Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0033
S. Okawa, T. Hirasawa, K. Tsujita, T. Kushibiki, M. Ishihara
The authors have been studying the photoacoustic imaging from its basic to clinical applications. As a part of the wide-ranged studies, the numerical simulations of the photoacoustic pressure wave have been carried out for the image reconstruction of the concentration of the photon absorber and for the evaluation of gold nanoparticle as a contrast agent. The numerical simulation can be applied to planning safe and effective treatments using photoacoustic effect in dermatology. This article reviews the numerical simulations and the applications of them.
{"title":"Numerical Simulation of Photoacoustic Effect and Its Possibility of Applications to Diagnostic Imaging and Treatment Support","authors":"S. Okawa, T. Hirasawa, K. Tsujita, T. Kushibiki, M. Ishihara","doi":"10.2530/jslsm.jslsm-40_0033","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0033","url":null,"abstract":"The authors have been studying the photoacoustic imaging from its basic to clinical applications. As a part of the wide-ranged studies, the numerical simulations of the photoacoustic pressure wave have been carried out for the image reconstruction of the concentration of the photon absorber and for the evaluation of gold nanoparticle as a contrast agent. The numerical simulation can be applied to planning safe and effective treatments using photoacoustic effect in dermatology. This article reviews the numerical simulations and the applications of them.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88018781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0072
{"title":"The 30th Annual Meeting of the Japan Photodynamic Association The 16th Japan Photodynamic Neurosurgical Society","authors":"","doi":"10.2530/jslsm.jslsm-40_0072","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0072","url":null,"abstract":"","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"191 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75017640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/JSLSM.JSLSM-40_0028
Y. Aizu, Takaaki Maeda, I. Nishidate, Tomonori Yuasa
We developed a multi-layered optical phantom which models a layered structure of human skin tissue. Spectral reflectance similar to that of human skin was realized in the visible wavelength range by optimizing volume concentrations of absorber, scatterer, and base material in each of nine layers. We also investigated reproducibility and temporal deterioration property of fabricated phantoms. Finally, we tried to make a pigmented purpura-like phantom as an example of applications and confirmed its color characteristics.
{"title":"Multi-layered Optical Phantom for Spectroscopic Measurements of Skin","authors":"Y. Aizu, Takaaki Maeda, I. Nishidate, Tomonori Yuasa","doi":"10.2530/JSLSM.JSLSM-40_0028","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-40_0028","url":null,"abstract":"We developed a multi-layered optical phantom which models a layered structure of human skin tissue. Spectral reflectance similar to that of human skin was realized in the visible wavelength range by optimizing volume concentrations of absorber, scatterer, and base material in each of nine layers. We also investigated reproducibility and temporal deterioration property of fabricated phantoms. Finally, we tried to make a pigmented purpura-like phantom as an example of applications and confirmed its color characteristics.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91413333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/JSLSM.JSLSM-40_0031
美香 水野
Cervical intraepithelial neoplasia is a premalignancy of cervical cancer, and is not a rare disease. Standard treatment for cervical intraepithelial neoplasia (CIN) 3 is surgery, but this method has been shown to lead to premature birth. Photodynamic therapy (PDT) is a minimally invasive treatment option for carcinoma in situ (CIS). Several authors have reported the efficacy of conventional PDT, but the diffusion rate continues to be set low, due to concerns regarding side effects and the need for prolonged hospitalization. We have conducted an innovative clinical trial for patients with CIN using 5-Aminolevulinic acid (5ALA) and LED technology.
