Pub Date : 2026-02-01Epub Date: 2025-11-28DOI: 10.1016/j.joca.2025.11.011
Eva A. Bax , Roel J.H. Custers , Nienke van Egmond , Moyo C. Kruyt , Hassan Rayegan , Margreet Kloppenburg , Francisco J. Blanco , Ida K. Haugen , Francis Berenbaum , Frank W. Roemer , Harrie Weinans , Simon C. Mastbergen , Mylène P. Jansen
Objective
To investigate the associations between whole joint cartilage and meniscal morphology on MRI and radiographic joint space width (JSW) measures and in knee osteoarthritis (KOA), to determine whether bicompartmental measures demonstrate stronger associations than unicompartmental ones, and to evaluate their correlations with Kellgren and Lawrence grading.
Design
A cross-sectional analysis of baseline radiographs and MRIs from 262 KOA participants in the prospective, multicenter IMI-APPROACH cohort was conducted. Radiographic measures included minimum joint space width (mJSW), fixed location JSW (JSW(x)), mean JSW, and joint line convergence angle (JLCA), assessed using fully automated software. JSW was evaluated both unicompartmentally and bicompartmentally. Cartilage morphology, full-thickness cartilage loss, meniscal extrusion, tears, and maceration were assessed using the semi-quantitative MRI Osteoarthritis Knee Score to summarize whole-joint cartilage and meniscal morphology. Associations of radiographic measures with MRI outcomes were assessed using multivariable linear regression; Spearman correlations with Kellgren and Lawrence (KL) were also evaluated.
Results
MRI-defined meniscal maceration was associated with unicompartmental and bicompartmental JSW measures. Full-thickness cartilage loss was associated with unicompartmental (95% CI [-0.16;-0.02]) and bicompartmental mJSW (95% CI [-0.14;-0.02]), and JLCA (95% CI [0.04;0.22]). Models explained 32–39% of variance for unicompartmental and 23–45% for bicompartmental measures (R²). Bicompartmental measures showed stronger correlations with KL grading than unicompartmental measures (95% CI: –0.31 to –0.02).
Conclusions
Associations between whole-joint cartilage and meniscal degeneration are similar for uni- and bicompartmental JSW, with bicompartmental JSW showing stronger correlations with KL grades. These findings support including both compartments in radiographic assessment to improve structural evaluation in KOA.
{"title":"Unicompartmental versus bicompartmental joint space width measures: Which reflect whole joint structural damage better? Data from IMI-APPROACH","authors":"Eva A. Bax , Roel J.H. Custers , Nienke van Egmond , Moyo C. Kruyt , Hassan Rayegan , Margreet Kloppenburg , Francisco J. Blanco , Ida K. Haugen , Francis Berenbaum , Frank W. Roemer , Harrie Weinans , Simon C. Mastbergen , Mylène P. Jansen","doi":"10.1016/j.joca.2025.11.011","DOIUrl":"10.1016/j.joca.2025.11.011","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the associations between whole joint cartilage and meniscal morphology on MRI and radiographic joint space width (JSW) measures and in knee osteoarthritis (KOA), to determine whether bicompartmental measures demonstrate stronger associations than unicompartmental ones, and to evaluate their correlations with Kellgren and Lawrence grading.</div></div><div><h3>Design</h3><div>A cross-sectional analysis of baseline radiographs and MRIs from 262 KOA participants in the prospective, multicenter IMI-APPROACH cohort was conducted. Radiographic measures included minimum joint space width (mJSW), fixed location JSW (JSW(x)), mean JSW, and joint line convergence angle (JLCA), assessed using fully automated software. JSW was evaluated both unicompartmentally and bicompartmentally. Cartilage morphology, full-thickness cartilage loss, meniscal extrusion, tears, and maceration were assessed using the semi-quantitative MRI Osteoarthritis Knee Score to summarize whole-joint cartilage and meniscal morphology. Associations of radiographic measures with MRI outcomes were assessed using multivariable linear regression; Spearman correlations with Kellgren and Lawrence (KL) were also evaluated.</div></div><div><h3>Results</h3><div>MRI-defined meniscal maceration was associated with unicompartmental and bicompartmental JSW measures. Full-thickness cartilage loss was associated with unicompartmental (95% CI [-0.16;-0.02]) and bicompartmental mJSW (95% CI [-0.14;-0.02]), and JLCA (95% CI [0.04;0.22]). Models explained 32–39% of variance for unicompartmental and 23–45% for bicompartmental measures (R²). Bicompartmental measures showed stronger correlations with KL grading than unicompartmental measures (95% CI: –0.31 to –0.02).</div></div><div><h3>Conclusions</h3><div>Associations between whole-joint cartilage and meniscal degeneration are similar for uni- and bicompartmental JSW, with bicompartmental JSW showing stronger correlations with KL grades. These findings support including both compartments in radiographic assessment to improve structural evaluation in KOA.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 2","pages":"Pages 297-303"},"PeriodicalIF":9.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-10-10DOI: 10.1016/j.joca.2025.10.001
Tingting Sha , Yilun Wang , Yuqing Zhang , Jian Zhang , Cong Lu , Jie Wei , Guanghua Lei , Chao Zeng
Objective
Sexual minorities, including lesbian, gay, and bisexual individuals, experience persistent health disparities due to chronic exposure to minority stressors; however, its relation to osteoarthritis (OA) risk remains unexplored. This study aims to investigate the association between sexual orientation and OA risk and evaluate the mediating effect of health behaviors and psychosocial factors in related disparities.
