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Upconversion Fluorescent Materials Studies to Lead the Development of Near Infrared Biophotonics 上转换荧光材料研究引领近红外生物光子学的发展
Pub Date : 2022-01-01 DOI: 10.5650/oleoscience.22.211
K. Soga
: Studies on up-conversion (UC) fluorescent materials are closely related to the emergence of materials that exhibit UC fluorescence and the development of their synthetic processes, and is also an opportunity to develop biophotonics using near-infrared light as excitation light, which has been at-tracting attention in recent years. The basis of the design of a fluorescent material is how to emit the given excitation energy as light without converting it into heat. The establishment of a method for synthesizing fluoride nanoparticles had a great influence on the development of UC fluorescent materials for biophotonics, and once a stable method for synthesizing nanoparticles is established, the design and synthesis of organic-inorganic composites using them had broken out. An important guideline in this case is again how to avoid the heat generation. It was inevitable to consider the effect of organic molecules, which have not been discussed so far, on the thermal relaxation of the excited electrons of rare earth ions in ceramic nanoparticles. This paper introduces the development of biophotonics, which originated from the studies on UC fluorescent materials, and presents the concept of the influence of organic molecular systems on electrons of rare earth ions in inorganic nanoparticles.
上转换(UC)荧光材料的研究与UC荧光材料的出现及其合成工艺的发展密切相关,也是利用近红外光作为激发光发展生物光子学的契机,近年来备受关注。设计荧光材料的基础是如何以光的形式发射给定的激发能,而不将其转化为热。氟纳米颗粒合成方法的建立对UC生物光子学荧光材料的发展产生了很大的影响,一旦建立了稳定的纳米颗粒合成方法,利用它们设计和合成有机-无机复合材料的工作就开始了。在这种情况下,一个重要的指导方针是如何避免产生热量。有机分子对稀土离子在陶瓷纳米颗粒中激发电子的热弛豫的影响,目前尚未讨论。本文介绍了生物光子学的发展,它起源于UC荧光材料的研究,并提出了有机分子体系对无机纳米粒子中稀土离子电子影响的概念。
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引用次数: 0
Role of Packaging in Maintaining Food Quality 包装在保持食品质量中的作用
Pub Date : 2021-01-01 DOI: 10.5650/OLEOSCIENCE.21.93
H. Kitazawa
Long-term food storage has recently drawn attention owing to the interest in reducing food loss and to lifestyle changes brought about by the coronavirus disease 2019 pandemic. Packaging plays an important role in the long-term storage of preser ved or emergency foods. This review explains the primary function of packaging and discusses typical materials that perform such functions; it also describes the role of packaging in maintaining food quality. The development of technology for maintaining the quality of fresh produce during long-term storage is also garnering attention. However, fresh produce packaging usually dif fers from non-perishable food packaging. Therefore, this review includes a separate section that explains the requirements for fresh produce packaging and provides the latest research on such packaging.
由于人们对减少粮食损失感兴趣,以及2019年冠状病毒病大流行带来的生活方式改变,长期粮食储存最近引起了人们的关注。包装在保存食品或应急食品的长期储存中起着重要作用。这篇综述解释了包装的主要功能,并讨论了执行这些功能的典型材料;它还描述了包装在保持食品质量方面的作用。保鲜技术的发展也引起了人们的关注。然而,新鲜农产品的包装通常不同于不易腐烂的食品包装。因此,这篇综述包括一个单独的部分,解释了新鲜农产品包装的要求,并提供了这类包装的最新研究。
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引用次数: 2
Composition and Biological Activities of Exosomal Lipids Bilayers 外泌体脂质双层的组成及生物活性
Pub Date : 2021-01-01 DOI: 10.5650/OLEOSCIENCE.21.69
Nao Nishida-Aoki
: Exosomes, lipid bilayer vesicles secreted from almost all cells, have emerged as a novel signal mediator of cell-to-cell communication. Lipids are essential components of exosomes to outline the boundaries of exosomes and to sequester their components from the external environment. Addi-tionally, recent studies have suggested that exosomal lipids engage in exosome formation, uptake, and signal transduction to receiver cells. Lipids consisting of exosomal membrane are similar to those of cellular membrane, but some lipids seem to be actively enriched in exosomes, indicating a selective lipid loading system during exosome formation. Despite the importance and intriguing biological functions, the lipid composition of exosomes is less studied than other components due to technical diffi-culties. Here I summarize current knowledge and limitations of lipid studies of exosomes.
