Pub Date : 2025-12-11DOI: 10.1038/s41587-025-02953-w
Recent moves of note in and around the biotech and pharma industries.
生物技术和制药行业的最新动向。
{"title":"People","authors":"","doi":"10.1038/s41587-025-02953-w","DOIUrl":"10.1038/s41587-025-02953-w","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"2078-2078"},"PeriodicalIF":41.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1038/s41587-025-02913-4
Paige E. Erpf, Felix Meier, Roy S. K. Walker, Hugh D. Goold, Jef D. Boeke, Ian T. Paulsen, Isak S. Pretorius
The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. This Comment summarizes the design- and construction-related defects revealed during the construction of 16 synthetic chromosomes, and the solutions applied, drawing out the key biological and technical insights that will inform future genome-scale engineering.
{"title":"Building synthetic chromosomes one yeast at a time: insights from Sc2.0","authors":"Paige E. Erpf, Felix Meier, Roy S. K. Walker, Hugh D. Goold, Jef D. Boeke, Ian T. Paulsen, Isak S. Pretorius","doi":"10.1038/s41587-025-02913-4","DOIUrl":"10.1038/s41587-025-02913-4","url":null,"abstract":"The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. This Comment summarizes the design- and construction-related defects revealed during the construction of 16 synthetic chromosomes, and the solutions applied, drawing out the key biological and technical insights that will inform future genome-scale engineering.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"1911-1918"},"PeriodicalIF":41.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1038/s41587-025-02935-y
Mateo Aboy, Kathleen Liddell, Cristina Crespo, Matthew Jordan, Stuart Hogarth, John Powell
After two decades of sustained growth, cancer diagnostics patents peaked in 2020 and have since stabilized, with a broad set of public and private players driving innovation.
{"title":"Mapping the patent landscape of cancer diagnostics","authors":"Mateo Aboy, Kathleen Liddell, Cristina Crespo, Matthew Jordan, Stuart Hogarth, John Powell","doi":"10.1038/s41587-025-02935-y","DOIUrl":"10.1038/s41587-025-02935-y","url":null,"abstract":"After two decades of sustained growth, cancer diagnostics patents peaked in 2020 and have since stabilized, with a broad set of public and private players driving innovation.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"1921-1928"},"PeriodicalIF":41.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1038/s41587-025-02947-8
Zhicheng Lin
The right AI workflow can help you to read more widely and think more deeply — without sacrificing rigor.
正确的人工智能工作流程可以帮助你更广泛地阅读，更深入地思考，而不会牺牲严谨。
{"title":"FOCUS: an AI-assisted reading workflow for information overload","authors":"Zhicheng Lin","doi":"10.1038/s41587-025-02947-8","DOIUrl":"10.1038/s41587-025-02947-8","url":null,"abstract":"The right AI workflow can help you to read more widely and think more deeply — without sacrificing rigor.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"2070-2075"},"PeriodicalIF":41.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1038/s41587-025-02951-y
Michael Francisco
This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems facing our world.
{"title":"Five questions with Pranam Chatterjee","authors":"Michael Francisco","doi":"10.1038/s41587-025-02951-y","DOIUrl":"10.1038/s41587-025-02951-y","url":null,"abstract":"This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems facing our world.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"2076-2077"},"PeriodicalIF":41.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1038/s41587-025-02940-1
Recent patents relating to methods, devices and use of liquid biopsy.
最近的专利涉及液体活检的方法、设备和使用。
{"title":"Liquid biopsy","authors":"","doi":"10.1038/s41587-025-02940-1","DOIUrl":"10.1038/s41587-025-02940-1","url":null,"abstract":"Recent patents relating to methods, devices and use of liquid biopsy.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"1929-1929"},"PeriodicalIF":41.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1038/s41587-025-02966-5
Rong Li
{"title":"Metagenomic editing integrates large DNA sequences into gut bacteria in vivo","authors":"Rong Li","doi":"10.1038/s41587-025-02966-5","DOIUrl":"10.1038/s41587-025-02966-5","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"1930-1930"},"PeriodicalIF":41.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1038/s41587-025-02955-8
Andrew Marshall
In-body manufacturing promises a faster, cheaper and simpler alternative to CAR-T cell therapy — if the field can deliver clinical readouts that prove long-term safety and efficacy.
{"title":"In vivo CAR-Ts captivate big pharma","authors":"Andrew Marshall","doi":"10.1038/s41587-025-02955-8","DOIUrl":"10.1038/s41587-025-02955-8","url":null,"abstract":"In-body manufacturing promises a faster, cheaper and simpler alternative to CAR-T cell therapy — if the field can deliver clinical readouts that prove long-term safety and efficacy.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 12","pages":"1893-1896"},"PeriodicalIF":41.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145719868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：