Methods
We conducted a prospective cohort study of 346,320 UK Biobank participants without OA at baseline (2006–2010), followed through December 2021. Coarsened exact matching was applied to balance age, birth cohort, and ethnicity. Sex-stratified Cox models (using age as the time scale) were used to estimate hazard ratios (HRs) for OA risk. Mediation analyses examined the roles of modifiable factors, including body mass index (BMI), socioeconomic status, lifestyle behaviors, and mental health.
Results
Over a median follow-up of 11.3 years, 40,728 participants developed OA. Both bisexual and lesbian women had a higher OA risk than heterosexual women (adjusted HR: 1.17, 95%CI [confidence interval]: 1.07–1.28 and HR: 1.36, 95%CI: 1.10–1.68, respectively). Mediation analysis identified BMI, Townsend index, smoking, and depression as potential mediators, with mediation proportions ranging from 12.1% to 34.2%. In men, gay individuals had lower OA risk (HR: 0.72, 95%CI: 0.60–0.85), with BMI and education explaining 17.5–18.4% of the reduction; no significant difference was observed for bisexual men.
Conclusion
Sexual orientation is associated with OA risk, with bisexual and lesbian women showing higher risk and gay men lower risk than heterosexuals. These disparities are partially explained by BMI, smoking, depression, and socioeconomic status.
{"title":"Disparities in incident osteoarthritis between sexual minority and heterosexual adults: Findings from a large cohort study","authors":"Tingting Sha , Yilun Wang , Yuqing Zhang , Jian Zhang , Cong Lu , Jie Wei , Guanghua Lei , Chao Zeng","doi":"10.1016/j.joca.2025.10.001","DOIUrl":"10.1016/j.joca.2025.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>Sexual minorities, including lesbian, gay, and bisexual individuals, experience persistent health disparities due to chronic exposure to minority stressors; however, its relation to osteoarthritis (OA) risk remains unexplored. This study aims to investigate the association between sexual orientation and OA risk and evaluate the mediating effect of health behaviors and psychosocial factors in related disparities.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study of 346,320 UK Biobank participants without OA at baseline (2006–2010), followed through December 2021. Coarsened exact matching was applied to balance age, birth cohort, and ethnicity. Sex-stratified Cox models (using age as the time scale) were used to estimate hazard ratios (HRs) for OA risk. Mediation analyses examined the roles of modifiable factors, including body mass index (BMI), socioeconomic status, lifestyle behaviors, and mental health.</div></div><div><h3>Results</h3><div>Over a median follow-up of 11.3 years, 40,728 participants developed OA. Both bisexual and lesbian women had a higher OA risk than heterosexual women (adjusted HR: 1.17, 95%CI [confidence interval]: 1.07–1.28 and HR: 1.36, 95%CI: 1.10–1.68, respectively). Mediation analysis identified BMI, Townsend index, smoking, and depression as potential mediators, with mediation proportions ranging from 12.1% to 34.2%. In men, gay individuals had lower OA risk (HR: 0.72, 95%CI: 0.60–0.85), with BMI and education explaining 17.5–18.4% of the reduction; no significant difference was observed for bisexual men.</div></div><div><h3>Conclusion</h3><div>Sexual orientation is associated with OA risk, with bisexual and lesbian women showing higher risk and gay men lower risk than heterosexuals. These disparities are partially explained by BMI, smoking, depression, and socioeconomic status.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 2","pages":"Pages 271-278"},"PeriodicalIF":9.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-31DOI: 10.1016/j.joca.2026.01.630
M. Hartog, S.G.P.J. Korsten, C.D. Popa, T. Pelle, A. Gavriilidou, B.J.F. van den Bemt, L.E.M. Willemsen, M.I. Koenders, J.P.W. Vermeiden, H. Smidt, C.H.M. van den Ende
