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Effects of campus dining sustainable practices on consumers' perception and behavioral intention in the United States. 美国校园餐饮可持续实践对消费者感知和行为意向的影响。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-07-17 DOI: 10.4162/nrp.2023.17.5.1019
Borham Yoon, Kyungyul Jun

Background/objectives: Sustainability has become one of the top priorities in the foodservice industry. With an increase in consumer interest in sustainability and educational opportunities in higher education, it is important to know what sustainable practices are implemented in campus dining and how sustainable practices affect consumers' responses. This study aims to identify the key sustainable practices in the campus dining context, and investigate the relationship by applying the stimulus-organism-response framework to determine whether the key sustainable practices influence consumers' perception and behavioral intentions.

Subjects/methods: The self-administered online survey was distributed to college students in 8 dining halls at a large southeastern university in the United States from September 20-October 10, 2019. A total of 382 valid questionnaires were collected, and factor analysis and multiple regressions were utilized to test the research model.

Results: This study identified 4 dimensions of campus sustainability with a total of sustainable practices: sustainable food, waste management, energy/water conservation, and recycling/reuse. Three dimensions of sustainable campus practices (i.e., sustainable food, waste management, recycling/reuse) played a significant role in consumers forming a perceived value while energy/water conservation did not significantly influence the consumers' perceived value toward the campus dining. Waste management was identified as the most important practice to enhance consumers' perceived value (β = 0.330). Using sustainable food and recycling/reuse were ranked second and third, respectively (β = 0.262, β = 0.154). The findings confirmed the significant positive relationship between perceived value and revisit intentions.

Conclusions: The findings support the inclusion of dining sustainability as a critical component in explaining college students' perceived value and revisit intention toward campus dining. Furthermore, this study provides practical implications for university administrators and foodservice operators to consider the key sustainable practices to meet the consumers' value and revisit intentions.

背景/目标:可持续发展已成为餐饮业的首要任务之一。随着消费者对可持续性的兴趣和高等教育机会的增加,了解校园餐饮中实施了哪些可持续做法以及可持续做法如何影响消费者的反应是很重要的。本研究旨在确定校园餐饮环境中的关键可持续实践,并通过应用刺激-有机体反应框架来调查两者之间的关系,以确定关键可持续实践是否影响消费者的感知和行为意图。主题/方法:这项自行管理的在线调查于2019年9月20日至10月10日在美国东南部一所大型大学的8个餐厅向大学生分发。共收集382份有效问卷,采用因子分析和多元回归对研究模型进行检验。结果:这项研究确定了校园可持续性的4个维度,共有可持续实践:可持续食品、废物管理、能源/水资源保护和回收/再利用。可持续校园实践的三个维度(即可持续食品、废物管理、回收/再利用)在消费者形成感知价值方面发挥了重要作用,而节能/节水并没有显著影响消费者对校园餐饮的感知价值。废物管理被认为是提高消费者感知价值的最重要实践(β=0.330)。使用可持续食品和回收/再利用分别排名第二和第三(β=0.262,β=0.154)。研究结果证实了感知价值与重访意愿之间的显著正相关。结论:研究结果支持将餐饮可持续性作为解释大学生对校园餐饮的感知价值和重新审视意图的关键组成部分。此外,本研究为大学管理人员和餐饮服务运营商考虑关键的可持续做法以满足消费者的价值并重新审视其意图提供了实际启示。
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引用次数: 0
Associations of dietary vitamin A and C intake with asthma, allergic rhinitis, and allergic respiratory diseases. 饮食中维生素A和C的摄入与哮喘、过敏性鼻炎和过敏性呼吸道疾病的关系。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-08-21 DOI: 10.4162/nrp.2023.17.5.997
Carolina García-García, Minju Kim, Inkyung Baik

Background/objectives: Asthma and allergic rhinitis (AR) are closely related and considered as allergic respiratory diseases (ARD), and their prevalence has recently increased. Data on the association of dietary antioxidant vitamin intake with asthma and AR in adults are limited. The present study aimed to investigate the associations of vitamin A and C intake with asthma, AR, and all cases of both diseases in young adults who participated in a cross-sectional national survey, with the use of high-sensitivity C-reactive protein (hs-CRP) level as an effect modifier.

Subjects/methods: This study included 6,293 male and female adults aged 20-49 years from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted between 2016 and 2018. The questionnaire-based reports on asthma and AR diagnosis were used to determine outcome variables. Further, 24-h recall data on dietary vitamin A and C, carotene, and retinol intake were acquired. Logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence interval (CI).

