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Effect of various pharmacotherapy regimens on the state of carbohydrate metabolism in patients with urination disorders 各种药物治疗方案对排尿障碍患者碳水化合物代谢状态的影响
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-77-81
V. V. Danilov, E. V. Eliseeva, V. V. Danilov, I. Volnykh, A. V. Tyrtyshnikova, M. M. Piskun, V. V. Danilov
Aim. To evaluate the efficacy and safety of various pharmacotherapy regimens in patients with urination disorders and type 2 diabetes mellitus during their preparation for surgery.Materials and methods. In total, 130 people (56 men and 74 women) aged from 18 to 81 years (average 65 years) were included in the research. All the patients were on standardized hypoglycemic therapy in combination with alpha1-blockers (doxazosin, terazosin) and vitamin-like drugs (alpha-lipoic acid, levocarnitine). Patients were divided into male and female subgroups, as well as into age subgroups, including under 65 years and over 65 years. Tabular methods of assessing the clinical symptoms of urinary disorders were used, along with instrumental, laboratory, and statistical methods (Mann-Whitney test, Spearman rank correlation coefficient).Results. The duration of therapy averaged 16± 2 months. The observation found that alpha1-blockers lead to a number of positive changes in the composition of carbohydrate metabolism, i.e., the level of serum glucose and insulin. In the general observation group, a significant decrease in blood glucose from 6.64 to 6.27 mmol/L, insulin from 18.07 to 14.03 mU/mL, and C-peptide from 3.67 to 2.98 ng/mL was detected. In the male subgroup, glucose levels decreased from 6.45 to 6.00 mmol/L, insulin from 18.92 to 13.99 mU/mL, and C-peptide from 3.76 to 2.97 ng/mL. In the female subgroup, blood glucose levels decreased from 6.98 to 6.77 mmol/L, insulin from 16.41 to 14.1 mU/mL, and C-peptide from 3.51 to 2.99 ng/mL. In the group of patients younger than 65 years of age, a decrease in glucose from 6.22 to 5.93 mmol/L, insulin from 17.87 to 14.36 mU/mL, and C-peptide from 3.49 to 3.01 ng/mL were also observed. In the group of patients older than 65 years of age, similar dynamics of the above parameters was established.Conclusions. The data obtained suggest that alpha1-blockers in combination with vitamin-like drugs contribute to reducing the level of serum glucose, insulin, and C-peptide during a long-term (at least 1 year) therapy, which may be promising in the correction of metabolic disorders during preparation of patients for surgery.
目的评估排尿障碍和 2 型糖尿病患者在准备手术期间各种药物治疗方案的有效性和安全性。共有 130 人(56 名男性和 74 名女性)参与了研究,年龄从 18 岁到 81 岁不等(平均 65 岁)。所有患者均在接受标准化降糖治疗的同时服用α1-受体阻滞剂(多沙唑嗪、特拉唑嗪)和维生素类药物(α-硫辛酸、左旋肉碱)。患者被分为男性亚组和女性亚组,以及年龄亚组,包括 65 岁以下和 65 岁以上。采用表格法评估泌尿系统疾病的临床症状,同时使用仪器、实验室和统计方法(曼-惠特尼检验、斯皮尔曼等级相关系数)。治疗时间平均为 16±2 个月。观察发现,α1-受体阻滞剂导致碳水化合物代谢组成,即血清葡萄糖和胰岛素水平发生了一些积极变化。在普通观察组中,血糖从 6.64 mmol/L 显著降至 6.27 mmol/L,胰岛素从 18.07 mU/mL 降至 14.03 mU/mL,C 肽从 3.67 ng/mL 降至 2.98 ng/mL。在男性亚组中,血糖水平从 6.45 mmol/L 降至 6.00 mmol/L,胰岛素从 18.92 mU/mL 降至 13.99 mU/mL,C 肽从 3.76 ng/mL 降至 2.97 ng/mL。在女性亚组中,血糖水平从 6.98 mmol/L 降至 6.77 mmol/L,胰岛素从 16.41 mU/mL 降至 14.1 mU/mL,C 肽从 3.51 ng/mL 降至 2.99 ng/mL。在 65 岁以下的患者组中,还观察到血糖从 6.22 mmol/L 降至 5.93 mmol/L,胰岛素从 17.87 mU/mL 降至 14.36 mU/mL,C 肽从 3.49 ng/mL 降至 3.01 ng/mL。在 65 岁以上的患者组中,上述参数的动态变化相似。所获得的数据表明,α1-受体阻滞剂与类维生素药物联合使用有助于在长期(至少一年)治疗期间降低血清葡萄糖、胰岛素和 C 肽的水平,这对于纠正手术准备期间患者的代谢紊乱很有帮助。
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引用次数: 0
Health dynamics of children and adolescents in the Far Eastern federal district in 2013–2020 2013-2020 年远东联邦区儿童和青少年的健康动态
