Abstract In this study, the lyophilized extracts of grape (Vitis vinifera L. cv. Dimrit) seeds [0 (control), 4, 5 and 6 mg/100 mL)] were incorporated into ayran drinks, and the total solids, fat, pH, acidity (% lactic acid) and CIELAB color values, total phenolic content, antioxidant activity values, some microbiological and sensory properties of ayran drinks were determined during storage at 4±1 °C for 10 days. The addition of grape seed extract powder (GSEP) had an insignificant effect on the pH, acidity and L* values of ayran drinks (p > 0.05), but the a* and b* color values of drinks increased as its concentration increased. The incorporation of GSEP into ayran drinks increased the total phenolic content and antioxidant activity values of samples significantly in comparison to control samples (p < 0.05). Addition of GSEP to ayran drinks did not change the counts of lactobacilli and lactococci in ayran drinks during storage. Panelists in sensory evaluation liked the flavor and color properties of control and ayran drinks with 4 mg/100 mL GSEP more than other samples (p < 0.05). Results indicated that GSEP might have a great potential to increase the antioxidant activity of ayran drinks, but its concentration is primarily limited by its bitter taste in drinks.
{"title":"Effect of grape (Vitis vinifera L. cv. Dimrit) seed extract powder on total phenolic content and antioxidant properties of ayran drink","authors":"R. Faki, Kubra Kocaturk, O. Gursoy, Y. Yılmaz","doi":"10.2478/auoc-2022-0021","DOIUrl":"https://doi.org/10.2478/auoc-2022-0021","url":null,"abstract":"Abstract In this study, the lyophilized extracts of grape (Vitis vinifera L. cv. Dimrit) seeds [0 (control), 4, 5 and 6 mg/100 mL)] were incorporated into ayran drinks, and the total solids, fat, pH, acidity (% lactic acid) and CIELAB color values, total phenolic content, antioxidant activity values, some microbiological and sensory properties of ayran drinks were determined during storage at 4±1 °C for 10 days. The addition of grape seed extract powder (GSEP) had an insignificant effect on the pH, acidity and L* values of ayran drinks (p > 0.05), but the a* and b* color values of drinks increased as its concentration increased. The incorporation of GSEP into ayran drinks increased the total phenolic content and antioxidant activity values of samples significantly in comparison to control samples (p < 0.05). Addition of GSEP to ayran drinks did not change the counts of lactobacilli and lactococci in ayran drinks during storage. Panelists in sensory evaluation liked the flavor and color properties of control and ayran drinks with 4 mg/100 mL GSEP more than other samples (p < 0.05). Results indicated that GSEP might have a great potential to increase the antioxidant activity of ayran drinks, but its concentration is primarily limited by its bitter taste in drinks.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"24 1","pages":"143 - 149"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82827770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract An investigation was carried out to extract the polyphenols from Cynodon dactylon L. by ultrasound-assisted extraction (UAE) and maceration assisted extraction (MAE), and to assess the antioxidant and antimicrobial activities, as well as the evaluation of the cytotoxic effect of ethanolic extracts. The yields of crude extracts were 9.40 % for the MAE extract and 12.52 % for the UAE extract. The results showed that the extract obtained by MAE contains a high level of polyphenols and flavonoids estimated by 42.14 ± 0.75 mg EAG/gE and 23.57 ± 0.78 mg EQ/gE. In contrast, the content of condensed tannins in the extract of UAE (19.34 ± 0.48 mg EC/gE) is higher. The evaluation of the antioxidant activity revealed a considerable antioxidant response, the MAE extract represents the most active extract, with an IC50 =7.52 ± 0.037 mg/mL for the DPPH test, and 15.83 ± 0.37 mg EAA/gE for the FRAP test. The results of antimicrobial activity showed that all the strains targeted have high susceptibility to the two ethanolic extracts of Cynodon dactylon L. The evaluation of cytotoxicity against RBCs was carried, the results shown the non-toxic effect of C. dactylon extracts and hence support its ethnomedicinal application.
