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Social Determinants of Health and Stillbirth: Time for the Next-Generation. 健康和死产的社会决定因素:下一代的时代。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-01 DOI: 10.1097/aog.0000000000006168
Robert M Silver
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引用次数: 0
Association Between Neighborhood Social Determinants of Health and Stillbirth. 邻里社会健康决定因素与死产之间的关系。
IF 4.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-01 Epub Date: 2025-11-07 DOI: 10.1097/AOG.0000000000006115
Tetsuya Kawakita, Misa Hayasaka, Ann M Harper, John Brush, George Saade

Objective: To examine the association between neighborhood-level social determinants of health and stillbirth.

Methods: We performed a retrospective cohort study of deliveries that occurred at a gestational age of at least 20 weeks within a five-hospital system (2012-2022). Electronic health record data mapped to the Observational Medical Outcomes Partnership Common Data Model were geocoded using addresses at the time of delivery and linked to neighborhood health indices, which included the Area Deprivation Index (ADI), Maternal Vulnerability Index (MVI), and Social Vulnerability Index (SVI) at the Census tract level. Stillbirths were adjudicated by medical record review. Modified Poisson regression generated relative risks (RRs) and 95% CIs, controlling for maternal age, body mass index (BMI), parity, marital status, chronic hypertension, and pregestational diabetes.

Results: Among 61,008 pregnancies, 288 (0.5%, 95% CI, 0.4-0.5%) resulted in stillbirths. The ADI quartiles (relative to Census tracts within the United States as a whole) 2, 3, and 4 were associated with an increased risk of stillbirth (RR [95% CI] 2.32 [1.34-4.03], 3.08 [1.74-5.44], and 2.07 [1.03-4.14], respectively) compared with quartile 1. The ADI relative to Census tracts within the states showed comparable gradients. MVI quartiles 2 and 3 were associated with an increased risk of stillbirth (RR [95% CI] 1.44 [1.01-2.05] and 1.49 [1.02-2.19], respectively) compared with quartile 1. Similarly, SVI quartiles 2 and 3 were associated with an increased risk of stillbirth (RR [95% CI] 1.46 [1.03-2.07] and 1.86 [1.32-2.63], respectively) compared with quartile 1. Neither MVI nor SVI quartile 4 showed a statistically significant association with stillbirth. Among MVI subthemes, the mental health domain demonstrated a strong association with stillbirth (quartiles 2-4 RR range 1.64-2.07).

Conclusion: Neighborhood deprivation, quantified by ADI score, was a robust independent predictor of stillbirth, whereas the associations between the MVI or SVI and stillbirth were modest. Integrating the ADI into obstetric risk assessment and directing resources, especially perinatal mental health services, to highly deprived areas may help reduce persistent stillbirth disparities.

目的:探讨社区健康社会决定因素与死产之间的关系。方法:我们对五家医院系统(2012-2022)中胎龄至少为20周的分娩进行了回顾性队列研究。映射到观察性医疗结果伙伴关系公共数据模型的电子健康记录数据使用分娩时的地址进行地理编码,并与社区健康指数相关联,其中包括人口普查区层面的地区剥夺指数(ADI)、孕产妇脆弱性指数(MVI)和社会脆弱性指数(SVI)。死产是通过医疗记录审查来判定的。在控制了产妇年龄、体重指数(BMI)、胎次、婚姻状况、慢性高血压和妊娠糖尿病的情况下,修正泊松回归生成了相对危险度(rr)和95% ci。结果:在61008例妊娠中,288例(0.5%,95% CI, 0.4-0.5%)导致死产。与四分位数1相比,ADI四分位数(相对于整个美国人口普查区)2、3和4与死产风险增加相关(RR [95% CI]分别为2.32[1.34-4.03]、3.08[1.74-5.44]和2.07[1.03-4.14])。相对于各州内人口普查区的ADI显示出可比较的梯度。与四分位数1相比,MVI四分位数2和3与死产风险增加相关(RR [95% CI]分别为1.44[1.01-2.05]和1.49[1.02-2.19])。同样,与四分位数1相比,SVI四分位数2和3与死产风险增加相关(RR [95% CI]分别为1.46[1.03-2.07]和1.86[1.32-2.63])。MVI和SVI四分位数均未显示与死产有统计学意义的关联。在MVI子主题中,心理健康领域与死产有很强的关联(四分位数2-4 RR范围1.64-2.07)。结论:邻里剥夺,量化的ADI评分,是一个强大的独立预测死产,而MVI或SVI和死产之间的关联是适度的。将ADI纳入产科风险评估,并将资源,特别是围产期心理健康服务,导向高度贫困地区,可能有助于减少持续存在的死产差异。
