Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-53-59
G. A. Merkulova, E. V. Pegova, E. Y. Rishko, S. P. Kryzhanovsky
Objective. To assess the rehabilitation potential of patients with cerebrovascular disorders for prospective follow-up and effective medical rehabilitation. Materials and methods. The study group included patients with cerebrovascular diseases (n=20) and acute cerebrovascular accident (n=22). Integral assessment of the state of health was carried out using diagnostic complex “Computer dermograph for the topical diagnosis of pathology lesions of internal organs” (DgKTD-01). Following studying the baseline indicators, a comparative analysis of the study group and the control group (n=10) was carried out. The patients of the study group had their state of health corrected by means of the Computerized corrector ANKF-01 using low-intensity electromagnetic field for normalization of functional activity of the central and peripheral nervous system. The course consisted of 10 sessions weekly with preliminary functional and topical diagnostics using the DgKTD-01 complex. Results. Patients with acute cerebrovascular accident revealed a functional restructuring of autonomic regulation with a greater severity of activation of the sympathetic link, patients with cerebrovascular diseases – of the parasympathetic one. The determining factor in cerebral circulation disorder consists in the indices of basic functions F2 and F3. The study identified a model for predicting the likelihood of acute recurrent disorders of cerebral circulation, as well as additional diagnostic criteria for differential diagnosis. Purposeful change of excitatory (inhibitory) potentials in cortical-subcortical relations changes vegetative balance, stimulates microcirculation, muscle-tonic function, neurotrophic regulation. These effects stabilize and improve the condition of patients. The effectiveness of rehabilitation measures using ANKF-01 is considered to be higher in patients with acute cerebrovascular accident. Conclusion. Patients with cerebral circulation disorders have specific features of the adaptive capabilities of the body. This indicates the differentiation in the formation of the functional status of the body, taking into account the characteristics of the disease, individual resources and compensatory capabilities. Rehabilitation based on the use of ANKF-01 increases the effectiveness of measures aimed at preventing organic changes in the brain, and can significantly improve the prognosis and reduce the percentage of disability in this category of patients.
{"title":"Experience and prospects of introducing information technologies in the program of medical rehabilitation of patients with cerebral circulation disorders","authors":"G. A. Merkulova, E. V. Pegova, E. Y. Rishko, S. P. Kryzhanovsky","doi":"10.34215/1609-1175-2024-1-53-59","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-53-59","url":null,"abstract":"Objective. To assess the rehabilitation potential of patients with cerebrovascular disorders for prospective follow-up and effective medical rehabilitation. Materials and methods. The study group included patients with cerebrovascular diseases (n=20) and acute cerebrovascular accident (n=22). Integral assessment of the state of health was carried out using diagnostic complex “Computer dermograph for the topical diagnosis of pathology lesions of internal organs” (DgKTD-01). Following studying the baseline indicators, a comparative analysis of the study group and the control group (n=10) was carried out. The patients of the study group had their state of health corrected by means of the Computerized corrector ANKF-01 using low-intensity electromagnetic field for normalization of functional activity of the central and peripheral nervous system. The course consisted of 10 sessions weekly with preliminary functional and topical diagnostics using the DgKTD-01 complex. Results. Patients with acute cerebrovascular accident revealed a functional restructuring of autonomic regulation with a greater severity of activation of the sympathetic link, patients with cerebrovascular diseases – of the parasympathetic one. The determining factor in cerebral circulation disorder consists in the indices of basic functions F2 and F3. The study identified a model for predicting the likelihood of acute recurrent disorders of cerebral circulation, as well as additional diagnostic criteria for differential diagnosis. Purposeful change of excitatory (inhibitory) potentials in cortical-subcortical relations changes vegetative balance, stimulates microcirculation, muscle-tonic function, neurotrophic regulation. These effects stabilize and improve the condition of patients. The effectiveness of rehabilitation measures using ANKF-01 is considered to be higher in patients with acute cerebrovascular accident. Conclusion. Patients with cerebral circulation disorders have specific features of the adaptive capabilities of the body. This indicates the differentiation in the formation of the functional status of the body, taking into account the characteristics of the disease, individual resources and compensatory capabilities. Rehabilitation based on the use of ANKF-01 increases the effectiveness of measures aimed at preventing organic changes in the brain, and can significantly improve the prognosis and reduce the percentage of disability in this category of patients.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"113 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-64-68