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-72-76
O. Gritsina, A. Yatsenko, L. V. Trankovskaya, Yu. V. Maistrovskaya, D. A. Ermakova, S. D. Shestakova
Aim. To identify trends in the primary morbidity of children and adolescents in the Far Eastern Federal District.Materials and methods. A retrospective analytical study of the dynamics of primary morbidity in children and adolescents by disease class was conducted.Results. Among the children population, a very high and high stability of the decrease in morbidity rates was established (R = -0.714– (-1.0)) for all classes of diseases. Among the adolescent population, a weak stability in the decrease in morbidity rates was characteristic of VII Diseases of the eye and adnexa (R = -0.262) and X Respiratory diseases (R = -0.262); a moderate stability of IV Diseases of the endocrine system, nutritional disorders, and metabolic disorders (R = -0.333); a moderate stability of IX Diseases of the circulatory system (R = -0.623); and a high stability among all other classes (R= -0.738 – (-0.928)). In the older age group, weak resistance to growth dynamics was determined in classes III Diseases of the blood, hematopoietic organs, and certain disorders involving the immune mechanism (R = 0.024) and VIII Diseases of the ear and mastoid process (R = 0.095).Conclusion. The data obtained forms a basis for further research into regional risk factors that contribute to poor health of the population. The findings can also be used to predict the health status of younger generations.
目的确定远东联邦区儿童和青少年原发病的发展趋势。按疾病类别对儿童和青少年的原发病动态进行了回顾性分析研究。在儿童群体中,所有类别疾病的发病率下降都具有很高的稳定性(R = -0.714- (-1.0))。在青少年群体中,第七类眼部和附件疾病(R=-0.262)和第十类呼吸系统疾病(R=-0.262)的发病率下降稳定性较弱;第四类内分泌系统疾病、营养失调和代谢紊乱的发病率下降稳定性中等(R=-0.333);第九类循环系统疾病的发病率下降稳定性中等(R=-0.623);其他各类疾病的发病率下降稳定性较高(R=-0.738-(-0.928))。在老年组中,血液、造血器官疾病和涉及免疫机制的某些疾病(R=0.024)以及耳和乳突疾病(R=0.095)III 类对增长动态的抵抗力较弱。所获得的数据为进一步研究造成人口健康状况不良的地区风险因素奠定了基础。研究结果还可用于预测年轻一代的健康状况。
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引用次数: 0
Effect of various pharmacotherapy regimens on the state of carbohydrate metabolism in patients with urination disorders 各种药物治疗方案对排尿障碍患者碳水化合物代谢状态的影响
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-77-81
V. V. Danilov, E. V. Eliseeva, V. V. Danilov, I. Volnykh, A. V. Tyrtyshnikova, M. M. Piskun, V. V. Danilov
Aim. To evaluate the efficacy and safety of various pharmacotherapy regimens in patients with urination disorders and type 2 diabetes mellitus during their preparation for surgery.Materials and methods. In total, 130 people (56 men and 74 women) aged from 18 to 81 years (average 65 years) were included in the research. All the patients were on standardized hypoglycemic therapy in combination with alpha1-blockers (doxazosin, terazosin) and vitamin-like drugs (alpha-lipoic acid, levocarnitine). Patients were divided into male and female subgroups, as well as into age subgroups, including under 65 years and over 65 years. Tabular methods of assessing the clinical symptoms of urinary disorders were used, along with instrumental, laboratory, and statistical methods (Mann-Whitney test, Spearman rank correlation coefficient).Results. The duration of therapy averaged 16± 2 months. The observation found that alpha1-blockers lead to a number of positive changes in the composition of carbohydrate metabolism, i.e., the level of serum glucose and insulin. In the general observation group, a significant decrease in blood glucose from 6.64 to 6.27 mmol/L, insulin from 18.07 to 14.03 mU/mL, and C-peptide from 3.67 to 