Axel Josefsson, Magnus Simrén, Adam Smolak, Nour Sabbagh, Hans Törnblom
Esophagogastric junction outflow obstruction (EGJOO) is a condition characterized by poor relaxation of the lower esophageal sphincter (LES), which can manifest as dysphagia and chest pain. The best treatment of EGJOO is unknown as some patients improve without any specific therapy, whereas some patients undergo invasive therapy. Currently, prognostic factors are lacking. We aimed to assess the long-term prognosis and predictors of dysphagia and chest pain by the rapid drink challenge and solid bolus swallows in EGJOO.
{"title":"Natural history of symptoms and prognostic information of the rapid drink challenge and solid bolus swallows in esophagogastric junction outflow obstruction defined by manometry","authors":"Axel Josefsson, Magnus Simrén, Adam Smolak, Nour Sabbagh, Hans Törnblom","doi":"10.1111/nmo.14720","DOIUrl":"https://doi.org/10.1111/nmo.14720","url":null,"abstract":"Esophagogastric junction outflow obstruction (EGJOO) is a condition characterized by poor relaxation of the lower esophageal sphincter (LES), which can manifest as dysphagia and chest pain. The best treatment of EGJOO is unknown as some patients improve without any specific therapy, whereas some patients undergo invasive therapy. Currently, prognostic factors are lacking. We aimed to assess the long-term prognosis and predictors of dysphagia and chest pain by the rapid drink challenge and solid bolus swallows in EGJOO.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138575450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revati Varma, Jeffrey P. Staab, Eric T. Matey, Jessica A. Wright, Brototo Deb, Konstantinos N. Lazaridis, Lawrence A. Szarka, Kent R. Bailey, Adil E. Bharucha
How variations predicted by pharmacogenomic testing to alter drug metabolism and therapeutic response affect outcomes for patients with disorders of gut- brain interaction is unclear.
{"title":"Most patients with disorders of gut-brain interaction receive pharmacotherapy with major or moderate drug-gene interactions","authors":"Revati Varma, Jeffrey P. Staab, Eric T. Matey, Jessica A. Wright, Brototo Deb, Konstantinos N. Lazaridis, Lawrence A. Szarka, Kent R. Bailey, Adil E. Bharucha","doi":"10.1111/nmo.14722","DOIUrl":"https://doi.org/10.1111/nmo.14722","url":null,"abstract":"How variations predicted by pharmacogenomic testing to alter drug metabolism and therapeutic response affect outcomes for patients with disorders of gut- brain interaction is unclear.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"173 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138575158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarrah M. Dowrick, Lisa Jungbauer Nikolas, Sarah J. Offutt, Peter Tremain, Jonathan C. Erickson, Timothy R. Angeli-Gordon
Despite evidence that slow-wave dysrhythmia in the stomach is associated with clinical conditions such as gastroparesis and functional dyspepsia, there is still no widely available device for long-term monitoring of gastric electrical signals. Actionable biomarkers of gastrointestinal health are critically needed, and an implantable slow-wave monitoring device could aid in the establishment of causal relationships between symptoms and gastric electrophysiology. Recent developments in the area of wireless implantable gastric monitors demonstrate potential, but additional work and validation are required before this potential can be realized.
{"title":"Translation of an existing implantable cardiac monitoring device for measurement of gastric electrical slow-wave activity","authors":"Jarrah M. Dowrick, Lisa Jungbauer Nikolas, Sarah J. Offutt, Peter Tremain, Jonathan C. Erickson, Timothy R. Angeli-Gordon","doi":"10.1111/nmo.14723","DOIUrl":"https://doi.org/10.1111/nmo.14723","url":null,"abstract":"Despite evidence that slow-wave dysrhythmia in the stomach is associated with clinical conditions such as gastroparesis and functional dyspepsia, there is still no widely available device for long-term monitoring of gastric electrical signals. Actionable biomarkers of gastrointestinal health are critically needed, and an implantable slow-wave monitoring device could aid in the establishment of causal relationships between symptoms and gastric electrophysiology. Recent developments in the area of wireless implantable gastric monitors demonstrate potential, but additional work and validation are required before this potential can be realized.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138553995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erin Hollis, Helen Burton Murray, Henry P. Parkman
Patients with symptoms of gastroparesis (Gp) often reduce food intake in attempt to manage their symptoms. Up to 40% of adults with Gp have been reported to have symptoms of a non-body image-based eating disorder, avoidant/restrictive food intake disorder (ARFID). However, whether ARFID symptoms precede or follow the diagnosis of Gp is unknown.