N. E. Lavrova, A. A. Grigoryuk
Objective. To evaluate the effectiveness of treatment of breast cysts with an ozone-oxygen mixture using ultrasound guidance. Materials and methods. The methodology included a retrospective analysis of the ultrasound-guided treatment of breast cysts. Treatment was carried out according to clinical recommendations using a conservative method and involved outpatient ultrasound-guided removal of cystic content without sclerosant and with introduction of ozone-oxygen mixture. Results. 445 patients with fibrocystic mastopathy were treated. The age of the patients ranged from 18 to 55 years. The detected cysts up to 2 cm represented regular-shaped, rounded anechoic masses with clear even contours and homogeneous structure. Cysts larger than 2 cm were sometimes irregular in shape with anechoic, homogeneous content. In most cases, the multilocular cysts had an irregular shape with anechoic contents, without intracavitary parietal inclusions. The average size of the cysts comprised 2.8±0.9 cm. The analysis showed the effectiveness of the treatment methods. The best effect was obtained with the use of an ozone-oxygen mixture. Complications of the procedure were observed in 6 (2%) patients (hematoma and recurrence). Conclusion. The findings of the study showed that treatment of breast cysts with an ozone-oxygen mixture using ultrasound guidance proved to be a highly effective, low-traumatic, and safe method. This technique is performed on outpatient basis, does not require the administration of anesthetics, is well tolerated by patients, has a selective effect, has no serious complications and risk of cosmetic defects.
{"title":"Treatment of breast cysts with ozone-oxygen mixture using ultrasonic guidance","authors":"N. E. Lavrova, A. A. Grigoryuk","doi":"10.34215/1609-1175-2024-1-64-68","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-64-68","url":null,"abstract":"Objective. To evaluate the effectiveness of treatment of breast cysts with an ozone-oxygen mixture using ultrasound guidance. Materials and methods. The methodology included a retrospective analysis of the ultrasound-guided treatment of breast cysts. Treatment was carried out according to clinical recommendations using a conservative method and involved outpatient ultrasound-guided removal of cystic content without sclerosant and with introduction of ozone-oxygen mixture. Results. 445 patients with fibrocystic mastopathy were treated. The age of the patients ranged from 18 to 55 years. The detected cysts up to 2 cm represented regular-shaped, rounded anechoic masses with clear even contours and homogeneous structure. Cysts larger than 2 cm were sometimes irregular in shape with anechoic, homogeneous content. In most cases, the multilocular cysts had an irregular shape with anechoic contents, without intracavitary parietal inclusions. The average size of the cysts comprised 2.8±0.9 cm. The analysis showed the effectiveness of the treatment methods. The best effect was obtained with the use of an ozone-oxygen mixture. Complications of the procedure were observed in 6 (2%) patients (hematoma and recurrence). Conclusion. The findings of the study showed that treatment of breast cysts with an ozone-oxygen mixture using ultrasound guidance proved to be a highly effective, low-traumatic, and safe method. This technique is performed on outpatient basis, does not require the administration of anesthetics, is well tolerated by patients, has a selective effect, has no serious complications and risk of cosmetic defects.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"125 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-35-38
V. Bazarnyi, M. Kopenkin, L. Polushina, E. A. Sementsova, Y. Mandra
Objective. To evaluate the vascular endothelial growth factor A and brain-derived neurotrophic factor in the oral fluid of mature and elderly patients with chronic periodontitis and oral lichen planus. Materials and methods. The study involved 56 participants. The control group consisted of healthy volunteers aged 18–44 (n=10). The comparison group included relatively healthy elderly people aged 60–74 (n=12). The distinguished groups of patients with age-associated dental diseases included: moderate chronic periodontitis mature patients of 45–59 years (n=10) and elderly patients (n=14), as well as elderly patients with oral lichen planus (n=10). The patients underwent dental examination. The content of neurotrophins and vascular endothelial growth factor A in saliva (BDNF/ NGF beta/ VEGF-A Human ProcartaPlex Simplex Kit, Invitrogen, USA) was determined by the multiparametric fluorescence analysis with magnetic microspheres (xMAP, Luminex 200, USA) in compliance with the manufacturer protocol. Results. The groups reveal no differences in the level of brain-derived neurotrophic factor and nerve growth factor beta. The elderly patients with oral lichen planus were found to obtain the highest angiogenesis factor, which diagnostic value was assessed by ROC-analysis. The test appears moderately accurate (AUC=0.875). Conclusion. Vascular endothelial growth factor A can be considered for laboratory monitoring of elderly patients with oral lichen planus.