{"title":"Comparison of ultrasound and maceration methods on antioxidant and antimicrobial efficacy of phenolic compounds extracted from Cynodon dactylon L. of Algeria","authors":"M. Tlili, Chaima Benine","doi":"10.2478/auoc-2022-0018","DOIUrl":"https://doi.org/10.2478/auoc-2022-0018","url":null,"abstract":"Abstract An investigation was carried out to extract the polyphenols from Cynodon dactylon L. by ultrasound-assisted extraction (UAE) and maceration assisted extraction (MAE), and to assess the antioxidant and antimicrobial activities, as well as the evaluation of the cytotoxic effect of ethanolic extracts. The yields of crude extracts were 9.40 % for the MAE extract and 12.52 % for the UAE extract. The results showed that the extract obtained by MAE contains a high level of polyphenols and flavonoids estimated by 42.14 ± 0.75 mg EAG/gE and 23.57 ± 0.78 mg EQ/gE. In contrast, the content of condensed tannins in the extract of UAE (19.34 ± 0.48 mg EC/gE) is higher. The evaluation of the antioxidant activity revealed a considerable antioxidant response, the MAE extract represents the most active extract, with an IC50 =7.52 ± 0.037 mg/mL for the DPPH test, and 15.83 ± 0.37 mg EAA/gE for the FRAP test. The results of antimicrobial activity showed that all the strains targeted have high susceptibility to the two ethanolic extracts of Cynodon dactylon L. The evaluation of cytotoxicity against RBCs was carried, the results shown the non-toxic effect of C. dactylon extracts and hence support its ethnomedicinal application.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"52 1","pages":"121 - 128"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77065101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract This paper presents a new solution to use the cathode ray tube glass wastes for iron oxide rich waste vitrification. The obtained glass-ceramics, synthesized at three heat treatment temperatures: 800, 900 and 1000 °C were characterized in terms of the effect of the CRT waste glass addition upon the dimensional stability, apparent porosity and density, chemical stability and lead barium and iron ions retention capacity.
{"title":"Cathode ray tubes glass wastes used for vitrification of iron oxide rich waste resulted from the groundwater treatment","authors":"C. Vancea, G. Mosoarca, R.-M. Jurca","doi":"10.2478/auoc-2022-0025","DOIUrl":"https://doi.org/10.2478/auoc-2022-0025","url":null,"abstract":"Abstract This paper presents a new solution to use the cathode ray tube glass wastes for iron oxide rich waste vitrification. The obtained glass-ceramics, synthesized at three heat treatment temperatures: 800, 900 and 1000 °C were characterized in terms of the effect of the CRT waste glass addition upon the dimensional stability, apparent porosity and density, chemical stability and lead barium and iron ions retention capacity.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"73 1","pages":"172 - 176"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74109602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract A topic of high interest, the plastic degradation in the environment, is approached in this work, to serve for future research. The problem of plastics pollution became critical with the exponential development of plastic materials industry in last decades. Soil and water are primarily polluted, then degradation to microplastics leads to spatial distribution of plastic debris in all ecosystems. Slow natural degradation and pollutants accumulation on the plastic particles are responsible for environment unbalancies. This work follows the new research about the induced degradation methods, abiotic and biotic, pointing out the most notable results. Most research took place in laboratories, but promising results of some biotic methods will hopefully lead to industrial scale-up.
