physical-based attribution study employing a km-scale pseudo-global warming storyline approach to assess the contribution of anthropogenic climate change. We show that present-day conditions led to a 20% °C⁻¹ increase in 1-hour rainfall intensity, exceeding Clausius-Clapeyron scaling. This intensification was driven by enhanced atmospheric moisture from warmer sea surface temperatures, leading to increased convective available potential energy, stronger updrafts, and microphysical changes including elevated graupel concentrations. These results demonstrate that anthropogenic climate change could intensify the occurrence of flash-floods in the Western Mediterranean region: in this particular case, it intensified the 6-h rainfall rate by 21%, amplified the area with total rainfall above 180 mm by 55%, and increased the volume of total rain within the Jucar River catchment by 19% compared to the pre-industrial era. This study highlights the urgent need for effective adaptation strategies and improved urban planning to reduce the growing risks of hydrometeorological extremes in a rapidly warming world.

全球变暖改变了水文循环，增加了世界范围内的强降雨事件。2024年10月，西班牙瓦伦西亚在几小时内的降雨量超过了年平均水平（官方气象站Turís在16小时内的降雨量为771.8毫米），并打破了西班牙一小时降雨量的记录（184.6毫米），造成230人死亡。在这里，我们提出了一个基于物理的归因研究，采用千米尺度的伪全球变暖故事线方法来评估人为气候变化的贡献。我们表明，目前的条件导致1小时降雨强度增加20%°C（⁻¹），超过克劳修斯-克拉珀龙尺度。海面温度升高导致大气湿度增强，导致对流有效势能增加，上升气流增强，以及包括霰浓度升高在内的微物理变化。结果表明，人为气候变化加剧了西地中海地区山洪暴发的发生：与工业化前相比，该地区6 h降雨率增加了21%，总降雨量超过180 mm的面积增加了55%，朱卡尔河流域总降雨量增加了19%。这项研究强调，迫切需要有效的适应战略和改进城市规划，以减少在快速变暖的世界中日益增长的水文气象极端风险。

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引用次数: 0

Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer 循环肿瘤反应性T细胞表型预测非小细胞肺癌的免疫检查点抑制剂反应

IF 16.6 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69680-x

Katsuhiro Ito, Kei Iida, Tomoko Hirano, Merrin Man Long Leong, Kenji Morii, Toshi Menju, Hiroshi Date, Hiroaki Ozasa, Hironori Yoshida, Toyohiro Hirai, Shusuke Kawashima, Kazuhiro Aoyama, Yuka Saeki, Takashi Inozume, Takashi Kobayashi, Kenji Chamoto, Tomonori Yaguchi

Peripheral blood (PB) is a source of tumor-infiltrating tumor-reactive T cells (TR-T). Circulating TR-Ts (cTR-T) in PB are expected to contribute to the efficacy of immune checkpoint inhibitors (ICIs), but their phenotype remains poorly understood. Here we analyse paired tumor-infiltrating and peripheral CD8 + T cells from patients with non-small cell lung carcinoma (NSCLC), using single-cell RNA and T cell receptor (TCR) sequencing. Tumor-infiltrating TR-Ts are defined based on the reported TR-T-associated gene signatures. Using their TCR sequence as a barcode, we identify cTR-Ts and their specific surface markers, including CD49a, CD49b, and HLA-DR. Trajectory analysis assigns a progenitor-like phenotype to cTR-Ts, suggesting a potential developmental relationship with tumor-infiltrating TR-Ts. By single-cell transcriptomic and flow cytometric analysis on an ICI-treated cohort we show that pre-treatment cTR-Ts in responders are characterized by a relatively low expression of exhaustion-related CD38. Following the first dose, cTR-Ts of responders transit towards a TCF7 + stem-like phenotype. Additionally, we validate cTR-T’s phenotypic changes following PD-1 blockade therapy in mouse tumor models with artificial antigen. These findings suggest that the phenotypic state and transition of cTR-Ts may reflect their functional potential after tumor infiltration and are associated with therapeutic outcomes of ICIs.

