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Bacterial biofilm formation on ceramics of various composition used for orthopedic endoprosthetics 细菌生物膜在用于骨科内修复术的各种组成的陶瓷上的形成
Pub Date : 2023-04-13 DOI: 10.34215/1609-1175-2023-1-50-54
Y. Skurikhina, E. Papynov, E. Zaitseva, O. Shichalin
Aim. To assess the intensity and characteristics of bacterial biofilms formed by non-fermenting gram-negative bacteria Pseudomonas aeruginosa and Acinetobacter baumannii on ceramic biocomposite samples based on wollastonite and zirconia, including those modified with the bioactive phase of hydroxyapatite (HA).Materials and methods. Biofilms formed on bioceramic samples, prepared according to the author’s original method, were examined by scanning electron microscopy (SEM). The studied samples included non-composite ceramics based on wollastonite (CaSiO3); composite ceramics based on wollastonite with HA (CaSiO3-HA); non-composite ceramics based on zirconium dioxide ZrO2; ceramics based on zirconia with HA 15 wt% (ZrO2-(15 wt % HA); ceramics based on zirconia with (ZrO2-(50 wt% HA). Biofilms were obtained by placing the samples in a nutrient medium with P. aeruginosa and A. baumannii. Cultivation was carried out at 37 °С for 24 and 48 h, respectively. The dynamics of bacterial growth of the surface of the studied samples was assessed by analyzing SEM images using an LBP classifier.Results. A noticeable difference was observed in the activity and structure of bacterial biofilm formation on all studied samples. The intensity of biofilm formation (surface coverage of ZrO2-based samples) determined using an LBP-based classifier was as follows: ZrO2 ceramics without HA – 28.13%; ZrO2 + 15 wt% HA – 28.33%; and ZrO2 + 50 wt% HA – 88.46%. All samples with HA addition demonstrated higher susceptibility to biofilm formation.Conclusion. The presence of HA in the composition of bioceramics increases the intensity of biofilm formation. This also indicates a higher biocompatibility of such materials. When selecting bioceramic materials for bone defect repair, preference should be given to materials containing no more than 15 wt% HA in the view of reducing the risk of infection.
的目标。评估非发酵革兰氏阴性细菌铜绿假单胞菌和鲍曼不动杆菌在硅灰石和氧化锆陶瓷复合材料样品上形成的细菌生物膜的强度和特征,包括羟基磷灰石(HA)生物活性相修饰的样品。材料和方法。用扫描电子显微镜(SEM)观察了按原方法制备的生物陶瓷样品上形成的生物膜。研究样品包括硅灰石(CaSiO3)非复合陶瓷;硅灰石-HA (CaSiO3-HA)复合陶瓷;二氧化锆ZrO2基非复合陶瓷;含HA 15wt % (ZrO2-(15wt % HA))氧化锆陶瓷;(ZrO2-(50wt % HA)氧化锆基陶瓷。将样品置于含有铜绿假单胞菌和鲍曼假单胞菌的营养培养基中获得生物膜。在37°С温度下分别培养24和48 h。利用LBP分类器分析扫描电镜图像,对研究样品表面细菌生长的动态进行了评估。在所有研究样品中,细菌生物膜形成的活性和结构都有明显的差异。基于lbp的分类器测定的生物膜形成强度(基于ZrO2的样品表面覆盖率)为:不含HA的ZrO2陶瓷- 28.13%;ZrO2 + 15wt % HA - 28.33%;ZrO2 + 50 wt% HA - 88.46%。所有添加了透明质酸的样品对生物膜的形成都有较高的敏感性。生物陶瓷成分中HA的存在增加了生物膜形成的强度。这也表明这种材料具有较高的生物相容性。在选择用于骨缺损修复的生物陶瓷材料时,为了减少感染的风险,应优先选择HA含量不超过15%的材料。
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引用次数: 0
Microbiological properties of opportunistic saccharomycetes of the genus Candida in chronic, recurrent infectious inflammatory processes (literature review) 念珠菌属机会性酵母菌在慢性、复发性感染性炎症过程中的微生物特性(文献综述)
Pub Date : 2023-04-13 DOI: 10.34215/1609-1175-2023-1-19-26
I. P. Koltsov, N. Strelnikova, E. V. Vitko, L. G. Vitko, O. E. Savlyuk
Literature review involves a problem analysis of current scientific publications on yeast-like fungi of the genus Candida of the family Saccharomycetaceae. In 90% of cases, the etiological factor of chronic, recurrent infectious and inflammatory processes is represented by residents of oral, intestinal, urogenital and skin microbiome, opportunistic Candida albicans fungi. The paper considers the relevant medical and social problem of endogenous opportunistic infections on the example of candidiasis (candidamycosis). The review presents a conceptual analysis of changes in the microbiological properties of clinically significant candida species with ubiquitous distribution: Candida albicans, Candida tropicalis, Candida glabrata, Candida krusei, Candida parapsilosis, Candida dubliniensis, Candida auris. The authors provide a current perspective on the risk of superficial and invasive candidomycosis as an opportunistic, non-cyclic infection. Signs of the same type of pathological process develop with the participation of different species of opportunistic fungi in monoculture and associations against the background of immunodeficiency.