{"title":"Experimental investigations on polyethylene and polyethylene terephthalate microplastics’ degradation. A review","authors":"Aila-Elmaz Geambulat, T. Dobre, C. Koncsag","doi":"10.2478/auoc-2022-0023","DOIUrl":"https://doi.org/10.2478/auoc-2022-0023","url":null,"abstract":"Abstract A topic of high interest, the plastic degradation in the environment, is approached in this work, to serve for future research. The problem of plastics pollution became critical with the exponential development of plastic materials industry in last decades. Soil and water are primarily polluted, then degradation to microplastics leads to spatial distribution of plastic debris in all ecosystems. Slow natural degradation and pollutants accumulation on the plastic particles are responsible for environment unbalancies. This work follows the new research about the induced degradation methods, abiotic and biotic, pointing out the most notable results. Most research took place in laboratories, but promising results of some biotic methods will hopefully lead to industrial scale-up.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"11 1","pages":"156 - 165"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88802870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract L-alanine and β-alanine are important biological molecules and have zwitterion structure. In this study, L- alanine and β-alanine’s microscopic protonation constants and thermodynamic parameters (enthalpy, entropy, and free energy changes) for the proton–ligand systems of L-alanine methyl ester, β-alanine and β-alanine methyl ester have been determined at 5; 20; 35 °C, in ACN-water (25% ACN and 50% ACN (v/v)) mixtures at constant ionic strength of 0.1000 mol L–1 NaClO4 by potentiometric method. The results shown that, L-alanine and β-alanine’s microscopic protonation constants generally tend to decrease with temperature rise and their protonation reactions in ACN-water mixtures generally favor enthalpy-driven.
{"title":"Temperature dependence studies and microscopic protonation constants of L-alanine and β-alanine in acetonitrile – water mixtures","authors":"Hande Erensoy, D. Alkaya, S. Seyhan","doi":"10.2478/auoc-2022-0014","DOIUrl":"https://doi.org/10.2478/auoc-2022-0014","url":null,"abstract":"Abstract L-alanine and β-alanine are important biological molecules and have zwitterion structure. In this study, L- alanine and β-alanine’s microscopic protonation constants and thermodynamic parameters (enthalpy, entropy, and free energy changes) for the proton–ligand systems of L-alanine methyl ester, β-alanine and β-alanine methyl ester have been determined at 5; 20; 35 °C, in ACN-water (25% ACN and 50% ACN (v/v)) mixtures at constant ionic strength of 0.1000 mol L–1 NaClO4 by potentiometric method. The results shown that, L-alanine and β-alanine’s microscopic protonation constants generally tend to decrease with temperature rise and their protonation reactions in ACN-water mixtures generally favor enthalpy-driven.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"69 1","pages":"99 - 103"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83270995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azrul Nurfaiz Mohd-Faizal, Mohd Shafiq Hakimi Mohd-Shaid, Muhammad Abbas Ahmad-Zaini
Abstract Solid fuel briquette from biomass materials has gained considerable attention as sustainable replacement source of energy. The characteristics of briquette are imperative to ensure its effectiveness as fuel in a long run. This paper is aimed to summarize the key properties of solid briquette made from various natural and waste-based resources, and to highlight the future research directions in the briquette manufacture. The commentary is expected to shed insight towards the greener, cleaner, and efficient briquette materials.
{"title":"Solid fuel briquette from biomass: Recent trends","authors":"Azrul Nurfaiz Mohd-Faizal, Mohd Shafiq Hakimi Mohd-Shaid, Muhammad Abbas Ahmad-Zaini","doi":"10.2478/auoc-2022-0022","DOIUrl":"https://doi.org/10.2478/auoc-2022-0022","url":null,"abstract":"Abstract Solid fuel briquette from biomass materials has gained considerable attention as sustainable replacement source of energy. The characteristics of briquette are imperative to ensure its effectiveness as fuel in a long run. This paper is aimed to summarize the key properties of solid briquette made from various natural and waste-based resources, and to highlight the future research directions in the briquette manufacture. The commentary is expected to shed insight towards the greener, cleaner, and efficient briquette materials.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"40 1","pages":"150 - 155"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83775130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ogoko Emeka Chima, Mgbemana Nkoli, H. Kelle, C. I. Osu, Esther Aju