有胃痉挛（Gp）症状的患者通常会减少食物摄入量，试图控制症状。据报道，多达 40% 的成人胃瘫患者有非身体形象性进食障碍的症状，即回避/限制性食物摄入障碍（ARFID）。然而，ARFID 症状是在 Gp 诊断之前还是之后出现尚不清楚。
{"title":"Relationships among symptoms of gastroparesis to those of avoidant/restrictive food intake disorder in patients with gastroparesis","authors":"Erin Hollis, Helen Burton Murray, Henry P. Parkman","doi":"10.1111/nmo.14725","DOIUrl":"https://doi.org/10.1111/nmo.14725","url":null,"abstract":"Patients with symptoms of gastroparesis (Gp) often reduce food intake in attempt to manage their symptoms. Up to 40% of adults with Gp have been reported to have symptoms of a non-body image-based eating disorder, avoidant/restrictive food intake disorder (ARFID). However, whether ARFID symptoms precede or follow the diagnosis of Gp is unknown.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138554067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate the mechanism of Lactobacillus rhamnosus GG (LGG)‐secreted protein, P75, on the regulation of the expression of serotonin transporter (SERT) through the epidermal growth factor receptor (EGFR) and nuclear factor‐κB (NF‐κB) pathway.
{"title":"The secreted protein P75 of Lactobacillus rhamnosus GG regulates the SERT expression via EGFR and NF‐κB pathway","authors":"Xin Wang, Ying Li, Jun-Jie Hou, Zelan Wang, Yiming Chen, Shuai Su, Xin Xu, J Zhang, Weilong Zhong, Bangmao Wang, Yuming Wang","doi":"10.1111/nmo.14437","DOIUrl":"https://doi.org/10.1111/nmo.14437","url":null,"abstract":"To investigate the mechanism of Lactobacillus rhamnosus GG (LGG)‐secreted protein, P75, on the regulation of the expression of serotonin transporter (SERT) through the epidermal growth factor receptor (EGFR) and nuclear factor‐κB (NF‐κB) pathway.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85270828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Wuestenberghs, M. Baron, C. Melchior, C. Desprez, J. Cornu, A. Leroi, G. Gourcerol
Functional dyspepsia and bladder pain syndrome are well‐known to overlap with irritable bowel syndrome. Whether functional dyspepsia overlaps with bladder pain syndrome remains unknown. Our aim was to evaluate the presence of bladder pain syndrome in functional dyspepsia patients and its impact.
{"title":"Overlaps with bladder pain syndrome and irritable bowel syndrome are associated with higher symptom burden and reduced quality of life in functional dyspepsia","authors":"F. Wuestenberghs, M. Baron, C. Melchior, C. Desprez, J. Cornu, A. Leroi, G. Gourcerol","doi":"10.1111/nmo.14414","DOIUrl":"https://doi.org/10.1111/nmo.14414","url":null,"abstract":"Functional dyspepsia and bladder pain syndrome are well‐known to overlap with irritable bowel syndrome. Whether functional dyspepsia overlaps with bladder pain syndrome remains unknown. Our aim was to evaluate the presence of bladder pain syndrome in functional dyspepsia patients and its impact.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81178506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Disorders of gut‐brain interaction (DGBI) are highly prevalent, estimated to affect about 40% of the global population. Patients with DGBI are still inadequately treated and face stigma which adversely impacts their disease course.
{"title":"Gastroenterology Trainees’ Attitudes and Knowledge towards Patients with Disorders of Gut‐Brain Interaction","authors":"Yuying Luo, R. Dixon, B. Shah, L. Keefer","doi":"10.1111/nmo.14410","DOIUrl":"https://doi.org/10.1111/nmo.14410","url":null,"abstract":"Disorders of gut‐brain interaction (DGBI) are highly prevalent, estimated to affect about 40% of the global population. Patients with DGBI are still inadequately treated and face stigma which adversely impacts their disease course.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89723153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Systemic sclerosis (SSc) is a chronic and generalized disease affecting the connective tissue of the skin and many internal organs, in particular the gastrointestinal tract. The esophagus is involved in up to 80% of the cases and represents a major cause of serious morbidities that deeply impact on the quality of life and survival of patients. Indeed, the presence of esophageal dysfunction is a good prognostic indicator in SSc, primarily due to its impact on pulmonary disease. Thus, the detection of esophageal motility alterations plays a critical role to prevent the development of both esophageal and pulmonary complications and to improve the survival of these patients. Currently, this diagnostic work‐up has been limited to the use of esophageal manometry, which is considered the gold standard for the evaluation of motor physiology and pathophysiology of this organ in different clinical situations. However, in recent years, new equipments such as high‐resolution (−impedance) manometry and functional luminal imaging probe have been developed and used in many esophageal clinical settings, including SSc. In this mini‐review, we summarize current evidence regarding esophageal dysmotility, in the light of new data on secondary peristalsis published in this issue of the journal.