{"title":"Neurotrophins and vascular endothelial growth factor in oral fluid of elderly patients: diagnostic value for chronic periodontitis and oral lichen planus","authors":"V. Bazarnyi, M. Kopenkin, L. Polushina, E. A. Sementsova, Y. Mandra","doi":"10.34215/1609-1175-2024-1-35-38","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-35-38","url":null,"abstract":"Objective. To evaluate the vascular endothelial growth factor A and brain-derived neurotrophic factor in the oral fluid of mature and elderly patients with chronic periodontitis and oral lichen planus. Materials and methods. The study involved 56 participants. The control group consisted of healthy volunteers aged 18–44 (n=10). The comparison group included relatively healthy elderly people aged 60–74 (n=12). The distinguished groups of patients with age-associated dental diseases included: moderate chronic periodontitis mature patients of 45–59 years (n=10) and elderly patients (n=14), as well as elderly patients with oral lichen planus (n=10). The patients underwent dental examination. The content of neurotrophins and vascular endothelial growth factor A in saliva (BDNF/ NGF beta/ VEGF-A Human ProcartaPlex Simplex Kit, Invitrogen, USA) was determined by the multiparametric fluorescence analysis with magnetic microspheres (xMAP, Luminex 200, USA) in compliance with the manufacturer protocol. Results. The groups reveal no differences in the level of brain-derived neurotrophic factor and nerve growth factor beta. The elderly patients with oral lichen planus were found to obtain the highest angiogenesis factor, which diagnostic value was assessed by ROC-analysis. The test appears moderately accurate (AUC=0.875). Conclusion. Vascular endothelial growth factor A can be considered for laboratory monitoring of elderly patients with oral lichen planus.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"110 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-29-34
V. V. Lavreniuk, S. N. Beniova, A. I. Simakova, I. Gorelova, A. O. Mikhaylov, A. V. Nagornaia, Yu. L. Kondrashova
The paper presents a critical analysis of the data on incidence and etiology of pneumonia among patients with human immunodeficiency virus (HIV). The features and prospects of differential diagnosis for various types of pneumonia are considered. The paper emphasizes the urgency of highly sensitive methods for diagnostics of pneumonia and its features in HIV-positive patients.
{"title":"HIV-associated pneumonia: bacterial, fungal, viral","authors":"V. V. Lavreniuk, S. N. Beniova, A. I. Simakova, I. Gorelova, A. O. Mikhaylov, A. V. Nagornaia, Yu. L. Kondrashova","doi":"10.34215/1609-1175-2024-1-29-34","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-29-34","url":null,"abstract":"The paper presents a critical analysis of the data on incidence and etiology of pneumonia among patients with human immunodeficiency virus (HIV). The features and prospects of differential diagnosis for various types of pneumonia are considered. The paper emphasizes the urgency of highly sensitive methods for diagnostics of pneumonia and its features in HIV-positive patients.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"108 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-69-71
V. M. Panchoyan, O. O. Belyakova, S. A. Belov
Polyorchism is a rare congenital anomaly defined as the incidence of more than two testicles. This pathology is considered to be extremely rare and may remain asymptomatic for a long time. The disease is detected predominantly during the examination of other urologic pathologies such as inflammation, hydrocele, testicular torsion, inguinal hernia, male infertility, and malignant changes. The reported case of polyorchism was confirmed during surgery for left testicular hydatid torsion in a 17-yearold boy. The abnormal testis had its own tunica vaginalis testis, epididymis, common deferent duct, and shared blood supply with the left testis. The testes were preserved during surgery. No impaired spermatogenesis was detected in the patient.