Results: Dietary vitamin C intake was inversely associated with asthma prevalence among participants with hs-CRP levels (≥ 1 mg/L); the OR of asthma prevalence was 0.27 (95% CI, 0.08-0.84) for participants with vitamin C consumption ≥ 75 mg/day compared with those consuming < 20 mg/day. Similar association analyses limiting to non-users of dietary supplements were performed to rule out the potential effects of supplement intake on the outcomes; results showed a stronger association. However, the association between vitamin C and asthma was not significant in participants with hs-CRP levels < 1 mg/L; the OR of asthma was 1.44 (95% CI, 0.66-3.16) for participants with vitamin C consumption ≥ 75 mg/day compared with those consuming < 20 mg/day. Vitamin C intake was not associated with AR. Moreover, there was no association between vitamin A intake and neither asthma nor AR.

Conclusions: These findings suggest that higher vitamin C intake may play a potential role in reducing asthma prevalence. Nevertheless, further studies should be conducted to evaluate whether this association is causal.

背景/目的:哮喘和过敏性鼻炎(AR)密切相关,被认为是过敏性呼吸道疾病(ARD),其发病率最近有所上升。关于成人饮食中抗氧化剂维生素摄入与哮喘和AR之间关系的数据有限。本研究旨在调查参与横断面全国调查的年轻人中维生素A和C的摄入与哮喘、AR以及这两种疾病的所有病例的关系,并使用高敏C反应蛋白(hs-CRP)水平作为效果调节剂。受试者/方法:本研究纳入了6293名20-49岁的男性和女性成年人,他们来自2016年至2018年间进行的韩国国家健康和营养检查调查(KNHANES)。使用基于哮喘和AR诊断的问卷调查报告来确定结果变量。此外,还获得了膳食维生素A和C、胡萝卜素和视黄醇摄入量的24小时回忆数据。结果:在hs-CRP水平(≥1mg/L)的参与者中,膳食维生素C摄入量与哮喘患病率呈负相关;维生素C摄入量≥75mg/天的参与者与摄入量<20mg/天的参与者相比,哮喘患病率的OR为0.27(95%CI,0.08-0.84)。进行了类似的关联分析,仅限于非膳食补充剂使用者,以排除补充剂摄入对结果的潜在影响;结果显示出更强的关联性。然而,在hs-CRP水平<1 mg/L的参与者中,维生素C与哮喘之间的相关性并不显著;维生素C摄入量≥75mg/天的参与者与摄入量<20mg/天的参与者相比,哮喘的OR为1.44(95%CI,0.66-3.16)。维生素C摄入与AR无关。此外,维生素A摄入与哮喘和AR之间也没有关联。结论:这些发现表明,较高的维生素C摄入可能在降低哮喘患病率方面发挥潜在作用。然而,应该进行进一步的研究来评估这种关联是否是因果关系。
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引用次数: 0
Association between plant protein intake and grip strength in Koreans aged 50 years or older: Korea National Health and Nutrition Examination Survey 2016-2018. 50岁及以上韩国人的植物蛋白摄入量与握力之间的关系:2016-2018年韩国国家健康和营养检查调查。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-07-12 DOI: 10.4162/nrp.2023.17.5.969
Sook-Hyun Jun, Jung Woo Lee, Woo-Kyoung Shin, Seung-Yeon Lee, Yookyung Kim

Background/objectives: We investigated the association of plant and animal protein intake with grip strength in Koreans aged ≥ 50 yrs.

Subjects/methods: The data was collected from 3,610 men and 4,691 women (≥ 50 yrs) from the 2016-2018 Korea National Health and Nutrition Examination Survey. We calculated the total energy intake, and the intake of animal and plant protein and collected dietary data using 1-day 24-h dietary recalls. Low grip strength (LGS) was defined as the lowest quintile (men: up to 26.8 kg, women: up to 15.7 kg). The association of protein intake with grip strength was examined using Pearson's correlation and multiple linear regression analysis.

Results: The results proved that participants with LGS had lower daily energy, protein and fat intake, and percent energy from protein than those with normal or high grip strength (P < 0.0001). Total energy intake, animal protein, and plant protein were positively associated with grip strength. A higher intake of total plant protein (P for trend = 0.004 for men, 0.05 for women) and legumes, nuts, and seeds (LNS) protein (P for trend = 0.01 for men, 0.02 for women) was significantly associated with a lower prevalence of LGS. However, non-LNS plant protein intake was not associated with LGS (P for trend = 0.10 for men, 0.15 for women). In women, a higher total animal protein intake was significantly associated with decreased LGS (P for trend = 0.03).