{"title":"Towards a more precise classification of esophageal motility disorders in patients with systemic sclerosis","authors":"E. Marabotto, V. Savarino, E. Savarino","doi":"10.1111/nmo.14416","DOIUrl":"https://doi.org/10.1111/nmo.14416","url":null,"abstract":"Systemic sclerosis (SSc) is a chronic and generalized disease affecting the connective tissue of the skin and many internal organs, in particular the gastrointestinal tract. The esophagus is involved in up to 80% of the cases and represents a major cause of serious morbidities that deeply impact on the quality of life and survival of patients. Indeed, the presence of esophageal dysfunction is a good prognostic indicator in SSc, primarily due to its impact on pulmonary disease. Thus, the detection of esophageal motility alterations plays a critical role to prevent the development of both esophageal and pulmonary complications and to improve the survival of these patients. Currently, this diagnostic work‐up has been limited to the use of esophageal manometry, which is considered the gold standard for the evaluation of motor physiology and pathophysiology of this organ in different clinical situations. However, in recent years, new equipments such as high‐resolution (−impedance) manometry and functional luminal imaging probe have been developed and used in many esophageal clinical settings, including SSc. In this mini‐review, we summarize current evidence regarding esophageal dysmotility, in the light of new data on secondary peristalsis published in this issue of the journal.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75874539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We aimed to evaluate anorectal function of normal infants and children through three dimension high‐definition anorectal manometry (3D ARM) to fill the research blank in this area.
{"title":"Three dimension high‐definition manometry in evaluation of anorectal function in 104 normal infants and children: A clinical study from China","authors":"Jiawei Zhao, Yanan Zhang, Yuning Xiong, Jingbin Du, Yong-wei Chen, Wei-hong Guo, Jinshi Huang","doi":"10.1111/nmo.14395","DOIUrl":"https://doi.org/10.1111/nmo.14395","url":null,"abstract":"We aimed to evaluate anorectal function of normal infants and children through three dimension high‐definition anorectal manometry (3D ARM) to fill the research blank in this area.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"273 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91511380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To the editor; We are grateful to Trindade et al. 1 for their interest in our paper, which examined the factor structure of the visceral sensitivity index (VSI) among 811 individuals with Rome IV irritable bowel syndrome (IBS) from the UK.2 The VSI is a measure of gastrointestinal symptomspecific anxiety that had not been validated in the UK population. The original validation study from the USA reported an unifactorial structure,3 whereas our analysis identified three separate factors. Moreover, we found no evidence that VSI mediated the relationship between measures of generalized anxiety and symptom severity in IBS. In their analysis of 424 Swedish patients with IBS, Trindade et al. report a singlefactor structure in agreement with the original VSI study.1 They discuss that cultural and linguistic differences between studies may have influenced the responses to the VSI, but this seems unlikely. The original VSI was developed in English, and while differences in spelling and usage exist between the UK and the USA, there is nothing that should affect understanding of the VSI in the UK population. Whether Trindade et al. translated the VSI into Swedish is unclear. However, this is unlikely to explain the differences between their results and ours, given the similarity between their findings and those from the USA. The cultural concepts discussed in the VSI, such as eating out in restaurants, will be familiar to people from any Westernized society. Consequently, methodological differences between the studies are likely to be of greater relevance to understanding the contrasting results. The original validation study involved only 96 individuals who selfidentified with IBS, of whom 85% met Rome II criteria.3 We also recruited individuals who selfidentified with IBS, but our study cohort was much larger, and we only included those who met diagnostic criteria for IBS. Moreover, we defined IBS using the current Rome IV criteria.4 These are more specific for diagnosing IBS compared with previous iterations,5,6 but they also select for patients who have more severe symptoms and greater psychological comorbidity.7,8 This may explain why analysis of the VSI in our study yielded a different factor structure than was originally described. Trindade et al. recruited patients referred to a tertiary center among whom reporting gastrointestinal symptomspecific anxiety may conceivably be more homogeneous. Furthermore, it is unclear how they defined IBS in their study. Importantly, their results are not fully published, limiting comparison with our study; however, we agree that further work to validate and refine the VSI is warranted.
