Á. Priego-Ranero, G. Opdenakker, N. Uribe-Uribe, D. Aguilar-León, C. Nuñez-Alvarez, D. Hernández-Ramírez, E. Olivares-Martínez, E. Coss-Adame, M. Valdovinos, J. Furuzawa-Carballeda, G. Torres-Villalobos
Serum anti‐myenteric autoantibodies define autoimmune achalasia and tissue MMP‐9 activity may locally process autoantigenic proteins in the muscle of the lower esophageal sphincter (LES) of achalasia patients.
{"title":"Autoantigen characterization in the lower esophageal sphincter muscle of patients with achalasia","authors":"Á. Priego-Ranero, G. Opdenakker, N. Uribe-Uribe, D. Aguilar-León, C. Nuñez-Alvarez, D. Hernández-Ramírez, E. Olivares-Martínez, E. Coss-Adame, M. Valdovinos, J. Furuzawa-Carballeda, G. Torres-Villalobos","doi":"10.1111/nmo.14348","DOIUrl":"https://doi.org/10.1111/nmo.14348","url":null,"abstract":"Serum anti‐myenteric autoantibodies define autoimmune achalasia and tissue MMP‐9 activity may locally process autoantigenic proteins in the muscle of the lower esophageal sphincter (LES) of achalasia patients.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80305064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Memoriam: Sidney F. Phillips, MD","authors":"M. Camilleri, A. Bharucha, P. Kamath","doi":"10.1111/nmo.13801","DOIUrl":"https://doi.org/10.1111/nmo.13801","url":null,"abstract":"","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84369379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The vagus nerve is the tenth and longest of the cranial nerves, whose course runs from the brainstem to the splenic flexure. It is the main neural substrate of the parasympathetic nervous system and has both afferent and efferent pathways, although the former predominate (80%). An increasing body of evidence has demonstrated it has a central role in modulating gastrointestinal pain, inflammation, and motility. Within this issue of the Journal, Gottfried‐Blackmore and colleagues report the results from an open‐label pilot study examining the role of non‐invasive vagus nerve stimulation (VNS) in idiopathic gastroparesis. This mini review provides a contemporaneous summary of the current methods by which non‐invasive VNS can be achieved, its potential indications within the field particularly with respect to gastroparesis. In addition, this review also addresses some of the pitfalls and propose the outstanding questions which may inform and guide the future research agenda.
{"title":"Non‐inasive vagus nerve stimulation—Hope or hype?","authors":"A. Farmer","doi":"10.1111/nmo.13822","DOIUrl":"https://doi.org/10.1111/nmo.13822","url":null,"abstract":"The vagus nerve is the tenth and longest of the cranial nerves, whose course runs from the brainstem to the splenic flexure. It is the main neural substrate of the parasympathetic nervous system and has both afferent and efferent pathways, although the former predominate (80%). An increasing body of evidence has demonstrated it has a central role in modulating gastrointestinal pain, inflammation, and motility. Within this issue of the Journal, Gottfried‐Blackmore and colleagues report the results from an open‐label pilot study examining the role of non‐invasive vagus nerve stimulation (VNS) in idiopathic gastroparesis. This mini review provides a contemporaneous summary of the current methods by which non‐invasive VNS can be achieved, its potential indications within the field particularly with respect to gastroparesis. In addition, this review also addresses some of the pitfalls and propose the outstanding questions which may inform and guide the future research agenda.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90926170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ribolsi, C. Gyawali, E. Savarino, Benjamin D. Rogers, A. Rengarajan, M. Della Coletta, M. Ghisa, M. Cicala
Mean nocturnal baseline impedance (MNBI) augments the diagnostic yield of multichannel intraluminal impedance‐pH (MII‐pH) monitoring. While acid exposure time (AET) correlates with MNBI, it remains unclear whether esophageal motility affects MNBI values. The present study was aimed at evaluating the respective roles of esophageal motor function and AET on MNBI.
{"title":"Correlation between reflux burden, peristaltic function, and mucosal integrity in GERD patients","authors":"M. Ribolsi, C. Gyawali, E. Savarino, Benjamin D. Rogers, A. Rengarajan, M. Della Coletta, M. Ghisa, M. Cicala","doi":"10.1111/nmo.13752","DOIUrl":"https://doi.org/10.1111/nmo.13752","url":null,"abstract":"Mean nocturnal baseline impedance (MNBI) augments the diagnostic yield of multichannel intraluminal impedance‐pH (MII‐pH) monitoring. While acid exposure time (AET) correlates with MNBI, it remains unclear whether esophageal motility affects MNBI values. The present study was aimed at evaluating the respective roles of esophageal motor function and AET on MNBI.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91066322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caroline A Cobine, Karen I. Hannigan, Megan McMahon, Emer Ni Bhraonain, S. Baker, K. Keef
The internal anal sphincter (IAS) exhibits slow waves (SWs) and tone that are dependent upon L‐type Ca2+ channels (CavL) suggesting that phasic events (ie, SWs) play a fundamental role in tone generation. The present study further examined phasic activity in the IAS by measuring the spatiotemporal properties of Ca2+ transients (CTs) in IAS smooth muscle cells (SMCs).