{"title":"Rare case of testicular abnormality in a 17-year-old adolescent boy","authors":"V. M. Panchoyan, O. O. Belyakova, S. A. Belov","doi":"10.34215/1609-1175-2024-1-69-71","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-69-71","url":null,"abstract":"Polyorchism is a rare congenital anomaly defined as the incidence of more than two testicles. This pathology is considered to be extremely rare and may remain asymptomatic for a long time. The disease is detected predominantly during the examination of other urologic pathologies such as inflammation, hydrocele, testicular torsion, inguinal hernia, male infertility, and malignant changes. The reported case of polyorchism was confirmed during surgery for left testicular hydatid torsion in a 17-yearold boy. The abnormal testis had its own tunica vaginalis testis, epididymis, common deferent duct, and shared blood supply with the left testis. The testes were preserved during surgery. No impaired spermatogenesis was detected in the patient.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"119 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-17-23
A. A. Shumeyko, I. M. Batyrshin, A. E. Demko, D. S. Sklizkov, J. S. Ostroumova, D. V. Fomin
Iliopsoas abscess comprises a frequently missed and late-diagnosed pathology that can be encountered by specialists of various profiles. Depending on the etiology and pathogenesis, iliopsoas abscess can be primary, if the infectious process initially develops in the iliopsoas muscle, or secondary, if the infection spreads from another inflammatory focus. The disease often has non-specific clinical manifestations and, in secondary abscesses, may be masked by symptoms of the underlying disease. The most informative diagnostic methods include CT scanning and magnetic resonance imaging. In the case of early detection and adequate treatment, the prognosis is generally good. Untimely treatment can lead to such serious complications as purulent leakage into neighboring areas, severe sepsis, septic shock, and persistent functional disorders. Without treatment, the mortality rate reaches 100%. To date, no uniform approaches to the management of patients with iliopsoas abscess has been developed.
{"title":"Iliopsoas abscess: etiology, pathogenesis, methods of diagnosis and treatment (literature review)","authors":"A. A. Shumeyko, I. M. Batyrshin, A. E. Demko, D. S. Sklizkov, J. S. Ostroumova, D. V. Fomin","doi":"10.34215/1609-1175-2024-1-17-23","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-17-23","url":null,"abstract":"Iliopsoas abscess comprises a frequently missed and late-diagnosed pathology that can be encountered by specialists of various profiles. Depending on the etiology and pathogenesis, iliopsoas abscess can be primary, if the infectious process initially develops in the iliopsoas muscle, or secondary, if the infection spreads from another inflammatory focus. The disease often has non-specific clinical manifestations and, in secondary abscesses, may be masked by symptoms of the underlying disease. The most informative diagnostic methods include CT scanning and magnetic resonance imaging. In the case of early detection and adequate treatment, the prognosis is generally good. Untimely treatment can lead to such serious complications as purulent leakage into neighboring areas, severe sepsis, septic shock, and persistent functional disorders. Without treatment, the mortality rate reaches 100%. To date, no uniform approaches to the management of patients with iliopsoas abscess has been developed.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"109 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-11-16
S. Edranov, S. Kalinichenko, N. Matveeva, I. V. Kovaleva
Morphogenetic and growth molecules, a key participant in reparative dentinogenesis, determine viability of the dentin-pulp complex (DPC), periodontium and dentogingival junction. They are secreted in microvessels, nerve fibers and connective tissue cells of the dental pulp, exerting homeostatic influence on the immediate surrounding. The present paper reviews the data on the localization of growth factors and signaling mechanisms that control histogenesis and reparative processes in the DPC. The paper points out the significance of these factors in the regulation of proinflammatory and immunocompetent cells in caries, periodontitis and osteoinductive processes in the alveolar outgrowth. The study of growth molecules appears crucial in the development of the latest clinical strategies to maintain the viability of the DPC and to integrate artificial materials in dental tissue restoration.