{"title":"Effectiveness of Sustained Release Calcium Butyrate on the microbiome and clinical burden in osteoarthritis of the hand: a proof-of-concept placebo-controlled randomized trial","authors":"M. Hartog, S.G.P.J. Korsten, C.D. Popa, T. Pelle, A. Gavriilidou, B.J.F. van den Bemt, L.E.M. Willemsen, M.I. Koenders, J.P.W. Vermeiden, H. Smidt, C.H.M. van den Ende","doi":"10.1016/j.joca.2026.01.630","DOIUrl":"https://doi.org/10.1016/j.joca.2026.01.630","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"288 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.joca.2026.01.013
Tim Schleimer, Tiziano Innocenti, Nadine E. Foster, Manuela L. Ferreira, Alessandro Chiarotto
Clinical relevance is an umbrella term that encompasses methods used to determine thresholds of relevant effects from the perspectives of patients, clinicians, and/or researchers. However, what represents a clinically relevant effect remains contentious. We provide an overview of current challenges and potential solutions for defining and interpreting the clinical relevance of between-group differences in osteoarthritis (OA) trials.
{"title":"Defining and interpreting between-group differences in clinical trials of patients with osteoarthritis: challenges and potential solutions","authors":"Tim Schleimer, Tiziano Innocenti, Nadine E. Foster, Manuela L. Ferreira, Alessandro Chiarotto","doi":"10.1016/j.joca.2026.01.013","DOIUrl":"https://doi.org/10.1016/j.joca.2026.01.013","url":null,"abstract":"Clinical relevance is an umbrella term that encompasses methods used to determine thresholds of relevant effects from the perspectives of patients, clinicians, and/or researchers. However, what represents a clinically relevant effect remains contentious. We provide an overview of current challenges and potential solutions for defining and interpreting the clinical relevance of between-group differences in osteoarthritis (OA) trials.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"8 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1016/j.joca.2026.01.003
Jenna M. Qualter, Alexandra N. Chertok, Amy Buhler, Elise K. Laende, Kerry E. Costello
{"title":"Osteoarthritis year in review 2025: Biomechanics","authors":"Jenna M. Qualter, Alexandra N. Chertok, Amy Buhler, Elise K. Laende, Kerry E. Costello","doi":"10.1016/j.joca.2026.01.003","DOIUrl":"https://doi.org/10.1016/j.joca.2026.01.003","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"53 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVETo estimate the effect of denosumab compared with bisphosphonates on reducing the risk of knee or hip osteoarthritis (OA) among adults with osteoporosis in a real-world cohort.METHODThis new-user, active-comparator retrospective real-world cohort utilized electronic health records from the TriNetX Network. Participants diagnosed with osteoporosis between January 1, 2014 and December 31, 2023 were selected. We used propensity-score matching (PSM) to balance potential confounders between denosumab users and bisphosphonate users. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of incident knee and hip OA by comparing PSM groups.RESULTS59,157 new users of denosumab were matched on propensity score to 59,157 participants of bisphosphonate users (mean age 70 years; 87% female). The 10-year incidence probability of knee and hip OA in denosumab users was 19.2% (4,839 events and 14.5% (3,396 events), while in bisphosphonate users it was 21.4% (5,389 events) and 14.4% (3,388 events). Compared with bisphosphonate, denosumab users were significantly associated with a reduced risk of any OA (HR 0.96, 95% CI 0.94-0.98), knee OA (HR, 0.87, 95% CI, 0.84-0.91), but not with hip OA (HR, 0.98, 95% CI, 0.94-1.03), or thumb carpometacarpal OA (HR 0.94, 95% CI 0.87-1.01). These associations were more pronounced among older participants (≥ 65 years, HR 0.88, 95% CI 0.84-0.91 for knee OA), females (HR 0.87, 95% CI 0.83-0.91 for knee OA), and individuals of Asian ethnicity (HR 0.73, 95% CI 0.63-0.84 for knee OA).CONCLUSIONSDenosumab use was associated with a reduced risk of incident knee OA compared with bisphosphonates in adults with osteoporosis, with the association being more pronounced among older adults, females, and individuals of Asian ethnicity. This study suggests that denosumab could attenuate the development of knee OA, warranting further clinical trials.
