Pub Date : 2020-01-15DOI: 10.2530/JSLSM.JSLSM-40_0044
Kana Iwai, K. Oka, E. Niiro, Yuki Yamada, Y. Tanase, R. Kawaguchi, Hiroshi Kobayashi
Ultrasonic testing and cytodiagnosis have been used for the diagnosis of endometrial disease. However, lesions can not be observed under direct view with these techniques. Laser therapy facilitates observation and treatment of the uterine body. The images produced by the minimally invasive laser therapy system are of high quality, and it is easier to irradiate a laser beam on target lesions. This technology may provide a new treatment strategy of early endometrial cancer.
{"title":"Future Perspective of Clinical Application of the Minimally Invasive Laser Therapy Using Composite-type Optical Fiber for Endometrial Lesions","authors":"Kana Iwai, K. Oka, E. Niiro, Yuki Yamada, Y. Tanase, R. Kawaguchi, Hiroshi Kobayashi","doi":"10.2530/JSLSM.JSLSM-40_0044","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-40_0044","url":null,"abstract":"Ultrasonic testing and cytodiagnosis have been used for the diagnosis of endometrial disease. However, lesions can not be observed under direct view with these techniques. Laser therapy facilitates observation and treatment of the uterine body. The images produced by the minimally invasive laser therapy system are of high quality, and it is easier to irradiate a laser beam on target lesions. This technology may provide a new treatment strategy of early endometrial cancer.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"7 1","pages":"386-391"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90408526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0050
T. Nishimura, Yu Shimojo, H. Hazama, K. Awazu
This paper proposes a computational clinical trial of laser treatment for rapid and low cost evaluation of novel medical laser devices. The optical propagation and photothermal damage process after pulse laser irradiation are modeled and the safety of the laser treatment with the evaluation target devices is evaluated by numerical simulation. The computational clinical trial result shows the safety of a novel nanosecond laser device for skin treatment is equivalent to the device that has approved for clinical use.
{"title":"A Method of Computational Clinical Trial of a Nanosecond Pulsed Laser Skin Treatment Device by Numerical Simulation of Photothermal Damage","authors":"T. Nishimura, Yu Shimojo, H. Hazama, K. Awazu","doi":"10.2530/jslsm.jslsm-40_0050","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0050","url":null,"abstract":"This paper proposes a computational clinical trial of laser treatment for rapid and low cost evaluation of novel medical laser devices. The optical propagation and photothermal damage process after pulse laser irradiation are modeled and the safety of the laser treatment with the evaluation target devices is evaluated by numerical simulation. The computational clinical trial result shows the safety of a novel nanosecond laser device for skin treatment is equivalent to the device that has approved for clinical use.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79335891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0069
{"title":"The 41st Annual Meeting of Japan Society for Laser Surgery and Medicine","authors":"","doi":"10.2530/jslsm.jslsm-40_0069","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0069","url":null,"abstract":"","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78258731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0052
S. Imamoto
main treatments for cancer treatment in the veterinary medicine. Treatment using immunity has attracted attention as the fourth treatment. However, immunotherapy for tumor in veterinary field is not put to practical use as a standard therapy yet. Except for immunotherapy, hyperthermia, cryotherapy, and photodynamic therapy are also being carried out for canine cancer treatment, but these therapies are not spread out because of insufficient evidence, and high cost of instrument and drug. In this study, we will introduce two canine cases in which the mammary gland tumor has shrunk by conducting combination ablation using semiconductor laser and interferon γ against tumor.
{"title":"Ablation Using Laser Beam Irradiation and Dog Recombinant Interferon γ for Two Canine Mammary Tumors","authors":"S. Imamoto","doi":"10.2530/jslsm.jslsm-40_0052","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0052","url":null,"abstract":"main treatments for cancer treatment in the veterinary medicine. Treatment using immunity has attracted attention as the fourth treatment. However, immunotherapy for tumor in veterinary field is not put to practical use as a standard therapy yet. Except for immunotherapy, hyperthermia, cryotherapy, and photodynamic therapy are also being carried out for canine cancer treatment, but these therapies are not spread out because of insufficient evidence, and high cost of instrument and drug. In this study, we will introduce two canine cases in which the mammary gland tumor has shrunk by conducting combination ablation using semiconductor laser and interferon γ against tumor.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84993762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/JSLSM.JSLSM-40_0024
Masamichi Yamashita, T. Osaki, Y. Sunden, Shouko Saito, Mizuho Inai, N. Honda, T. Nishimura, H. Hazama, K. Awazu, Y. Kaneda, Y. Okamoto
It was reported that tumor specific immunity is induced by local administration of hemagglutinating virus of Japan envelope (HVJ-E) to malignant tumor tissue. In the present case report, we tried to activate tumor specific immunity in feline mammary adenocarcinoma by NPe6 HVJ-E PDT where photodynamic therapy (PDT) was performed after local administration of HVJ-E containing taraporfin sodium (NPe6) into the tumor tissue. As a result of the treatment, necrosis of tumor cells and infiltration of macrophages in tumor tissue which were induced by NPe6 HVJ-E PDT were confirmed in and around the tumor. In addition, lymphocyte infiltration was remarkably observed around the tumor as compared with untreated tumor, and the immunity induction effect of NPe6 HVJ-E PDT was confirmed.
