Nuclear medicine and biology最新文献

{"title":"New Phase Transfer Catalysts for Fluorine-18 Radiolabelling","authors":"Zélie Faudemer, Rémi Pelletier, Simon Specklin, Bertrand Kuhnast","doi":"10.1016/j.nucmedbio.2025.109167","DOIUrl":"10.1016/j.nucmedbio.2025.109167","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109167"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCR8-targeting radioimmunotherapy enhances anti-CTLA-4 immunotherapy through expansion of anti-tumor macrophages, T cells and NK cells in colorectal cancer models","authors":"Connor Frank, Kevin Allen, Rubin Jiao, Mackenzie Malo, Ekaterina Dadachova","doi":"10.1016/j.nucmedbio.2025.109163","DOIUrl":"10.1016/j.nucmedbio.2025.109163","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109163"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[18F]FDG-PET provides insights into the liver-brain axis and confirms SUVgluc as a surrogate for MRGlu in a mouse model of liver fibrosis","authors":"Thomas Wanek ,&nbsp;Mari Teuter ,&nbsp;Asha Balakrishnan ,&nbsp;Tobias L. Ross ,&nbsp;Frank M. Bengel ,&nbsp;Michael Ott ,&nbsp;Marion Bankstahl ,&nbsp;Jens P. Bankstahl","doi":"10.1016/j.nucmedbio.2025.109095","DOIUrl":"10.1016/j.nucmedbio.2025.109095","url":null,"abstract":"<div><h3>Purpose</h3><div>The liver-brain axis regulates metabolic homeostasis, with glucose metabolism playing a key role. Liver dysfunction, such as fibrosis, may impact brain metabolism and consequently, brain function. Positron emission tomography (PET) imaging provides a non-invasive approach to study glucose metabolism in both organs. A recent longitudinal PET/CT study utilizing 2-deoxy-2-[¹⁸F]-fluoro-<span>d</span>-glucose ([¹⁸F]FDG) amongst other radiotracers revealed significant metabolic changes in the liver in a mouse model of liver fibrosis. Here, we retrospectively analyzed those data to quantify potential associated changes in brain glucose metabolism.</div></div><div><h3>Procedures</h3><div>Eleven male C57BL/6N mice underwent repeated PET imaging with [¹⁸F]FDG at baseline, pre-fibrosis, fibrosis, and remission stages. Cerebral glucose metabolism was assessed using standardized uptake value (<em>SUV</em>), blood glucose-corrected <em>SUV</em> (<em>SUV</em>_{<em>gluc</em>}), and kinetic modeling (Patlak and two-tissue compartment models) for calculation of the glucose metabolic rate (<em>MR</em>_<em>Glu</em>).</div></div><div><h3>Results</h3><div>Both <em>SUV</em>_{<em>gluc</em>} and <em>MR</em>_<em>Glu</em> significantly decreased during pre-fibrosis and fibrosis on whole brain level and recovered at remission. <em>SUV</em>_{<em>gluc</em>} statistical parametric mapping identified multiple brain areas with reduced glucose metabolism, which was confirmed by regional analysis showing progressive reduction in SUV_gluc. Correlation analyses confirmed <em>SUV</em>_{<em>gluc</em>} as a reliable surrogate for <em>MR</em>_<em>Glu</em>, unlike uncorrected <em>SUV</em>. Liver [¹⁸F]FDG uptake increased during fibrosis and normalized at remission, mirroring changes in blood glucose concentrations.</div></div><div><h3>Conclusions</h3><div>[¹⁸F]FDG PET imaging revealed that liver fibrosis alters glucose metabolism in both liver and brain, emphasizing the potential of molecular imaging for future assessment of metabolic interaction between liver and brain. [¹⁸F]FDG uptake in terms of <em>SUV</em>_{<em>gluc</em>} strongly correlated with <em>MR</em>_<em>Glu</em> from kinetic modeling, supporting its utility as a valid surrogate parameter to quantify cerebral glucose metabolism in mice.</div></div>","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109095"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of the binding potential of the PET ligand [18F]FEDAC to translocator protein 18 kDa (TSPO) in the brain of experimental stroke model rats","authors":"Tomoteru Yamasaki ,&nbsp;Yiding Zhang ,&nbsp;Wakana Mori ,&nbsp;Katsushi Kumata ,&nbsp;Hidekatsu Wakizaka ,&nbsp;Daisuke Arashi ,&nbsp;Yusuke Kurihara ,&nbsp;Masanao Ogawa ,&nbsp;Nobuki Nengaki ,&nbsp;Masayuki Fujinaga ,&nbsp;Ming-Rong Zhang","doi":"10.1016/j.nucmedbio.2025.109579","DOIUrl":"10.1016/j.nucmedbio.2025.109579","url":null,"abstract":"<div><h3>Purpose</h3><div>Translocator protein 18 kDa (TSPO) is a biomarker for neuroinflammation, and [¹⁸F]FEDAC was developed as a clinically usable radioligand for its imaging. Here, quantitative PET analyses of [¹⁸F]FEDAC in the brain of transient middle cerebral artery occlusion (tMCAO) rats were conducted for the first time.