{"title":"Photodynamic Therapy Using 5-Aminolevulinic Acid for Cervical Intraepithelial Neoplasia","authors":"美香 水野","doi":"10.2530/JSLSM.JSLSM-40_0031","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-40_0031","url":null,"abstract":"Cervical intraepithelial neoplasia is a premalignancy of cervical cancer, and is not a rare disease. Standard treatment for cervical intraepithelial neoplasia (CIN) 3 is surgery, but this method has been shown to lead to premature birth. Photodynamic therapy (PDT) is a minimally invasive treatment option for carcinoma in situ (CIS). Several authors have reported the efficacy of conventional PDT, but the diffusion rate continues to be set low, due to concerns regarding side effects and the need for prolonged hospitalization. We have conducted an innovative clinical trial for patients with CIN using 5-Aminolevulinic acid (5ALA) and LED technology.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"15 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82579330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0054
Y. Kawaharada, Fusako Sato, Tsuyoshi Kani
We conducted a drug use-results survey of Penles® Tape 18 mg, a patch formulation containing lidocaine 18 mg, for pain relief in skin laser treatment and collected case report forms of 304 cases. Five adverse drug reactions occurred in four patients (1.43%) of 280 patients in the safety population, all of which were non-serious. The effectiveness measured by the pain level at the time of laser irradiation to the skin evaluated by physicians was 80.6% (241/299 cases). The above results confirmed the safety and effectiveness of Penles® Tape 18 mg for pain relief in skin laser treatment.
{"title":"Safety and Effectiveness of Penles® Tape 18 mg (Lidocaine) for Pain Relief in Skin Laser Treatment (Drug Use-results Survey)","authors":"Y. Kawaharada, Fusako Sato, Tsuyoshi Kani","doi":"10.2530/jslsm.jslsm-40_0054","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0054","url":null,"abstract":"We conducted a drug use-results survey of Penles® Tape 18 mg, a patch formulation containing lidocaine 18 mg, for pain relief in skin laser treatment and collected case report forms of 304 cases. Five adverse drug reactions occurred in four patients (1.43%) of 280 patients in the safety population, all of which were non-serious. The effectiveness measured by the pain level at the time of laser irradiation to the skin evaluated by physicians was 80.6% (241/299 cases). The above results confirmed the safety and effectiveness of Penles® Tape 18 mg for pain relief in skin laser treatment.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78388430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/JSLSM.JSLSM-40_0023
E. Yamada, H. Sumiyoshi
For the purpose of development of the laser technique in veterinary medicine, the new bowel welding method using a diode laser were devised. A special intestinal clamp was developed for these studies, and it was named laser welding intestinal clamp (LW clamp). In fundamental researches, laser welding of bowel in dogs and cats was confirmed to be possible using the LW clamp and the contact probes under a diode laser. Therefore, we expected that this method is applicable to clinical cases. Laser bowel anastomoses were performed for cats with megacolon and toy-breed dogs with severe bowel obstruction. As short- and long-term clinical results, any severe postoperative complications were not found, and all patients revealed favorable recovery.
{"title":"Laser Bowel Anastomosis for Dogs and Cats","authors":"E. Yamada, H. Sumiyoshi","doi":"10.2530/JSLSM.JSLSM-40_0023","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-40_0023","url":null,"abstract":"For the purpose of development of the laser technique in veterinary medicine, the new bowel welding method using a diode laser were devised. A special intestinal clamp was developed for these studies, and it was named laser welding intestinal clamp (LW clamp). In fundamental researches, laser welding of bowel in dogs and cats was confirmed to be possible using the LW clamp and the contact probes under a diode laser. Therefore, we expected that this method is applicable to clinical cases. Laser bowel anastomoses were performed for cats with megacolon and toy-breed dogs with severe bowel obstruction. As short- and long-term clinical results, any severe postoperative complications were not found, and all patients revealed favorable recovery.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88014177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0046
Mie Tasaka, H. Kaneko, Hideko Kotani
Since 2004, our hospital has performed photofrin photodynamic therapy (PDT) on 81 patients with cervical intraepithelial neoplasia 3 of the uterine cervix. No patients displayed recurrence after photofrin PDT. Of these patients, 27 became pregnant, with a total gravidity of 46. This study retrospectively reports the perinatal prognosis of pregnancy in 21 patients following photofrin PDT and compares it to that in 17 patients following cervix conization who delivered at our hospital. Following cervix conization in primipara, premature labor rate and emergency caesarean section rate increased, and following cervix conization in multipara, the gestational age at birth decreased. Conversely, following photofrin PDT in primipara, the premature labor rate was low, but bleeding during childbirth increased. No significant difference was identified in the partograph; therefore we compared the partograph with Friedman’s curve. Furthermore, following photofrin PDT, the premonitory stage of labor was prolonged, but the first stage of labor was not prolonged. Conversely, following cervix conization, the duration of labor decreased with Friedman’s curve. In our hospital, pregnancies following photofrin PDT were generally favorable, without premature delivery. Additionally, the emergency cesarean section rate was low for deliveries following photofrin PDT. However, care is necessary because there is an increase in bleeding during childbirth following photofrin PDT. We aim to have a safe perinatal prognosis following photofrin PDT to ensure its continuity in future.
