I. Masuy, F. Carbone, L. Holvoet, A. Vandenberghe, T. Vanuytsel, J. Tack
Rikkunshito, a traditional Kampo medicine, has shown efficacy to treat functional dyspepsia (FD) in controlled trials in Japan. Its putative benefit for European patients and mechanism of action has not been established.
{"title":"The effect of rikkunshito on gastrointestinal symptoms and gastric motor function: The first study in a Belgian functional dyspepsia population","authors":"I. Masuy, F. Carbone, L. Holvoet, A. Vandenberghe, T. Vanuytsel, J. Tack","doi":"10.1111/nmo.13739","DOIUrl":"https://doi.org/10.1111/nmo.13739","url":null,"abstract":"Rikkunshito, a traditional Kampo medicine, has shown efficacy to treat functional dyspepsia (FD) in controlled trials in Japan. Its putative benefit for European patients and mechanism of action has not been established.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"57 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91451171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Sallam, P. Urvil, T. Savidge, Jiande D. Z. Chen
In severe burns, increased intestinal permeability facilitates bacterial translocation, resulting in systemic endotoxemia and multi‐organ failure. We investigated the role of burn‐induced gastrointestinal dysmotility (BIGD) in promoting bacterial translocation following burn injury, and the protective effect of ghrelin in this process.
{"title":"Ghrelin abates bacterial translocation following burn injury by improving gastric emptying","authors":"H. Sallam, P. Urvil, T. Savidge, Jiande D. Z. Chen","doi":"10.1111/nmo.13742","DOIUrl":"https://doi.org/10.1111/nmo.13742","url":null,"abstract":"In severe burns, increased intestinal permeability facilitates bacterial translocation, resulting in systemic endotoxemia and multi‐organ failure. We investigated the role of burn‐induced gastrointestinal dysmotility (BIGD) in promoting bacterial translocation following burn injury, and the protective effect of ghrelin in this process.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81092948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Nandhra, E. Mark, G. D. Di Tanna, A. Haase, J. Poulsen, S. Christodoulides, V. Kung, M. Klinge, K. Knudsen, P. Borghammer, Katrine O Andersen, L. Fynne, Nanna Sutter, V. Schlageter, K. Krogh, A. Drewes, M. Birch, S. Scott
The 3D‐Transit electromagnet tracking system (Motilis Medica, SA, Lausanne, Switzerland) is an emerging tool for the ambulatory assessment of gastrointestinal (GI) transit and motility. Using this tool, we aimed to derive normative values for region‐specific colonic and GI transit times and to assess the influence of age, gender, and body mass index (BMI).
3D - Transit电磁跟踪系统(Motilis Medica, SA，洛桑，瑞士)是一种用于胃肠(GI)运输和运动动态评估的新兴工具。使用该工具，我们旨在得出特定地区结肠和胃肠道运输时间的规范值，并评估年龄、性别和体重指数(BMI)的影响。
{"title":"Normative values for region‐specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D‐Transit electromagnet tracking system: Influence of age, gender, and body mass index","authors":"G. Nandhra, E. Mark, G. D. Di Tanna, A. Haase, J. Poulsen, S. Christodoulides, V. Kung, M. Klinge, K. Knudsen, P. Borghammer, Katrine O Andersen, L. Fynne, Nanna Sutter, V. Schlageter, K. Krogh, A. Drewes, M. Birch, S. Scott","doi":"10.1111/nmo.13734","DOIUrl":"https://doi.org/10.1111/nmo.13734","url":null,"abstract":"The 3D‐Transit electromagnet tracking system (Motilis Medica, SA, Lausanne, Switzerland) is an emerging tool for the ambulatory assessment of gastrointestinal (GI) transit and motility. Using this tool, we aimed to derive normative values for region‐specific colonic and GI transit times and to assess the influence of age, gender, and body mass index (BMI).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78436263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Basso, Mehdi Benamar, Xavier Mas-Orea, C. Deraison, C. Blanpied, N. Cenac, A. Saoudi, G. Dietrich
The opioid‐mediated analgesic activity of mucosal CD4+ T lymphocytes in colitis has been reported in immunocompetent mice so far. Here, we investigated whether CD4+ T lymphocytes alleviate from inflammation‐induced abdominal pain in mice with defective immune regulation.