Conclusions: Higher total plant protein and LNS protein intake are negatively associated with LGS.

背景/目的:我们调查了年龄≥50岁的韩国人的植物和动物蛋白质摄入量与握力的关系。受试者/方法:数据来自2016-2018年韩国国家健康和营养检查调查的3610名男性和4691名女性(≥50岁)。我们计算了总能量摄入以及动物和植物蛋白质的摄入,并使用1天24小时的饮食回忆收集了饮食数据。低握力(LGS)被定义为最低的五分之一(男性:高达26.8公斤,女性:高达15.7公斤)。蛋白质摄入量与握力的关系采用Pearson相关和多元线性回归分析进行检验。结果:与握力正常或高的参与者相比,LGS参与者的每日能量、蛋白质和脂肪摄入量以及蛋白质能量百分比较低(P<0.0001)。总能量摄入、动物蛋白和植物蛋白与握力呈正相关。植物总蛋白(男性趋势P=0.004,女性趋势0.05)和豆类、坚果和种子(LNS)蛋白的摄入量较高(男性趋势=0.01,女性趋势0.02)与LGS患病率较低显著相关。然而,非LNS植物蛋白摄入与LGS无关(男性趋势P=0.10,女性趋势P=0.15)。在女性中,较高的动物总蛋白摄入量与LGS降低显著相关(趋势P=0.03)。结论:较高的植物总蛋白和LNS蛋白摄入量与LGAS呈负相关。
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引用次数: 0
Gender differences in the association between food costs and obesity in Korean adults: an analysis of a population-based cohort. 韩国成年人食物成本与肥胖相关性的性别差异:基于人群的队列分析。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-08-22 DOI: 10.4162/nrp.2023.17.5.984
Soim Park, Jihye Kim

Background/objectives: Prior studies, mostly conducted in Western countries, have suggested that the low cost of energy-dense foods is associated with an increased risk of obesity. This study aimed to investigate the association between food costs and obesity risk among Koreans who may have different food cost and dietary patterns than those of Western populations.

Subjects/methods: We used baseline data from a cohort of 45,193 men and 83,172 women aged 40-79 years (in 2006-2013). Dietary intake information was collected using a validated food frequency questionnaire. Prudent and Western dietary patterns extracted via principal component analysis. Food cost was calculated based on Korean government data and market prices. Logistic regression analyses were performed to investigate the association of daily total, prudent, and Western food cost per calorie with obesity.

Results: Men in the highest total food cost quintile had 15% higher odds of obesity, after adjusting for demographic characteristics and lifestyle factors (adjusted odds ratio, 1.15; 95% confidence interval, 1.08-1.22; P-trend < 0.001); however, this association was not clear in women (P-trend = 0.765). While both men and women showed positive associations between prudent food cost and obesity (P-trends < 0.001), the association between Western food cost and obesity was only significant in men (P-trend < 0.001).

Conclusions: In countries in which consumption of Western foods is associated with higher food costs, higher food costs are associated with an increased risk of obesity; however, this association differs between men and women.

背景/目的:先前的研究大多在西方国家进行,表明高能量食品的低成本与肥胖风险增加有关。这项研究旨在调查韩国人的食物成本与肥胖风险之间的关系,这些人的食物成本和饮食模式可能与西方人群不同。受试者/方法:我们使用了年龄在40-79岁(2006-2013年)的45193名男性和83172名女性的基线数据。饮食摄入信息是使用经过验证的食物频率问卷收集的。通过主成分分析提取的谨慎和西方饮食模式。食品成本是根据韩国政府数据和市场价格计算的。进行Logistic回归分析,以调查每日总热量、谨慎热量和每卡路里西餐成本与肥胖的关系。结果:在对人口统计学特征和生活方式因素进行调整后,总食物成本最高的五分之一人群中的男性肥胖几率高出15%(调整后的比值比为1.15;95%置信区间为1.08-1.22;P趋势<0.001);然而,这种关联在女性中并不明显(P趋势=0.765)。虽然男性和女性都表现出谨慎的食物成本与肥胖之间的正相关(P趋势<0.001),但西餐成本与肥胖的关联仅在男性中显著(P趋势P<0.001)。结论:在西餐消费与较高食物成本相关的国家,较高的食品成本与肥胖风险的增加有关;然而,这种联系在男性和女性之间是不同的。
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引用次数: 0
Protective effect of Lycium barbarum leaf extracts on atopic dermatitis: in vitro and in vivo studies. 枸杞叶提取物对特应性皮炎的保护作用:体外和体内研究。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-07-11 DOI: 10.4162/nrp.2023.17.5.855
Han Sol Lee, Eun Young Bae, Sun Yung Ly

Background/objectives: Atopic dermatitis (AD) is a chronic disease with an increasing incidence globally; therefore, there is a growing demand for natural compounds effective in treating dermatitis. In this study, the protective effects of Lycium barbarum leaves with and without chlorophyll (LLE and LLE[Ch-]) on AD were investigated in animal models of AD and HaCaT cells. Further, we investigated whether LLE and LLE(Ch-) show any differences in physiological activity.