2.98 ng/mL was detected. In the male subgroup, glucose levels decreased from 6.45 to 6.00 mmol/L, insulin from 18.92 to 13.99 mU/mL, and C-peptide from 3.76 to 2.97 ng/mL. In the female subgroup, blood glucose levels decreased from 6.98 to 6.77 mmol/L, insulin from 16.41 to 14.1 mU/mL, and C-peptide from 3.51 to 2.99 ng/mL. In the group of patients younger than 65 years of age, a decrease in glucose from 6.22 to 5.93 mmol/L, insulin from 17.87 to 14.36 mU/mL, and C-peptide from 3.49 to 3.01 ng/mL were also observed. In the group of patients older than 65 years of age, similar dynamics of the above parameters was established.Conclusions. The data obtained suggest that alpha1-blockers in combination with vitamin-like drugs contribute to reducing the level of serum glucose, insulin, and C-peptide during a long-term (at least 1 year) therapy, which may be promising in the correction of metabolic disorders during preparation of patients for surgery.
目的评估排尿障碍和 2 型糖尿病患者在准备手术期间各种药物治疗方案的有效性和安全性。共有 130 人(56 名男性和 74 名女性)参与了研究,年龄从 18 岁到 81 岁不等(平均 65 岁)。所有患者均在接受标准化降糖治疗的同时服用α1-受体阻滞剂(多沙唑嗪、特拉唑嗪)和维生素类药物(α-硫辛酸、左旋肉碱)。患者被分为男性亚组和女性亚组,以及年龄亚组,包括 65 岁以下和 65 岁以上。采用表格法评估泌尿系统疾病的临床症状,同时使用仪器、实验室和统计方法(曼-惠特尼检验、斯皮尔曼等级相关系数)。治疗时间平均为 16±2 个月。观察发现,α1-受体阻滞剂导致碳水化合物代谢组成,即血清葡萄糖和胰岛素水平发生了一些积极变化。在普通观察组中,血糖从 6.64 mmol/L 显著降至 6.27 mmol/L,胰岛素从 18.07 mU/mL 降至 14.03 mU/mL,C 肽从 3.67 ng/mL 降至 2.98 ng/mL。在男性亚组中,血糖水平从 6.45 mmol/L 降至 6.00 mmol/L,胰岛素从 18.92 mU/mL 降至 13.99 mU/mL,C 肽从 3.76 ng/mL 降至 2.97 ng/mL。在女性亚组中,血糖水平从 6.98 mmol/L 降至 6.77 mmol/L,胰岛素从 16.41 mU/mL 降至 14.1 mU/mL,C 肽从 3.51 ng/mL 降至 2.99 ng/mL。在 65 岁以下的患者组中,还观察到血糖从 6.22 mmol/L 降至 5.93 mmol/L,胰岛素从 17.87 mU/mL 降至 14.36 mU/mL,C 肽从 3.49 ng/mL 降至 3.01 ng/mL。在 65 岁以上的患者组中,上述参数的动态变化相似。所获得的数据表明,α1-受体阻滞剂与类维生素药物联合使用有助于在长期(至少一年)治疗期间降低血清葡萄糖、胰岛素和 C 肽的水平,这对于纠正手术准备期间患者的代谢紊乱很有帮助。
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引用次数: 0
Software application for predicting the efficacy of rehabilitation treatment in patients with discirculatory encephalopathy 预测盘状脑病患者康复治疗疗效的应用软件
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-86-88
E. V. Moroz, O. V. Perelomova, V. V. Knyshоva
Aim. To develop a software application for determining the rehabilitation potential and predicting the efficacy of rehabilitation treatment in elderly and senile patients with stage III discirculatory encephalopathy (DE).Methods. A database of 185 patients with stage III DE was used. The indicators were assessed in dynamics, i.e., prior to the rehabilitation treatment and following three and six months from the onset of treatment course. The software application was developed using the Visual Basic for Applications (VBA) programming language built into Microsoft Excel 2010.Results. The developed application comprises several first-order subroutines to assess the patient’s neurological status, memory, attention, functional activity in everyday life, as well as second-order subroutines to calculate the rehabilitation potential and predict the treatment efficacy. At the first stage, personal data and characteristics of neurological disorders, cognitive functions, scale of instrumental activities in daily living (IADL) are entered. At the second stage, the indicator of rehabilitation potential is automatically calculated and its qualitative assessment is provided. On the basis of prediction of the efficacy of the three complexes, further rehabilitation tactics for a particular patient is determined.Conclusions. The developed software application is useful for automating and optimizing the work of rehabilitation neurologists.
