Pub Date : 2025-11-17DOI: 10.1038/s41587-025-02939-8
{"title":"New algorithm enables fast ‘gold-standard’ search of the world’s largest microbial DNA archives","authors":"","doi":"10.1038/s41587-025-02939-8","DOIUrl":"https://doi.org/10.1038/s41587-025-02939-8","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"38 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41587-025-02888-2
Sophie Brown, David Borton
{"title":"Stem cells help restore hand function after spinal cord injury in monkeys","authors":"Sophie Brown, David Borton","doi":"10.1038/s41587-025-02888-2","DOIUrl":"https://doi.org/10.1038/s41587-025-02888-2","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"114 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41587-025-02865-9
Eleni Sinopoulou, Ephron S. Rosenzweig, John H. Brock, Hiromi Kumamaru, Ernesto A. Salegio, Michael J. Castle, Janet L. Weber, Rachele Wurr, Ryan Macon, Michelle W. Chow, J. Russell Huie, Nikos Kyritsis, Leif A. Havton, Yvette S. Nout-Lomas, Carolyn J. Sparrey, Adam R. Ferguson, Michael S. Beattie, Jacqueline C. Bresnahan, Mark H. Tuszynski
{"title":"Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell transplantation","authors":"Eleni Sinopoulou, Ephron S. Rosenzweig, John H. Brock, Hiromi Kumamaru, Ernesto A. Salegio, Michael J. Castle, Janet L. Weber, Rachele Wurr, Ryan Macon, Michelle W. Chow, J. Russell Huie, Nikos Kyritsis, Leif A. Havton, Yvette S. Nout-Lomas, Carolyn J. Sparrey, Adam R. Ferguson, Michael S. Beattie, Jacqueline C. Bresnahan, Mark H. Tuszynski","doi":"10.1038/s41587-025-02865-9","DOIUrl":"https://doi.org/10.1038/s41587-025-02865-9","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"17 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145532058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1038/s41587-025-02926-z
Charles S. Craik
{"title":"William J. Rutter 1927–2025","authors":"Charles S. Craik","doi":"10.1038/s41587-025-02926-z","DOIUrl":"10.1038/s41587-025-02926-z","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"1919-1920"},"PeriodicalIF":41.7,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1038/s41587-025-02882-8
Mostafa Aakhte, Gesine F. Müller, Lennart Roos, Joe Li, Torben Göpel, Kurt R. Weiss, Aleyna M. Diniz, Jan Wenzel, Markus Schwaninger, Tobias Moser, Jan Huisken
Light-sheet microscopy is ideal for imaging large and cleared tissues, but achieving a high isotropic resolution for a centimeter-sized sample is limited by slow and often aberrated, axially scanned light sheets. Here, we introduce a compact, high-speed light-sheet fluorescence microscope achieving 850 nm isotropic resolution across cleared samples up to 1 cm³ and refractive indices ranging from 1.33 to 1.56. Using off-the-shelf optics, we combine an air objective and a meniscus lens with an axially swept light sheet to achieve diffraction-limited resolution and aberration correction. The effective field of view is increased by twofold by correcting the field curvature of the light sheet using a concave mirror in the remote focusing unit. Adapting the light sheet’s motion with a closed-loop feedback enhances the imaging speed by tenfold, reaching 100 frames per second while maintaining resolution and field of view. We benchmark the system performance across scales, from subcellular structure up to centimeter scale, using various clearing methods.
{"title":"Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue","authors":"Mostafa Aakhte, Gesine F. Müller, Lennart Roos, Joe Li, Torben Göpel, Kurt R. Weiss, Aleyna M. Diniz, Jan Wenzel, Markus Schwaninger, Tobias Moser, Jan Huisken","doi":"10.1038/s41587-025-02882-8","DOIUrl":"https://doi.org/10.1038/s41587-025-02882-8","url":null,"abstract":"Light-sheet microscopy is ideal for imaging large and cleared tissues, but achieving a high isotropic resolution for a centimeter-sized sample is limited by slow and often aberrated, axially scanned light sheets. Here, we introduce a compact, high-speed light-sheet fluorescence microscope achieving 850 nm isotropic resolution across cleared samples up to 1 cm³ and refractive indices ranging from 1.33 to 1.56. Using off-the-shelf optics, we combine an air objective and a meniscus lens with an axially swept light sheet to achieve diffraction-limited resolution and aberration correction. The effective field of view is increased by twofold by correcting the field curvature of the light sheet using a concave mirror in the remote focusing unit. Adapting the light sheet’s motion with a closed-loop feedback enhances the imaging speed by tenfold, reaching 100 frames per second while maintaining resolution and field of view. We benchmark the system performance across scales, from subcellular structure up to centimeter scale, using various clearing methods.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"180 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The New York University Biomedical Entrepreneurship Educational Program’s career development awards boost early-stage scientists’ business knowledge and acumen to ease their transition from academia to industry.
{"title":"Career development awards support early-stage researchers in life sciences entrepreneurship","authors":"Justin Ong, Zachary Hill-Whilton, Colleen Gillespie, Daniel Cobos, Gabrielle Gold-von Simson","doi":"10.1038/s41587-025-02899-z","DOIUrl":"10.1038/s41587-025-02899-z","url":null,"abstract":"The New York University Biomedical Entrepreneurship Educational Program’s career development awards boost early-stage scientists’ business knowledge and acumen to ease their transition from academia to industry.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 11","pages":"1881-1887"},"PeriodicalIF":41.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1038/s41587-025-02907-2
{"title":"Biotech news from around the world","authors":"","doi":"10.1038/s41587-025-02907-2","DOIUrl":"10.1038/s41587-025-02907-2","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 11","pages":"1752-1752"},"PeriodicalIF":41.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1038/s41587-025-02902-7
Recent moves of note in and around the biotech and pharma industries.
生物技术和制药行业的最新动向。
{"title":"People","authors":"","doi":"10.1038/s41587-025-02902-7","DOIUrl":"10.1038/s41587-025-02902-7","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 11","pages":"1888-1888"},"PeriodicalIF":41.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1038/s41587-025-02917-0
Mark Peplow
{"title":"Chemistry Nobel materials in the clinic","authors":"Mark Peplow","doi":"10.1038/s41587-025-02917-0","DOIUrl":"10.1038/s41587-025-02917-0","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 11","pages":"1751-1751"},"PeriodicalIF":41.7,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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