Materials/methods: AD was induced by 2,4-dinitrochlorobenzene (DNCB) for three weeks, while NC/Nga mice were fed LLE or LLE(Ch-) extracts for 7 weeks. Serum immunoglobulin E (IgE) and cytokine (tumor necrosis factor [TNF]-α, interleukin [IL]-6, and IL-4) concentrations and the degree of DNA fragmentation in lymphocytes were examined. A histopathological examination (haematoxylin & eosin staining and blue spots of toluidine) of the dorsal skin of mice was performed. To elucidate the mechanism of action, the expression of the thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) were measured in HaCaT cells.

Results: Serum IgE and cytokines (TNF-α and IL-6) levels as well as DNA fragmentation of lymphocytes were significantly decreased in AD-induced mice treated with LLE or LLE(Ch-) compared to those of the control group. The epidermal thickness of the dorsal skin and mast cell infiltration in the LLE group significantly reduced compared to that in the control group. The LLE extracts showed no cytotoxicity up to 1,000 µg/mL in HaCaT cells. LLE or LLE(Ch-)-treated group showed a reduction of TARC and MDC in TNF-α-and IFN-γ-stimulated HaCaT cells.

Conclusions: These results suggest that LLE potentially improves inflammation by reducing the expression of chemokines that inhibit T helper 2 cell migration. LLE(Ch-) showed similar effects to LLE on blood levels of IgE, TNF-α and IL-6 and protein expression in HaCat cells, but the ultimate effect of skin improvement was not statistically significant. Therefore, both LLE and LLE(Ch-) can be used as functional materials to alleviate AD, but LLE(Ch-) appears to require more research to improve inflammation.