{"title":"Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice","authors":"L. Basso, Mehdi Benamar, Xavier Mas-Orea, C. Deraison, C. Blanpied, N. Cenac, A. Saoudi, G. Dietrich","doi":"10.1111/nmo.13743","DOIUrl":"https://doi.org/10.1111/nmo.13743","url":null,"abstract":"The opioid‐mediated analgesic activity of mucosal CD4+ T lymphocytes in colitis has been reported in immunocompetent mice so far. Here, we investigated whether CD4+ T lymphocytes alleviate from inflammation‐induced abdominal pain in mice with defective immune regulation.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73697245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Funaki, N. Ogasawara, Yurika Kawamura, T. Yoshimine, Yasuhiro Tamura, S. Izawa, M. Ebi, M. Sasaki, K. Kasugai
Functional dyspepsia (FD) and non‐erosive reflux disease (NERD) are gastrointestinal disorders that often overlap. In this randomized, double‐blind, placebo‐controlled crossover study, the effects of adding acotiamide to treatment with proton pump inhibitors (PPI) were investigated in FD patients with heartburn who failed PPI treatment, corresponding to PPI‐resistant NERD.
{"title":"Effects of acotiamide on functional dyspepsia patients with heartburn who failed proton pump inhibitor treatment in Japanese patients: A randomized, double‐blind, placebo‐controlled crossover study","authors":"Y. Funaki, N. Ogasawara, Yurika Kawamura, T. Yoshimine, Yasuhiro Tamura, S. Izawa, M. Ebi, M. Sasaki, K. Kasugai","doi":"10.1111/nmo.13749","DOIUrl":"https://doi.org/10.1111/nmo.13749","url":null,"abstract":"Functional dyspepsia (FD) and non‐erosive reflux disease (NERD) are gastrointestinal disorders that often overlap. In this randomized, double‐blind, placebo‐controlled crossover study, the effects of adding acotiamide to treatment with proton pump inhibitors (PPI) were investigated in FD patients with heartburn who failed PPI treatment, corresponding to PPI‐resistant NERD.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84375880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anshuman C. Desai, P. Low, M. Camilleri, W. Singer, D. Burton, S. Chakraborty, A. Bharucha
The relationship between cardiovascular and gastrointestinal (ie, plasma pancreatic polypeptide [PP] response to modified sham feeding [MSF]) indices of vagal function is unclear. Hyperglycemia inhibits PP secretion via vagally mediated mechanisms. Our aims were to (a) compare the PP response, (b) its relationship with glycemia, and (c) the relationship between PP response to MSF, gastric emptying (GE) of solids, and symptoms during GE study in healthy controls, patients with diabetic gastroenteropathy (DM), and non‐ulcer dyspepsia (NUD).
{"title":"Utility of the plasma pancreatic polypeptide response to modified sham feeding in diabetic gastroenteropathy and non‐ulcer dyspepsia","authors":"Anshuman C. Desai, P. Low, M. Camilleri, W. Singer, D. Burton, S. Chakraborty, A. Bharucha","doi":"10.1111/nmo.13744","DOIUrl":"https://doi.org/10.1111/nmo.13744","url":null,"abstract":"The relationship between cardiovascular and gastrointestinal (ie, plasma pancreatic polypeptide [PP] response to modified sham feeding [MSF]) indices of vagal function is unclear. Hyperglycemia inhibits PP secretion via vagally mediated mechanisms. Our aims were to (a) compare the PP response, (b) its relationship with glycemia, and (c) the relationship between PP response to MSF, gastric emptying (GE) of solids, and symptoms during GE study in healthy controls, patients with diabetic gastroenteropathy (DM), and non‐ulcer dyspepsia (NUD).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80018844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Goelen, J. D. de Hoon, John F. Morales, C. Varon, S. Van Huffel, P. Augustijns, R. Mols, Marissa Herbots, K. Verbeke, T. Vanuytsel, J. Tack, P. Janssen
The use of opioids as analgesic is on the rise, despite their inhibitory effect on gastric emptying. A novel feeding catheter with integrated intragastric balloon was developed to continuously assess gastric motility, enabling to investigate the effect of opioids on motility and emptying simultaneously. We aimed to discriminate normal and pharmacologically impaired gastric motility and its impact on gastric emptying in healthy adults.
