首页 > 最新文献

Obstetrics and gynecology最新文献

英文 中文
Association Between Comorbidity and Clinical Trial Enrollment for Patients With Uterine Cancer. 子宫癌患者合并症与临床试验入组的关系
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-04 DOI: 10.1097/aog.0000000000006135
Ann Oluloro,Mindy Pike,Tiffany Luu,Adrienne Moore,Soledad Jorge,Kemi M Doll
OBJECTIVETo characterize the presenting comorbidity profile of patients with uterine cancer by race and ethnicity and use real-world data to quantify expected effects of common comorbidity eligibility criteria on uterine cancer trial accrual.METHODSThis observational, cross-sectional study used the Vizient Clinical Data Base to identify individuals aged 18 years or older with a uterine cancer diagnosis from 2002 to 2021. Demographic variables and comorbidity diagnoses were identified by International Classification of Diseases, Ninth and Tenth Revision codes and used to construct Charlson, Elixhauser, and National Cancer Institute comorbidity indices. Summary theoretical ineligibility rates were calculated by race based on a modified set of comorbidity-eligibility criteria. Ineligibility rates were compared between groups and differences assessed with logistic regression.RESULTSWe identified 384,093 patients with uterine cancer; 70.0% of the patients were non-Hispanic White, 13.4% were non-Hispanic Black, 7.1% were of unknown race, and 2.8% were non-Hispanic Asian. Across all comorbidity indices, non-Hispanic Black individuals persistently had the highest scores among all racial groups. Comorbidity prevalence varied significantly by race. Non-Hispanic Black individuals had the highest rates of renal failure (11.6%), diabetes (23.4%), and hypertension (49.8%) compared with non-Hispanic White and non-Hispanic Asian individuals. In modeling analyses, non-Hispanic Black individuals had twofold higher odds of trial exclusion based on comorbidities than non-Hispanic White individuals (adjusted odds ratio [aOR] 2.06; 95% CI, 2.02-2.10). Those of unknown race had slightly higher odds (aOR 1.02; 95% CI, 0.99-1.05) and non-Hispanic Asians slightly lower odds (aOR 0.98; 95% CI, 0.94-1.02) of being ineligible relative to non-Hispanic White individuals.CONCLUSIONFor patients with uterine cancer, comorbidity prevalence and comorbidity index scores varied by race. This results in differences in trial eligibility at baseline before any patient engagement. Quantifying the distribution of comorbidities is critical because it allows us to statistically anticipate how individual comorbidity eligibility criteria may hamper the accrual of patients from minoritized groups. This, in turn, can support equity efforts to plan trial eligibility criteria and targeted recruitment.
目的按种族和民族划分子宫癌患者的合并症特征,并使用真实世界数据量化常见合并症资格标准对子宫癌试验累积的预期影响。方法:本观察性横断面研究使用Vizient临床数据库,识别2002年至2021年诊断为子宫癌的18岁及以上个体。人口统计学变量和合并症诊断由《国际疾病分类》第九版和第十版代码确定,并用于构建Charlson、Elixhauser和国家癌症研究所合并症指数。总结理论不合格率是根据一套修改的合并症-合格标准按种族计算的。比较两组间的不合格率,并用逻辑回归评估差异。结果发现384093例子宫癌患者;70.0%的患者为非西班牙裔白人,13.4%为非西班牙裔黑人,7.1%为未知种族,2.8%为非西班牙裔亚裔。在所有共病指数中,非西班牙裔黑人个体在所有种族群体中得分一直最高。共病患病率因种族而有显著差异。与非西班牙裔白人和非西班牙裔亚裔相比,非西班牙裔黑人的肾衰竭(11.6%)、糖尿病(23.4%)和高血压(49.8%)发生率最高。在建模分析中,非西班牙裔黑人个体因合并症而被排除试验的几率比非西班牙裔白人个体高两倍(校正优势比[aOR] 2.06; 95% CI, 2.02-2.10)。与非西班牙裔白人相比,未知种族的人不合格的几率略高(aOR 1.02; 95% CI, 0.99-1.05),非西班牙裔亚洲人不合格的几率略低(aOR 0.98; 95% CI, 0.94-1.02)。结论子宫癌患者的合并症患病率及合并症指数评分存在种族差异。这导致在任何患者参与之前,基线试验资格的差异。量化合并症的分布是至关重要的,因为它使我们能够从统计上预测个体合并症的资格标准如何阻碍少数群体患者的累积。这反过来又可以支持公平努力,以规划试验资格标准和有针对性的招聘。
