{"title":"Molecular genetic characterization of Fusarium graminearum genes identified as encoding a precocene II-binding protein","authors":"Kazuyuki Maeda, S. Ohsato","doi":"10.2520/MYCO.67-1-3","DOIUrl":"https://doi.org/10.2520/MYCO.67-1-3","url":null,"abstract":"","PeriodicalId":19069,"journal":{"name":"Mycotoxins","volume":"101 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89678333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Report of Joint meeting of the 9 th World Mycotoxin Forum and 14 th IUPAC International Symposium on Mycotoxins","authors":"K. Yabe","doi":"10.2520/MYCO.67-1-10","DOIUrl":"https://doi.org/10.2520/MYCO.67-1-10","url":null,"abstract":"","PeriodicalId":19069,"journal":{"name":"Mycotoxins","volume":"14 4 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90237719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Humans are heterotrophic organisms. Humans had to be a lot of struggling with food from their ancestors. Concept and definition of food safety are not always the same on every country or race in each area. International standardization, also in the food safety field, is in progress in spite of the difference with geographical conditions and food culture. Food self-sufficiency rate of Japan is low. It should be especially important that Japan perform the food chain approach from farm to table as same as risk analysis of food. If there is no cooperation with everyone, it is difficult to obtain safe food constantly. Food chain of Japan has been extended to the entire earth. We need to explain it to the public. And, it is necessary to obtain their understanding. All of the people should prepare for a climate change and a natural disaster for the unexpected situations such as terrorism more.
{"title":"Food safety and food chain approach","authors":"K. Isshiki","doi":"10.2520/MYCO.67-1-1","DOIUrl":"https://doi.org/10.2520/MYCO.67-1-1","url":null,"abstract":"Humans are heterotrophic organisms. Humans had to be a lot of struggling with food from their ancestors. Concept and definition of food safety are not always the same on every country or race in each area. International standardization, also in the food safety field, is in progress in spite of the difference with geographical conditions and food culture. Food self-sufficiency rate of Japan is low. It should be especially important that Japan perform the food chain approach from farm to table as same as risk analysis of food. If there is no cooperation with everyone, it is difficult to obtain safe food constantly. Food chain of Japan has been extended to the entire earth. We need to explain it to the public. And, it is necessary to obtain their understanding. All of the people should prepare for a climate change and a natural disaster for the unexpected situations such as terrorism more.","PeriodicalId":19069,"journal":{"name":"Mycotoxins","volume":"36 1","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76450097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Nagoya Protocol to the Convention on Biological Diversity entered into force in Japan on 20 th August, 2017. This manuscript is a thumbnail sketch briefly introducing the background and the requirements of the Nagoya Protocol, touching on Japanese domestic measures.
{"title":"Entering into force of the Nagoya Protocol in Japan: - its background and requirements -","authors":"Akio Yamamoto","doi":"10.2520/myco.67_2_6","DOIUrl":"https://doi.org/10.2520/myco.67_2_6","url":null,"abstract":"The Nagoya Protocol to the Convention on Biological Diversity entered into force in Japan on 20 th August, 2017. This manuscript is a thumbnail sketch briefly introducing the background and the requirements of the Nagoya Protocol, touching on Japanese domestic measures.","PeriodicalId":19069,"journal":{"name":"Mycotoxins","volume":"42 1","pages":"105-114"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82874658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impression of the 1 st China Mycotoxin Conference 2016","authors":"S. Sakuda","doi":"10.2520/MYCO.67-1-4","DOIUrl":"https://doi.org/10.2520/MYCO.67-1-4","url":null,"abstract":"","PeriodicalId":19069,"journal":{"name":"Mycotoxins","volume":"6 1","pages":"43-44"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76062497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The acquisition of stemness, which epigenetically induced and maintained by Yamanaka factors, Oct4, Sox2, Klf4, and c-Myc, is a hallmark of malignant hepatocellular carcinoma (HCC). We found that deregulated expression of Sry (sex-determing region Y) is involved in the acquisition of tumor malignancy of aflatoxin B1 (AFB1)-induced male rodent (r) HCC K2 cells, in which 89% of the population is cancer stem cells (CSCs) due to the robust potentiation of Sry/SGF29/c-Myc pathway. In human (h) HCCs, overexpressed Sry activates directly the CSC marker Oct4 expression, while its knockdown decreases Oct4 expression and CSC natures including selfrenewal, tumorigenicity and chemoresistance. Thus, these facts indicate that Sry takes part in the induction and maintenance of CSCs in HCCs. Moreover, CSCs from hHCCs could differentiate into Tuj1-positive and Ki67-negative neurons having long neurites in the presence of retinoic acid (RA). Taken together with the fact that deregulated expression of Sry mRNA can be detected in three out of the eighteen male patients with HCC tested, differentiation-inducing therapy targeting HCCs-derived CSCs, which play a central role in tumor redevelopment, is fully promised for rooting out of cancer.