目的：在现实世界队列中评估denosumab与双膦酸盐在降低成人骨质疏松症患者膝关节或髋关节骨关节炎（OA）风险方面的作用。方法这项新用户、主动比较者回顾性现实世界队列研究利用TriNetX网络的电子健康记录。选择2014年1月1日至2023年12月31日期间诊断为骨质疏松症的参与者。我们使用倾向得分匹配（PSM）来平衡denosumab使用者和双膦酸盐使用者之间的潜在混杂因素。通过比较PSM组，采用Cox比例风险模型估计发生膝、髋关节炎的风险比（hr）和95%置信区间（ci）。结果59,157名denosumab新使用者与59,157名双膦酸盐使用者（平均年龄70岁，87%为女性）的倾向评分相匹配。denosumab使用者的10年膝关节和髋关节OA发生率分别为19.2%(4839例和14.5%（3396例），而双膦酸盐使用者的10年发生率分别为21.4%（5389例）和14.4%（3388例）。与双膦酸盐相比，denosumab使用者与任何OA （HR 0.96, 95% CI 0.94-0.98）、膝关节OA （HR 0.87, 95% CI 0.84-0.91）的风险降低显著相关，但与髋关节OA （HR 0.98, 95% CI 0.94-1.03）或拇指掌骨OA （HR 0.94, 95% CI 0.87-1.01）的风险降低无关。这些关联在老年人（≥65岁，HR 0.88, 95% CI 0.84-0.91）、女性（HR 0.87, 95% CI 0.83-0.91）和亚洲人（HR 0.73, 95% CI 0.63-0.84）中更为明显。结论：与双膦酸盐相比，使用sdenosumab可降低成人骨质疏松症患者发生膝关节炎的风险，这种相关性在老年人、女性和亚裔人群中更为明显。这项研究表明，denosumab可以减轻膝关节OA的发展，需要进一步的临床试验。
{"title":"Association between denosumab use and risk of osteoarthritis among adults with osteoporosis in a real-world cohort.","authors":"Zhaohua Zhu,Jing-Yang Huang,Weishu Wang,Sisi Liu,Hao Zhang,Qian Wang,Kai Fu,Changhai Ding,James Cheng-Chung Wei,David J Hunter","doi":"10.1016/j.joca.2026.01.001","DOIUrl":"https://doi.org/10.1016/j.joca.2026.01.001","url":null,"abstract":"OBJECTIVETo estimate the effect of denosumab compared with bisphosphonates on reducing the risk of knee or hip osteoarthritis (OA) among adults with osteoporosis in a real-world cohort.METHODThis new-user, active-comparator retrospective real-world cohort utilized electronic health records from the TriNetX Network. Participants diagnosed with osteoporosis between January 1, 2014 and December 31, 2023 were selected. We used propensity-score matching (PSM) to balance potential confounders between denosumab users and bisphosphonate users. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of incident knee and hip OA by comparing PSM groups.RESULTS59,157 new users of denosumab were matched on propensity score to 59,157 participants of bisphosphonate users (mean age 70 years; 87% female). The 10-year incidence probability of knee and hip OA in denosumab users was 19.2% (4,839 events and 14.5% (3,396 events), while in bisphosphonate users it was 21.4% (5,389 events) and 14.4% (3,388 events). Compared with bisphosphonate, denosumab users were significantly associated with a reduced risk of any OA (HR 0.96, 95% CI 0.94-0.98), knee OA (HR, 0.87, 95% CI, 0.84-0.91), but not with hip OA (HR, 0.98, 95% CI, 0.94-1.03), or thumb carpometacarpal OA (HR 0.94, 95% CI 0.87-1.01). These associations were more pronounced among older participants (≥ 65 years, HR 0.88, 95% CI 0.84-0.91 for knee OA), females (HR 0.87, 95% CI 0.83-0.91 for knee OA), and individuals of Asian ethnicity (HR 0.73, 95% CI 0.63-0.84 for knee OA).CONCLUSIONSDenosumab use was associated with a reduced risk of incident knee OA compared with bisphosphonates in adults with osteoporosis, with the association being more pronounced among older adults, females, and individuals of Asian ethnicity. This study suggests that denosumab could attenuate the development of knee OA, warranting further clinical trials.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"24 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08DOI: 10.1016/j.joca.2025.12.024
Armaghan Mahmoudian
{"title":"Persistent symptoms after ACL injury - clarifying the link to OA.","authors":"Armaghan Mahmoudian","doi":"10.1016/j.joca.2025.12.024","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.024","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"20 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2025-02-26DOI: 10.1016/j.joca.2025.01.006
Sophia N. Ziemian , Adrien Y. Antoinette , Ana Witkowski , Miguel Otero , Steven R. Goldring , Mary B. Goldring , Marjolein C.H. van der Meulen
Objective
While physiological loads maintain cartilage health, both joint overload and abnormal joint mechanical loading contribute to osteoarthritis (OA) development. Here, we examined the role of abnormal mechanical loading on joint health by comparing the severity of OA development following a single overload event and repetitive joint overloads.