Abstract The concentrations of heavy metals (Pb, As, Cr, Cu, Cd and Fe) were determined in the gills, liver and muscles of thirty-five fishes, water and sediment samples from Aba River using atomic absorption spectrophotometer. Heavy metal concentrations varied markedly among fish species and organs. Results revealed that Pb, Cr, Fe had maximum concentration levels of 0.63±0.01, 0.81±0.01 and 16.91 ± 0.20 mg/kg in Chrysichthys nigrodigitatus respectively. As and Cd recorded the highest concentration of 0.18±0.03 and 0.87±0.02 mg/kg in Malapterurus electricus respectively, while Trachurus trachurus had 1.05±0.03 mg/kg of Cu. Orenchromis niloticus, Tilapia ziili and Malapterurus electricus had higher concentrations of As and Cr in the liver compared to gills and muscles. The gills had higher concentrations of these heavy metals than liver and muscles in the rest of fish species studied. The concentrations of Cd, Pb and As in freshwater samples were higher than the standard maximum permissible limit. The sediments had higher concentrations of these metals than in fish and water samples. Heavy metal concentrations in fish species exceeded the standard guideline limit in food substances for human consumption. Malapterurus electricus, Parachanna obscura and Chrysichthys nigrodigitatus had bioaccumulation factors for Cd which ranged from 1.069-1.663, indicating potential Cd poisoning or contamination of the three fish species. The estimated daily intake in both adult and children ranged from 8.611 x 10−7 to 9.72 x 10−3 mg/kgbw/day and were within the standard limit of daily intake for the human population. The hazard quotient for adult and children populations ranged from 0.0041-1.3972 and 0.000287 - 0.2080 respectively. The hazard quotient was less than one in most of the metals except for iron, but hazard index was greater than one, indicating potential chronic health hazards. Incremental life cancer risk for the adult population was within safe limits.
{"title":"Health risk assessment of exposure to heavy metals in fish species consumed in Aba, Abia State, Nigeria","authors":"Ogoko Emeka Chima, Mgbemana Nkoli, H. Kelle, C. I. Osu, Esther Aju","doi":"10.2478/auoc-2022-0026","DOIUrl":"https://doi.org/10.2478/auoc-2022-0026","url":null,"abstract":"Abstract The concentrations of heavy metals (Pb, As, Cr, Cu, Cd and Fe) were determined in the gills, liver and muscles of thirty-five fishes, water and sediment samples from Aba River using atomic absorption spectrophotometer. Heavy metal concentrations varied markedly among fish species and organs. Results revealed that Pb, Cr, Fe had maximum concentration levels of 0.63±0.01, 0.81±0.01 and 16.91 ± 0.20 mg/kg in Chrysichthys nigrodigitatus respectively. As and Cd recorded the highest concentration of 0.18±0.03 and 0.87±0.02 mg/kg in Malapterurus electricus respectively, while Trachurus trachurus had 1.05±0.03 mg/kg of Cu. Orenchromis niloticus, Tilapia ziili and Malapterurus electricus had higher concentrations of As and Cr in the liver compared to gills and muscles. The gills had higher concentrations of these heavy metals than liver and muscles in the rest of fish species studied. The concentrations of Cd, Pb and As in freshwater samples were higher than the standard maximum permissible limit. The sediments had higher concentrations of these metals than in fish and water samples. Heavy metal concentrations in fish species exceeded the standard guideline limit in food substances for human consumption. Malapterurus electricus, Parachanna obscura and Chrysichthys nigrodigitatus had bioaccumulation factors for Cd which ranged from 1.069-1.663, indicating potential Cd poisoning or contamination of the three fish species. The estimated daily intake in both adult and children ranged from 8.611 x 10−7 to 9.72 x 10−3 mg/kgbw/day and were within the standard limit of daily intake for the human population. The hazard quotient for adult and children populations ranged from 0.0041-1.3972 and 0.000287 - 0.2080 respectively. The hazard quotient was less than one in most of the metals except for iron, but hazard index was greater than one, indicating potential chronic health hazards. Incremental life cancer risk for the adult population was within safe limits.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"57 1","pages":"177 - 187"},"PeriodicalIF":0.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88506972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Various studies have shown that ultrafiltration membranes are successfully involved in the removal process of most organic pollutants from wastewater. In this context, the hydrodynamic characteristics of a modified cellulose ultrafiltration membrane were evaluated. This composite membrane type has been proposed for the separation of colloidal matter from industrial wastewater in Galati City area (Romania). Another purpose of this paper was also to determine the volume flows, along with the permeate and concentrate fluxes through the technical membrane taken under study. Furthermore, a comparative analysis of three samples of industrial water from Galați City area in terms of the degree of contamination was performed. Surface modification was evaluated using scanning electron microscopy. Results indicated that the industrial wastewater from the steel factory Liberty Galati was significantly more impure than the water from Cătuşa Lake, which in turn was more impure than the water from Siret River, as indicated by comparative analysis of the water samples subjected to the ultrafiltration operation through semipermeable technical membranes. It was shown that the decrease of the permeate flux at the modified cellulosic membrane was accentuated in the first moments, probably due to the clogging of the surface pores that present an uneven distribution. The results of the present study show that the cellulosic membrane used has pore diameters which correspond to the values recommended for the retention of colloidal matter.