{"title":"Histological Changes of Feline Mammary Carcinoma Treated by NPe6 HVJ-E PDT","authors":"Masamichi Yamashita, T. Osaki, Y. Sunden, Shouko Saito, Mizuho Inai, N. Honda, T. Nishimura, H. Hazama, K. Awazu, Y. Kaneda, Y. Okamoto","doi":"10.2530/JSLSM.JSLSM-40_0024","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-40_0024","url":null,"abstract":"It was reported that tumor specific immunity is induced by local administration of hemagglutinating virus of Japan envelope (HVJ-E) to malignant tumor tissue. In the present case report, we tried to activate tumor specific immunity in feline mammary adenocarcinoma by NPe6 HVJ-E PDT where photodynamic therapy (PDT) was performed after local administration of HVJ-E containing taraporfin sodium (NPe6) into the tumor tissue. As a result of the treatment, necrosis of tumor cells and infiltration of macrophages in tumor tissue which were induced by NPe6 HVJ-E PDT were confirmed in and around the tumor. In addition, lymphocyte infiltration was remarkably observed around the tumor as compared with untreated tumor, and the immunity induction effect of NPe6 HVJ-E PDT was confirmed.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89788607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0058
E. Sano, K. Awazu
To obtain a fingerprint pattern without being affected by protrusions and indentations on the skin surface is important for fingerprint identification. In our previous work, we discovered a fine structure corresponding to the fingerprint pattern in the stratum corneum and surrounding area from observation of OCT images, and developed a method which detects the light from the light source goes through a fine structure and create grayscale images corresponding to a fingerprint pattern. In this paper, to clarify the origins of the greyscale image, we propose a simple simulated model of the fine structure of different light scattering properties alternately arranged in the epidermis of finger skin. We calculated the light intensity distribution via a Monte Carlo simulation of light scattering with two parameter sets at 640 nm. We found that the light passing through this model created a greyscale image that corresponded to the epidermis structure.
{"title":"Relationship between Transparent Skin Tissue Image Shading and Skin Tissue Light Scattering Intensity","authors":"E. Sano, K. Awazu","doi":"10.2530/jslsm.jslsm-40_0058","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0058","url":null,"abstract":"To obtain a fingerprint pattern without being affected by protrusions and indentations on the skin surface is important for fingerprint identification. In our previous work, we discovered a fine structure corresponding to the fingerprint pattern in the stratum corneum and surrounding area from observation of OCT images, and developed a method which detects the light from the light source goes through a fine structure and create grayscale images corresponding to a fingerprint pattern. In this paper, to clarify the origins of the greyscale image, we propose a simple simulated model of the fine structure of different light scattering properties alternately arranged in the epidermis of finger skin. We calculated the light intensity distribution via a Monte Carlo simulation of light scattering with two parameter sets at 640 nm. We found that the light passing through this model created a greyscale image that corresponded to the epidermis structure.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86581853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Photosensitizers have been widely used for diagnosis and therapy for malignant tumors in clinical setting. Porphyrin compounds have been known as not only a photosensitizer but also radiosensitizer. In clinical neurosurgery, 5-aminolevulinic acid (ALA) is available for intraoperative fluorescence marker for malignant gliomas. Recently, combination therapy using 5ALA and ionizing irradiation for malignant tumors have been investigated. 5-ALA can highly accumulate protoporphyrin IX (PpIX) in mitochondria of tumor cells via the heme biosynthesis. PpIX can induce oxidative stress on mitochondria of tumor cells under the ionizing irradiation exposure. In this review, we discuss radiotherapy using 5-ALA, so called radio-dynamic therapy, for malignant tumors.