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引用次数: 0
Evolving Paradigms in Human Papillomavirus-Associated Vulvar Intraepithelial Neoplasia Management: Surgery, Immunotherapy, and the Pursuit of Functional Outcomes. 人类乳头瘤病毒相关外阴上皮内瘤变管理的演变范式:手术、免疫治疗和功能结局的追求。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-01 DOI: 10.1097/aog.0000000000006144
Teresa K L Boitano,Charles A Leath
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引用次数: 0
Human Papillomavirus Self-Collection: It's Time to Support Patient Choice. 人类乳头瘤病毒自我收集:是时候支持患者的选择了。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-29 DOI: 10.1097/aog.0000000000006190
Rebecca B Perkins,Jessica B DiSilvestro
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引用次数: 0
Childhood Pulmonary Outcomes After Late Preterm Antenatal Corticosteroids. 晚期早产儿使用皮质类固醇后的儿童肺部预后。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-22 DOI: 10.1097/aog.0000000000006162
Cynthia Gyamfi-Bannerman,Rebecca G Clifton,Robert A Wise,Alan T N Tita,Jessica A de Voest,Sharon A McGrath-Morrow,Elizabeth C Matsui,Sean C Blackwell,Monica Longo,Sabine Z Bousleiman,Felecia Ortiz,Sankaran Krishnan,Dwight J Rouse,Torri D Metz,George R Saade,Maged M Costantine,Kent D Heyborne,John M Thorp,Kelly S Gibson,Geeta K Swamy,William A Grobman,Yasser Y El-Sayed,George A Macones,
OBJECTIVETo evaluate whether antenatal betamethasone affects childhood respiratory impairment.METHODSThis was a prospective follow-up study of children aged 6 years and older from parents in the ALPS (Antenatal Late Preterm Steroids) trial randomized to betamethasone or placebo from 34 0/7 to 36 6/7 weeks of gestation. Primary outcome composite included the following: 1) abnormal spirometry, forced expiratory volume in 1 second (FEV1) below the lower limit of normal, FEV1/forced vital capacity (FVC) below the lower limit of normal, or FVC below the lower limit of normal, defined as below the 5th percentile by the Global Lung Initiative; 2) physician-diagnosed asthma and daily asthma medication; or 3) daily asthma medication use in the past year. Children whose parents were enrolled in a concurrent trial were recruited to provide a term reference cohort for lung function. Adjusted analyses were performed controlling for confounders.RESULTSOf 2,831 ALPS children, 1,218 enrolled, and 1,194 (98.0%) completed spirometry. There were no differences in the primary outcome (35.3% betamethasone, 35.8% placebo; adjusted relative risk [RR] 1.02, 95% CI, 0.87-1.18) or its individual components, although ever-noting wheezing or whistling in the chest was less common (40.7% betamethasone, 45.5% placebo, adjusted RR 0.88, 95% CI, 0.77-0.996). Compared with 432 children from the term reference cohort, ALPS children had more wheezing with exercise in the past year (7.2% betamethasone vs 4.4% term control group, adjusted RR 1.77, 95% CI, 1.03-3.06; 8.8% placebo vs term control group, adjusted RR 2.09, 95% CI, 1.25-3.48).CONCLUSIONAmong children aged 6 years or older, late preterm antenatal exposure to betamethasone was associated with lower rates of wheezing or whistling in the chest but no differences in other respiratory outcomes.