{"title":"Association Between Comorbidity and Clinical Trial Enrollment for Patients With Uterine Cancer.","authors":"Ann Oluloro,Mindy Pike,Tiffany Luu,Adrienne Moore,Soledad Jorge,Kemi M Doll","doi":"10.1097/aog.0000000000006135","DOIUrl":"https://doi.org/10.1097/aog.0000000000006135","url":null,"abstract":"OBJECTIVETo characterize the presenting comorbidity profile of patients with uterine cancer by race and ethnicity and use real-world data to quantify expected effects of common comorbidity eligibility criteria on uterine cancer trial accrual.METHODSThis observational, cross-sectional study used the Vizient Clinical Data Base to identify individuals aged 18 years or older with a uterine cancer diagnosis from 2002 to 2021. Demographic variables and comorbidity diagnoses were identified by International Classification of Diseases, Ninth and Tenth Revision codes and used to construct Charlson, Elixhauser, and National Cancer Institute comorbidity indices. Summary theoretical ineligibility rates were calculated by race based on a modified set of comorbidity-eligibility criteria. Ineligibility rates were compared between groups and differences assessed with logistic regression.RESULTSWe identified 384,093 patients with uterine cancer; 70.0% of the patients were non-Hispanic White, 13.4% were non-Hispanic Black, 7.1% were of unknown race, and 2.8% were non-Hispanic Asian. Across all comorbidity indices, non-Hispanic Black individuals persistently had the highest scores among all racial groups. Comorbidity prevalence varied significantly by race. Non-Hispanic Black individuals had the highest rates of renal failure (11.6%), diabetes (23.4%), and hypertension (49.8%) compared with non-Hispanic White and non-Hispanic Asian individuals. In modeling analyses, non-Hispanic Black individuals had twofold higher odds of trial exclusion based on comorbidities than non-Hispanic White individuals (adjusted odds ratio [aOR] 2.06; 95% CI, 2.02-2.10). Those of unknown race had slightly higher odds (aOR 1.02; 95% CI, 0.99-1.05) and non-Hispanic Asians slightly lower odds (aOR 0.98; 95% CI, 0.94-1.02) of being ineligible relative to non-Hispanic White individuals.CONCLUSIONFor patients with uterine cancer, comorbidity prevalence and comorbidity index scores varied by race. This results in differences in trial eligibility at baseline before any patient engagement. Quantifying the distribution of comorbidities is critical because it allows us to statistically anticipate how individual comorbidity eligibility criteria may hamper the accrual of patients from minoritized groups. This, in turn, can support equity efforts to plan trial eligibility criteria and targeted recruitment.","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"129 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145674132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nationwide Prevalence of Cannabidiol Use in Pregnancy and in Women of Reproductive Age. 全国范围内怀孕和育龄妇女大麻二酚的使用情况。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-04 DOI: 10.1097/aog.0000000000006140
Chidimma Azubuike,Amy Deng,Amie Goodin
Clinical guidelines recommend avoiding cannabinoids, including cannabidiol (CBD), during pregnancy and lactation. Use of CBD is widespread, but prevalence in pregnancy and among women of reproductive age is not well documented. We conducted a cross-sectional analysis using data from the 2022 and 2023 National Survey on Drug Use and Health, with incorporation of survey sampling weights to estimate the prevalence of CBD use. Similar proportions of pregnant women and reproductive-aged women reported ever using CBD in 2022 (353.4 vs 365.1, respectively) and in 2023 (323.4 [95% CI, 259.2-387.6] vs 361.3 [95% CI, 353.6-367.0], respectively) per 1,000 population. More reproductive-aged women had used CBD within the past 30 days compared with pregnant women in 2022 (121.3 vs 43.9, respectively) and in 2023 (113.2 [95% CI, 107.4-118.9] vs 39.3 [95% CI, 16.2-62.4], respectively) per 1,000 population. Due to unknown effects of CBD during pregnancy and prevalent use, clinicians should screen for CBD use to facilitate counseling patients against use in pregnancy and while breastfeeding.