{"title":"Colloidal matter separation of industrial wastewaters from Galați City area by semipermeable membranes","authors":"A. Tǎbǎcaru, S. Butan, R. Crețu","doi":"10.2478/auoc-2022-0008","DOIUrl":"https://doi.org/10.2478/auoc-2022-0008","url":null,"abstract":"Abstract Various studies have shown that ultrafiltration membranes are successfully involved in the removal process of most organic pollutants from wastewater. In this context, the hydrodynamic characteristics of a modified cellulose ultrafiltration membrane were evaluated. This composite membrane type has been proposed for the separation of colloidal matter from industrial wastewater in Galati City area (Romania). Another purpose of this paper was also to determine the volume flows, along with the permeate and concentrate fluxes through the technical membrane taken under study. Furthermore, a comparative analysis of three samples of industrial water from Galați City area in terms of the degree of contamination was performed. Surface modification was evaluated using scanning electron microscopy. Results indicated that the industrial wastewater from the steel factory Liberty Galati was significantly more impure than the water from Cătuşa Lake, which in turn was more impure than the water from Siret River, as indicated by comparative analysis of the water samples subjected to the ultrafiltration operation through semipermeable technical membranes. It was shown that the decrease of the permeate flux at the modified cellulosic membrane was accentuated in the first moments, probably due to the clogging of the surface pores that present an uneven distribution. The results of the present study show that the cellulosic membrane used has pore diameters which correspond to the values recommended for the retention of colloidal matter.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"33 1","pages":"56 - 63"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76297714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract The present work was aimed to evaluate the optimum mass of crab shell biochar and adsorption contact time in a two-stage adsorber design for malachite green. The model was developed to predict optimum adsorbent mass and adsorption profiles at specified volumes and concentrations of dye effluent. Results show that the adsorbent mass can only be reduced by 1.91 % because of the adsorbent’s strong affinity towards malachite green. Accordingly, the adsorption contact time to achieve equilibrium has dramatically reduced from 150 min to 31 min. In the performance evaluation, the adsorbent mass in stage-1 is always higher than that in stage-2 to subside the adsorbent load in achieving the target removal at optimum dosage. From the response surface methodology, the most significant parameters in two-stage adsorber design are adsorption time at stage-2 and malachite green concentration. The predicted values of adsorbent mass and time are essential in designing the cost-competitive two-stage adsorption process for industrial wastewater treatment.
