Osteoarthritis and Cartilage最新文献

英文中文

Letter to the Editor concerning: T2 mapping of the articular cartilage as a biomarker for knee osteoarthritis: An analysis of the population-based Rotterdam Study 致编辑的信关于：关节软骨作为膝骨关节炎的生物标志物的T2制图：基于人群的鹿特丹研究分析

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-30 DOI: 10.1016/j.joca.2025.10.015

Yimei Que, Qilin Lu, Xugui Li

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Excessive Compression Induces Cartilage Endplate Degeneration via the Piezo1/NAT10/mTOR Signaling Axis 过度压缩通过Piezo1/NAT10/mTOR信号轴诱导软骨终板退变

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-30 DOI: 10.1016/j.joca.2025.10.014

Hongzhou Sun, Zhongxuan Wu, Yu Zhang, Chen Liu, Daokuan Gao, Quanlai Zhao, Liang Xiao

引用次数: 0

Unraveling the Shared Genetic Architecture of Osteoarthritis and Metabolic Traits through Multi-Omics Insights 通过多组学见解揭示骨关节炎和代谢特征的共享遗传结构

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-29 DOI: 10.1016/j.joca.2025.10.010

Binzhi Liao, Yumeng Mu, Mengliang Luo, Yinjiang Liu, Qingtao Yang, Haibo Yang, Jihua Ye, Yuanyuan Wu, Feifei Cheng, Xianding Sun, Mao Nie

引用次数: 0

Pathophysiological mechanisms linking osteoarthritis and neurodegenerative disease risk 骨关节炎与神经退行性疾病风险相关的病理生理机制

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-28 DOI: 10.1016/j.joca.2025.10.009

Pranav Prasoon , Kayla L. Nguyen , Payam A. Fathi , Shruti Gupta , Sreejita Arnab , Erin Jones , Aravind Meyyappan , Elena J. Stehle , John R. Bethea

Objective

This review aims to assess the existing evidence that connects osteoarthritis (OA) with neurodegenerative diseases, specifically Alzheimer’s disease (AD) and Parkinson’s disease (PD), and to elucidate shared mechanisms that may contribute to the development of innovative therapeutic approaches.

Method

We present a narrative review of prior epidemiological, genetic, and mechanistic studies that describe overlapping risk factors and convergent pathological pathways linking OA and neurodegenerative diseases. Key focus areas include metabolic and hormonal influences, inflammatory cytokine signaling, and mitochondrial dysfunction that arise in both OA and neurodegenerative diseases.

Results

Emerging evidence indicates that OA and neurodegenerative diseases share core drivers—advanced age, obesity, metabolic syndrome, and genetic susceptibility. Central to both are chronic inflammation, mediated by tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β), as well as mitochondrial dysfunction, which promote both cartilage degradation and neuronal death. Genetic data reveal consistent activation of NF-κB and JAK/STAT signaling, with contributions from MAPK, TGF-β, and WNT signaling pathways. Preclinical models demonstrate that OA-induced peripheral inflammation can amplify neuroinflammation and accelerate AD-like pathology, underscoring a potential bidirectional link. Despite these associations, causal relationships have not been concretely established.

Conclusion

OA may contribute to neurodegenerative risk through shared inflammatory and metabolic mechanisms, representing an underrecognized intersection between musculoskeletal and neurological diseases. Targeting these convergent pathways offers a promising avenue for dual-purpose interventions. Establishing causality through longitudinal and mechanistic studies could enable early identification of at-risk patients and guide the development of therapies that mitigate both joint degeneration and neurodegeneration.