临床指南建议在怀孕和哺乳期避免使用大麻素,包括大麻二酚(CBD)。CBD的使用很普遍,但在怀孕和育龄妇女中的流行情况没有很好的记录。我们使用2022年和2023年全国药物使用和健康调查的数据进行了横断面分析,并结合调查抽样权重来估计CBD使用的流行程度。在2022年(353.4 vs 365.1)和2023年(323.4 [95% CI, 259.2-387.6] vs 361.3 [95% CI, 353.6-367.0])每1000人报告使用过CBD的孕妇和育龄妇女比例相似。与2022年(121.3比43.9)和2023年(113.2 [95% CI, 107.4-118.9]比39.3 [95% CI, 16.2-62.4])的孕妇相比,在过去30天内使用过CBD的育龄妇女更多。由于CBD在怀孕期间的未知影响和普遍使用,临床医生应该筛查CBD的使用,以方便咨询患者在怀孕和哺乳期间不要使用CBD。
{"title":"Nationwide Prevalence of Cannabidiol Use in Pregnancy and in Women of Reproductive Age.","authors":"Chidimma Azubuike,Amy Deng,Amie Goodin","doi":"10.1097/aog.0000000000006140","DOIUrl":"https://doi.org/10.1097/aog.0000000000006140","url":null,"abstract":"Clinical guidelines recommend avoiding cannabinoids, including cannabidiol (CBD), during pregnancy and lactation. Use of CBD is widespread, but prevalence in pregnancy and among women of reproductive age is not well documented. We conducted a cross-sectional analysis using data from the 2022 and 2023 National Survey on Drug Use and Health, with incorporation of survey sampling weights to estimate the prevalence of CBD use. Similar proportions of pregnant women and reproductive-aged women reported ever using CBD in 2022 (353.4 vs 365.1, respectively) and in 2023 (323.4 [95% CI, 259.2-387.6] vs 361.3 [95% CI, 353.6-367.0], respectively) per 1,000 population. More reproductive-aged women had used CBD within the past 30 days compared with pregnant women in 2022 (121.3 vs 43.9, respectively) and in 2023 (113.2 [95% CI, 107.4-118.9] vs 39.3 [95% CI, 16.2-62.4], respectively) per 1,000 population. Due to unknown effects of CBD during pregnancy and prevalent use, clinicians should screen for CBD use to facilitate counseling patients against use in pregnancy and while breastfeeding.","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"1 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents: Correction. 跨性别青少年月经抑制特征及其与心理健康的关系:纠正。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 DOI: 10.1097/AOG.0000000000006096
Dehlia Moussaoui, Michele A O'Connell, Charlotte V Elder, Sonia R Grover, Ken C Pang
{"title":"Characteristics of Menstrual Suppression and Its Association With Mental Health in Transgender Adolescents: Correction.","authors":"Dehlia Moussaoui, Michele A O'Connell, Charlotte V Elder, Sonia R Grover, Ken C Pang","doi":"10.1097/AOG.0000000000006096","DOIUrl":"10.1097/AOG.0000000000006096","url":null,"abstract":"","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"146 6","pages":"925-927"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maximum Oxytocin Dose and Uterine Rupture During Trial of Labor After Cesarean. 剖宫产后分娩试验中最大催产素剂量与子宫破裂。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1097/AOG.0000000000006106
Ann M Bruno, Amanda A Allshouse, Torri D Metz
<p><strong>Objective: </strong>To evaluate the association between maximum oxytocin dose and uterine rupture among individuals undertaking a trial of labor after cesarean (TOLAC). Secondarily, to evaluate the association between total time on oxytocin and time at maximum oxytocin dose and uterine rupture.