{"title":"Morphogenetic and growth factors in damaging to the dentin-pulp complex and periodontium","authors":"S. Edranov, S. Kalinichenko, N. Matveeva, I. V. Kovaleva","doi":"10.34215/1609-1175-2024-1-11-16","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-11-16","url":null,"abstract":"Morphogenetic and growth molecules, a key participant in reparative dentinogenesis, determine viability of the dentin-pulp complex (DPC), periodontium and dentogingival junction. They are secreted in microvessels, nerve fibers and connective tissue cells of the dental pulp, exerting homeostatic influence on the immediate surrounding. The present paper reviews the data on the localization of growth factors and signaling mechanisms that control histogenesis and reparative processes in the DPC. The paper points out the significance of these factors in the regulation of proinflammatory and immunocompetent cells in caries, periodontitis and osteoinductive processes in the alveolar outgrowth. The study of growth molecules appears crucial in the development of the latest clinical strategies to maintain the viability of the DPC and to integrate artificial materials in dental tissue restoration.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"103 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-43-47
E. M. Gordina, S. Bozhkova, A. Rukina
Objective. To evaluate an etiologic significance of S. maltophilia in the development of orthopedic implant-associated infections. Materials and methods. The study involved a retrospective analysis of the frequency of excretion of S. maltophilia in patients with periprosthetic infection and osteomyelitis, using the Microbe-2 program in period of 2005–2020. Clinical isolates were excreted according to standard methods. Identification was performed via Microlatest panels using iEMS Reader MF. Antibiotic susceptibility was studied in accordance with EUCAST. Results. Over 16 years 69 strains of S. maltophilia have been identified, comprising 0.33% of all isolated pathogens (n=20631). 50% of isolates were excreted from tissue biopsies, 30% – from wound exudates. In 89% of cases, S. maltophilia was isolated in microbial associations, including 65% of cases together with Grampositive bacteria, 18% with other non-fermenting Gram-negative bacteria, and 6% with other pathogens. 63% appeared sensitive to trimethoprim/sulfamethoxazole and 25.5% of isolates were resistant. The proportion of cultures sensitive to this drug was found to increase from 63% in 2011–2014 to 81% in 2015–2019 (p = 0.08). Conclusion. S. maltophilia should be considered as a causative etiologic agent of severe chronic orthopedic infections.
{"title":"Stenotrophomonas maltophilia as a causative agent of implant-associated infection in trauma and orthopedic patients","authors":"E. M. Gordina, S. Bozhkova, A. Rukina","doi":"10.34215/1609-1175-2024-1-43-47","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-43-47","url":null,"abstract":"Objective. To evaluate an etiologic significance of S. maltophilia in the development of orthopedic implant-associated infections. Materials and methods. The study involved a retrospective analysis of the frequency of excretion of S. maltophilia in patients with periprosthetic infection and osteomyelitis, using the Microbe-2 program in period of 2005–2020. Clinical isolates were excreted according to standard methods. Identification was performed via Microlatest panels using iEMS Reader MF. Antibiotic susceptibility was studied in accordance with EUCAST. Results. Over 16 years 69 strains of S. maltophilia have been identified, comprising 0.33% of all isolated pathogens (n=20631). 50% of isolates were excreted from tissue biopsies, 30% – from wound exudates. In 89% of cases, S. maltophilia was isolated in microbial associations, including 65% of cases together with Grampositive bacteria, 18% with other non-fermenting Gram-negative bacteria, and 6% with other pathogens. 63% appeared sensitive to trimethoprim/sulfamethoxazole and 25.5% of isolates were resistant. The proportion of cultures sensitive to this drug was found to increase from 63% in 2011–2014 to 81% in 2015–2019 (p = 0.08). Conclusion. S. maltophilia should be considered as a causative etiologic agent of severe chronic orthopedic infections.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"124 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.34215/1609-1175-2024-1-48-52
A. K. Dausheva, E. G. Zarubina, Yu. V. Bogdanova