目的评价产前倍他米松对儿童呼吸功能损害的影响。方法:本研究是一项前瞻性随访研究,对来自父母的6岁及以上儿童进行ALPS(产前晚期早产儿类固醇)试验,从妊娠34 0/7周至36 6/7周随机分配至倍他米松或安慰剂。主要结局包括:1)肺活量测量异常,1秒用力呼气量(FEV1)低于正常下限,FEV1/用力肺活量(FVC)低于正常下限,或FVC低于正常下限,定义为低于全球肺倡议的第5个百分点;2)医生诊断的哮喘和日常哮喘药物;3)过去一年每天服用哮喘药物的情况。父母同时参加试验的儿童被招募来提供肺功能的长期参考队列。进行校正分析,控制混杂因素。结果在2831例ALPS患儿中,1218例入组,1194例(98.0%)完成肺量测定。主要结局(倍他米松35.3%,安慰剂35.8%;校正相对危险度[RR] 1.02, 95% CI, 0.87-1.18)或其单独组成部分没有差异,尽管无症状喘息或胸鸣较少见(倍他米松40.7%,安慰剂45.5%,校正RR 0.88, 95% CI, 0.77-0.996)。与长期参考队列的432名儿童相比,ALPS儿童在过去一年中运动时出现更多喘息(倍他米松组7.2% vs长期对照组4.4%,调整RR 1.77, 95% CI 1.03-3.06;安慰剂组8.8% vs长期对照组,调整RR 2.09, 95% CI 1.25-3.48)。结论在6岁及以上的儿童中,晚期早产儿产前暴露于倍他米松与较低的胸部喘息或口哨发生率相关,但与其他呼吸结局无差异。
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引用次数: 0
Noncardiovascular Medical Conditions in the Pregnancy Mortality Surveillance System, 2012-2022. 2012-2022年妊娠死亡率监测系统中的非心血管疾病
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-22 DOI: 10.1097/aog.0000000000006175
Fanny Njie,Ashley A Busacker,Crystal Gibson,Carla Syverson,Kristi Seed,David A Goodman,Lisa M Hollier
Pregnancy Mortality Surveillance System (PMSS) data from 2012-2022 were analyzed for this descriptive study. Specific subclassifications of deaths within the PMSS category of "other noncardiovascular medical conditions" (OMC) were analyzed by sociodemographic characteristics, and pregnancy-related mortality ratios (PRMRs; pregnancy-related deaths/100,000 live births) were calculated within each subclassification. Prepandemic (2012-2019) and coronavirus disease 2019 (COVID-19) pandemic (2020-2022) time periods are reported separately. The overall OMC-specific PRMR was 2.20 (95% CI, 2.06-2.35). Epilepsy was the most frequent specific subclassification of pregnancy-related OMC deaths before (15.7%) and during (16.1%) the COVID-19 pandemic. Diabetes (10.7%) and asthma (10.1%) followed epilepsy prepandemic, and asthma (13.1%) and diabetes (10.2%) followed during the pandemic. Reporting subclassifications of pregnancy-related deaths improves the ability to focus attention and interventions on these less frequently occurring consistent causes of pregnancy-related death.