</p><p><strong>Methods: </strong>We conducted a secondary analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Assessment of Perinatal Excellence study, an observational cohort of deliveries after 23 weeks of gestation across 25 U.S. hospitals from 2008 to 2011. Individuals with a singleton, cephalic, live fetus who had one prior cesarean delivery and were undertaking TOLAC, including those undergoing spontaneous, augmented, or induced labor, were included. Those with a contraindication to TOLAC or a fetus with an anomaly or known genetic abnormality were excluded. The exposure was intrapartum oxytocin dose in milli-international units per minute (milli-international units/min), assessed both categorically (0, 1-20, more than 20 milli-international units/min) and continuously. The primary outcome was uterine rupture. Secondary outcomes were vaginal birth after cesarean (VBAC), blood transfusion, and intensive care unit (ICU) admission. Trends in outcomes by oxytocin were assessed using the Cochran-Armitage trend test. Multivariable modeling estimated the association between maximum oxytocin dose (both as a categorical and continuous variable) and outcomes. The duration of any oxytocin, the duration at the maximum dose of oxytocin, and outcomes were assessed.</p><p><strong>Results: </strong>Of 5,201 individuals undergoing TOLAC, 3,406 (65.5%) received 0 milli-international units/min of oxytocin, 1,659 (31.9%) received 1-20 milli-international units/min, and 136 (2.6%) received more than 20 milli-international units/min. The majority of the cohort (n=3,391) entered spontaneous labor; 1,076 patients received augmentation and 733 were induced. The range of maximum oxytocin doses was 0-60 milli-international units/min. There were 37 cases of uterine rupture (0.7%, 95% CI, 0.5-0.9%). The frequency of uterine rupture by maximum oxytocin dose category was 0.2% (n=7) with no oxytocin (0 milli-international units/min), 1.6% (n=27) with an oxytocin dose of 1-20 milli-international units/min, and 2.2% (n=3) with oxytocin doses greater than 20 milli-international units/min. Higher maximum oxytocin doses were associated with a trend of an increase in uterine rupture (P<.001 Cochran-Armitage test of trend). In adjusted modeling, maximum oxytocin doses of 1-20 milli-international units/min and doses greater than 20 milli-international units/min were associated with uterine rupture (adjusted odds ratio [aOR] 8.82, 95% CI, 3.61-21.6; and aOR 11.0, 95% CI, 2.67-45.3, respectively), compared with 0 milli-international units/min; however, a higher maximum dose (more than 20 milli-interna
目的:探讨剖宫产后分娩试验(TOLAC)患者最大催产素剂量与子宫破裂的关系。其次,评估总催产素时间和最大催产素剂量时间与子宫破裂之间的关系。方法:我们对尤尼斯肯尼迪施莱弗国家儿童健康与人类发展研究所母胎医学单位网络围产期优生评估研究进行了二次分析,该研究是一项观察性队列研究,研究对象是2008年至2011年美国25家医院妊娠23周后分娩的产妇。曾有过一次剖宫产且正在进行TOLAC的单胎、头位活胎个体,包括自然分娩、增强分娩或引产的个体。那些有TOLAC禁忌症或胎儿异常或已知的遗传异常被排除在外。暴露量为分娩时催产素剂量,单位为毫国际单位/分钟(毫国际单位/分钟),分为分类评估(0、1-20、超过20毫国际单位/分钟)和连续评估。主要结局为子宫破裂。次要结局为剖宫产后阴道分娩(VBAC)、输血和入住重症监护病房(ICU)。使用Cochran-Armitage趋势检验评估催产素对结果的影响趋势。多变量模型估计最大催产素剂量(作为分类变量和连续变量)与结果之间的关系。评估任何催产素的持续时间,最大剂量催产素的持续时间和结果。结果:5201例接受TOLAC的患者中,3406例(65.5%)接受0毫国际单位/分钟催产素治疗,1659例(31.9%)接受1-20毫国际单位/分钟催产素治疗,136例(2.6%)接受20毫国际单位/分钟催产素治疗。大多数队列(n= 3391)进入自然分娩;增强1076例,诱导733例。最大催产素剂量范围为0-60毫国际单位/分钟。子宫破裂37例(0.7%,95% CI, 0.5 ~ 0.9%)。按最大剂量分类,无催产素(0毫国际单位/分钟)组子宫破裂发生率为0.2% (n=7), 1-20毫国际单位/分钟组为1.6% (n=27),大于20毫国际单位/分钟组为2.2% (n=3)。更高的最大催产素剂量与子宫破裂增加的趋势相关(结论:与没有催产素暴露相比,接受低剂量和高剂量的催产素与整个队列中子宫破裂的几率更高有关,也与成功的VBAC有关。虽然观察到高剂量催产素有增加子宫破裂的趋势,但与低剂量相比,产时最大高剂量催产素(大于20毫国际单位/分钟)与子宫破裂无关。因此,不能确定最大剂量催产素的最高安全阈值。