目的开发一款应用软件,用于确定老年盘状脑病(DE)III期患者的康复潜力和预测康复治疗的疗效。方法:使用一个包含 185 名 III 期盘状脑病患者的数据库。对各项指标进行动态评估,即康复治疗前以及治疗开始后的三个月和六个月。应用软件是使用 Microsoft Excel 2010 中内置的 Visual Basic for Applications(VBA)编程语言开发的。所开发的应用程序包括几个一阶子程序,用于评估患者的神经状态、记忆力、注意力、日常生活中的功能活动,以及用于计算康复潜力和预测治疗效果的二阶子程序。在第一阶段,输入个人数据和神经系统疾病特征、认知功能、日常生活工具活动(IADL)量表。在第二阶段,将自动计算康复潜力指标并对其进行定性评估。在预测三种复合方法的有效性的基础上,确定特定患者的进一步康复策略。所开发的软件应用程序有助于自动化和优化康复神经科医生的工作。
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引用次数: 0
Combined application of exercise therapy and reflexotherapy for ischemic stroke patients in the acute period 缺血性脑卒中患者急性期运动疗法和反射疗法的联合应用
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-64-68
E. V. Pavlushchenko, L. Y. Petrova, L. I. Kisel, L. A. Klersfeld
Aim. Search for new effective methods of physical rehabilitation for patients with ischemic stroke.Materials and methods. In total, 60 ischemic stroke patients aged from 51 to 80 years in the acute period were included in the rehabilitation program. All patients showed motor and speech disorders, problems with self-care and mobility, and reduced quality of life indicators. The program of early rehabilitation included the combination of reflexotherapy (RT) and differentiated choice of exercise therapy (ET).Results. The comparative analysis of the results of three therapeutic programs for rehabilitation of patients with acute cerebral circulation disorders (ACCD) in the acute period showed the high efficacy of a combined use of RT and ET with a differentiated approach to method selection.Conclusions. The combined application of neurorehabilitation methods for ischemic stroke patients has confirmed its high efficacy. The developed rehabilitation programs may improve the quality of life of patients after acute cerebral circulation disorders and increase their independence in everyday life.
