M. Kawai, M. Kawai, Fumihiko Kohno, M. Sakumoto, Ayumi Taeda, N. Shiotsu, Toshio Yamamoto, K. Ohura
{"title":"A pilot study of dental pharmacotherapy for alveolar bone regeneration","authors":"M. Kawai, M. Kawai, Fumihiko Kohno, M. Sakumoto, Ayumi Taeda, N. Shiotsu, Toshio Yamamoto, K. Ohura","doi":"10.11263/JSOTP.17.13","DOIUrl":"https://doi.org/10.11263/JSOTP.17.13","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"36 1","pages":"101-107"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63802104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-08-01DOI: 10.1080/19424396.2011.12221930
Vivek K Bains, Vivek Gupta, G P Singh, Rhythm Bains
Mucogingival problems are developmental and acquired aberrations in the morphology, position, and/or the amount of gingiva surrounding teeth. According to an academic report by American Academy of Periodontology, mucogingival therapy should be advocated for gingival augmentation and to create adequate vestibular depth in areas with insufficient attached gingiva. This paper provides an overview on mucogingival surgical procedures from its inception to the current time.
{"title":"Mucogingival surgery: where we stand today.","authors":"Vivek K Bains, Vivek Gupta, G P Singh, Rhythm Bains","doi":"10.1080/19424396.2011.12221930","DOIUrl":"10.1080/19424396.2011.12221930","url":null,"abstract":"<p><p>Mucogingival problems are developmental and acquired aberrations in the morphology, position, and/or the amount of gingiva surrounding teeth. According to an academic report by American Academy of Periodontology, mucogingival therapy should be advocated for gingival augmentation and to create adequate vestibular depth in areas with insufficient attached gingiva. This paper provides an overview on mucogingival surgical procedures from its inception to the current time.</p>","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"1 1","pages":"573-83"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85859789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Triacylated lipopeptide, a component of Gram-positive bacteria, induces osteoclastogenesis in the absence of RANKL and resorbs calvarial bone in vivo through Toll-like receptor 2","authors":"Keiko Suzuki, S. Yamada","doi":"10.11263/JSOTP.29.9","DOIUrl":"https://doi.org/10.11263/JSOTP.29.9","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"29 1","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63802411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-12-01DOI: 10.11263/JSOTP1982.27.143
M. Ushiyama, R. Ikeda, T. Nitta, Yusuke Tazitsu, A. Miyawaki, Tatsuya Yamaguchi, Y. Shimodouzono, K. Ushinohama, R. Matsui, K. Sugihara, N. Nakamura, Katsushi Yamada
{"title":"Analysis of the stability and microbiological safety of aznol saline gargle in hospital preparations widely used for the treatment of oral cancer patients with oral mucositis","authors":"M. Ushiyama, R. Ikeda, T. Nitta, Yusuke Tazitsu, A. Miyawaki, Tatsuya Yamaguchi, Y. Shimodouzono, K. Ushinohama, R. Matsui, K. Sugihara, N. Nakamura, Katsushi Yamada","doi":"10.11263/JSOTP1982.27.143","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.143","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"27 1","pages":"143-150"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-12-01DOI: 10.11263/JSOTP1982.27.151
Yoshio Saito
{"title":"Results of medicine revaluation in the odontology department","authors":"Yoshio Saito","doi":"10.11263/JSOTP1982.27.151","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.151","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"27 1","pages":"151-156"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-08-01DOI: 10.11263/JSOTP1982.27.103
H. Matsumoto, R. Takeuchi, M. Ono, Y. Akimoto, A. Fujii
In the present study, the results of characters in nifedipine responders (NIFr) and nifedipine non-responders (NIFn) are summarized, and the possibility of using tenidap and 18ƒ¿ -glycyrrhetinic acid (18ƒ¿-GA) as a therapeutic for gingival overgrowth caused by calcium channel blockers is investigated. 18ƒ¿-GA inhibited cell proliferation and G1/S transition were induced in NIFr cells. It was also shown that cell cycle control proteins were down-stream targets in the growth-inhibition activity of 18ƒ¿-GA in NIFr cells. Tenidap discharges intracellular Ca2+ store, resulting in a depletion of intracellular Ca2+ store in NIFr cells. It also inhibits cell growth, DNA and collagen syntheses, lowered intracellular pH, and enhanced matrix metalloproteinase-1 formation in NIFr cells. These results suggest that 18ƒ¿-GA and tenidap might be effective for the prevention of gingival overgrowth caused by calcium channel blockers.