文献综述涉及对酵母科念珠菌属酵母样真菌的当前科学出版物的问题分析。在90%的病例中,慢性、复发性感染和炎症过程的病因是口腔、肠道、泌尿生殖和皮肤微生物群的居民,机会性白色念珠菌真菌。本文以念珠菌病(candidamycosis)为例,探讨内源性机会性感染的相关医学和社会问题。本文综述了广泛分布的具有临床意义的念珠菌种类:白色念珠菌、热带念珠菌、光秃念珠菌、克鲁氏念珠菌、假丝酵母菌、巴黎念珠菌、耳念珠菌的微生物特性变化的概念分析。作者提供了一个目前的观点,浅表和侵袭性假丝酵母菌病的风险作为一个机会性的,非循环感染。同一类型的病理过程的迹象与不同种类的机会性真菌在单一培养和免疫缺陷背景下的参与有关。
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引用次数: 0
Anesthetic aspects of robot-assisted surgery (a review) 机器人辅助手术的麻醉方面(综述)
Pub Date : 2023-04-13 DOI: 10.34215/1609-1175-2023-1-11-18
R. Bogdanov, A. F. Nurimanshin, A. A. Husaenova, A. R. Khasanov
The introduction of modern robot-assisted and laparoscopic methods of surgical interventions have extended the range of surgical indications, at the same time as raising a number of specific problems related to the technical features of minimally invasive treatment. This fact makes us consider the effect of surgical aggression on the patient from a new perspective. In particular, the influence of pneumoperitoneum and the patient’s position on venous return, regional blood flow changes, and concomitant shifts of some homeokinetic systems require elucidation. This article reviews the available literature to describe the main features of anesthesia during robot-assisted surgical interventions. Recommendations from systematic reviews and meta-analyses were used. The search depth comprised the period of 12 years (2011–2022). Such factors as antiphysiological position on the operating table, tense carboxyperitoneum, and carboxythorax affect almost all organs and many regulatory mechanisms, thus having a pathological effect on the cardiovascular and respiratory systems, kidney, liver, intestines, blood coagulation system, immune system, and thermoregulation mechanisms. These effects are particularly pronounced in patients with concomitant diseases. In addition to knowledge in the field of pathophysiology, surgeons should be capable of predicting the course of events to take actions aimed at preventing the development of complications. Robot-assisted surgical interventions, although being less traumatic, are characterized by specific features that should be taken into account when preparing a patient to undergo surgery, selecting an optimal method of surgical intervention, and managing the patient in the intra- and postoperative period with rehabilitation.