Method
Cyclic tibial compression was applied to the left limbs of 26-week-old male mice at a peak load of 9N for either a single bout or daily bouts to initiate OA disease. Joint damage severity was morphologically examined using histology and microcomputed tomography at 6 weeks following the start of loading. Early-stage transcriptomic responses to loading were evaluated.
Results
Joint damage was more severe at 6 weeks following a single bout of loading than after daily loading bouts. Severe cartilage damage, subchondral plate erosions, and soft tissue calcifications occurred following the single bout of loading. Daily loading bouts resulted in less severe cartilage damage and preserved subchondral plate integrity. A diverging transcriptomic response was identified in cartilage at 1 week with increased expression of fibrosis- and inflammation-related genes following a single bout of loading compared to daily loading.
Conclusions
Even applied at hyperphysiological load magnitudes known to initiate cartilage damage, repetitive loading may induce protective effects in the joint and attenuate OA progression over time relative to a single bout of loading. Our findings suggest the potential of mechanotherapies that use repetitive loading as disease-modifying treatments for OA disease.
{"title":"Joint damage is more severe following a single bout than multiple bouts of high magnitude loading in mice","authors":"Sophia N. Ziemian , Adrien Y. Antoinette , Ana Witkowski , Miguel Otero , Steven R. Goldring , Mary B. Goldring , Marjolein C.H. van der Meulen","doi":"10.1016/j.joca.2025.01.006","DOIUrl":"10.1016/j.joca.2025.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>While physiological loads maintain cartilage health, both joint overload and abnormal joint mechanical loading contribute to osteoarthritis (OA) development. Here, we examined the role of abnormal mechanical loading on joint health by comparing the severity of OA development following a single overload event and repetitive joint overloads.</div></div><div><h3>Method</h3><div>Cyclic tibial compression was applied to the left limbs of 26-week-old male mice at a peak load of 9N for either a single bout or daily bouts to initiate OA disease. Joint damage severity was morphologically examined using histology and microcomputed tomography<span> at 6 weeks following the start of loading. Early-stage transcriptomic responses to loading were evaluated.</span></div></div><div><h3>Results</h3><div>Joint damage was more severe at 6 weeks following a single bout of loading than after daily loading bouts. Severe cartilage damage, subchondral plate erosions, and soft tissue calcifications occurred following the single bout of loading. Daily loading bouts resulted in less severe cartilage damage and preserved subchondral plate integrity. A diverging transcriptomic response was identified in cartilage at 1 week with increased expression of fibrosis- and inflammation-related genes following a single bout of loading compared to daily loading.</div></div><div><h3>Conclusions</h3><div>Even applied at hyperphysiological load magnitudes known to initiate cartilage damage, repetitive loading may induce protective effects in the joint and attenuate OA progression over time relative to a single bout of loading. Our findings suggest the potential of mechanotherapies that use repetitive loading as disease-modifying treatments for OA disease.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 1","pages":"Pages 58-69"},"PeriodicalIF":9.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01Epub Date: 2025-10-30DOI: 10.1016/j.joca.2025.10.016
Kranti C. Rumalla , Sumanth R. Chandrupatla , Jasvinder A. Singh
Objective
To identify the presence and magnitude of total joint arthroplasty (TJA) disparities in length of stay (LOS).