{"title":"Maximum Oxytocin Dose and Uterine Rupture During Trial of Labor After Cesarean.","authors":"Ann M Bruno, Amanda A Allshouse, Torri D Metz","doi":"10.1097/AOG.0000000000006106","DOIUrl":"10.1097/AOG.0000000000006106","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the association between maximum oxytocin dose and uterine rupture among individuals undertaking a trial of labor after cesarean (TOLAC). Secondarily, to evaluate the association between total time on oxytocin and time at maximum oxytocin dose and uterine rupture.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a secondary analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Assessment of Perinatal Excellence study, an observational cohort of deliveries after 23 weeks of gestation across 25 U.S. hospitals from 2008 to 2011. Individuals with a singleton, cephalic, live fetus who had one prior cesarean delivery and were undertaking TOLAC, including those undergoing spontaneous, augmented, or induced labor, were included. Those with a contraindication to TOLAC or a fetus with an anomaly or known genetic abnormality were excluded. The exposure was intrapartum oxytocin dose in milli-international units per minute (milli-international units/min), assessed both categorically (0, 1-20, more than 20 milli-international units/min) and continuously. The primary outcome was uterine rupture. Secondary outcomes were vaginal birth after cesarean (VBAC), blood transfusion, and intensive care unit (ICU) admission. Trends in outcomes by oxytocin were assessed using the Cochran-Armitage trend test. Multivariable modeling estimated the association between maximum oxytocin dose (both as a categorical and continuous variable) and outcomes. The duration of any oxytocin, the duration at the maximum dose of oxytocin, and outcomes were assessed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of 5,201 individuals undergoing TOLAC, 3,406 (65.5%) received 0 milli-international units/min of oxytocin, 1,659 (31.9%) received 1-20 milli-international units/min, and 136 (2.6%) received more than 20 milli-international units/min. The majority of the cohort (n=3,391) entered spontaneous labor; 1,076 patients received augmentation and 733 were induced. The range of maximum oxytocin doses was 0-60 milli-international units/min. There were 37 cases of uterine rupture (0.7%, 95% CI, 0.5-0.9%). The frequency of uterine rupture by maximum oxytocin dose category was 0.2% (n=7) with no oxytocin (0 milli-international units/min), 1.6% (n=27) with an oxytocin dose of 1-20 milli-international units/min, and 2.2% (n=3) with oxytocin doses greater than 20 milli-international units/min. Higher maximum oxytocin doses were associated with a trend of an increase in uterine rupture (P&lt;.001 Cochran-Armitage test of trend). In adjusted modeling, maximum oxytocin doses of 1-20 milli-international units/min and doses greater than 20 milli-international units/min were associated with uterine rupture (adjusted odds ratio [aOR] 8.82, 95% CI, 3.61-21.6; and aOR 11.0, 95% CI, 2.67-45.3, respectively), compared with 0 milli-international units/min; however, a higher maximum dose (more than 20 milli-interna","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"146 6","pages":"843-850"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Consultants. 编辑顾问。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 DOI: 10.1097/AOG.0000000000006117
{"title":"Editorial Consultants.","authors":"","doi":"10.1097/AOG.0000000000006117","DOIUrl":"10.1097/AOG.0000000000006117","url":null,"abstract":"","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"146 6","pages":"e127-e133"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Notice of Retraction: "Does an Early Isolated Increase in Fetal Abdominal Circumference Heighten the Risk of Macrosomia? [ID 1242]" and Notice of Retraction: "Does an Early Isolated Decrease in Fetal Abdominal Circumference Heighten the Risk of Growth Restriction? [ID 1300]". 撤回通知:“早期孤立的胎儿腹围增加会增加巨大儿的风险吗?”[id1242]和撤回通知:“早期孤立的胎儿腹围减小会增加生长受限的风险吗?”[ID 1300]”。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 DOI: 10.1097/AOG.0000000000006097