背景/目的:特应性皮炎(AD)是一种在全球发病率不断上升的慢性疾病;因此,对治疗皮炎有效的天然化合物的需求越来越大。在本研究中,在AD和HaCaT细胞的动物模型中研究了含有和不含有叶绿素(LLE和LLE[Ch-])的枸杞叶对AD的保护作用。此外,我们还研究了LLE和LLE(Ch-)在生理活性方面是否存在任何差异。材料/方法:2,4-二硝基氯苯(DNCB)诱导AD 3周,同时给予NC/Nga小鼠LLE或LLE(Ch-)提取物7周。检测血清免疫球蛋白E(IgE)和细胞因子(肿瘤坏死因子[TNF]-α、白细胞介素[IL]-6和IL-4)的浓度以及淋巴细胞中DNA断裂的程度。对小鼠背部皮肤进行组织病理学检查(苏木精和伊红染色和甲苯胺蓝斑)。为了阐明其作用机制,测定了HaCaT细胞中胸腺和活化调节趋化因子(TARC)以及巨噬细胞衍生趋化因子的表达。结果:与对照组相比,LLE或LLE(Ch-)治疗的AD诱导小鼠血清IgE和细胞因子(TNF-α和IL-6)水平以及淋巴细胞DNA断裂显著降低。LLE组的背侧皮肤表皮厚度和肥大细胞浸润与对照组相比显著减少。LLE提取物在HaCaT细胞中显示出高达1000µg/mL的细胞毒性。LLE或LLE(Ch-)处理组显示TNF-α和IFN-γ刺激的HaCaT细胞的TARC和MDC降低。结论:这些结果表明,LLE可能通过减少抑制T辅助细胞2迁移的趋化因子的表达来改善炎症。LLE(Ch-)对血液中IgE、TNF-α和IL-6水平以及HaCat细胞中蛋白质表达的影响与LLE相似,但皮肤改善的最终效果没有统计学意义。因此,LLE和LLE(Ch-)都可以作为减轻AD的功能材料,但LLE(Ch-)似乎需要更多的研究来改善炎症。
{"title":"Protective effect of <i>Lycium barbarum</i> leaf extracts on atopic dermatitis: <i>in vitro</i> and <i>in vivo</i> studies.","authors":"Han Sol Lee,&nbsp;Eun Young Bae,&nbsp;Sun Yung Ly","doi":"10.4162/nrp.2023.17.5.855","DOIUrl":"https://doi.org/10.4162/nrp.2023.17.5.855","url":null,"abstract":"<p><strong>Background/objectives: </strong>Atopic dermatitis (AD) is a chronic disease with an increasing incidence globally; therefore, there is a growing demand for natural compounds effective in treating dermatitis. In this study, the protective effects of <i>Lycium barbarum</i> leaves with and without chlorophyll (LLE and LLE[Ch-]) on AD were investigated in animal models of AD and HaCaT cells. Further, we investigated whether LLE and LLE(Ch-) show any differences in physiological activity.</p><p><strong>Materials/methods: </strong>AD was induced by 2,4-dinitrochlorobenzene (DNCB) for three weeks, while NC/Nga mice were fed LLE or LLE(Ch-) extracts for 7 weeks. Serum immunoglobulin E (IgE) and cytokine (tumor necrosis factor [TNF]-α, interleukin [IL]-6, and IL-4) concentrations and the degree of DNA fragmentation in lymphocytes were examined. A histopathological examination (haematoxylin & eosin staining and blue spots of toluidine) of the dorsal skin of mice was performed. To elucidate the mechanism of action, the expression of the thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) were measured in HaCaT cells.</p><p><strong>Results: </strong>Serum IgE and cytokines (TNF-α and IL-6) levels as well as DNA fragmentation of lymphocytes were significantly decreased in AD-induced mice treated with LLE or LLE(Ch-) compared to those of the control group. The epidermal thickness of the dorsal skin and mast cell infiltration in the LLE group significantly reduced compared to that in the control group. The LLE extracts showed no cytotoxicity up to 1,000 µg/mL in HaCaT cells. LLE or LLE(Ch-)-treated group showed a reduction of TARC and MDC in TNF-α-and IFN-γ-stimulated HaCaT cells.</p><p><strong>Conclusions: </strong>These results suggest that LLE potentially improves inflammation by reducing the expression of chemokines that inhibit T helper 2 cell migration. LLE(Ch-) showed similar effects to LLE on blood levels of IgE, TNF-α and IL-6 and protein expression in HaCat cells, but the ultimate effect of skin improvement was not statistically significant. Therefore, both LLE and LLE(Ch-) can be used as functional materials to alleviate AD, but LLE(Ch-) appears to require more research to improve inflammation.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"17 5","pages":"855-869"},"PeriodicalIF":2.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/f8/nrp-17-855.PMC10522814.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Newly developed care food enhances grip strength in older adults with dysphagia: a preliminary study. 一项初步研究表明,新开发的护理食品可增强老年吞咽困难患者的握力。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-07-18 DOI: 10.4162/nrp.2023.17.5.934
Hyejin Han, Yoonhee Park, Hyeji Kwon, Yeseung Jeong, Soyoung Joo, Mi Sook Cho, Ju Yeon Park, Hee-Won Jung, Yuri Kim

Background/objectives: Maintaining total muscle mass in the older adults with swallowing difficulty (dysphagia) is important for preserving swallowing function. Increasing protein intake can help sustain lean body mass in the older adults. The aim of this study was to evaluate the effect of various high-protein texture-modified foods (HPTMFs) on muscle mass and perform dietary assessment in ≥ 65-yrs-old patients with dysphagia.

Subjects/methods: Participants (n = 10) received the newly developed HPTMFs (average 595.23 ± 66.75 kcal/day of energy, 54.22 ± 6.32 g/day of protein) for 10 days. Relative hand-grip strength (RHS), mid-upper arm circumference (MUAC), body composition, mini nutritional assessment (MNA), mini dietary assessment (MDA), and Euro Quality-of-Life questionnaire 5-dimensional classification (EQ-5D) were assessed.

Results: After 10 days, an increase in MUAC (26.36 ± 2.35 cm to 28.50 ± 3.17 cm, P = 0.013) and RHS (0.38 ± 0.24 kg/kg body weight to 0.42 ± 0.22 kg/kg body weight, P = 0.046) was observed. Although MNA, MDA, EQ-5D, subjective health status, muscle mass, and calf circumference showed a tendency to increase after intervention, no significant differences were found.

Conclusions: These results suggest that the HPTMFs can be used for improving the nutritional and health status in patients with dysphagia.