</div></div><div><h3>Methods</h3><div>Quantitative PET analysis was performed on rats subjected to tMCAO, with blood sampling also conducted as part of the study. To estimate the kinetic parameters of [¹⁸F]FEDAC, two-tissue compartment model (2TCM) and simplified reference tissue model (SRTM) analyses were conducted.</div></div><div><h3>Results</h3><div>The input rate (<em>K</em>₁) and distribution volume (<em>V</em>_T) (a macroparameter consisting of the <em>K</em>₁–<em>k</em>₄ rate constants from 2TCM analysis) of [¹⁸F]FEDAC in the ipsilateral area of tMCAO rats were 0.38 ± 0.19 mL/cm³/min and 5.4 ± 2.7 mL/cm³, respectively, which are roughly twice as high as those in the contralateral area. These results strongly suggest that ipsilateral binding potential (BP_ND), a quantitative index derived from the <em>V</em>_T ratio with respect to the reference region, depends not only on the binding of [¹⁸F]FEDAC to TSPO, but also on increases in the input rate from blood. Therefore, in SRTM analyses, we corrected apparent BP_ND using <em>R</em>1, an index for probe delivery. In validation studies, SRTM analysis with the corrected BP_ND (corBP_ND), using the cerebellum as a reference, showed a high correlation with direct BP_ND (<em>k</em>₃/<em>k</em>₄) in 2TCM analyses.</div></div><div><h3>Conclusion</h3><div>The acquisition of quantitative PET images of TSPO distribution in the tMCAO rat brain was successfully achieved by scaling with corBP_ND.</div></div>","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109579"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating mRNA Delivery Using Nuclear Medicine","authors":"James Humphries ,&nbsp;Andrea Witjaksono ,&nbsp;Abishek Poudel ,&nbsp;Karine Mardon ,&nbsp;Mary-anne Migotto ,&nbsp;Seth Cheetham ,&nbsp;Christopher Howard ,&nbsp;Kristofer Thurecht","doi":"10.1016/j.nucmedbio.2025.109117","DOIUrl":"10.1016/j.nucmedbio.2025.109117","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109117"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging with Nanobody-based bimodal PET/fluorescence tracers for improved clinical decision making","authors":"Jelena Saliën ,&nbsp;Sam Floru ,&nbsp;Romane Vizier ,&nbsp;Jessica Bridoux ,&nbsp;Victor Goncalves ,&nbsp;Franck Denat ,&nbsp;Sophie Hernot","doi":"10.1016/j.nucmedbio.2025.109148","DOIUrl":"10.1016/j.nucmedbio.2025.109148","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109148"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of Blood-Brain Barrier-Penetrating Bispecific Antibodies for Brain ImmunoPET in Alzheimer's Disease and Glioblastoma","authors":"Lara Garcia-Varela ,&nbsp;Dag Sehlin ,&nbsp;Alberto Ouro ,&nbsp;Jessica Codesido ,&nbsp;María Muñoz ,&nbsp;Sahar Roshanbin ,&nbsp;Emma Ramos-Docampo ,&nbsp;Ximena Aguilar ,&nbsp;Noemí Gómez-Lado ,&nbsp;Tomás Sobrino ,&nbsp;Pablo Aguiar ,&nbsp;Stina Syvaenen","doi":"10.1016/j.nucmedbio.2025.109102","DOIUrl":"10.1016/j.nucmedbio.2025.109102","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109102"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delivery of the Auger Therapeutic [125I]IUdR via Nanocarriers for Treatment of Glioblastoma","authors":"Natan Straathof ,&nbsp;Qing Tang ,&nbsp;Aaraby Nielsen ,&nbsp;Katharina Ravn ,&nbsp;Vigga Gammelsrød ,&nbsp;Amaia Huarte Lorens ,&nbsp;Mikkel Andersen ,&nbsp;Matthias Herth ,&nbsp;Bo Halle ,&nbsp;Helge Thisgaard ,&nbsp;Andreas Jensen","doi":"10.1016/j.nucmedbio.2025.109173","DOIUrl":"10.1016/j.nucmedbio.2025.109173","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109173"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cGMP-Compliant Multi-Dose Synthesis of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT) on the Trasis AllInOne Synthesizer via an Orthogonal RP/Chiral HPLC Purification","authors":"Madelyn Hallisey,&nbsp;Jacob Hooker,&nbsp;Joseph Downey","doi":"10.1016/j.nucmedbio.2025.109160","DOIUrl":"10.1016/j.nucmedbio.2025.109160","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109160"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ubiquitin-specific protease 14 (USP14): An emerging biomarker for molecular imaging of cancer.","authors":"Jenilee Woodfield,&nbsp;Melinda Wuest,&nbsp;Frank Wuest","doi":"10.1016/j.nucmedbio.2025.109190","DOIUrl":"10.1016/j.nucmedbio.2025.109190","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109190"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}