Patrick Kim, David J Rivera Vazquez, Tiffany Lowtan, Kelsey Pozerski, Bradley H Sipe, Rachelle Schwartz
{"title":"Notice of Retraction: \"Does an Early Isolated Increase in Fetal Abdominal Circumference Heighten the Risk of Macrosomia? [ID 1242]\" and Notice of Retraction: \"Does an Early Isolated Decrease in Fetal Abdominal Circumference Heighten the Risk of Growth Restriction? [ID 1300]\".","authors":"Patrick Kim, David J Rivera Vazquez, Tiffany Lowtan, Kelsey Pozerski, Bradley H Sipe, Rachelle Schwartz","doi":"10.1097/AOG.0000000000006097","DOIUrl":"https://doi.org/10.1097/AOG.0000000000006097","url":null,"abstract":"","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"146 6","pages":"928"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PUBLICATIONS: December 2025. 出版物:2025年12月。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 DOI: 10.1097/AOG.0000000000006111
{"title":"PUBLICATIONS: December 2025.","authors":"","doi":"10.1097/AOG.0000000000006111","DOIUrl":"https://doi.org/10.1097/AOG.0000000000006111","url":null,"abstract":"","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"146 6","pages":"929"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost Effectiveness of Salpingectomy Compared With Vasectomy for Permanent Contraception. 输卵管切除术与输精管切除术用于永久避孕的成本效益比较。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.1097/AOG.0000000000006042
Amy Pearson, Katerina Shvartsman, Wu Zeng, Jill Brown

Objective: To evaluate the cost effectiveness of salpingectomy compared with vasectomy for couples seeking permanent contraception.

Methods: We developed a decision tree model that used TreeAge to evaluate the cost effectiveness of vasectomy compared with salpingectomy for a hypothetical cohort of 800,000 people, the number of male and female patients who undergo permanent contraception procedures in the United States annually. Effectiveness was expressed in quality-adjusted life-years (QALYs), and the willingness-to-pay (WTP) threshold was set to $100,000 per QALY gained or lost. We derived costs, probabilities, and utilities from the literature, and estimated the incremental cost-effectiveness ratio (ICER) between the two strategies. We completed a probabilistic sensitivity analysis with 10,000 simulations and created a cost-effectiveness acceptability curve for WTP thresholds from $0 to $200,000. Secondary outcomes included the number of unintended pregnancies, ovarian cancer cases, and ovarian cancer deaths.

Results: Salpingectomy was not a cost-effective strategy, with an ICER of $143,769 per QALY gained compared with vasectomy. Probabilistic sensitivity analysis showed that the chance of vasectomy being cost effective was 81.5% but decreased to 14.7% with a WTP threshold of $200,000. Annually, salpingectomy was associated with 1,215 fewer unintended pregnancies, 6,085 fewer ovarian cancer cases, and 4,921 fewer ovarian cancer deaths compared with vasectomy.

Conclusion: Salpingectomy is not cost effective compared with vasectomy at a WTP threshold of $100,000, despite lower unintended pregnancy rates and societal ovarian cancer burden. Shared decision making, including a discussion of the long-term health benefits of salpingectomy, is important for couples deciding on permanent contraception procedures.