{"title":"The Clinical Course of Pregnancy and Delivery Following Photofrin Photodynamic Therapy for Cervical Intraepithelial Neoplasia 3: Comparison with Cervix Conization","authors":"Mie Tasaka, H. Kaneko, Hideko Kotani","doi":"10.2530/jslsm.jslsm-40_0046","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0046","url":null,"abstract":"Since 2004, our hospital has performed photofrin photodynamic therapy (PDT) on 81 patients with cervical intraepithelial neoplasia 3 of the uterine cervix. No patients displayed recurrence after photofrin PDT. Of these patients, 27 became pregnant, with a total gravidity of 46. This study retrospectively reports the perinatal prognosis of pregnancy in 21 patients following photofrin PDT and compares it to that in 17 patients following cervix conization who delivered at our hospital. Following cervix conization in primipara, premature labor rate and emergency caesarean section rate increased, and following cervix conization in multipara, the gestational age at birth decreased. Conversely, following photofrin PDT in primipara, the premature labor rate was low, but bleeding during childbirth increased. No significant difference was identified in the partograph; therefore we compared the partograph with Friedman’s curve. Furthermore, following photofrin PDT, the premonitory stage of labor was prolonged, but the first stage of labor was not prolonged. Conversely, following cervix conization, the duration of labor decreased with Friedman’s curve. In our hospital, pregnancies following photofrin PDT were generally favorable, without premature delivery. Additionally, the emergency cesarean section rate was low for deliveries following photofrin PDT. However, care is necessary because there is an increase in bleeding during childbirth following photofrin PDT. We aim to have a safe perinatal prognosis following photofrin PDT to ensure its continuity in future.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86819801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-15DOI: 10.2530/jslsm.jslsm-40_0059
I. Nishidate, S. Kawauchi, Shunichi Sato, M. Sato, K. Niizeki, Y. Aizu
Diffuse optical spectroscopy provides functional and morphological information of living tissues based on optical absorption and scattering properties. Diffuse reflectance spectroscopy (DRS) can be achieved with simple and low cost equipment, and has been widely applied to in vivo measurements and imaging of biological tissues. In the present article, in vivo evaluation of hemodynamics and changes in tissue morphology by using DRS based on the Monte Carlo simulation for light transport in biological tissues and its application to biomedical imaging are described.
{"title":"Spectral Diffuse Reflectance Imaging Based on Numerical Simulation for Light Transport in Biological Tissues","authors":"I. Nishidate, S. Kawauchi, Shunichi Sato, M. Sato, K. Niizeki, Y. Aizu","doi":"10.2530/jslsm.jslsm-40_0059","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0059","url":null,"abstract":"Diffuse optical spectroscopy provides functional and morphological information of living tissues based on optical absorption and scattering properties. Diffuse reflectance spectroscopy (DRS) can be achieved with simple and low cost equipment, and has been widely applied to in vivo measurements and imaging of biological tissues. In the present article, in vivo evaluation of hemodynamics and changes in tissue morphology by using DRS based on the Monte Carlo simulation for light transport in biological tissues and its application to biomedical imaging are described.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"33 1","pages":"359-368"},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77969167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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