{"title":"A possible therapeutic for gingival overgrowth caused by calcium channel blockers","authors":"H. Matsumoto, R. Takeuchi, M. Ono, Y. Akimoto, A. Fujii","doi":"10.11263/JSOTP1982.27.103","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.103","url":null,"abstract":"In the present study, the results of characters in nifedipine responders (NIFr) and nifedipine non-responders (NIFn) are summarized, and the possibility of using tenidap and 18ƒ¿ -glycyrrhetinic acid (18ƒ¿-GA) as a therapeutic for gingival overgrowth caused by calcium channel blockers is investigated. 18ƒ¿-GA inhibited cell proliferation and G1/S transition were induced in NIFr cells. It was also shown that cell cycle control proteins were down-stream targets in the growth-inhibition activity of 18ƒ¿-GA in NIFr cells. Tenidap discharges intracellular Ca2+ store, resulting in a depletion of intracellular Ca2+ store in NIFr cells. It also inhibits cell growth, DNA and collagen syntheses, lowered intracellular pH, and enhanced matrix metalloproteinase-1 formation in NIFr cells. These results suggest that 18ƒ¿-GA and tenidap might be effective for the prevention of gingival overgrowth caused by calcium channel blockers.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"27 1","pages":"103-108"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-08-01DOI: 10.11263/JSOTP1982.27.125
S. Ogura, K. Shinohara, Katsuhisa Sunada, H. Takamori, Kiminari Nakamura
{"title":"A randomized controlled trial comparison between ropivacaine and 2% lidocaine containing adrenalin for inferior alveolar nerve block during implant surgery","authors":"S. Ogura, K. Shinohara, Katsuhisa Sunada, H. Takamori, Kiminari Nakamura","doi":"10.11263/JSOTP1982.27.125","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.125","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"27 1","pages":"125-130"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11263/JSOTP1982.27.125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-08-01DOI: 10.11263/JSOTP1982.27.86
Takahiro Kato
Gingival overgrowth is a serious adverse effect associated with the administration of phenytoin (PHT), with PHT-induced gingival overgrowth characterized by a massive accumulation of extracellular matrix components, especially collagen, in gingival connective tissues. However, the etiology of such collagen accumulation is still largely unknown. We examined the effects of PHT on the collagen degradation process leading to collagen accumulation in human gingival fibroblasts (HGF). PHT causes an impaired degradation of collagen by suppression of enzymatic degradation with MMPs/TIMP-1 and ƒ¿2 ƒÀ1 integrin mediated endocytosis. These synergistic effects may cause collagen accumulation, leading to gingival overgrowth. It has also been reported that dental plaque is the most important factor to enhance deterioration caused by PHT-induced
{"title":"Study on the mechanism of collagen metabolism in phenytoin-induced gingival overgrowth","authors":"Takahiro Kato","doi":"10.11263/JSOTP1982.27.86","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.86","url":null,"abstract":"Gingival overgrowth is a serious adverse effect associated with the administration of phenytoin (PHT), with PHT-induced gingival overgrowth characterized by a massive accumulation of extracellular matrix components, especially collagen, in gingival connective tissues. However, the etiology of such collagen accumulation is still largely unknown. We examined the effects of PHT on the collagen degradation process leading to collagen accumulation in human gingival fibroblasts (HGF). PHT causes an impaired degradation of collagen by suppression of enzymatic degradation with MMPs/TIMP-1 and ƒ¿2 ƒÀ1 integrin mediated endocytosis. These synergistic effects may cause collagen accumulation, leading to gingival overgrowth. It has also been reported that dental plaque is the most important factor to enhance deterioration caused by PHT-induced","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"27 1","pages":"86-91"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-08-01DOI: 10.11263/JSOTP1982.27.68
Koichi Ito
Gingival hyperplasia (overgrowth) is a well-documented unwanted effect, associated with phenytoin, the calcium channel blockers, and cyclosporin. The pathogenesis of drug-induced gingival hyperplasia is uncertain. However, the identification of risk factors associated with both the prevalence and severity of drug-induced gingival hyperplasia is important for all parties involved with this unwanted effect. Prevalence of gingival hyperplasia with phenytoin, the calcium channel blockers, and cyclosporin is approximately 50%, 10-20%, and 8-70%, respectively. The inflammatory components of drug-induced gingival hyperplasia can be managed effectively for the majority of patients with a plaque control program and nonsurgical periodontal therapy including oral hygiene instruction, scaling and root planing coupled with continued periodontal maintenance procedures. After reevaluation, some patients may need surgical periodontal therapy and maintenance procedures. Maintenance therapy including appropriate oral home care appear to be effective in controlling the drug-induced gingival hyperplasia and in maintaining clinical improvements for a long time.
{"title":"Current status of treatment modalities for drug-induced gingival overgrowth","authors":"Koichi Ito","doi":"10.11263/JSOTP1982.27.68","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.68","url":null,"abstract":"Gingival hyperplasia (overgrowth) is a well-documented unwanted effect, associated with phenytoin, the calcium channel blockers, and cyclosporin. The pathogenesis of drug-induced gingival hyperplasia is uncertain. However, the identification of risk factors associated with both the prevalence and severity of drug-induced gingival hyperplasia is important for all parties involved with this unwanted effect. Prevalence of gingival hyperplasia with phenytoin, the calcium channel blockers, and cyclosporin is approximately 50%, 10-20%, and 8-70%, respectively. The inflammatory components of drug-induced gingival hyperplasia can be managed effectively for the majority of patients with a plaque control program and nonsurgical periodontal therapy including oral hygiene instruction, scaling and root planing coupled with continued periodontal maintenance procedures. After reevaluation, some patients may need surgical periodontal therapy and maintenance procedures. Maintenance therapy including appropriate oral home care appear to be effective in controlling the drug-induced gingival hyperplasia and in maintaining clinical improvements for a long time.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"27 1","pages":"68-78"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-08-01DOI: 10.11263/JSOTP1982.27.116
Yohko Kaku, K. Enami, M. Fukumoto, M. Yamaguchi, K. Shibutani
{"title":"Medical lawsuits judged by using drug package inserts as criteria for the judicial decisions","authors":"Yohko Kaku, K. Enami, M. Fukumoto, M. Yamaguchi, K. Shibutani","doi":"10.11263/JSOTP1982.27.116","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.116","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"27 1","pages":"116-124"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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