{"title":"Photosensitizer and Radio-Dynamic Therapy (RDT)","authors":"J. Yamamoto, Takehiro Kitagawa, Ryo Miyaoka, Kohei Suzuki, Seishiro Takamatsu, Takeshi Saito, Yoshiteru Nakano","doi":"10.2530/jslsm.jslsm-40_0056","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0056","url":null,"abstract":"Photosensitizers have been widely used for diagnosis and therapy for malignant tumors in clinical setting. Porphyrin compounds have been known as not only a photosensitizer but also radiosensitizer. In clinical neurosurgery, 5-aminolevulinic acid (ALA) is available for intraoperative fluorescence marker for malignant gliomas. Recently, combination therapy using 5ALA and ionizing irradiation for malignant tumors have been investigated. 5-ALA can highly accumulate protoporphyrin IX (PpIX) in mitochondria of tumor cells via the heme biosynthesis. PpIX can induce oxidative stress on mitochondria of tumor cells under the ionizing irradiation exposure. In this review, we discuss radiotherapy using 5-ALA, so called radio-dynamic therapy, for malignant tumors.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76078165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-09DOI: 10.2530/jslsm.jslsm-40_0057
Hiroyuki Kobayashi
Malignant glioma is the adult brain tumor with the poorest prognosis, and its median overall survival is around one year. In the treatment of this disease, the surgical removal rate has the most significant influence on the prognosis, which means that adjuvant therapy such as radiation or chemotherapy has not exerted sufficient effect. Therefore it is indispensable to develop totally different ideas and methods. Among the new attempts, photodynamic therapy (PDT) has been a unique presence. We focused on 〒 062-8513 札幌市豊平区月寒東 1条 15丁目 7-20 TEL: 011-851-2333, FAX: 011-851-2131 (15-7-20 Tsukisamu higashi 1Jo, Toyohira-ku, Sapporo, Hokkaido 062-8513, Japan) Corresponding author: hiro.lausanne@gmail.com(小林浩之) Nippon Laser Igakkaishi
{"title":"Sonodynamic Therapy Using Transcranial Focused Ultrasound for Malignant Gliomas","authors":"Hiroyuki Kobayashi","doi":"10.2530/jslsm.jslsm-40_0057","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0057","url":null,"abstract":"Malignant glioma is the adult brain tumor with the poorest prognosis, and its median overall survival is around one year. In the treatment of this disease, the surgical removal rate has the most significant influence on the prognosis, which means that adjuvant therapy such as radiation or chemotherapy has not exerted sufficient effect. Therefore it is indispensable to develop totally different ideas and methods. Among the new attempts, photodynamic therapy (PDT) has been a unique presence. We focused on 〒 062-8513 札幌市豊平区月寒東 1条 15丁目 7-20 TEL: 011-851-2333, FAX: 011-851-2131 (15-7-20 Tsukisamu higashi 1Jo, Toyohira-ku, Sapporo, Hokkaido 062-8513, Japan) Corresponding author: hiro.lausanne@gmail.com(小林浩之) Nippon Laser Igakkaishi","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83969769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-15DOI: 10.2530/jslsm.jslsm-40_0036
T. Ohshiro, T. Ohshiro, K. Sasaki, Reiko Sakio, Saki Ando, Tomoko Suganuma, Yukie Takatsuka, Kiyofumi Takenouchi, Yuichi Kageyama, Mitsuaki Kozuma, Yasuhiro Suzuki, T. Sudo, Mitsuyuki Morishita
In the field of dermatology and plastic surgery, laser equipment have been more sophisticated and compact since the 1990s, and many types of medical laser equipment have become to be available. In addition, the number of manufacturers dealing with medical laser equipment has increased, making it easy to use medical laser equipment in many facilities. On the other hand, since the maintenance of medical laser equipment and the laser safety measures have not been so problematic, various accident reports concerning about the medical laser safety have been reported. In this manuscript, we introduce our 44-years’ efforts toward laser safety, and make a practical proposal on laser safety in our fields.
{"title":"Laser Safety in the Field of Dermatology and Plastic Surgery: Our Approach in Ohshiro Clinic","authors":"T. Ohshiro, T. Ohshiro, K. Sasaki, Reiko Sakio, Saki Ando, Tomoko Suganuma, Yukie Takatsuka, Kiyofumi Takenouchi, Yuichi Kageyama, Mitsuaki Kozuma, Yasuhiro Suzuki, T. Sudo, Mitsuyuki Morishita","doi":"10.2530/jslsm.jslsm-40_0036","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0036","url":null,"abstract":"In the field of dermatology and plastic surgery, laser equipment have been more sophisticated and compact since the 1990s, and many types of medical laser equipment have become to be available. In addition, the number of manufacturers dealing with medical laser equipment has increased, making it easy to use medical laser equipment in many facilities. On the other hand, since the maintenance of medical laser equipment and the laser safety measures have not been so problematic, various accident reports concerning about the medical laser safety have been reported. In this manuscript, we introduce our 44-years’ efforts toward laser safety, and make a practical proposal on laser safety in our fields.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86167635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-15DOI: 10.2530/JSLSM.JSLSM-40_0037
Y. Hashishin
It describes the guidelines for users in accordance with the safety standards for medical laser devices established by Japanese standards and international standards. The responsible person appoints a laser safety officer, and the laser safety officer sets up a laser safety management area. Laser safety officer perform risk assessments from incidents and accidents and take safety measures. Administrative procedures and health management, and protection against secondary risks are also important. Anyone entering the controlled area must wear personal protective glasses and clothing. Regular safety education and safety training are essential. Maintenance management and inspection of laser equipment should be performed systematically.
{"title":"The Safety Standards of Medical Laser Equipment and User’s Guide","authors":"Y. Hashishin","doi":"10.2530/JSLSM.JSLSM-40_0037","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-40_0037","url":null,"abstract":"It describes the guidelines for users in accordance with the safety standards for medical laser devices established by Japanese standards and international standards. The responsible person appoints a laser safety officer, and the laser safety officer sets up a laser safety management area. Laser safety officer perform risk assessments from incidents and accidents and take safety measures. Administrative procedures and health management, and protection against secondary risks are also important. Anyone entering the controlled area must wear personal protective glasses and clothing. Regular safety education and safety training are essential. Maintenance management and inspection of laser equipment should be performed systematically.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89351911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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