外周血（PB）是肿瘤浸润性肿瘤反应T细胞（TR-T）的来源。预计PB中循环tr - t （ctrt）有助于免疫检查点抑制剂（ICIs）的疗效，但其表型仍知之甚少。在这里，我们使用单细胞RNA和T细胞受体（TCR）测序分析来自非小细胞肺癌（NSCLC）患者的成对肿瘤浸润和外周CD8 + T细胞。肿瘤浸润性tr - t是根据报道的tr - t相关基因特征来定义的。使用它们的TCR序列作为条形码，我们识别了cr - t及其特定的表面标记，包括CD49a， CD49b和HLA-DR。轨迹分析将祖细胞样表型分配给了TR-Ts，表明其与肿瘤浸润性TR-Ts的潜在发育关系。通过对ici治疗队列的单细胞转录组学和流式细胞术分析，我们发现治疗前应答者的cr - ts的特征是相对较低的衰竭相关CD38表达。在第一次给药后，应答者的cr - t向TCF7 +茎样表型转移。此外，我们在使用人工抗原的小鼠肿瘤模型中验证了PD-1阻断治疗后ctrt的表型变化。这些发现提示，cr - ts的表型状态和转变可能反映了其肿瘤浸润后的功能潜能，并与ICIs的治疗结果相关。

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引用次数: 0

Activating plasmonic catalysis through light-mediated steady-state spin modulation 通过光介导的稳态自旋调制激活等离子体催化

IF 16.6 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69577-9

Xinge Hu, Jinjie Liu, Zhijie Zhu, Shuang Liu, Lei Wang, Jianjun Cheng, Xiong Huang, Chaoran Li, Kai Feng, Yuxuan Zhou, Yuqing Xu, Qianyue Feng, Binbin Zhang, Xiankai Chen, Liang Zhang, Qingfeng Zhang, Bo Wu, Jun Yin, Xingda An, Xiao-Hong Zhang, Le He

引用次数: 0

Detecting genuine multipartite entanglement in multi-qubit devices with restricted measurements 在测量受限的多量子位器件中检测真正的多部纠缠

IF 16.6 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69320-4

Nicky Kai Hong Li, Xi Dai, Manuel H. Muñoz-Arias, Kevin Reuer, Marcus Huber, Nicolai Friis

Detecting genuine multipartite entanglement (GME) is a state-characterization task that benchmarks coherence and experimental control in quantum systems. Existing GME tests often require joint measurements on many qubits, posing challenges for systems like time-bin encoded qubits and microwave photons from superconducting circuits, where qubit connectivity is limited or measurement noise grows with the number of jointly measured qubits. Here we introduce versatile GME and k -inseparability criteria applicable to any state, which only require measuring O ( n 2 ) out of 2 n (at most) m -body stabilizers of n -qubit target graph states, with m upper-bounded by twice the graph’s maximum degree. For cluster or ring-graph states, only constant-weight stabilizers are needed. Using semidefinite programming (and sometimes graph-local complementations), we can reduce the number or weight of required stabilizers. Analytical and numerical results show that our criteria are noise-robust and may infer state infidelity from certified k -inseparability in microwave photonic graph states generated under realistic conditions.

检测真正的多部纠缠（GME）是一项状态表征任务，它对量子系统中的相干性和实验控制进行了基准测试。现有的GME测试通常需要对许多量子位进行联合测量，这给时间盒编码的量子位和超导电路中的微波光子等系统带来了挑战，在这些系统中，量子位的连通性受到限制，或者测量噪声随着共同测量的量子位的数量而增加。这里我们引入了适用于任何状态的通用GME和k -不可分准则，它们只需要测量n -量子比特目标图状态的2n（最多）m个体稳定器中的O （n 2）个，且m的上界为图的最大度的两倍。对于簇态或环图态，只需要等权稳定剂。使用半定规划（有时是图局部互补），我们可以减少所需稳定器的数量或权重。分析和数值结果表明，我们的准则具有噪声鲁棒性，可以从实际条件下产生的微波光子图态的证明k不可分性中推断出状态不忠。

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引用次数: 0

Strategically significant synthesis of conjugated porous organic polymers via retro diazotization chemistry 通过复古重氮化化学合成具有战略意义的共轭多孔有机聚合物

IF 16.6 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69515-9

Melek Sermin Ozer, Zafer Eroglu, Sermet Koyuncu, Onder Metin

引用次数: 0

A slight mismatch between a gene’s codon usage and the cellular tRNA supply is beneficial 基因密码子使用和细胞tRNA供应之间的轻微不匹配是有益的