背景/目的:在有吞咽困难(吞咽困难)的老年人中,保持总肌肉质量对保持吞咽功能很重要。增加蛋白质摄入有助于维持老年人的瘦体重。本研究的目的是评估各种高蛋白质地修饰食品(HPTMF)对≥65岁吞咽困难患者肌肉质量的影响,并对其进行饮食评估。受试者/方法:受试者(n=10)接受新开发的HPTMF(平均能量595.23±66.75 kcal/天,蛋白质54.22±6.32 g/天)治疗10天。评估相对握力(RHS)、中上臂围(MUAC)、身体成分、迷你营养评估(MNA)、迷你饮食评估(MDA)和欧洲生活质量问卷5维分类(EQ-5D)。结果:10天后,观察到MUAC(26.36±2.35 cm至28.50±3.17 cm,P=0.013)和RHS(0.38±0.24 kg/kg体重至0.42±0.22 kg/公斤体重,P=0.046)增加。尽管干预后MNA、MDA、EQ-5D、主观健康状况、肌肉质量和小腿周长有增加的趋势,但没有发现显著差异。结论:HPTMFs可用于改善吞咽困难患者的营养和健康状况。
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引用次数: 0
Effects of Pogonatherum paniceum (Lamk) Hack extract on anti-mitochondrial DNA mediated inflammation by attenuating Tlr9 expression in LPS-induced macrophages. 穗黄精提取物通过减弱LPS诱导的巨噬细胞中Tlr9的表达对抗线粒体DNA介导的炎症的影响。
IF 2 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-05-26 DOI: 10.4162/nrp.2023.17.5.827
Rungthip Thongboontho, Kanoktip Petcharat, Narongsuk Munkong, Chakkraphong Khonthun, Atirada Boondech, Kanokkarn Phromnoi, Arthid Thim-Uam

Background/objectives: Mitochondrial DNA leakage leads to inflammatory responses via endosome activation. This study aims to evaluate whether the perennial grass water extract (Pogonatherum panicum) ameliorate mitochondrial DNA (mtDNA) leakage.

Materials/methods: The major bioactive constituents of P. paniceum (PPW) were investigated by high-performance liquid chromatography, after which their antioxidant activities were assessed. In addition, RAW 264.7 macrophages were stimulated with lipopolysaccharide, resulting in mitochondrial damage. Quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to examine the gene expression and cytokines.

Results: Our results showed that PPW extract-treated activated cells significantly decrease reactive oxygen species and nitric oxide levels by reducing the p22phox and iNOS expression and lowering cytokine-encoding genes, including IL-6, TNF-α, IL-1β, PG-E2 and IFN-γ relative to the lipopolysaccharide (LPS)-activated macrophages. Furthermore, we observed that LPS enhanced the mtDNA leaked into the cytoplasm, increasing the transcription of Tlr9 and signaling both MyD88/Irf7-dependent interferon and MyD88/NF-κb p65-dependent inflammatory cytokine mRNA expression but which was alleviated in the presence of PPW extract.

Conclusions: Our data show that PPW extract has antioxidant and anti-inflammatory activities by facilitating mtDNA leakage and lowering the Tlr9 expression and signaling activation.

背景/目的:线粒体DNA泄漏通过内体激活导致炎症反应。本研究旨在评估多年生草水提取物(Pogonatherum panicum)是否改善线粒体DNA(mtDNA)泄漏。材料/方法:采用高效液相色谱法对大白菜的主要生物活性成分进行了研究,并对其抗氧化活性进行了评价。此外,脂多糖刺激RAW 264.7巨噬细胞,导致线粒体损伤。采用定量聚合酶链式反应和酶联免疫吸附试验检测基因表达和细胞因子。结果:与脂多糖(LPS)激活的巨噬细胞相比,PPW提取物处理的活化细胞通过降低p22phox和iNOS的表达以及降低细胞因子编码基因,包括IL-6、TNF-α、IL-1β、PG-E2和IFN-γ,显著降低活性氧和一氧化氮水平。此外,我们观察到LPS增强了泄漏到细胞质中的mtDNA,增加了Tlr9的转录,并向MyD88/Irf7依赖性干扰素和MyD88/NF-κb p65依赖性炎症细胞因子mRNA表达发出信号,但在PPW提取物存在的情况下,这种情况有所缓解。结论:我们的数据表明,PPW提取物通过促进mtDNA泄漏、降低Tlr9的表达和信号激活而具有抗氧化和抗炎活性。
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引用次数: 0
Peanut sprout tea extract inhibits lung metastasis of 4T1 murine mammary carcinoma cells by suppressing the crosstalk between cancer cells and macrophages in BALB/c mice. 花生芽茶提取物通过抑制BALB/c小鼠中癌症细胞与巨噬细胞之间的串扰来抑制4T1小鼠乳腺癌细胞的肺转移。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-06-23 DOI: 10.4162/nrp.2023.17.5.917
Jae In Jung, Hyun Sook Lee, Jaehak Lee, Eun Ji Kim

Background/objectives: As peanuts germinate, the content of the components beneficial to health, such as resveratrol, increases within the peanut sprout. This study examined whether the ethanol extract of peanut sprout tea (PSTE) inhibits breast cancer growth and metastasis.