给编辑;我们感谢Trindade et al. 1对我们的论文感兴趣，该论文研究了来自英国的811例罗马IV型肠易激综合征(IBS)患者的内脏敏感性指数(VSI)的因子结构。VSI是胃肠道症状特异性焦虑的一种测量方法，尚未在英国人群中得到验证。来自美国的原始验证研究报告了一个单因素结构，而我们的分析确定了三个独立的因素。此外，我们没有发现VSI介导IBS中广泛性焦虑测量和症状严重程度之间的关系的证据。在他们对424名瑞典IBS患者的分析中，Trindade等人报告了与原始VSI研究一致的单因素结构他们讨论了研究之间的文化和语言差异可能影响了对VSI的反应，但这似乎不太可能。最初的VSI是在英语中开发的，虽然英国和美国之间存在拼写和用法的差异，但没有什么应该影响英国人口对VSI的理解。Trindade等人是否将VSI翻译成瑞典语尚不清楚。然而，考虑到他们的发现与美国的发现之间的相似性，这不大可能解释他们的结果与我们的结果之间的差异。在VSI中讨论的文化概念，比如在餐馆吃饭，对于来自任何西化社会的人来说都是熟悉的。因此，研究之间的方法差异可能对理解对比结果具有更大的相关性。最初的验证研究只涉及96名自认为患有肠易激综合征的个体，其中85%符合罗马II标准我们也招募了自认为患有肠易激综合征的人，但我们的研究队列要大得多，而且我们只包括那些符合肠易激综合征诊断标准的人。此外，我们使用当前的罗马IV标准定义肠易激综合征与之前的迭代相比，这些方法在诊断肠易激综合征方面更具体，但它们也会选择那些症状更严重、心理合并症更严重的患者。这也许可以解释为什么在我们的研究中对VSI的分析产生了不同于最初描述的因素结构。Trindade等人招募了转介到三级中心的患者，其中报告胃肠道症状特异性焦虑的患者可能更为均匀。此外，尚不清楚他们在研究中如何定义肠易激综合征。重要的是，他们的结果没有完全发表，限制了与我们研究的比较;然而，我们同意进一步验证和完善VSI的工作是有必要的。
{"title":"Letter in response to Black et al. (2020): Authors’ Reply","authors":"C. Black, A. Ford","doi":"10.1111/nmo.14388","DOIUrl":"https://doi.org/10.1111/nmo.14388","url":null,"abstract":"To the editor; We are grateful to Trindade et al. 1 for their interest in our paper, which examined the factor structure of the visceral sensitivity index (VSI) among 811 individuals with Rome IV irritable bowel syndrome (IBS) from the UK.2 The VSI is a measure of gastrointestinal symptomspecific anxiety that had not been validated in the UK population. The original validation study from the USA reported an unifactorial structure,3 whereas our analysis identified three separate factors. Moreover, we found no evidence that VSI mediated the relationship between measures of generalized anxiety and symptom severity in IBS. In their analysis of 424 Swedish patients with IBS, Trindade et al. report a singlefactor structure in agreement with the original VSI study.1 They discuss that cultural and linguistic differences between studies may have influenced the responses to the VSI, but this seems unlikely. The original VSI was developed in English, and while differences in spelling and usage exist between the UK and the USA, there is nothing that should affect understanding of the VSI in the UK population. Whether Trindade et al. translated the VSI into Swedish is unclear. However, this is unlikely to explain the differences between their results and ours, given the similarity between their findings and those from the USA. The cultural concepts discussed in the VSI, such as eating out in restaurants, will be familiar to people from any Westernized society. Consequently, methodological differences between the studies are likely to be of greater relevance to understanding the contrasting results. The original validation study involved only 96 individuals who selfidentified with IBS, of whom 85% met Rome II criteria.3 We also recruited individuals who selfidentified with IBS, but our study cohort was much larger, and we only included those who met diagnostic criteria for IBS. Moreover, we defined IBS using the current Rome IV criteria.4 These are more specific for diagnosing IBS compared with previous iterations,5,6 but they also select for patients who have more severe symptoms and greater psychological comorbidity.7,8 This may explain why analysis of the VSI in our study yielded a different factor structure than was originally described. Trindade et al. recruited patients referred to a tertiary center among whom reporting gastrointestinal symptomspecific anxiety may conceivably be more homogeneous. Furthermore, it is unclear how they defined IBS in their study. Importantly, their results are not fully published, limiting comparison with our study; however, we agree that further work to validate and refine the VSI is warranted.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85343174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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