本描述性研究分析了2012-2022年妊娠死亡率监测系统(PMSS)的数据。根据社会人口学特征分析了PMSS“其他非心血管疾病”(OMC)类别中死亡的具体子分类,并在每个子分类中计算了与妊娠有关的死亡率(PRMRs;与妊娠有关的死亡/10万活产)。大流行前(2012-2019)和冠状病毒病2019 (COVID-19)大流行(2020-2022)时间段分别报告。总体omc特异性PRMR为2.20 (95% CI, 2.06-2.35)。癫痫是COVID-19大流行之前(15.7%)和期间(16.1%)妊娠相关OMC死亡中最常见的特定亚型。癫痫大流行前继发糖尿病(10.7%)和哮喘(10.1%),大流行期间继发哮喘(13.1%)和糖尿病(10.2%)。报告与妊娠有关的死亡的分类,有助于将注意力和干预措施集中在这些不太经常发生的与妊娠有关的死亡原因上。
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引用次数: 0
Comparing Efficacy of Medication Abortion by Health Care Modality at a California Health System. 加州某医疗系统中不同医疗保健方式药物流产的疗效比较。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-22 DOI: 10.1097/aog.0000000000006174
Rajita Patil,Rebecca Woofter,May Sudhinaraset,Jessica D Gipson
OBJECTIVETo compare the efficacy and safety of telemedicine medication abortion and clinic-based medication abortion among patients at one academic health system in California.METHODSWe conducted a retrospective cohort study of electronic medical records for all patients who had either telemedicine medication abortion or clinic-based medication abortion up to 77 days of gestation between April 1, 2020, and December 31, 2022. All patients who met eligibility requirements were offered telemedicine medication abortion. Patients who were not eligible for or did not prefer telemedicine medication abortion completed clinic-based medication abortion. We examined attendance at follow-up visits, successful medication abortion without requiring surgical intervention, and occurrence of serious adverse events. Among patients who had telemedicine medication abortion, we also examined attendance at 4-week follow-up visits and results of home urine pregnancy tests.RESULTSOverall, 165 patients who had telemedicine medication abortion and 411 patients who had clinic-based medication abortion were included in the study. A total of 91.6% of patients who had telemedicine medication abortion and 84.5% of patients who had clinic-based medication abortion completed at least one follow-up visit, with no significant difference detected by modality after controlling for covariates (adjusted odds ratio [aOR] 1.90, 95% CI, 0.96-3.77). Ninety percent of patients who had telemedicine medication abortion and 88.4% of patients who had clinic-based medication abortion had successful abortions without requiring surgical intervention. Odds of successful abortions did not statistically significantly differ by medication abortion modality (aOR 0.78, 95% CI, 0.38-1.59). Because of the rarity of serious adverse events (less than 1% in both groups, all requiring either intravenous antibiotics or blood transfusions), we could not complete multivariable models for this outcome.CONCLUSIONOur findings from one academic health system in California support prior studies showing that telemedicine medication abortion and clinic-based medication abortion are equally effective. When possible, the provision of telemedicine medication abortion should be expanded to meet the growing demand for abortion access.
目的比较加州某学术卫生系统远程医疗药物流产与临床药物流产的疗效和安全性。方法对2020年4月1日至2022年12月31日期间妊娠77天以内的所有远程医疗药物流产或临床药物流产患者的电子病历进行回顾性队列研究。所有符合资格要求的患者均被提供远程医疗药物流产。不符合或不喜欢远程医疗药物流产的患者完成了基于临床的药物流产。我们检查了随访的出席率,不需要手术干预的药物流产的成功,以及严重不良事件的发生。在远程医疗药物流产的患者中,我们还检查了4周随访的出勤率和家庭尿妊娠试验的结果。结果共纳入165例远程医疗药物流产患者和411例临床药物流产患者。91.6%的远程医疗药物流产患者和84.5%的临床药物流产患者完成了至少一次随访,在控制协变量后,两组间的模态差异无统计学意义(校正优势比[aOR] 1.90, 95% CI, 0.96-3.77)。90%的远程医疗药物流产患者和88.4%的临床药物流产患者在不需要手术干预的情况下成功流产。不同药物流产方式流产成功率差异无统计学意义(aOR 0.78, 95% CI 0.38-1.59)。由于严重不良事件的罕见性(两组均小于1%,均需要静脉注射抗生素或输血),我们无法完成该结果的多变量模型。结论:我们在加州一个学术卫生系统的研究结果支持了先前的研究,即远程医疗药物流产和临床药物流产同样有效。在可能的情况下,应扩大提供远程医疗药物堕胎,以满足日益增长的堕胎服务需求。
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引用次数: 0
Understanding Postpartum Hospital Use Among Birthing People With Medicaid Insurance. 了解有医疗补助保险的产妇的产后医院使用情况。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-22 DOI: 10.1097/aog.0000000000006170
Sarah M Lindley,Kimberly B Glazer,Teresa Janevic,Molly Passarella,Angelina Malenda,Natalia N Egorova,Jennifer Zeitlin,Scott A Lorch,Elizabeth A Howell
Individuals with Medicaid insurance are more likely to have pregnancy-related complications than individuals with private insurance, but previous research has not described postpartum hospital use in the population of patients with Medicaid. Using Medicaid claims data, we analyzed time to the first instance of postpartum hospital use during the postpartum year using Kaplan-Meier curves and described causes of postpartum hospital use at different postpartum windows. Among 1,626,056 birthing individuals, 20.7% had postpartum hospital use at 1 year postpartum. We found a higher proportion of postpartum hospital use after the typical 30-day postpartum analysis window than within the initial 30 days postpartum, with causes of postpartum hospital use shifting away from delivery-related causes over time. This highlights the need to better understand postpartum hospital use in the population of patients with Medicaid insurance, because 40% of births in the United States occur in this population.