现代机器人辅助和腹腔镜手术干预方法的引入扩大了手术适应症的范围,同时也提出了一些与微创治疗技术特征相关的具体问题。这一事实使我们从一个新的角度来考虑手术攻击对患者的影响。特别是,气腹和患者体位对静脉回流、局部血流变化以及伴随的一些同代动力学系统变化的影响需要阐明。本文回顾了现有文献,描述了机器人辅助手术干预过程中麻醉的主要特征。采用了系统综述和荟萃分析的建议。搜索深度为12年(2011-2022年)。手术台上的反生理体位、紧绷的羧基腹膜、羧基胸等因素影响几乎所有器官和多种调节机制,从而对心血管、呼吸系统、肾、肝、肠、凝血系统、免疫系统、体温调节机制等产生病理作用。这些影响在伴有其他疾病的患者中尤为明显。除了在病理生理学领域的知识,外科医生应该能够预测事件的过程,采取措施,旨在防止并发症的发展。机器人辅助手术干预虽然创伤较小,但在准备患者接受手术,选择最佳手术干预方法以及在手术中和术后康复期间管理患者时应考虑到的特定特征。
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引用次数: 0
Accelerated bacteriological examination of urine and dialysate in the diagnosis of urinary tract infections in children 尿和透析液加速细菌学检查在儿童尿路感染诊断中的价值
Pub Date : 2023-04-13 DOI: 10.34215/1609-1175-2023-1-55-58
L. Boronina, E. V. Samatova, S. S. Ustyugova, S. Panova, O. Kutsevalova
Aim. To evaluate the feasibility of an accelerated method for determining the etiology of infections in urine, dialysate and residual antimicrobial activity by using laser light scattering technology.Materials and methods. From January to September 2019, 106 urine samples and 42 dialysate samples from children aged 1–16 with various urinary pathologies and those on peritoneal dialysis underwent culture-based examination on an ALIFAX HB&L LIGHT analyzer (Alifax, Italy) using laser light scattering technology.Results. Three hours after inoculation, 81 samples (76.4%) appeared to be negative and 25 samples (23.6%) proved to be positive. No microorganisms were detected in 38 dialysate samples (90.5%), two samples had Staphylococcus aureus (104 CFU/ml), and one dialysate sample had Corynebacterium sp. and associations of Escherichia coli + Candida albicans + Staphylococcus haemolyticus, associated with peritoneal catheter colonization. Bacteriuria was caused by Enterobacterales in 39.3% (E. coli, Morganella morganii, Citrobacter amalonaticus, Enterobacter cloacae), non-fermenting gram-negative bacteria – in 14.3% (Pseudomonas aeruginosa, Ralstonia picketii, Oligella sp., Acinetobacter baumannii), Enterococcus sp. – 21.4%, S. haemolyticus, Staphylococcus epidermidis – 10.7%, Candida albicans – 3.6%, contamination: Streptococcus viridians, Corynebacterium sp. – 7.1%. Residual antimicrobial activity in urine was detected in 30.1% of patients.Conclusion. The laser light scattering technology enables a minimal concentration of microorganisms to be detected in a smaller amount of urine or dialysate, which is very important for accelerated diagnosis of urinary tract infections and complications of peritoneal dialysis in children.
的目标。探讨激光光散射技术快速测定尿液、透析液感染病因及残留抗菌活性的可行性。材料和方法。2019年1 - 9月,采用激光光散射技术,在ALIFAX HB&L LIGHT分析仪(意大利ALIFAX)上对106份1-16岁不同泌尿系统疾病患儿和腹膜透析患儿的尿液样本和42份透析样本进行了培养检测。接种3 h后,81份(76.4%)呈阴性,25份(23.6%)呈阳性。38份透析液样品(90.5%)未检出微生物,2份样品检出金黄色葡萄球菌(104 CFU/ml), 1份透析液样品检出链杆菌,并伴有大肠杆菌+白色念珠菌+溶血性葡萄球菌,与腹膜导管定植有关。细菌尿由肠杆菌(大肠杆菌、摩根氏菌、单胞柠檬酸杆菌、阴沟肠杆菌)占39.3%,非发酵革兰氏阴性菌(铜绿假单胞菌、皮氏Ralstonia、Oligella sp.、鲍曼不动杆菌)占14.3%,肠球菌占21.4%,溶血链球菌、表皮葡萄球菌占10.7%,白色念珠菌占3.6%,污染:青绿链球菌、棒状杆菌占7.1%。30.1%的患者检出尿中残留抗菌活性。激光散射技术可以在更少量的尿液或透析液中检测到最低浓度的微生物,这对于加速诊断儿童尿路感染和腹膜透析并发症具有重要意义。
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引用次数: 0
A magnetic levitation-based system to study the mechanisms of bacterial flocculation and autoaggregation 基于磁悬浮系统的细菌絮凝和自聚集机理研究
Pub Date : 2023-04-13 DOI: 10.34215/1609-1175-2023-1-38-43
P. Domnin, A. E. Zakharchenko, D. T. Rejepov, S. Ermolaeva
