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A cGMP-Compliant Multi-Dose Synthesis of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT) on the Trasis AllInOne Synthesizer via an Orthogonal RP/Chiral HPLC Purification 基于正交RP/手性高效液相色谱法的Trasis AllInOne多剂量合成6-[18F]氟- l -m-酪氨酸([18F]FMT
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109160
Madelyn Hallisey, Jacob Hooker, Joseph Downey
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引用次数: 0
211At-metal N-Heterocyclic Carbene complexes: a promising alternative for targeted alpha therapy 211at -金属n -杂环卡宾配合物：靶向治疗的一个有前途的选择
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109131
Sébastien Guillet , Samuel Mador , Mathilde Ligeour , Cyrille Alliot , Nicolas Galland , Francois Guerard
{"title":"211At-metal N-Heterocyclic Carbene complexes: a promising alternative for targeted alpha therapy","authors":"Sébastien Guillet , Samuel Mador , Mathilde Ligeour , Cyrille Alliot , Nicolas Galland , Francois Guerard","doi":"10.1016/j.nucmedbio.2025.109131","DOIUrl":"10.1016/j.nucmedbio.2025.109131","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109131"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radioiodinated Carborane-based Indomethacin-Derivatives as Cyclooxygenase-2 Radiotracers 放射性碳硼烷基吲哚美辛衍生物作为环氧化酶-2放射性示踪剂
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109132
Jonas Schädlich , Christoph Selg , Cathleen Haase-Kohn , Klaus Kopka , Evamarie Hey-Hawkins , Jens Pietzsch , Markus Laube
{"title":"Radioiodinated Carborane-based Indomethacin-Derivatives as Cyclooxygenase-2 Radiotracers","authors":"Jonas Schädlich , Christoph Selg , Cathleen Haase-Kohn , Klaus Kopka , Evamarie Hey-Hawkins , Jens Pietzsch , Markus Laube","doi":"10.1016/j.nucmedbio.2025.109132","DOIUrl":"10.1016/j.nucmedbio.2025.109132","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109132"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ubiquitin-specific protease 14 (USP14): An emerging biomarker for molecular imaging of cancer. 泛素特异性蛋白酶14 (USP14)：一种新兴的癌症分子成像生物标志物。
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109190
Jenilee Woodfield, Melinda Wuest, Frank Wuest
{"title":"Ubiquitin-specific protease 14 (USP14): An emerging biomarker for molecular imaging of cancer.","authors":"Jenilee Woodfield, Melinda Wuest, Frank Wuest","doi":"10.1016/j.nucmedbio.2025.109190","DOIUrl":"10.1016/j.nucmedbio.2025.109190","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109190"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bifunctional Chelators for Cu-64/Pb-212 Theranostic Applications Cu-64/Pb-212双功能螯合剂的治疗应用
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109125
Daniel Hubin, Meltem Ocak, Longbo Li, Christine Lovingier, Carolyn Anderson
{"title":"Bifunctional Chelators for Cu-64/Pb-212 Theranostic Applications","authors":"Daniel Hubin, Meltem Ocak, Longbo Li, Christine Lovingier, Carolyn Anderson","doi":"10.1016/j.nucmedbio.2025.109125","DOIUrl":"10.1016/j.nucmedbio.2025.109125","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109125"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of the binding potential of the PET ligand [18F]FEDAC to translocator protein 18 kDa (TSPO) in the brain of experimental stroke model rats 脑卒中模型大鼠脑内PET配体FEDAC与转运蛋白18kda （TSPO）结合电位的估计[18F]
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109579
Tomoteru Yamasaki , Yiding Zhang , Wakana Mori , Katsushi Kumata , Hidekatsu Wakizaka , Daisuke Arashi , Yusuke Kurihara , Masanao Ogawa , Nobuki Nengaki , Masayuki Fujinaga , Ming-Rong Zhang

Purpose

Translocator protein 18 kDa (TSPO) is a biomarker for neuroinflammation, and [18F]FEDAC was developed as a clinically usable radioligand for its imaging. Here, quantitative PET analyses of [18F]FEDAC in the brain of transient middle cerebral artery occlusion (tMCAO) rats were conducted for the first time.

Methods

Quantitative PET analysis was performed on rats subjected to tMCAO, with blood sampling also conducted as part of the study. To estimate the kinetic parameters of [18F]FEDAC, two-tissue compartment model (2TCM) and simplified reference tissue model (SRTM) analyses were conducted.

Results

The input rate (K1) and distribution volume (VT) (a macroparameter consisting of the K1–k4 rate constants from 2TCM analysis) of [18F]FEDAC in the ipsilateral area of tMCAO rats were 0.38 ± 0.19 mL/cm3/min and 5.4 ± 2.7 mL/cm3, respectively, which are roughly twice as high as those in the contralateral area. These results strongly suggest that ipsilateral binding potential (BPND), a quantitative index derived from the VT ratio with respect to the reference region, depends not only on the binding of [18F]FEDAC to TSPO, but also on increases in the input rate from blood. Therefore, in SRTM analyses, we corrected apparent BPND using R1, an index for probe delivery. In validation studies, SRTM analysis with the corrected BPND (corBPND), using the cerebellum as a reference, showed a high correlation with direct BPND (k3/k4) in 2TCM analyses.