目的寻找缺血性脑卒中患者身体康复的新有效方法。共有60名急性期缺血性脑卒中患者参加了康复项目,年龄在51至80岁之间。所有患者均有运动和语言障碍,生活自理和行动不便,生活质量指标下降。早期康复计划包括再放疗(RT)和运动疗法(ET)的组合。对急性脑循环障碍(ACCD)患者急性期康复的三种治疗方案结果的比较分析表明,联合使用RT和ET,并在方法选择上有所区别,具有很高的疗效。缺血性脑卒中患者神经康复方法的联合应用证实了其高效性。所制定的康复计划可以改善急性脑循环障碍患者的生活质量,提高他们在日常生活中的独立性。
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引用次数: 0
Morbidity of circulatory diseases among the working-age population in the Far Eastern federal district in 2012–2021 2012-2021 年远东联邦区劳动适龄人口循环系统疾病发病率
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-57-63
A. A. Vazhenina, A. Shastin, L. V. Trankovskaya, I. L. Ivanova, E. Anishchenko, V. G. Panov, V. Gazimova, S. O. Zolotareva
Aim. To study the indicators and regional features of circulatory disease morbidity among the able-bodied population in the Far Eastern Federal District for the 2012–2021 period.Material and methods. A descriptive statistical study was conducted. The indicators of incidence and prevalence rates of circulatory system diseases, including ischemic heart diseases and cerebrovascular diseases, were calculated according to the data published by the Russian Research Institute of Health. To assess the statistical significance of differences in the incidence rate in 2020 and 2021 relative to the 2012–2019 period, a 95% CI for the average incidence rate in 2012–2019 was used by generating repeated samples. Differences in the incidence and prevalence rates in 2020 and 2021 above the upper or below the lower CI boundary for the average values in 2012–2019 were considered statistically significant.Results. An analysis of the incidence and prevalence rates of circulatory system diseases among the working-age population in the Far Eastern Federal District in 2012–2021 was carried out. The obtained data are characterized by a significant variability and heterogeneity of indicators, showing significant differences from the all-Russian data for the 2012–2019 period. Changes in the incidence and prevalence rates of circulatory system diseases in the Far Eastern Federal District during the spread of COVID-19 in 2020–2021 were found to be multidirectional. In general, the statistically significant increase in the incidence of coronary heart disease in the Far Eastern Federal District in 2020 and 2021 is largely associated with the growth of indicators in the Khabarovsk Krai.Conclusions. The obtained characteristics of the incidence and prevalence rates of circulatory system diseases, including ischemic heart diseases and cerebrovascular diseases, indicate the presence of pronounced regional characteristics. The revealed multiple differences in the morbidity rates in the subjects of the Far Eastern Federal District require further research to determine their priority and significance for monitoring the health of the population.
目的研究 2012-2021 年远东联邦区健全人口循环系统疾病发病率的指标和地区特征。进行了描述性统计研究。循环系统疾病(包括缺血性心脏病和脑血管疾病)的发病率和流行率指标是根据俄罗斯卫生研究院公布的数据计算得出的。为了评估2020年和2021年发病率相对于2012-2019年期间的差异的统计意义,通过生成重复样本,使用了2012-2019年平均发病率的95% CI。2020年和2021年的发病率和流行率高于或低于2012-2019年平均值的CI上限或下限的差异被认为具有显著的统计学意义。对远东联邦区 2012-2021 年劳动适龄人口循环系统疾病的发病率和流行率进行了分析。所获得的数据具有显著的可变性和指标的异质性,与2012-2019年期间的全俄数据存在显著差异。在 2020-2021 年 COVID-19 传播期间,远东联邦区循环系统疾病发病率和流行率的变化是多向的。总体而言,2020 年和 2021 年远东联邦区冠心病发病率的显著增长在统计学上主要与哈巴罗夫斯克边疆区的指标增长有关。所获得的循环系统疾病(包括缺血性心脏病和脑血管疾病)的发病率和患病率特征表明,存在明显的区域特征。远东联邦区居民发病率的多重差异需要进一步研究,以确定其对监测居民健康的优先性和重要性。
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引用次数: 0
Training program for primary care physicians in medical rehabilitation at the Pacifi c Medical University 太平洋医科大学医疗康复初级保健医生培训计划
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-93-96
T. N. Kuzmina, G. V. Kuznetsova, L. Y. Petrova
This article describes the experience of training primary care physicians in the field of medical rehabilitation. The existing procedure for the arrangement of medical rehabilitation prescribes its rules and order of implementation in medical primary health care organizations both in outpatient and day patient settings. The Pacific State Medical University (PSMU) runs training programs for primary care physicians within the 31.05.01 educational program “General Medicine”, direction “02 Healthcare”. In accordance with the curriculum, a training program “Medical Rehabilitation” that includes both lectures and training sessions was developed. This program is aimed at forming the necessary competencies of future primary care physicians in implementing and monitoring the effectiveness of the patient’s medical rehabilitation. Training is carried out at the facilities of the PSMU Institute of Clinical Neurology and Rehabilitation Medicine by specialists having experience in medical rehabilitation and having completed the program “Modern aspects of specialist training in the field of physical and rehabilitation medicine”.