目的本综述旨在评估骨关节炎（OA）与神经退行性疾病，特别是阿尔茨海默病（AD）和帕金森病（PD）之间联系的现有证据，并阐明可能有助于开发创新治疗方法的共同机制。方法我们对先前的流行病学、遗传学和机制研究进行了综述，这些研究描述了OA和神经退行性疾病之间重叠的危险因素和趋同的病理通路。重点关注的领域包括代谢和激素的影响，炎症细胞因子信号，线粒体功能障碍出现在OA和神经退行性疾病。结果越来越多的证据表明，骨性关节炎和神经退行性疾病具有共同的核心驱动因素——高龄、肥胖、代谢综合征和遗传易感性。两者的核心是慢性炎症，由肿瘤坏死因子-α (TNF-α)和白细胞介素-1β (IL-1β)介导，以及线粒体功能障碍，促进软骨降解和神经元死亡。遗传数据显示NF-κB和JAK/STAT信号的一致激活，与MAPK、TGF-β和WNT信号通路有关。临床前模型表明，oa诱导的外周炎症可以放大神经炎症并加速ad样病理，强调了潜在的双向联系。尽管存在这些关联，但因果关系尚未具体确立。结论oa可能通过共同的炎症和代谢机制增加神经退行性风险，这代表了肌肉骨骼和神经系统疾病之间未被充分认识的交叉。针对这些趋同途径为双重干预提供了一条有希望的途径。通过纵向和机制研究建立因果关系，可以早期识别高危患者，并指导开发减轻关节变性和神经变性的治疗方法。

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引用次数: 0

Artificial Intelligence, Machine Learning and Omic Data Integration in Osteoarthritis 骨关节炎的人工智能、机器学习和组学数据集成

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-28 DOI: 10.1016/j.joca.2025.10.012

Divya Sharma

引用次数: 0

Effectiveness of Exercise Therapy in Patients with Thumb Carpometacarpal Osteoarthritis: a Multicenter, Randomized Controlled Trial. 运动疗法对拇指手掌骨关节炎患者的疗效：一项多中心随机对照试验。

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-23 DOI: 10.1016/j.joca.2025.10.005

Robbert M Wouters,Lisa Mj Esteban Lopez,Stella Cm Heemskerk,Sita Ma Bierma-Zeinstra,Gerald A Kraan,Joost Colaris,J Michiel Zuidam,Guus M Vermeulen,Ruud W Selles,

OBJECTIVETo compare the effectiveness and costs of an orthosis + exercise therapy with only an orthosis on pain at 3 months and conversion to surgery <1 year in patients with thumb carpometacarpal (CMC-1) osteoarthritis (OA).DESIGNMulticenter, single-blinded, randomized controlled trial.SETTINGEighteen outpatient hand surgery and therapy clinics in the Netherlands.PARTICIPANTSAdult patients with CMC-1 OA.INTERVENTIONSOrthosis + exercise therapy versus orthosis-only.PRIMARY OUTCOME MEASURESPain at 3 months (Michigan Hand Outcomes Questionnaire pain subscale) and conversion to surgery <1 year.RESULTSWe included 166 patients (81 orthosis + exercise, 85 orthosis-only). There was no difference between the orthosis + exercise group and the orthosis-only group in pain at three months (least mean square difference 3.7 [95% CI -1.0 to 8.3]). Conversion to surgery was 4.9% (n=4) in the orthosis + exercise group and 9.4% (n=8) in the orthosis-only group, which was not significantly different (risk difference 4.7% [-3.3% to 12.2%) due to the low conversion to surgery rates. The total societal costs for orthosis + exercise were 37% (-€825 [-2072 to 421]) lower per patient than orthosis-only. The orthosis + exercise group had favorable outcomes in MHQ subscale activities of daily living scores (6mo), work ability (all time points), satisfaction with hand (3mo), the MHQ total score (3mo, 6mo), satisfaction with treatment results (all except 6mo), grip strength (6w), and illness perceptions (3mo).CONCLUSIONSIn patients with CMC-1 OA, an orthosis + exercise therapy is preferred over orthosis-only because of the favorable secondary outcomes.TRIAL REGISTRATIONClinicalTrials.gov: NCT05772715.