Conclusion

The acquisition of quantitative PET images of TSPO distribution in the tMCAO rat brain was successfully achieved by scaling with corBPND.
目的转位蛋白18kda （TSPO）是神经炎症的生物标志物，[18F]FEDAC被开发为临床可用的放射配体用于其成像。本文首次对短暂性大脑中动脉闭塞（tMCAO）大鼠脑内[18F]FEDAC进行定量PET分析。方法对大鼠进行定量PET分析，并采血。为了估计[18F]FEDAC的动力学参数，我们进行了双组织室模型（2TCM）和简化参比组织模型（SRTM）分析。结果[18F]FEDAC在tMCAO大鼠同侧区的输入速率（K1）和分布体积（VT）分别为0.38±0.19 mL/cm3/min和5.4±2.7 mL/cm3，约为对侧区的2倍。这些结果强烈表明，同侧结合电位（BPND），一个由相对于参考区域的VT比率得出的定量指标，不仅取决于[18F]FEDAC与TSPO的结合，还取决于血液输入率的增加。因此，在SRTM分析中，我们使用R1（探针传递的指标）校正了明显的BPND。在验证研究中，以小脑为参照，SRTM分析与校正后的BPND （corBPND）在2个中医分析中显示与直接BPND （k3/k4）高度相关。结论corBPND标度法可成功获取TSPO分布的定量PET图像。
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引用次数: 0
Challenges in Pretargeted Imaging of Programmed Cell Death Ligand 1 (PD-L1) in Syngeneic Murine Models: In Vitro Studies with a Gallium-68-Labeled Tris(Hydroxypyridinone)-Tetrazine (THP-Tz) Tracer 同源小鼠模型中程序性细胞死亡配体1 （PD-L1）预靶向成像的挑战：镓-68标记的Tris（羟基吡啶酮）-四嗪（THP-Tz）示踪剂的体外研究
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109112
Alessia Centanni , Daniel Hauken , Surachet Imlimthan , You-Cheng Khng , Outi Keinänen , Mirkka Sarparanta
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引用次数: 0
A Pilot PET Imaging Study of Microtubule Dynamics in Older Adults with Cognitive Impairment 老年认知障碍患者微管动力学的PET显像研究
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109105
Naresh Damuka , Bhuvanachandra Bhoopal , Mack Miller , Ivan Krizan , Krishna Gollapelli , Caleb Bradley , Samuel Lockhart , Akiva Mintz , Suzanne Craft , Kiran Solingapuram Sai
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引用次数: 0
177Lu-labeled antibody-drug conjugate: a dual mechanistic treatment modality in solid tumors with heterogeneous antigen expression 177lu标记抗体-药物偶联物：一种双机制治疗异质抗原表达实体瘤的方式
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109165
Aiko Yamaguchi , Chisato Yamazaki , Yasuaki Anami , Summer Y.Y. Ha , Robert Ta , Wei Xiong , Ningyan Zhang , Zhiqiang An , Kyoji Tsuchikama , Charles Manning
{"title":"177Lu-labeled antibody-drug conjugate: a dual mechanistic treatment modality in solid tumors with heterogeneous antigen expression","authors":"Aiko Yamaguchi ,&nbsp;Chisato Yamazaki ,&nbsp;Yasuaki Anami ,&nbsp;Summer Y.Y. Ha ,&nbsp;Robert Ta ,&nbsp;Wei Xiong ,&nbsp;Ningyan Zhang ,&nbsp;Zhiqiang An ,&nbsp;Kyoji Tsuchikama ,&nbsp;Charles Manning","doi":"10.1016/j.nucmedbio.2025.109165","DOIUrl":"10.1016/j.nucmedbio.2025.109165","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109165"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted Alpha Therapy of Ovarian Cancer with ²¹²Pb-Labeled Anti-PTK7 Antibody: Efficient Production at Non-Clinical Scale and Preclinical Insights ²¹²铅标记的抗ptk7抗体靶向治疗卵巢癌：非临床规模的高效生产和临床前观察
IF 3 4区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear medicine and biology
Pub Date : 2025-11-01 DOI: 10.1016/j.nucmedbio.2025.109166
Yani Berckmans , Roxanne Wouters , Zeljka Raskovic-Lovre , Sara van Mechelen , Kim Lindland , Tina Bønsdorff , An Coosemans , Frederik Cleeren
{"title":"Targeted Alpha Therapy of Ovarian Cancer with ²¹²Pb-Labeled Anti-PTK7 Antibody: Efficient Production at Non-Clinical Scale and Preclinical Insights","authors":"Yani Berckmans ,&nbsp;Roxanne Wouters ,&nbsp;Zeljka Raskovic-Lovre ,&nbsp;Sara van Mechelen ,&nbsp;Kim Lindland ,&nbsp;Tina Bønsdorff ,&nbsp;An Coosemans ,&nbsp;Frederik Cleeren","doi":"10.1016/j.nucmedbio.2025.109166","DOIUrl":"10.1016/j.nucmedbio.2025.109166","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109166"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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