Materials/methods: After orthotopically injecting 4T1 cells into BALB/c mice to induce breast cancer, 0, 30, or 60 mg/kg body weight/day of PSTE was administered orally. Angiogenesis-related protein expression in the tumors and the degree of metastasis were analyzed. 4T1 and RAW 264.7 cells were co-cultured, and reverse transcription polymerase chain reaction was performed to measure the crosstalk between breast cancer cells and macrophages.

Results: PSTE reduced tumor growth and lung metastasis. In particular, PSTE decreased matrix metalloproteinase-9, platelet endothelial cell adhesion molecule-1, vascular endothelial growth factor-A, F4/80, CD11c, macrophage mannose receptor, macrophage colony-stimulating factor, and monocyte chemoattractant protein 1 expression in the tumors. Moreover, PSTE prevented 4T1 cell migration, invasion, and macrophage activity in RAW 264.7 cells. PSTE inhibited the crosstalk between 4T1 cells and RAW 264.7 cells and promoted the macrophage M1 subtype while inhibiting the M2 subtype.

Conclusions: These results suggest that PSTE blocks breast cancer growth and metastasis to the lungs. This may be because the PSTE treatment inhibits the crosstalk between mammary cancer cells and macrophages and inhibits the differentiation of macrophages into the M2 subtype.

背景/目的:随着花生发芽,花生芽中白藜芦醇等有益健康的成分含量增加。本研究检测了花生芽茶乙醇提取物(PSTE)是否抑制癌症生长和转移。材料/方法:将4T1细胞直接注射到BALB/c小鼠中以诱导乳腺癌症后,口服0、30或60mg/kg体重/天的PSTE。分析肿瘤血管生成相关蛋白的表达及转移程度。将4T1和RAW 264.7细胞共培养,并进行逆转录聚合酶链反应以测量乳腺癌症细胞与巨噬细胞之间的串扰。结果:PSTE降低了肿瘤的生长和肺转移。特别是,PSTE降低了肿瘤中基质金属蛋白酶-9、血小板内皮细胞粘附分子-1、血管内皮生长因子-A、F4/80、CD11c、巨噬细胞甘露糖受体、巨噬细胞集落刺激因子和单核细胞趋化蛋白1的表达。此外,PSTE阻止了RAW 264.7细胞中4T1细胞的迁移、侵袭和巨噬细胞活性。PSTE抑制4T1细胞和RAW 264.7细胞之间的串扰,并在抑制M2亚型的同时促进巨噬细胞M1亚型。结论:这些结果表明PSTE阻断了乳腺癌症的生长和转移到肺部。这可能是因为PSTE治疗抑制了乳腺癌症细胞和巨噬细胞之间的串扰,并抑制了巨噬细胞分化为M2亚型。
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引用次数: 0
Can tailored home-delivered meal services alleviate self-rated frailty of the low-income older adults in Korea? 量身定制的家庭送餐服务能否缓解韩国低收入老年人自我评估的脆弱性?
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-05-31 DOI: 10.4162/nrp.2023.17.5.1007
Junghyun Kim, Hyeja Chang

Background/objectives: This study aimed to examine whether the tailored home-delivered meal (HDM) services included nutrition counseling impacts alleviating self-rated frailty among low-income older adults in Korea.

Subjects/methods: Pre- and post-test were implemented on May 27 and on November 25 in 2019 during 3 weeks, respectively, before and after the 6 months intervention program. Participants completed a questionnaire measuring frailty, malnutrition, food security, depression, and underlying diseases. Initially, 136 older adults were selected as participants for this study, they were recipients of a free meal program from 2 senior welfare centers in Seoul, the final sample size of those who completed the intervention program was 117 (female 70.9%, male 29.1%). Statistical analyses were conducted with IBM SPSS package program, paired t-test and χ2 test to validate the test.

Results: There were statistically significant differences in the score of the Tilburg Frailty Indicator (TFI) before and after receiving the tailored HDM services (pre-test 9.46, post-test 2.8, P < 0.01). The differences in the score of TFI by 3 risk groups at the pre-test decreased as a result of receiving these services.

Conclusions: The tailored HDM services alleviated the self-rated frailty of low-income older adults with limited mobility in a community setting. Based on the positive outcomes this study could be applied to developing social services for aging in place.