目的:比较输卵管切除术与输精管切除术对寻求永久避孕的夫妇的成本效益。方法:我们开发了一个决策树模型,使用TreeAge来评估输精管切除术与输卵管切除术的成本效益,假设队列为80万人,即每年在美国接受永久避孕手术的男性和女性患者的数量。有效性以质量调整生命年(QALYs)表示,支付意愿(WTP)阈值设定为每获得或失去一个质量调整生命年10万美元。我们从文献中推导出成本、概率和效用,并估计了两种策略之间的增量成本-效果比(ICER)。我们完成了10,000次模拟的概率敏感性分析,并创建了从0美元到200,000美元的WTP阈值的成本效益可接受性曲线。次要结局包括意外怀孕、卵巢癌病例和卵巢癌死亡人数。结果:输卵管切除术不是一种划算的策略,与输精管切除术相比,每QALY获得的ICER为143,769美元。概率敏感性分析显示输精管切除术的成本效益几率为81.5%,但WTP阈值为20万美元时下降至14.7%。每年,与输精管切除术相比,输卵管切除术减少了1215例意外怀孕,减少了6085例卵巢癌病例,减少了4921例卵巢癌死亡。结论:在WTP阈值为10万美元时,输卵管切除术与输精管切除术相比并不具有成本效益,尽管意外妊娠率和社会卵巢癌负担较低。共同决策,包括讨论输卵管切除术的长期健康益处,对决定采取永久性避孕措施的夫妇很重要。
{"title":"Cost Effectiveness of Salpingectomy Compared With Vasectomy for Permanent Contraception.","authors":"Amy Pearson, Katerina Shvartsman, Wu Zeng, Jill Brown","doi":"10.1097/AOG.0000000000006042","DOIUrl":"10.1097/AOG.0000000000006042","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the cost effectiveness of salpingectomy compared with vasectomy for couples seeking permanent contraception.</p><p><strong>Methods: </strong>We developed a decision tree model that used TreeAge to evaluate the cost effectiveness of vasectomy compared with salpingectomy for a hypothetical cohort of 800,000 people, the number of male and female patients who undergo permanent contraception procedures in the United States annually. Effectiveness was expressed in quality-adjusted life-years (QALYs), and the willingness-to-pay (WTP) threshold was set to $100,000 per QALY gained or lost. We derived costs, probabilities, and utilities from the literature, and estimated the incremental cost-effectiveness ratio (ICER) between the two strategies. We completed a probabilistic sensitivity analysis with 10,000 simulations and created a cost-effectiveness acceptability curve for WTP thresholds from $0 to $200,000. Secondary outcomes included the number of unintended pregnancies, ovarian cancer cases, and ovarian cancer deaths.</p><p><strong>Results: </strong>Salpingectomy was not a cost-effective strategy, with an ICER of $143,769 per QALY gained compared with vasectomy. Probabilistic sensitivity analysis showed that the chance of vasectomy being cost effective was 81.5% but decreased to 14.7% with a WTP threshold of $200,000. Annually, salpingectomy was associated with 1,215 fewer unintended pregnancies, 6,085 fewer ovarian cancer cases, and 4,921 fewer ovarian cancer deaths compared with vasectomy.</p><p><strong>Conclusion: </strong>Salpingectomy is not cost effective compared with vasectomy at a WTP threshold of $100,000, despite lower unintended pregnancy rates and societal ovarian cancer burden. Shared decision making, including a discussion of the long-term health benefits of salpingectomy, is important for couples deciding on permanent contraception procedures.</p>","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":" ","pages":"911-917"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy-Related Complications in Osteogenesis Imperfecta. 成骨不全症的妊娠相关并发症。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 DOI: 10.1097/AOG.0000000000006103
Ruijuan Chen, Xiaojuan Wang, Binglin Li
{"title":"Pregnancy-Related Complications in Osteogenesis Imperfecta.","authors":"Ruijuan Chen, Xiaojuan Wang, Binglin Li","doi":"10.1097/AOG.0000000000006103","DOIUrl":"10.1097/AOG.0000000000006103","url":null,"abstract":"","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"146 6","pages":"e109"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PUBLICATIONS: December 2025. 出版物:2025年12月。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 DOI: 10.1097/AOG.0000000000006111
{"title":"PUBLICATIONS: December 2025.","authors":"","doi":"10.1097/AOG.0000000000006111","DOIUrl":"https://doi.org/10.1097/AOG.0000000000006111","url":null,"abstract":"","PeriodicalId":19483,"journal":{"name":"Obstetrics and gynecology","volume":"146 6","pages":"929"},"PeriodicalIF":4.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Obstetrics and gynecology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1