本文介绍了在医疗康复领域培训初级保健医生的经验。现有的医疗康复安排程序规定了其在门诊和日间病人医疗初级保健机构中的实施规则和顺序。太平洋国立医科大学(PSMU)在 31.05.01 教育计划 "全科 "方向 "02 医疗保健 "中开设了初级保健医生培训课程。根据教学大纲,制定了 "医疗康复 "培训计划,其中包括讲座和培训课程。该计划旨在培养未来的初级保健医生在实施和监督病人医疗康复有效性方面的必要能力。培训由具有医疗康复经验并完成了 "物理和康复医学领域专家培训的现代方面 "课程的专家在 PSMU 临床神经学和康复医学研究所的设施内进行。
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引用次数: 0
Experience of pediatric and adolescent rehabilitation in the department of rehabilitation of the regional children’s oncohematological center, Vladivostok 符拉迪沃斯托克地区儿童肿瘤中心康复部的儿童和青少年康复经验
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-89-92
G. V. Kuznetsova, L. M. Minkina, T. N. Kuzmina, I. A. Obukhova, A. V. Voskresenskaya, E. V. Prosekova
The development of modern treatment technologies in oncology has reduced the mortality of children and adolescents from malignant neoplasms and hematological diseases. As a result, the issue of organizing rehabilitation care has become urgent. In this article, we describe the experience of organizing and developing pediatric rehabilitation in the oncology/hematology profile in Primorsky Krai for the period from 1995 to 2022. Various medical, psychological, social, and environmental aspects are outlined along with rehabilitation technologies used. The effectiveness of rehabilitation and the peculiarities of its implementation in children with oncological and hematological diseases are shown. The expediency of carrying out stages of rehabilitation in the region of residence of patients is substantiated.
现代肿瘤治疗技术的发展降低了恶性肿瘤和血液病造成的儿童和青少年死亡率。因此,组织康复护理的问题变得迫在眉睫。本文介绍了 1995 年至 2022 年期间滨海边疆区在肿瘤/血液学领域组织和发展儿童康复的经验。文章概述了医疗、心理、社会和环境方面的问题以及所使用的康复技术。康复的有效性及其在患有肿瘤和血液病的儿童中实施的特殊性得到了体现。在患者居住地进行阶段性康复的便利性也得到了证实。
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引用次数: 0
Morbidity of circulatory diseases among the working-age population in the Far Eastern federal district in 2012–2021 2012-2021 年远东联邦区劳动适龄人口循环系统疾病发病率
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-57-63
A. A. Vazhenina, A. Shastin, L. V. Trankovskaya, I. L. Ivanova, E. Anishchenko, V. G. Panov, V. Gazimova, S. O. Zolotareva
Aim. To study the indicators and regional features of circulatory disease morbidity among the able-bodied population in the Far Eastern Federal District for the 2012–2021 period.Material and methods. A descriptive statistical study was conducted. The indicators of incidence and prevalence rates of circulatory system diseases, including ischemic heart diseases and cerebrovascular diseases, were calculated according to the data published by the Russian Research Institute of Health. To assess the statistical significance of differences in the incidence rate in 2020 and 2021 relative to the 2012–2019 period, a 95% CI for the average incidence rate in 2012–2019 was used by generating repeated samples. Differences in the incidence and prevalence rates in 2020 and 2021 above the upper or below the lower CI boundary for the average values in 2012–2019 were considered statistically significant.Results. An analysis of the incidence and prevalence rates of circulatory system diseases among the working-age population in the Far Eastern Federal District in 2012–2021 was carried out. The obtained data are characterized by a significant variability and heterogeneity of indicators, showing significant differences from the all-Russian data for the 2012–2019 period. Changes in the incidence and prevalence rates of circulatory system diseases in the Far Eastern Federal District during the spread of COVID-19 in 2020–2021 were found to be multidirectional. In general, the statistically significant increase in the incidence of coronary heart disease in the Far Eastern Federal District in 2020 and 2021 is largely associated with the growth of indicators in the Khabarovsk Krai.Conclusions. The obtained characteristics of the incidence and prevalence rates of circulatory system diseases, including ischemic heart diseases and cerebrovascular diseases, indicate the presence of pronounced regional characteristics. The revealed multiple differences in the morbidity rates in the subjects of the Far Eastern Federal District require further research to determine their priority and significance for monitoring the health of the population.