目的比较矫形器+运动治疗与单纯矫形器治疗拇指腕掌骨关节炎（CMC-1）患者疼痛3个月后转手术治疗<1年的疗效和成本。设计：多中心、单盲、随机对照试验。在荷兰有18家门诊手部手术和治疗诊所。参与者：成年CMC-1 OA患者。干预：矫形+运动治疗vs单纯矫形。主要结局测量：疼痛3个月（密歇根手部结局问卷疼痛亚量表），转行手术<1年。结果共纳入166例患者，其中矫形+运动81例，单纯矫形85例。矫形器+运动组与仅矫形器组在3个月时疼痛无差异（最小均方差3.7 [95% CI -1.0 ~ 8.3]）。矫形器+运动组转手术率为4.9% (n=4)，单纯矫形器组为9.4% (n=8)，由于转手术率较低，两者差异无统计学意义（风险差4.7%[-3.3% ~ 12.2%]）。与单纯矫形相比，矫形+运动的社会总成本每位患者低37%（- 825欧元[-2072至421]）。矫形器+运动组在日常生活活动分（6mo）、工作能力（所有时间点）、手部满意度（3mo）、MHQ总分（3mo、6mo）、治疗效果满意度（除6mo外）、握力（6w）、疾病感知（3mo）方面均有较好的结果。结论在CMC-1型OA患者中，矫形器+运动治疗优于单纯矫形器治疗，因为其次要结果较好。临床试验注册网站：NCT05772715。

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Reply to comment on "Effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis based on large randomized trials: A systematic review and network meta-analysis" 回复给编辑的信。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-16 DOI: 10.1016/j.joca.2025.10.007

Peter Jüni, Tiago V. Pereira, Bruno R. da Costa

引用次数: 0

Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? - Data from the FNIH and IMI-APPROACH cohorts. 轻度-中度髌骨-股骨结构损伤与重度髌骨-股骨结构损伤相比，Kellgren-Lawrence 2型和3型膝关节的股胫软骨丢失率是否不同？-数据来自FNIH和IMI-APPROACH队列。

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-12 DOI: 10.1016/j.joca.2025.10.003

Frank W Roemer,Mylène Jansen,Susanne Maschek,Simon Mastbergen,Anna Wisser,Harrie H Weinans,Francisco J Blanco,Francis Berenbaum,Margreet Kloppenburg,Ida K Haugen,David J Hunter,Ali Guermazi,Wolfgang Wirth

BACKGROUNDThe aim was to assess whether rates of quantitative femorotibial (FT) cartilage loss are increased for knees with semiquantitatively (sq)-defined severe patellofemoral (PF) cartilage damage and/or large bone marrow lesions (BMLs) vs. those without over a period of 24 months.METHODS626 knees with Kellgren-Lawrence 2 and 3 from the FNIH and IMI-APPROACH studies were included. MRI assessment was performed using the MRI Osteoarthritis Knee Score (MOAKS) instrument. Baseline FT cartilage damage severity was defined as mild, moderate, or severe. PF cartilage damage was defined as mild-moderate vs. severe. A 2nd definition was based on the presence or absence of large BMLs. Quantitative cartilage thickness loss (defined as the difference from baseline to follow-up in mean cartilage thickness in the medial and in the lateral femorotibial joint, which were computed by summing the cartilage thickness measures observed in the respective cartilage plates) was derived from baseline and 24-month manual segmentations. Between-group comparisons were performed using analysis of covariance (ANCOVA) adjusting for age, sex and body mass index.RESULTS410 (65%) knees were categorized as mild, 92 (15%) as moderate, and 124 (20%) as severe medial FT cartilage damage. For almost all categories of FT cartilage damage, the difference in quantitative medial FT cartilage loss was not statistically significant. Only for the category of knees with moderate medial FT cartilage damage, statistically higher rates of FT cartilage loss were observed for those with large PF BMLs compared to those without (mean adjusted difference -0.128 mm, 95% confidence interval [-0.238, -0.018], p=0.023).CONCLUSIONSScreening for PF cartilage damage and BMLs does not appear to be required in a disease-modifying OA drug trial.