拥有医疗补助保险的个体比拥有私人保险的个体更有可能出现与妊娠相关的并发症,但之前的研究并没有描述医疗补助患者群体的产后住院情况。使用医疗补助索赔数据,我们使用Kaplan-Meier曲线分析了产后一年内首次产后住院的时间,并描述了不同产后窗口期产后住院的原因。在1,626,056名分娩个体中,20.7%在产后1年使用过产后医院。我们发现,在典型的产后30天分析窗口后,产后住院的比例高于产后最初30天,随着时间的推移,产后住院的原因逐渐从分娩相关的原因转移。这突出了需要更好地了解医疗补助保险患者群体的产后医院使用情况,因为美国40%的分娩发生在这一人群中。
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引用次数: 0
Expression of Concern: Fezolinetant and Elinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: A Systematic Review and Meta-Analysis. 关注的表达:非唑啉奈坦和依兰那坦治疗出现血管舒缩症状的绝经妇女:一项系统回顾和荟萃分析。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-16 DOI: 10.1097/aog.0000000000006180
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引用次数: 0
The Hook & Roll Maneuver for Resolution of Shoulder Dystocia. 钩滚手法治疗肩难产。
IF 7.2 2区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-15 DOI: 10.1097/aog.0000000000006167
Erica A Heilman,Hannah E Sweeney,Ella Stern,Matthew K Hoffman
BACKGROUNDShoulder dystocia is an obstetric emergency with the potential to cause maternal and neonatal injuries.TECHNIQUEThe hook & roll maneuver is a modification of other posterior axilla maneuvers that involves hooking the posterior axilla with one finger and providing gentle traction, elevating the posterior shoulder toward the vaginal opening while simultaneously rolling the anterior shoulder toward the fetal face and rotating approximately 30-90°.EXPERIENCEAt the time of this submission, the hook & roll maneuver has been used 54 times in our institution, successfully resolving shoulder dystocia in 53 of the 54 cases (98.1%). In 16 cases in which the hook & roll maneuver was used as the primary internal maneuver, no neonatal injuries occurred.CONCLUSIONHook & roll is a posterior axilla maneuver combined with rotation of the anterior shoulder ventrally that is highly successful and easy to perform. The hook & roll maneuver is a promising alternative maneuver to consider in cases of shoulder dystocia, and early data suggest low rates of neonatal complications.
背景:肩难产是一种产科急诊,有可能导致孕产妇和新生儿损伤。钩滚手法是对其他后腋窝手法的改进,包括用一根手指钩住后腋窝并提供温和牵引,将后肩向阴道口抬高,同时将前肩向胎儿面部滚动并旋转约30-90°。在本文提交时,我们机构已使用钩滚手法54次,54例中53例(98.1%)成功解决肩难产。在16例以钩滚手法为主的患儿中,未发生新生儿损伤。结论钩滚是一种结合前肩腹侧旋转的后腋窝手法,成功率高,操作简单。钩滚手法是一种很有前途的替代手法,可以考虑在肩部难产的情况下,早期的数据表明新生儿并发症的发生率低。
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引用次数: 0
期刊
Obstetrics and gynecology
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