Methods
The National Inpatient Sample (2016–2019) was queried for patients with primary diagnoses of osteoarthritis (OA) and primary procedure code of primary total hip arthroplasty (THA) or total knee arthroplasty (TKA). Race and ethnicity and sex variables were recoded and combined into 12 categories. We determined the effect of this combined race and sex variable on extended length of stay, controlling for potential intermediates and demographic variables, and conducted analysis of individual heterogeneity and discriminatory accuracy (AIHDA) analyses.
Results
A total of 1507,085 THAs and 2534,749 TKAs were captured during the study period. White females constituted the greatest proportion of THAs and TKAs. Nearly all minoritized race/ethnicities, regardless of sex, were at greater risk of extended length of stay (eLOS, > 3 days) compared to White males. Black females experienced the greatest disparity of eLOS [THA, aOR 2.42 (95% CI: 2.26–2.60, p<0.001); TKA, aOR 2.07 (95% CI: 1.96–2.18, p<0.001)] followed by Black males [THA, aOR 1.86 (95% CI: 1.72–2.02, p<0.001); TKA, aOR 1.89 (95% CI: 1.77–2.02, p<0.001)]. AIHDA analysis showed that race/ethnicity and sex did not significantly improve discriminatory accuracy when included in the models.
Conclusion
There are significant racial and ethnic disparities in THA/TKA hospital LOS which are both statistically and clinically significant. Social determinants of health (SDOH) continue to play a meaningful role in these outcomes, though targeting race/ethnicity and sex directly may not improve eLOS in patients.
{"title":"Intersectional racial, ethnic, and sex-based disparities in length of stay after total hip and knee arthroplasty: An analysis of national data","authors":"Kranti C. Rumalla , Sumanth R. Chandrupatla , Jasvinder A. Singh","doi":"10.1016/j.joca.2025.10.016","DOIUrl":"10.1016/j.joca.2025.10.016","url":null,"abstract":"<div><h3>Objective</h3><div>To identify the presence and magnitude of total joint arthroplasty (TJA) disparities in length of stay (LOS).</div></div><div><h3>Methods</h3><div>The National Inpatient Sample (2016–2019) was queried for patients with primary diagnoses of osteoarthritis (OA) and primary procedure code of primary total hip arthroplasty (THA) or total knee arthroplasty (TKA). Race and ethnicity and sex variables were recoded and combined into 12 categories. We determined the effect of this combined race and sex variable on extended length of stay, controlling for potential intermediates and demographic variables, and conducted analysis of individual heterogeneity and discriminatory accuracy (AIHDA) analyses.</div></div><div><h3>Results</h3><div>A total of 1507,085 THAs and 2534,749 TKAs were captured during the study period. White females constituted the greatest proportion of THAs and TKAs. Nearly all minoritized race/ethnicities, regardless of sex, were at greater risk of extended length of stay (eLOS, > 3 days) compared to White males. Black females experienced the greatest disparity of eLOS [THA, aOR 2.42 (95% CI: 2.26–2.60, p<0.001); TKA, aOR 2.07 (95% CI: 1.96–2.18, p<0.001)] followed by Black males [THA, aOR 1.86 (95% CI: 1.72–2.02, p<0.001); TKA, aOR 1.89 (95% CI: 1.77–2.02, p<0.001)]. AIHDA analysis showed that race/ethnicity and sex did not significantly improve discriminatory accuracy when included in the models.</div></div><div><h3>Conclusion</h3><div>There are significant racial and ethnic disparities in THA/TKA hospital LOS which are both statistically and clinically significant. Social determinants of health (SDOH) continue to play a meaningful role in these outcomes, though targeting race/ethnicity and sex directly may not improve eLOS in patients.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 1","pages":"Pages 160-166"},"PeriodicalIF":9.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145396618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号