IF 16.6 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69643-2

Feng Chen, Yao Liu, Ziwei Zhou, Jia Liao, Xinran Fan, Yanying Huang, Yifei Chen, Jingyu Chen, Jian-Rong Yang

引用次数: 0

Engineering Co-ion vacancy in dynamically reconstructed Co-based catalysts for practical anion-exchange membrane electrolysis 阴离子交换膜电解中动态重构co基催化剂的工程co离子空位

IF 16.6 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69547-1

Jingxuan Zhao, Xinmei Li, Kunjie Wang, Yuan-Ting Hung, Qing Wang, Xingyu Cui, Guanyin Gao, Xiangyang Li, Ru-Shi Liu, Xu Zhao

引用次数: 0

Strategies to control the geometry and symmetry around lanthanide centres for tailored luminescence and magnetism. 控制镧系元素中心周围的几何和对称性的策略，以定制发光和磁性。

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69445-6

Thomas E Karpiuk, Daniel B Leznoff

The luminescent and magnetic properties of trivalent lanthanides (Ln³⁺) are indispensable for many emerging technologies, but exacting fine control over these properties requires an understanding of how to purposefully engineer the coordination geometry and site symmetry of Ln³⁺ centres. Here, we use the Cambridge Structural Database to extract the structures of 12,670 eight-coordinate Ln³⁺ centres and use Continuous Shape Measures, Continuous Symmetry Operation Measures, and a new structural similarity-based network analysis to survey geometry and structure trends. This survey is then leveraged to deliver concrete strategies for controlling the coordination geometry of eight-coordinate Ln³⁺ centres using familiar concepts like Ln³⁺ metal size and ligand denticity, bite angle, flexibility, shape, symmetry, and size. Ultimately, we present a roadmap for targeting each of the six common eight-coordinate geometries - hexagonal bipyramidal, cubic, square antiprismatic, dodecahedral, bicapped trigonal prismatic, and snub disphenoid - which are each demonstrated to have unique use-cases in diverse research areas. The effects of crystal packing and non-covalent interactions are also illustrated, allowing fine-grained control over the geometry and symmetry of Ln³⁺ centres. This work ultimately serves to inform the deliberate design of Ln³⁺ coordination complexes and materials for applications including data-storage, quantum information processing, lighting, thermometry, and medical bioimaging.

三价镧系元素（Ln3+）的发光和磁性对于许多新兴技术来说是必不可少的，但是对这些性质的精确控制需要了解如何有目的地设计Ln3+中心的配位几何和位置对称性。在此，我们利用剑桥结构数据库提取了12670个八坐标Ln3+中心的结构，并使用连续形状测量、连续对称操作测量和一种新的基于结构相似性的网络分析来调查几何和结构趋势。然后利用该调查提供控制八坐标Ln3+中心协调几何的具体策略，使用熟悉的概念，如Ln3+金属尺寸和配体密度、咬角、灵活性、形状、对称性和大小。最后，我们提出了针对六种常见的八坐标几何中的每一种的路线图-六边形双锥体，立方体，方形反棱柱体，十二面体，二头三角形棱柱体和凸二苯体-每一种都被证明在不同的研究领域有独特的用例。晶体填充和非共价相互作用的影响也被说明，允许对Ln3+中心的几何形状和对称性进行细粒度控制。这项工作最终为Ln3+配合物和材料的设计提供了信息，这些材料的应用包括数据存储、量子信息处理、照明、测温和医学生物成像。

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引用次数: 0

Author Correction: Complex de novo structural variants are an underestimated cause of rare disorders. 作者更正：复杂的从头结构变异是一种被低估的罕见疾病的原因。

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications

Pub Date : 2026-02-17 DOI: 10.1038/s41467-026-69646-z

Hyunchul Jung, Tsun-Po Yang, Susan Walker, Petr Danecek, O Isaac Garcia-Salinas, Matthew D C Neville, Joseph Christopher, Isidro Cortés-Ciriano, Helen Firth, Aylwyn Scally, Matthew Hurles, Peter Campbell, Raheleh Rahbari

引用次数: 0

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