外泌体是几乎所有细胞分泌的脂质双分子层囊泡,是细胞间通讯的一种新的信号介质。脂质是外泌体的重要组成部分,以勾勒外泌体的边界并将其成分与外部环境隔离。此外,最近的研究表明,外泌体脂质参与外泌体的形成、摄取和信号转导到受体细胞。由外泌体膜组成的脂质与细胞膜的脂质相似,但一些脂质似乎在外泌体中活跃富集,表明外泌体形成过程中存在选择性脂质装载系统。尽管外泌体具有重要的生物学功能,但由于技术上的困难,外泌体的脂质组成比其他成分的研究较少。在这里,我总结了目前外泌体脂质研究的知识和局限性。
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引用次数: 0
How about Thread-like Micelle? 线状胶束呢?
Pub Date : 2021-01-01 DOI: 10.5650/OLEOSCIENCE.21.235
Yasushi Yamamoto, K. Taga
: When small portion of surfactant which forms thread-like micelle is added in turbulent flow, drag reduction is occurred and may provide significant savings for electric power. As for screen-ing of the surfactant for the drag reduction, vortex inhibition and viscoelastic recoil were used. While, in oil solution, such as cyclohexane or heptane, reverse thread-like micelle by cationic gemini surfac-tants was stabilized by small portion of water as matrix and was succeeded in the oil gelation. The reverse thread-like oil solution also showed the vortex inhibition and viscoelastic recoil.
在湍流中加入少量表面活性剂,形成丝状胶团,可起到减阻的作用,并可显著节省电能。对于减阻表面活性剂的筛选,采用了涡阻和粘弹性反冲两种方法。而在环己烷或庚烷等油溶液中,阳离子gemini表面活性剂的反丝状胶团以少量水为基质稳定,成功凝胶化油。反螺纹油溶液也表现出旋涡抑制和粘弹性反冲。
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引用次数: 0
Developments and Applications of Photoresponsive Molecular Assemblies 光响应分子组件的研究进展与应用
Pub Date : 2021-01-01 DOI: 10.5650/OLEOSCIENCE.21.227
Masaaki Akamatsu, K. Sakai, H. Sakai
連絡者 :赤松 允顕 E-mail :makamatsu@rs.tus.ac.jp 論文要旨:界面活性剤が形成する分子集合体の構造を光刺激により変化させれば,内包した物質の放出制 御が可能となり,薬物や有効成分の送達システムが構築できる。本総説では,これまでに筆者らが開発した 光応答性界面活性剤について紹介する。アゾベンゼン修飾カチオン性界面活性剤は,紫外光および可視光照 射にともなう trans-cis 異性化により臨界ミセル濃度が大きく変化した。桂皮酸修飾光分解性界面活性剤は, 紫外光照射にともない界面物性が変化し,さらに紐状ミセル構造の変化に由来した水溶液粘度や微粒子分散 性の光制御に成功した。オンデマンドな界面物性制御を可能にするため,光応答性界面活性剤の光応答スピー ドの高速化を検討した。紫外光照射にともないロフィンダイマーから生成するロフィルラジカルの再結合反 応は,ミセル内部の閉鎖空間内で高速化することが分かった。両親媒性ロフィンダイマーを用いることで, その水溶液の表面張力を紫外光照射により数スケールで制御することができた。in situ 小角中性子散乱 (SANS)を用いた解析の結果,両親媒性ロフィンダイマーは楕円体ミセルを形成し,紫外光照射 ON-OFF にともない伸張・収縮を高速で繰り返すことが分かった。さらに,このミセル水溶液を用いることで,可溶 化されたモデル薬物を光照射により高速で放出制御できた。 酒井 健一 東京理科大学理工学部先端化学科 〒 278-8510 千葉県野田市山崎 2641
联系人:赤松允显E-mail:makamatsu@rs.tus.ac.jp论文摘要:通过光刺激改变表面活性剂形成的分子集合体的结构,内含物质就会释放出来御成为可能,可以构建药物和有效成分的输送系统。本总论将介绍迄今为止笔者开发的光响应性界面活性剂。偶苯修饰阳离子表面活性剂由于紫外光及可见光照射引起的trans-cis异构化,使临界色胶浓度发生了很大变化。桂皮酸修饰光分解性表面活性剂随着紫外光照射界面物性发生变化,进而成功实现了由绳状微米结构变化引起的水溶液粘度和微粒子分散性的光控。为了实现按需控制界面物性,研究了提高光响应性表面活性剂光响应速率的方案。研究表明,随着紫外光照射,罗芬二体生成的罗芬自由基的再组合反应在显示单元内部的封闭空间内会加速。通过使用母媒性罗芬二体,可以通过紫外光照射在数尺度上控制水溶液的表面张力。利用内电小角中子散射(SANS)的分析结果表明,双亲介质性罗芬二聚体形成椭圆体表面,随着紫外光照射ON-OFF高速反复进行伸展和收缩。另外,通过使用这种米塞尔水溶液,可通过光照高速释放控制可溶化的模型药物。酒井健一东京理科大学理工学部尖端化学系茂278-8510千叶县野田市山崎2641
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引用次数: 0
Self-organization under Nonequilibrium and Open Systems 非平衡和开放系统下的自组织
Pub Date : 2021-01-01 DOI: 10.5650/OLEOSCIENCE.21.215
S. Nakata
: Self-organization under nonequilibrium and open systems was reviewed using self-pro-pelled motors of which driving force is the difference in the surface tension. If nonlinearity is intro-duced into the self-propelled systems, autonomy of self-propelled objects is enhanced, and characteris-tic features of self-organization such as pattern formation, oscillation, synchronization, and bifurcation are produced. In this review, I would like to explain the mechanism of self-organized motion in various self-propelled systems.