{"title":"Malachite green adsorption by calcium-rich crab shell char via two-stage adsorber design","authors":"Tivya Sarawanan, S. Lawal, M. Zaini","doi":"10.2478/auoc-2022-0005","DOIUrl":"https://doi.org/10.2478/auoc-2022-0005","url":null,"abstract":"Abstract The present work was aimed to evaluate the optimum mass of crab shell biochar and adsorption contact time in a two-stage adsorber design for malachite green. The model was developed to predict optimum adsorbent mass and adsorption profiles at specified volumes and concentrations of dye effluent. Results show that the adsorbent mass can only be reduced by 1.91 % because of the adsorbent’s strong affinity towards malachite green. Accordingly, the adsorption contact time to achieve equilibrium has dramatically reduced from 150 min to 31 min. In the performance evaluation, the adsorbent mass in stage-1 is always higher than that in stage-2 to subside the adsorbent load in achieving the target removal at optimum dosage. From the response surface methodology, the most significant parameters in two-stage adsorber design are adsorption time at stage-2 and malachite green concentration. The predicted values of adsorbent mass and time are essential in designing the cost-competitive two-stage adsorption process for industrial wastewater treatment.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"30 1","pages":"36 - 40"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89604680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. J. Adepoju, D. F. Latona, Oluwafemi Gbenga Olafare, A. Oyebamiji, M. Abdul-Hammed, B. Semire
Abstract The Ebola virus disease causing hemorrhagic fever in human, has been known for nearly about 40 years, with the most recent outbreak being in West Africa creating humanitarian crisis, where over 11,308 deaths were recorded as reported in 30th March, 2016 (World Health Organization). Till now, Ebola virus drugs have been far from achieving regulatory FDA approval, and coupled with toxicity of these drugs, it is become imperative to appraise the available trail drugs, as well as looking into alternative natural resources of tackling menace. Therefore, in silico methods were used to assess the potency of the bioactive phytochemical, Curcumin from Turmeric and results compared with those obtained for some selected trial drugs in use for the treatment of Ebola virus. This study is focused on molecular docking of Curcumin and eight commercially available drugs (Amodiaquine, Apilimod, Azithromycin, Bepridil, Pyronaridine, Remedesivir and Tilorone) against Ebola transcription activator VP30 proteins (PDB: 2I8B, 4Z9P and 5T3T) and their ADMET profiling. The results showed that binding affinity (ΔG kJ/mol) ranged from -5.8 (Tilorone) to -7.3 (Remdesivir) for 218B, -6.4 (Tilorone) to -8.2 (Pyronaridine, Remedesivir) and -5.8 (Bepridil) to -7.4 (Pyronaridine). Curcumin could be more desirable as inhibitor for than Tilorone, Dronedarone and Bepridil in the treatment of Ebola virus; the ADMET profile revealed that Curcumin presents attractive pharmacokinetic properties than the trial drugs.
{"title":"Molecular docking and pharmacokinetics studies of Curcuma longa (Curcumin) potency against Ebola virus","authors":"A. J. Adepoju, D. F. Latona, Oluwafemi Gbenga Olafare, A. Oyebamiji, M. Abdul-Hammed, B. Semire","doi":"10.2478/auoc-2022-0004","DOIUrl":"https://doi.org/10.2478/auoc-2022-0004","url":null,"abstract":"Abstract The Ebola virus disease causing hemorrhagic fever in human, has been known for nearly about 40 years, with the most recent outbreak being in West Africa creating humanitarian crisis, where over 11,308 deaths were recorded as reported in 30th March, 2016 (World Health Organization). Till now, Ebola virus drugs have been far from achieving regulatory FDA approval, and coupled with toxicity of these drugs, it is become imperative to appraise the available trail drugs, as well as looking into alternative natural resources of tackling menace. Therefore, in silico methods were used to assess the potency of the bioactive phytochemical, Curcumin from Turmeric and results compared with those obtained for some selected trial drugs in use for the treatment of Ebola virus. This study is focused on molecular docking of Curcumin and eight commercially available drugs (Amodiaquine, Apilimod, Azithromycin, Bepridil, Pyronaridine, Remedesivir and Tilorone) against Ebola transcription activator VP30 proteins (PDB: 2I8B, 4Z9P and 5T3T) and their ADMET profiling. The results showed that binding affinity (ΔG kJ/mol) ranged from -5.8 (Tilorone) to -7.3 (Remdesivir) for 218B, -6.4 (Tilorone) to -8.2 (Pyronaridine, Remedesivir) and -5.8 (Bepridil) to -7.4 (Pyronaridine). Curcumin could be more desirable as inhibitor for than Tilorone, Dronedarone and Bepridil in the treatment of Ebola virus; the ADMET profile revealed that Curcumin presents attractive pharmacokinetic properties than the trial drugs.","PeriodicalId":19641,"journal":{"name":"Ovidius University Annals of Chemistry","volume":"11 1","pages":"22 - 35"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85769717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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