{"title":"Rhythmic calcium transients in smooth muscle cells of the mouse internal anal sphincter","authors":"Caroline A Cobine, Karen I. Hannigan, Megan McMahon, Emer Ni Bhraonain, S. Baker, K. Keef","doi":"10.1111/nmo.13746","DOIUrl":"https://doi.org/10.1111/nmo.13746","url":null,"abstract":"The internal anal sphincter (IAS) exhibits slow waves (SWs) and tone that are dependent upon L‐type Ca2+ channels (CavL) suggesting that phasic events (ie, SWs) play a fundamental role in tone generation. The present study further examined phasic activity in the IAS by measuring the spatiotemporal properties of Ca2+ transients (CTs) in IAS smooth muscle cells (SMCs).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"287 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77619898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures.
{"title":"Childhood gastroparesis is a unique entity in need of further investigation","authors":"Liz Febo-Rodriguez, B. Chumpitazi, R. Shulman","doi":"10.1111/nmo.13699","DOIUrl":"https://doi.org/10.1111/nmo.13699","url":null,"abstract":"Despite increasing knowledge regarding gastroparesis (GP) in adults, little is known regarding the incidence, prevalence, and natural history of childhood GP. Exacerbating the knowledge gap in pediatric GP is both the lack of normative data for gastric emptying scintigraphy in children and lack of GP‐specific pediatric reported outcome measures.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87748635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlo G Riva, S. Siboni, M. Sozzi, Veronica Lazzari, E. Asti, L. Bonavina
Magnetic sphincter augmentation with the Linx® system is a novel laparoscopic procedure for the treatment of gastro‐esophageal reflux disease (GERD). Only few data are available regarding the impact of Linx on high‐resolution manometry (HRM) variables.
{"title":"High‐resolution manometry findings after Linx procedure for gastro‐esophageal reflux disease","authors":"Carlo G Riva, S. Siboni, M. Sozzi, Veronica Lazzari, E. Asti, L. Bonavina","doi":"10.1111/nmo.13750","DOIUrl":"https://doi.org/10.1111/nmo.13750","url":null,"abstract":"Magnetic sphincter augmentation with the Linx® system is a novel laparoscopic procedure for the treatment of gastro‐esophageal reflux disease (GERD). Only few data are available regarding the impact of Linx on high‐resolution manometry (HRM) variables.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77622979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We previously reported that early life stress (ELS) dysregulated glucocorticoid receptor (GR) and corticotrophin‐releasing hormone (CRH) expression in the central nucleus of the amygdala (CeA). Epigenetic modifications serve as memories of adverse events that occurred during early life. Therefore, we hypothesized that epigenetic mechanisms alter GR and CRH expression in the CeA and underlie chronic visceral pain after ELS.
{"title":"Sex differences in the epigenetic regulation of chronic visceral pain following unpredictable early life stress","authors":"T. Louwies, B. Greenwood-Van Meerveld","doi":"10.1111/nmo.13751","DOIUrl":"https://doi.org/10.1111/nmo.13751","url":null,"abstract":"We previously reported that early life stress (ELS) dysregulated glucocorticoid receptor (GR) and corticotrophin‐releasing hormone (CRH) expression in the central nucleus of the amygdala (CeA). Epigenetic modifications serve as memories of adverse events that occurred during early life. Therefore, we hypothesized that epigenetic mechanisms alter GR and CRH expression in the CeA and underlie chronic visceral pain after ELS.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73356337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Zhang, Xiaxin Wu, Shuang Li, Jin-Feng Wu, Sen Han, Zhijie Lin, Shizhen Ding, Weijuan Gong
Low‐grade inflammation occurs in some patients with irritable bowel syndrome (IBS). However, the exact inflammatory markers of IBS and the relationship of these markers with IBS subtypes and symptoms are poorly defined. Peroxiredoxin 1 (PRDX1) plays an important role in inflammatory responses, including intestinal inflammation. We investigated whether PRDX1 is associated with the diagnosis, subtypes, and symptom severity of IBS.
{"title":"Peroxiredoxin 1 as an inflammatory marker in diarrhea‐predominant and postinfectious irritable bowel syndrome","authors":"Yu Zhang, Xiaxin Wu, Shuang Li, Jin-Feng Wu, Sen Han, Zhijie Lin, Shizhen Ding, Weijuan Gong","doi":"10.1111/nmo.13741","DOIUrl":"https://doi.org/10.1111/nmo.13741","url":null,"abstract":"Low‐grade inflammation occurs in some patients with irritable bowel syndrome (IBS). However, the exact inflammatory markers of IBS and the relationship of these markers with IBS subtypes and symptoms are poorly defined. Peroxiredoxin 1 (PRDX1) plays an important role in inflammatory responses, including intestinal inflammation. We investigated whether PRDX1 is associated with the diagnosis, subtypes, and symptom severity of IBS.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88562351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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