目的研究 2012-2021 年远东联邦区健全人口循环系统疾病发病率的指标和地区特征。进行了描述性统计研究。循环系统疾病(包括缺血性心脏病和脑血管疾病)的发病率和流行率指标是根据俄罗斯卫生研究院公布的数据计算得出的。为了评估2020年和2021年发病率相对于2012-2019年期间的差异的统计意义,通过生成重复样本,使用了2012-2019年平均发病率的95% CI。2020年和2021年的发病率和流行率高于或低于2012-2019年平均值的CI上限或下限的差异被认为具有显著的统计学意义。对远东联邦区 2012-2021 年劳动适龄人口循环系统疾病的发病率和流行率进行了分析。所获得的数据具有显著的可变性和指标的异质性,与2012-2019年期间的全俄数据存在显著差异。在 2020-2021 年 COVID-19 传播期间,远东联邦区循环系统疾病发病率和流行率的变化是多向的。总体而言,2020 年和 2021 年远东联邦区冠心病发病率的显著增长在统计学上主要与哈巴罗夫斯克边疆区的指标增长有关。所获得的循环系统疾病(包括缺血性心脏病和脑血管疾病)的发病率和患病率特征表明,存在明显的区域特征。远东联邦区居民发病率的多重差异需要进一步研究,以确定其对监测居民健康的优先性和重要性。
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引用次数: 0
Аnalysis of clinical cases of diabetic retinopathy progression in pregnant women with type 1 diabetes 1型糖尿病孕妇糖尿病视网膜病变进展的临床病例分析
Pub Date : 2024-02-02 DOI: 10.34215/1609-1175-2023-4-69-71
N. Pomytkina
This paper presents clinical cases of diabetic retinopathy (DR) progression in pregnant women with type 1 diabetes. In preproliferative DR, the formation of focal macular edema in both eyes with nonperfusion areas of perimacular localization was observed. Both eyes were subjected to laser coagulation of the retina. After one month, a regression of macular edema in the left eye and hemorrhagic phenomena in both eyes was established with the emergence of new nonperfusion zones. DR progression during pregnancy and in the postpartum period is determined by a number of factors, including diabetes mellitus compensation, retinopathy stabilization, and the presence of concomitant pathologies. In the aggressive course of proliferative DR, local traction retinal detachment and partial hemophthalmos of the left eye were revealed. In this case, three stages of panretinal laser coagulation of both eyes and endovitreal intervention with silicone tamponade on the left eye were performed. At 28 weeks of gestation, progression of retinal neovascularization was observed in the right eye, extensive areas of nonperfusion in the posterior pole. The areas of laser coagulation of the retina were compacted in the right eye.
本文介绍了 1 型糖尿病孕妇糖尿病视网膜病变(DR)进展的临床病例。在增殖前糖尿病视网膜病变中,两只眼睛都出现了黄斑区局灶性水肿,黄斑区周围出现非灌注区。两只眼睛都接受了视网膜激光凝固治疗。一个月后,左眼黄斑水肿消退,双眼出现出血现象,并出现了新的非灌注区。妊娠期和产后的 DR 进展由多种因素决定,包括糖尿病代偿、视网膜病变稳定以及并发症的存在。在增殖性 DR 的恶化过程中,左眼出现局部牵引性视网膜脱离和部分眼球下垂。在这个病例中,对双眼进行了三个阶段的全视网膜激光凝固术,并对左眼进行了硅酮填塞的玻璃体内介入治疗。妊娠 28 周时,观察到右眼视网膜新生血管进展,后极部出现大面积非灌注区。右眼视网膜的激光凝固区域被压缩。
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Pacific Medical Journal
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