用驱动力为表面张力差的自驱动马达,研究了非平衡和开放系统下的自组织。在自走系统中引入非线性,增强了自走物体的自主性,产生了模式形成、振荡、同步和分岔等自组织特征。在这篇综述中,我想解释各种自走系统的自组织运动机制。
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引用次数: 0
Toward the Elucidation of the Biological Mechanism for the Pleasant and Unpleasant Taste of Fatty Acids 脂肪酸喜味与苦味的生物学机制探讨
Pub Date : 2021-01-01 DOI: 10.5650/oleoscience.21.261
K. Yasumatsu, Mihoko Tada, Yumiko Nagai, Haruka Nakata
: Evidences have been accumulated that the taste organ is involved in the detection of fats since ~2000, because several molecules have been found to detect fatty acids in taste systems. The au-thors reported expression and function of GPR40 (FFAR1) and GPR120 (FFAR4) in mouse tongue to transmit fatty acid information to the brain. Particularly, GPR120 is involved in neural information pathway that plays role in distinguishing fatty acid taste from other primary tastes. The function of GPR120 was first reported to be involved in appetite and feeding control in the intestine through secretion of intestinal peptides, GLP-1. Recently, GPR120 is also reported in gastric ghrelin-expressing cells to suppress ghrelin secretion by fatty-acid stimulation. Taste information of fatty acids is suggested to be induce cephalic phase responses before food has reached the digestion, priming the body for an in-coming fats or oils. As for the relationship between taste and disease, due to poor taste sensitivity, obese and/or diabetic patients have a risk of taking too much lipids and seasonings. In conclusion, it is important to elucidate mechanisms for the pleasant and unpleasant taste of fats because taste is closely related to feeding behavior connecting to lifestyle-related diseases.
自2000年以来,由于在味觉系统中发现了几种检测脂肪酸的分子,越来越多的证据表明味觉器官参与了对脂肪的检测。作者报道了GPR40 (FFAR1)和GPR120 (FFAR4)在小鼠舌中的表达及其向大脑传递脂肪酸信息的功能。特别是GPR120参与了脂肪酸味觉与其他初级味觉的神经信息通路。GPR120的功能首次被报道为通过分泌肠肽GLP-1参与肠道的食欲和摄食控制。最近,GPR120也被报道在胃饥饿素表达细胞中通过脂肪酸刺激抑制饥饿素的分泌。脂肪酸的味道信息被认为是在食物到达消化之前诱导头期反应,为身体进入脂肪或油做好准备。至于味觉与疾病的关系,肥胖和/或糖尿病患者由于味觉敏感性差,有摄入过多脂类和调味料的风险。总之,阐明脂肪令人愉悦和令人不快的味道的机制是很重要的,因为味道与喂养行为密切相关,与生活方式相关的疾病密切相关。
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引用次数: 0
Analytical Methods for Plasmalogen Plasmalogen的分析方法
Pub Date : 2021-01-01 DOI: 10.5650/oleoscience.21.321
M. Nishimukai, R. Maeba, H. Hara
: Plasmalogen is a subclass of phospholipids widely distributed in the biological world, from anaerobic bacteria to mammals. Although the pathophysiologic roles of Plasmalogen are poorly understood, it has long been implicated in a number of neurodegenerative disorders such as Alzheim-er's disease. Recently, there have been various reports that changes of plasmalogen in the body are in-volved in metabolic diseases associated with oxidative stress and chronic inflammation. Thus, plasma/ serum Plasmalogen is a potential biomarker for these diseases. Here we describe the relationship between plasmalogen and diseases, and the various reports from conventional to new methods of plasmalogen measurement.