{"title":"Investigation into the acquisition mechanism of malignant phenotypes in aflatoxin B1-induced rat hepatocellular carcinoma K2 cells","authors":"F. Tashiro","doi":"10.2520/MYCO.66.119","DOIUrl":"https://doi.org/10.2520/MYCO.66.119","url":null,"abstract":"The acquisition of stemness, which epigenetically induced and maintained by Yamanaka factors, Oct4, Sox2, Klf4, and c-Myc, is a hallmark of malignant hepatocellular carcinoma (HCC). We found that deregulated expression of Sry (sex-determing region Y) is involved in the acquisition of tumor malignancy of aflatoxin B1 (AFB1)-induced male rodent (r) HCC K2 cells, in which 89% of the population is cancer stem cells (CSCs) due to the robust potentiation of Sry/SGF29/c-Myc pathway. In human (h) HCCs, overexpressed Sry activates directly the CSC marker Oct4 expression, while its knockdown decreases Oct4 expression and CSC natures including selfrenewal, tumorigenicity and chemoresistance. Thus, these facts indicate that Sry takes part in the induction and maintenance of CSCs in HCCs. Moreover, CSCs from hHCCs could differentiate into Tuj1-positive and Ki67-negative neurons having long neurites in the presence of retinoic acid (RA). Taken together with the fact that deregulated expression of Sry mRNA can be detected in three out of the eighteen male patients with HCC tested, differentiation-inducing therapy targeting HCCs-derived CSCs, which play a central role in tumor redevelopment, is fully promised for rooting out of cancer.","PeriodicalId":19069,"journal":{"name":"Mycotoxins","volume":"1 1","pages":"119-123"},"PeriodicalIF":0.0,"publicationDate":"2016-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84386016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yosuke Matsuo, Kentaro Takahara, Hidemi Hatabayashi, M. Kushiro, H. Nakagawa
Detection of fumonisin C1, C2 and C3 (FCs) in a reference material of corn powder was performed with LC-Orbitrap MS. The peaks of FCs were eluted 0.1 ~ 0.3 min earlier than those of fumonisin B1, B2 and B3 (FBs), from the C18 column, probably due to the lacking of terminal C-1 methyl group of FB molecule structures. At negative ionization mode scan with LC-MS analysis, the fragment ions of the tricarballylic acid (TCA) and characteristic fumonisin ions lacking TCA were detected at the identical retention times with those of respective parent FCs. Mass fragmentation patterns of FCs were confirmed to be almost in consistent with those of FBs. This study is the first report of natural co-occurrence of FC1, FC2, and FC3 in corn powder.
{"title":"Detection of fumonisin C1, C2 and C3 in corn powder by LC - Orbitrap MS","authors":"Yosuke Matsuo, Kentaro Takahara, Hidemi Hatabayashi, M. Kushiro, H. Nakagawa","doi":"10.2520/MYCO.66.111","DOIUrl":"https://doi.org/10.2520/MYCO.66.111","url":null,"abstract":"Detection of fumonisin C1, C2 and C3 (FCs) in a reference material of corn powder was performed with LC-Orbitrap MS. The peaks of FCs were eluted 0.1 ~ 0.3 min earlier than those of fumonisin B1, B2 and B3 (FBs), from the C18 column, probably due to the lacking of terminal C-1 methyl group of FB molecule structures. At negative ionization mode scan with LC-MS analysis, the fragment ions of the tricarballylic acid (TCA) and characteristic fumonisin ions lacking TCA were detected at the identical retention times with those of respective parent FCs. Mass fragmentation patterns of FCs were confirmed to be almost in consistent with those of FBs. This study is the first report of natural co-occurrence of FC1, FC2, and FC3 in corn powder.","PeriodicalId":19069,"journal":{"name":"Mycotoxins","volume":"156 1","pages":"111-118"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77527973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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