研究背景：研究目的是评估在24个月的时间里，有半定量（sq）定义的严重髌骨股骨（PF）软骨损伤和/或大骨髓病变（BMLs）的膝关节，与没有严重髌骨股骨（PF）软骨损伤的膝关节相比，定量股胫（FT）软骨损失的发生率是否增加。方法纳入626例来自FNIH和IMI-APPROACH研究的kelgren - lawrence 2和3膝关节。采用MRI骨关节炎膝关节评分（MOAKS）仪进行MRI评估。基线FT软骨损伤严重程度定义为轻度、中度或重度。PF软骨损伤分为轻、中度和重度。第二个定义是基于是否存在大型bml。定量软骨厚度损失（定义为从基线到随访期间股骨胫骨内侧和外侧关节平均软骨厚度的差异，通过将各自软骨板中观察到的软骨厚度测量值相加来计算）来源于基线和24个月的手工分割。采用协方差分析（ANCOVA）进行组间比较，调整年龄、性别和体重指数。结果410例膝关节（65%）为轻度，92例（15%）为中度，124例（20%）为重度内侧FT软骨损伤。对于几乎所有类型的FT软骨损伤，内侧FT软骨定量损失的差异无统计学意义。仅在膝关节内侧有中度FT软骨损伤的类别中，PF骨密度大的患者的FT软骨损失率高于无损伤的患者（调整后平均差为-0.128 mm， 95%可信区间[-0.238,-0.018],p=0.023）。结论：在改善疾病的OA药物试验中，似乎不需要筛选PF软骨损伤和bls。

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引用次数: 0

Fibroblast and Myeloid Cells with High Mitochondrial RNA Content Represent Biologically Significant Populations within the OA Synovium. 高线粒体RNA含量的成纤维细胞和髓样细胞在OA滑膜内具有重要的生物学意义。

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-12 DOI: 10.1016/j.joca.2025.10.002

Wesley Tran,Garth Blackler,Rebecca Luo,C Thomas Appleton,Matthew W Grol

OBJECTIVESStandard scRNA-seq QC often excludes cells with high mitochondrial RNA content (pMT), assuming they reflect low viability or dissociation-induced stress. Emerging evidence suggests high-pMT cells may represent disease-relevant cell populations. This study investigates how exclusion of high-pMT cells affects the transcriptional landscape of knee OA synovium and explores their potential role in disease pathobiology.DESIGNSeven published human and mouse scRNA-seq datasets were reanalyzed using QC thresholds and quantile-based filtering to include high-pMT cells. Analyses included pMT distribution, dissociation-induced stress scores, cell death-related and mitochondrial apoptotic gene signatures. Dissociation-induced stress was assessed using a gene set from three published studies, while cell death and mitochondrial signatures were derived from established GSEA gene sets. Focusing on a single human knee OA synovial dataset stratified by pain (GSE248453), differential gene expression and pathway enrichment were compared between conventionally filtered and high-pMT inclusive pipelines.RESULTSAcross all datasets, pMT showed no correlation with dissociation-induced stress scores (R= -0.036). High-pMT cells showed no association with apoptosis pathways, suggesting that they are not actively undergoing cell death. High-pMT cells primarily localized to fibroblast and myeloid subsets. High-pMT synovial fibroblasts were enriched in ECM remodeling processes, while high-pMT myeloid cells were linked to inflammatory signaling and immune activation.CONCLUSIONSThese findings suggest high-pMT cells are viable and potentially disease relevant, with their exclusion possibly obscuring key aspects of OA pathophysiology. This highlights the necessity of context-specific QC strategies in OA research and further exploration of high-pMT fibroblast and myeloid populations as potential disease drivers.

标准scRNA-seq QC通常排除高线粒体RNA含量（pMT）的细胞，假设它们反映低活力或解离诱导的应激。新出现的证据表明，高pmt细胞可能代表了与疾病相关的细胞群。本研究探讨了排除高pmt细胞如何影响膝关节OA滑膜的转录景观，并探讨了它们在疾病病理生物学中的潜在作用。design7个已发表的人和小鼠scRNA-seq数据集使用QC阈值和基于分位数的滤波重新分析，以包括高pmt细胞。分析包括pMT分布、解离诱导的应激评分、细胞死亡相关和线粒体凋亡基因特征。使用来自三个已发表研究的基因集来评估解离诱导的应激，而细胞死亡和线粒体特征则来自已建立的GSEA基因集。以单个按疼痛分层的人类膝关节OA滑膜数据集（GSE248453）为重点，比较了常规过滤和高pmt包容性管道之间的差异基因表达和途径富集。结果在所有数据集中，pMT与分离诱导的应激评分无相关性（R= -0.036）。高pmt细胞显示与凋亡途径无关，表明它们不主动经历细胞死亡。高pmt细胞主要定位于成纤维细胞和髓细胞亚群。高pmt滑膜成纤维细胞在ECM重塑过程中富集，而高pmt髓样细胞与炎症信号和免疫激活有关。结论这些发现表明高pmt细胞是有活力的，并且可能与疾病相关，它们的排除可能掩盖了OA病理生理的关键方面。这突出了OA研究中上下文特异性QC策略的必要性，以及进一步探索高pmt成纤维细胞和髓细胞群体作为潜在疾病驱动因素的必要性。