:磷脂原是广泛分布于生物界的一类磷脂,从厌氧菌到哺乳动物都有。尽管人们对Plasmalogen的病理生理作用知之甚少,但它长期以来被认为与许多神经退行性疾病(如阿尔茨海默病)有关。近年来,有多种报道指出,体内plasmalogen的变化与氧化应激和慢性炎症相关的代谢性疾病有关。因此,血浆/血清Plasmalogen是这些疾病的潜在生物标志物。在这里,我们描述了等离子体原与疾病之间的关系,以及从传统的到新的等离子体原测量方法的各种报道。
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引用次数: 0
Immuno-modulating Biomaterials~Apoptotic Cell-inspired Anti-inflammatory Polymers~ 免疫调节生物材料~凋亡细胞激发的抗炎聚合物~
Pub Date : 2021-01-01 DOI: 10.5650/oleoscience.21.447
M. Ebara, Akari Tasaki
The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called“immunomodulatory biomaterials”. Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-iner t biomaterials, (2) immuno-activating biomaterials, and (3) immuno-tolerant biomaterials. While many applications of immuno-inert biomaterials such as biocompatible medical implants have been already proposed in the past decades, the ability to engineer biological activity into synthetic materials greatly increases the number of their potential uses and improves their per formance in more traditional applications. The major focus of researchers is now set on developing immuno-tolerant biomaterials for anti-inflammatory therapies. In this review, we therefore introduce recent developments of immuno-tolerant biomaterials. Especially we introduce an apoptotic cell membrane inspired polymer and its post-inflammatory ef fects on immune cells in this ar ticle.
由于具有调节人体免疫系统的新潜力,生物材料领域出现了强劲的复兴。这种特殊的材料被称为“免疫调节生物材料”。一般来说,免疫调节生物材料的设计遵循三种基本策略:(1)免疫修饰生物材料,(2)免疫激活生物材料,(3)免疫耐受生物材料。虽然在过去几十年中已经提出了许多免疫惰性生物材料的应用,例如生物相容性医疗植入物,但将生物活性设计到合成材料中的能力大大增加了其潜在用途的数量,并改善了其在更传统应用中的性能。研究人员目前的主要重点是开发用于抗炎治疗的免疫耐受生物材料。在这篇综述中,我们因此介绍了免疫耐受生物材料的最新进展。本文特别介绍了一种凋亡细胞膜激发聚合物及其对免疫细胞的炎症后作用。
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引用次数: 0
Application to Heat Stroke Prevention Technology Based on Visualization of Hemodynamic Changes Using a General Single-Lens Camera 基于通用单镜头摄像机血流动力学变化可视化的中暑预防技术应用
Pub Date : 2021-01-01 DOI: 10.5650/oleoscience.21.377
Keiichiro Yoshida
: In these days, the number of patients suffering from heat stroke is increasing. But, to de-termine heat stroke, most people tend to be empirical evidence. Therefore, we recognized the need for technology to prevent heat stroke before it happens. We have converted a single-lens camera into a near-infrared camera to measure the hemodynamic changes before and after exercise. In this study, we measured the IR images from human skin surface and calculated the reflectance images from IR images. And we performed three types of experiments, 1) Forearm measurement in the darkroom, 2) Sole measurement in the darkroom, 3) Outdoor forearm measurement. The results show that the rela-tionship between reflectance images and hemodynamic changes, it was suggested that it could be used as a guide to prevent heat stroke.
最近,患中暑的病人越来越多。但是,为了确定中暑,大多数人倾向于根据经验证据。因此,我们认识到需要技术来预防中暑。我们将单镜头摄像机转换成近红外摄像机,测量运动前后的血流动力学变化。在本研究中,我们测量了人体皮肤表面的红外图像,并计算了红外图像的反射率。我们进行了三种类型的实验,1)暗房内前臂测量,2)暗房内鞋底测量,3)室外前臂测量。结果表明,反射图像与血流动力学变化之间存在一定的关系,可以作为预防中暑的指导。
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引用次数: 1
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