背景/目的:本研究旨在检验量身定制的家庭送餐(HDM)服务是否包括营养咨询对缓解韩国低收入老年人自我评估虚弱的影响。受试者/方法:分别于2019年5月27日和11月25日在6个月干预计划前后的3周内进行测试前和测试后。参与者完成了一份测量虚弱、营养不良、粮食安全、抑郁和潜在疾病的问卷。最初,136名老年人被选为本研究的参与者,他们是首尔2个老年福利中心的免费膳食计划的接受者,完成干预计划的最终样本量为117人(女性70.9%,男性29.1%)。使用IBM SPSS软件包程序、配对t检验和χ2检验进行统计分析以验证该检验。结果:接受量身定制的HDM服务前后,Tilburg Frailty Indicator(TFI)评分存在统计学显著差异(测试前9.46,测试后2.8,P<0.01)。3个风险组在测试前的TFI评分差异因接受这些服务而降低。结论:量身定制的HDM服务缓解了低收入老年人在社区环境中行动不便的自我评估脆弱性。基于积极的结果,这项研究可以应用于发展现有的老龄化社会服务。
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引用次数: 0
Association between diet quality and untreated dental caries: results from the Korea National Health and Nutrition Examination Survey. 饮食质量与未经治疗的龋齿之间的关系:韩国国家健康和营养检查调查的结果。
IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-10-01 Epub Date: 2023-07-06 DOI: 10.4162/nrp.2023.17.5.959
Seon-Ju Sim, Ja-Young Moon, Hye-Sun Shin

Background/objectives: Few studies have provided evidence of the association between diet quality and dental caries. This study aimed to examine the association between diet quality and untreated dental caries in a Korean representative population.

Subjects/methods: The study population included a sample of 13,815 participants, aged ≥ 19 from the Korea National Health and Nutrition Examination Survey during 2013-2015. The explanatory variable was diet quality and the outcome variable was untreated dental caries. Untreated dental caries were defined by the number of decayed teeth recorded according to the criteria established by the World Health Organization. Diet quality was defined by using the Korean Healthy Eating Index (KHEI) through the 24-h recall methods. We assessed the association between diet quality and untreated dental caries while adjusting for age, sex, education, income, smoking status, dental visits, toothbrushing frequencies, obesity, and diabetes mellitus.

Results: The mean overall KHEI scores in the untreated dental caries group were significantly lower than those in the group without untreated dental caries. Significant differences were observed in the untreated dental caries group based on the KHEI quartiles (P < 0.001). After adjusting for potential confounders, the quartiles of KHEI scores showed an association with untreated dental caries, demonstrating a dose-effect trend (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.35-1.84 for 1st quartile; OR, 1.38; 95% CI, 1.19-1.59 for 2nd quartile; OR, 1.32; 95% CI, 1.14-1.53 for 3rd quartile; reference quartile highest]).

Conclusions: The findings indicated an inverse association between diet quality and untreated dental caries in Korean adults. Healthcare providers should take into account the significant role of diet quality in preventing and managing oral health.

背景/目的:很少有研究提供饮食质量与龋齿之间关系的证据。本研究旨在检验韩国代表性人群的饮食质量与未经治疗的龋齿之间的关系。受试者/方法:研究人群包括来自2013-2015年韩国国家健康和营养检查调查的13815名参与者,年龄≥19岁。解释变量是饮食质量,结果变量是未治疗的龋齿。未治疗的龋齿是根据世界卫生组织制定的标准记录的龋齿数量来定义的。饮食质量是通过使用韩国健康饮食指数(KHEI)通过24小时回忆方法来定义的。我们评估了饮食质量与未治疗龋齿之间的关系,同时调整了年龄、性别、教育、收入、吸烟状况、牙科就诊、刷牙频率、肥胖和糖尿病。结果:未治疗龋齿组的KHEI平均总分显著低于未治疗龋齿的组。根据KHEI四分位数,在未治疗的龋齿组中观察到显著差异(P<0.001)。在校正潜在的混杂因素后,KHEI分数的四分位数显示出与未治疗的龋病相关,显示出剂量效应趋势(比值比[OR],1.57;第一个四分位数的95%置信区间[CI],1.35-1.84;OR,1.38;第二个四分位的95%CI,1.19-1.59;OR,1.33;第三个四分位组的95%CI为1.14-1.53;参考四分位数最高])。结论:研究结果表明,韩国成年人的饮食质量与未经治疗的龋齿呈负相关。医疗保健提供者应考虑到饮食质量在预防和管理口腔健康方面的重要作用。
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引用次数: 0
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Nutrition Research and Practice
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