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引用次数: 0

Disparities in incident osteoarthritis between sexual minority and heterosexual adults: Findings from a large cohort study 性少数和异性恋成人骨关节炎发病率的差异：来自一项大型队列研究的发现。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-10-10 DOI: 10.1016/j.joca.2025.10.001

Tingting Sha , Yilun Wang , Yuqing Zhang , Jian Zhang , Cong Lu , Jie Wei , Guanghua Lei , Chao Zeng

Objective

Sexual minorities, including lesbian, gay, and bisexual individuals, experience persistent health disparities due to chronic exposure to minority stressors; however, its relation to osteoarthritis (OA) risk remains unexplored. This study aims to investigate the association between sexual orientation and OA risk and evaluate the mediating effect of health behaviors and psychosocial factors in related disparities.

Methods

We conducted a prospective cohort study of 346,320 UK Biobank participants without OA at baseline (2006–2010), followed through December 2021. Coarsened exact matching was applied to balance age, birth cohort, and ethnicity. Sex-stratified Cox models (using age as the time scale) were used to estimate hazard ratios (HRs) for OA risk. Mediation analyses examined the roles of modifiable factors, including body mass index (BMI), socioeconomic status, lifestyle behaviors, and mental health.

Results

Over a median follow-up of 11.3 years, 40,728 participants developed OA. Both bisexual and lesbian women had a higher OA risk than heterosexual women (adjusted HR: 1.17, 95%CI [confidence interval]: 1.07–1.28 and HR: 1.36, 95%CI: 1.10–1.68, respectively). Mediation analysis identified BMI, Townsend index, smoking, and depression as potential mediators, with mediation proportions ranging from 12.1% to 34.2%. In men, gay individuals had lower OA risk (HR: 0.72, 95%CI: 0.60–0.85), with BMI and education explaining 17.5–18.4% of the reduction; no significant difference was observed for bisexual men.

Conclusion

Sexual orientation is associated with OA risk, with bisexual and lesbian women showing higher risk and gay men lower risk than heterosexuals. These disparities are partially explained by BMI, smoking, depression, and socioeconomic status.

性少数群体，包括女同性恋、男同性恋和双性恋个体，由于长期暴露于少数群体压力源，经历了持续的健康差异；然而，其与骨关节炎（OA）风险的关系尚不清楚。本研究旨在探讨性取向与OA风险的关系，并评估健康行为和心理社会因素在相关差异中的中介作用。方法：我们对346,320名基线（2006-2010年）无OA的英国生物银行参与者进行了一项前瞻性队列研究，随访至2021年12月。采用粗精确匹配来平衡年龄、出生队列和种族。使用性别分层Cox模型（以年龄为时间尺度）来估计OA风险的危险比（hr）。中介分析考察了可改变因素的作用，包括身体质量指数、社会经济地位、生活方式行为和心理健康。结果在中位随访11.3年期间，40,728名参与者发生OA。双性恋和女同性恋女性患OA的风险均高于异性恋女性（校正风险比[HR]: 1.17, 95%CI: 1.07-1.28; HR: 1.36, 95%CI: 1.10-1.68）。中介分析发现BMI、Townsend指数、吸烟和抑郁是潜在的中介因素，中介比例从12.1%到34.2%不等。在男性中，男同性恋者患OA的风险较低（HR: 0.72, 95%CI: 0.60-0.85）， BMI和受教育程度可以解释17.5% - 18.4%的降低；在双性恋男性中没有观察到显著差异。结论性取向与OA风险相关，双性恋和女同性恋女性风险较高，男同性恋者风险低于异性恋者。这些差异部分可以用BMI、吸烟、抑郁和社会经济地位来解释。

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