Objective. To analyze genetic markers of endothelial dysfunction in chronic obstructive pulmonary disease. Materials and methods. The study involved an examination of 285 patients with chronic obstructive pulmonary disease aged 67.12 ± 1.82, including males (73.68%) and females (26.32%). A control group consisted of 70 respondents, including 45 relatively healthy people, among whom males constituted 64.3% and females 35.7%. Polymorphisms of endothelial nitric oxide synthase NOS3 (C786T), endothelin-1 EDN1 Lys198Asn genes were examined by PCR method. Results. The cohort of COPD patients revealed a prevalence of pathological homozygous genotype 786SS NOS3 (χ2=12.84, df=1, p=0.0003). Carriage of heterozygous variant of LysAsn polymorphic marker Lys198Asn of EDN1 gene in COPD patients was detected in 32.5%. Conclusion. Manifestation of endothelial dysfunction in COPD patients is due to genotypic predisposition associated with carrying polymorphisms 786SS of NOS3 gene (OR 7.01, 95% CI 1.59-30.81) and Lys198Asn of EDN1 gene (OR 2.53, 95% CI 0.69-9.22)
{"title":"Genetic markers of endothelial dysfunction in chronic obstructive pulmonary disease","authors":"A. K. Dausheva, E. G. Zarubina, Yu. V. Bogdanova","doi":"10.34215/1609-1175-2024-1-48-52","DOIUrl":"https://doi.org/10.34215/1609-1175-2024-1-48-52","url":null,"abstract":"Objective. To analyze genetic markers of endothelial dysfunction in chronic obstructive pulmonary disease. Materials and methods. The study involved an examination of 285 patients with chronic obstructive pulmonary disease aged 67.12 ± 1.82, including males (73.68%) and females (26.32%). A control group consisted of 70 respondents, including 45 relatively healthy people, among whom males constituted 64.3% and females 35.7%. Polymorphisms of endothelial nitric oxide synthase NOS3 (C786T), endothelin-1 EDN1 Lys198Asn genes were examined by PCR method. Results. The cohort of COPD patients revealed a prevalence of pathological homozygous genotype 786SS NOS3 (χ2=12.84, df=1, p=0.0003). Carriage of heterozygous variant of LysAsn polymorphic marker Lys198Asn of EDN1 gene in COPD patients was detected in 32.5%. Conclusion. Manifestation of endothelial dysfunction in COPD patients is due to genotypic predisposition associated with carrying polymorphisms 786SS of NOS3 gene (OR 7.01, 95% CI 1.59-30.81) and Lys198Asn of EDN1 gene (OR 2.53, 95% CI 0.69-9.22)","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"116 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141125929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.34215/1609-1175-2023-4-97-100
A. B. Makarov, V. N. Tsygan, A. V. Lemeshchenko, M. V. Rezvantsev, T. A. Krivolutskaya, T. A. Bammatov
Aim. Тo train future specialists to effectively apply the methods of pathophysiological research (ultrasound diagnostics) in solving situational problems within the course of clinical pathophysiology.Materials and methods. The 2nd and 3rd year students were trained to use stationary and portable ultrasound machines Phillips CX50 and Chison Sonotouch 80. The students were trained to master ultrasound B and M modes, Doppler ultrasonography, as well as elastography of the most common diseases of the endocrine, digestive, and urinary systems. At the first stage, students worked in tandem with the lecture, observing the process of sensor manipulation. At the second stage, each student conducted a study on his or her fellow student.Results. When conducting ultrasound scanning of the hepatoduodenal zone and kidneys, 65% and 55% of students, respectively, failed to obtain an optimal image and to measure anatomical structures during the assigned time interval. Echocardioscopy was established to be the most difficult method to master when solving situational problems within the topic of “Impaired Systemic Circulation”. This task was successfully performed only by 20% of the students. The optimal student-lecturer ratio was established to be 6:1.Conclusion. The use of new ultrasound technologies in the training process is important for forming students’ professional competencies and increasing their motivation.
目的培训未来的专家有效应用病理生理学研究方法（超声诊断）解决临床病理生理学课程中的情景问题。培训二年级和三年级学生使用固定式和便携式超声波机 Phillips CX50 和 Chison Sonotouch 80。通过培训，学生们掌握了 B 型和 M 型超声波、多普勒超声波以及内分泌、消化和泌尿系统最常见疾病的弹性成像。在第一阶段，学生们配合讲课，观察传感器的操作过程。在第二阶段，每个学生都对自己的同学进行了研究。在对肝十二指肠区和肾脏进行超声扫描时，分别有 65% 和 55% 的学生未能在指定的时间间隔内获得最佳图像和测量解剖结构。在解决 "受损的全身循环 "专题中的情景问题时，超声心动图被认为是最难掌握的方法。只有 20% 的学生成功完成了这项任务。学生与教师的最佳比例为 6:1。在培训过程中使用新的超声技术对于培养学生的专业能力和提高他们的积极性非常重要。
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