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A mini-colon models colon cancer and its microenvironment. 迷你结肠模拟结肠癌及其微环境。
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-25 DOI: 10.1038/s41587-024-02343-8
Colin Hutton, Vivian S W Li
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引用次数: 0
Author Correction: Quantifying bias introduced by sample collection in relative and absolute microbiome measurements 作者更正：量化相对和绝对微生物组测量中样本采集带来的偏差。
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-24 DOI: 10.1038/s41587-024-02341-w
Dylan G. Maghini, Mai Dvorak, Alex Dahlen, Morgan Roos, Boryana Doyle, Scott Kuersten, Ami S. Bhatt
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引用次数: 0
Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants. 大规模发现染色质失调是由同源基因融合和其他蛋白质编码变异引起的。
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-24 DOI: 10.1038/s41587-024-02347-4
Max Frenkel, James E Corban, Margaux L A Hujoel, Zachary Morris, Srivatsan Raman

Population-scale databases have expanded to millions of protein-coding variants, yet insight into their mechanistic consequences has lagged. Here we present PROD-ATAC, a high-throughput method for discovering the effects of protein-coding variants on chromatin regulation. A pooled variant library is expressed in a disease-agnostic cell line, and single-cell assay for transposase-accessible chromatin resolves each variant's effect on the chromatin landscape. Using PROD-ATAC, we characterized the effects of more than 100 oncofusions (cancer-causing chimeric proteins) and controls and revealed that chromatin remodeling is common to fusions spanning an enormous range of fusion frequencies. Furthermore, fusion-induced dysregulation can be context agnostic, as observed mechanisms often overlapped with cancer and cell-type-specific prior knowledge. We also showed that gain-of-function activity is common among oncofusions. This work begins to outline a global map of fusion-induced chromatin alterations. We suggest that there might be convergent mechanisms among disparate oncofusions and shared modes of dysregulation among fusions present in tumors at different frequencies. PROD-ATAC is generalizable to any set of protein-coding variants.

群体规模的数据库已扩展到数百万个蛋白质编码变体，但对其机理后果的了解却很滞后。在这里，我们介绍一种发现蛋白质编码变异对染色质调控影响的高通量方法--PROD-ATAC。在疾病诊断细胞系中表达汇集的变异体文库，并对转座酶可进入的染色质进行单细胞检测，以确定每个变异体对染色质景观的影响。利用 PROD-ATAC，我们鉴定了 100 多种融合体（致癌嵌合蛋白）和对照组的影响，发现染色质重塑是跨越巨大融合频率范围的融合体的共同特征。此外，融合诱导的失调可能与背景无关，因为观察到的机制往往与癌症和细胞类型特异性的先验知识重叠。我们还发现，功能增益活动在核融合中很常见。这项工作开始勾勒出融合诱导染色质改变的全局图。我们认为，不同的融合体之间可能存在趋同的机制，不同频率的融合体之间也可能存在共同的失调模式。PROD-ATAC 可用于任何一组蛋白质编码变异。
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引用次数: 0
Editor’s pick: Indapta Therapeutics 编辑推荐Indapta Therapeutics
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-22 DOI: 10.1038/s41587-024-02334-9
Iris Marchal
Each year, Nature Biotechnology highlights companies that have received sizeable early-stage funding in the previous year. Indapta Therapeutics is using a subset of natural killer cells found in healthy donors to supercharge monoclonal antibodies to fight cancer and autoimmune disease.
自然-生物技术》每年都会重点介绍上一年获得大量早期融资的公司。Indapta Therapeutics 公司正在利用健康捐献者体内的自然杀伤细胞子集来增强单克隆抗体，以抗击癌症和自身免疫性疾病。
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引用次数: 0
A community effort to track commercial single-cell and spatial ’omic technologies and business trends 社区努力跟踪商业单细胞和空间'omic'技术和商业趋势。
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-17 DOI: 10.1038/s41587-024-02305-0
Joachim De Jonghe, James W. Opzoomer, Amaia Vilas-Zornoza, Peter Crane, Benedikt S. Nilges, Marco Vicari, Hower Lee, David Lara-Astiaso, Torsten Gross, Jörg Morf, Kim Schneider, Juliana Cudini, Lorenzo Ramos-Mucci, Dylan Mooijman, Katarína Tiklová, Sergio Marco Salas, Christoffer Mattsson Langseth, Nachiket D. Kashikar, Charles E. S. Roberts, The scTrends Consortium, Joakim Lundeberg, Mats Nilsson, Alex K. Shalek, Adam P. Cribbs, Jake P. Taylor-King
There is an ever-growing choice of single-cell and spatial ’omics platforms for industry and academia. The scTrends Consortium provides a brief historical overview of the established platforms and companies, revealing market trends and presenting possible angles for how technologies may differentiate themselves.
工业界和学术界有越来越多的单细胞和空间'omics'平台可供选择。scTrends Consortium 对已建立的平台和公司进行了简要的历史概述，揭示了市场趋势，并从可能的角度介绍了技术如何实现差异化。
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引用次数: 0
NIH Applicant Assistance Program counteracts decades of underrepresentation in SBIR grant awardees 美国国立卫生研究院（NIH）"申请人援助计划 "抵消了数十年来 SBIR 赠款获得者人数不足的问题。
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-17 DOI: 10.1038/s41587-024-02308-x
Katharine L. Korunes, Ethan C. Cissell, Tiger Xie, Eva R. Garland
The NIH Applicant Assistance Program represents a new paradigm guiding the design of meaningful policy interventions for increasing equity of participation in scientific grant funding.
美国国立卫生研究院（NIH）申请人援助计划代表了一种新的范式，它指导着设计有意义的政策干预措施，以提高参与科学基金资助的公平性。
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引用次数: 0
Roche bets on RNA exon editor 罗氏押宝 RNA 外显子编辑器。
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-17 DOI: 10.1038/s41587-024-02329-6
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引用次数: 0
Vision–language AI assistance in human pathology 人类病理学中的视觉语言人工智能辅助。
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-17 DOI: 10.1038/s41587-024-02326-9
Iris Marchal
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引用次数: 0
Super-resolution microscopy 超分辨率显微镜
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-17 DOI: 10.1038/s41587-024-02304-1
Recent patents relating to systems and methods for super-resolution microscopy.
有关超分辨率显微镜系统和方法的最新专利。
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引用次数: 0
People 人
IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Nature biotechnology
Pub Date : 2024-07-17 DOI: 10.1038/s41587-024-02312-1
Recent moves of note in and around the biotech and pharma industries.
近期生物技术和制药行业及其周边值得关注的动向。
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引用次数: 0
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