{"title":"Codeine delays gastric emptying through inhibition of gastric motility as assessed with a novel diagnostic intragastric balloon catheter","authors":"N. Goelen, J. D. de Hoon, John F. Morales, C. Varon, S. Van Huffel, P. Augustijns, R. Mols, Marissa Herbots, K. Verbeke, T. Vanuytsel, J. Tack, P. Janssen","doi":"10.1111/nmo.13733","DOIUrl":"https://doi.org/10.1111/nmo.13733","url":null,"abstract":"The use of opioids as analgesic is on the rise, despite their inhibitory effect on gastric emptying. A novel feeding catheter with integrated intragastric balloon was developed to continuously assess gastric motility, enabling to investigate the effect of opioids on motility and emptying simultaneously. We aimed to discriminate normal and pharmacologically impaired gastric motility and its impact on gastric emptying in healthy adults.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79136514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoshimasa Hoshikawa, K. Nikaki, S. Sonmez, K. Nakagawa, E. Yazaki, D. Sifrim, P. Woodland
Discontinuation of long‐term proton pump inhibitors (PPIs) on patients with reflux symptoms can be challenging, as symptoms often exacerbate after stopping. The mechanism remains unknown. Our aim was to evaluate the impact of stopping long‐term PPIs on patients with heartburn, and its association with esophageal acid exposure.
{"title":"Exacerbation of gastroesophageal reflux symptoms after discontinuation of proton pump inhibitors is not associated with increased esophageal acid exposure","authors":"Yoshimasa Hoshikawa, K. Nikaki, S. Sonmez, K. Nakagawa, E. Yazaki, D. Sifrim, P. Woodland","doi":"10.1111/nmo.13735","DOIUrl":"https://doi.org/10.1111/nmo.13735","url":null,"abstract":"Discontinuation of long‐term proton pump inhibitors (PPIs) on patients with reflux symptoms can be challenging, as symptoms often exacerbate after stopping. The mechanism remains unknown. Our aim was to evaluate the impact of stopping long‐term PPIs on patients with heartburn, and its association with esophageal acid exposure.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82456244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Geysen, E. Gielis, E. Deloose, T. Vanuytsel, J. Tack, J. Biesiekierski, A. Pauwels
Dietary measures are often advised to patients with gastro‐esophageal reflux disease (GERD). Fermentable Oligo‐, Di‐, Mono‐saccharides and Polyols (FODMAPs) induce lower gastrointestinal (GI) symptoms. However, their effects on esophageal motility, including transient lower esophageal sphincter relaxations (TLESRs), reflux events and GERD symptoms are unknown. We investigated the effect of acute administration of two FODMAPs, fructose, and fructans, on the number of TLESRs, reflux episodes and symptom perception in healthy volunteers (HVs).
{"title":"Acute administration of fructans increases the number of transient lower esophageal sphincter relaxations in healthy volunteers","authors":"H. Geysen, E. Gielis, E. Deloose, T. Vanuytsel, J. Tack, J. Biesiekierski, A. Pauwels","doi":"10.1111/nmo.13727","DOIUrl":"https://doi.org/10.1111/nmo.13727","url":null,"abstract":"Dietary measures are often advised to patients with gastro‐esophageal reflux disease (GERD). Fermentable Oligo‐, Di‐, Mono‐saccharides and Polyols (FODMAPs) induce lower gastrointestinal (GI) symptoms. However, their effects on esophageal motility, including transient lower esophageal sphincter relaxations (TLESRs), reflux events and GERD symptoms are unknown. We investigated the effect of acute administration of two FODMAPs, fructose, and fructans, on the number of TLESRs, reflux episodes and symptom perception in healthy volunteers (HVs).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74928733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yinglian Xiao, D. Carlson, Zhiyue Lin, J. Pandolfino
The contractile activity of Jackhammer esophagus(JE) is heterogeneous and abnormalities in the balance of pre‐ and post‐peak contractile activity has been reported. We observed that the progression of the peak contraction is disordered in JE patients, which reflect underlying abnormalities in the inhibitory and excitatory influence in esophageal contraction. In order to better define this abnormality, we developed novel time metrics to define trajectory of the pressure wave peak and assessed it in healthy controls and JE patients.
{"title":"Chaotic peak propagation in patients with Jackhammer esophagus","authors":"Yinglian Xiao, D. Carlson, Zhiyue Lin, J. Pandolfino","doi":"10.1111/nmo.13725","DOIUrl":"https://doi.org/10.1111/nmo.13725","url":null,"abstract":"The contractile activity of Jackhammer esophagus(JE) is heterogeneous and abnormalities in the balance of pre‐ and post‐peak contractile activity has been reported. We observed that the progression of the peak contraction is disordered in JE patients, which reflect underlying abnormalities in the inhibitory and excitatory influence in esophageal contraction. In order to better define this abnormality, we developed novel time metrics to define trajectory of the pressure wave peak and assessed it in healthy controls and JE patients.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75984374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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