Objective. To evaluate the potential of magnetic levitation systems when studying the autoaggregation of gram-negative and gram-positive pathogenic bacteria and elucidating mechanisms controlling autoaggregation.Materials and methods. Escherichia coli O157:H7, Pseudomonas aeruginosa, Staphylococcus aureus, and Listeria monocytogenes were used. The number of alive bacteria was determined using a Live/Dead® dye. E. coli curli were stained with Congo red.Results. All four tested bacterial species formed autoaggregates that levitated within the liquid volume for up to 72 hours (observation time). After 72 hours, the number of alive bacteria in the autoaggregates ranged from 82% (E. coli) to 99% (L. monocytogenes). The formation of E. coli autoaggregates was shown to depend on the production of curli, which represent surface structures playing an important role in biofilm formation.Conclusion. The proposed system of magnetic levitation can be used to study molecular mechanisms of bacterial autoaggregation and flocculation.
目标。在研究革兰氏阴性和革兰氏阳性病原菌的自聚集和阐明控制自聚集的机制时,评估磁悬浮系统的潜力。材料和方法。采用大肠杆菌O157:H7、铜绿假单胞菌、金黄色葡萄球菌和单核增生李斯特菌。使用Live/Dead®染料测定活菌数量。用刚果红对大肠杆菌进行染色。所有四种被测试的细菌都形成了自动聚集体,漂浮在液体体积内长达72小时(观察时间)。72h后,自聚集体中活菌的数量从82%(大肠杆菌)到99%(单核增生乳杆菌)不等。大肠杆菌自聚集体的形成依赖于卷曲蛋白的产生,卷曲蛋白代表了在生物膜形成中起重要作用的表面结构。提出的磁悬浮系统可用于研究细菌自聚集和絮凝的分子机制。
{"title":"A magnetic levitation-based system to study the mechanisms of bacterial flocculation and autoaggregation","authors":"P. Domnin, A. E. Zakharchenko, D. T. Rejepov, S. Ermolaeva","doi":"10.34215/1609-1175-2023-1-38-43","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-1-38-43","url":null,"abstract":"Objective. To evaluate the potential of magnetic levitation systems when studying the autoaggregation of gram-negative and gram-positive pathogenic bacteria and elucidating mechanisms controlling autoaggregation.Materials and methods. Escherichia coli O157:H7, Pseudomonas aeruginosa, Staphylococcus aureus, and Listeria monocytogenes were used. The number of alive bacteria was determined using a Live/Dead® dye. E. coli curli were stained with Congo red.Results. All four tested bacterial species formed autoaggregates that levitated within the liquid volume for up to 72 hours (observation time). After 72 hours, the number of alive bacteria in the autoaggregates ranged from 82% (E. coli) to 99% (L. monocytogenes). The formation of E. coli autoaggregates was shown to depend on the production of curli, which represent surface structures playing an important role in biofilm formation.Conclusion. The proposed system of magnetic levitation can be used to study molecular mechanisms of bacterial autoaggregation and flocculation.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90319623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of organ perfusion and intravascular volume status by ultrasound 超声评价器官灌注和血管内容积状况
Pub Date : 2023-04-13 DOI: 10.34215/1609-1175-2023-1-27-34
M. Zozulya, A. Lenkin
This review article is devoted to ultrasound monitoring of intravascular volume status and organ perfusion in critically ill patients. In particular, approaches to determination of fluid responsiveness using Doppler-estimated blood flow in peripheral arteries are discussed. The reliability and accuracy of these parameters are substantiated by their comparison with the parameters obtained by prepulmonary and transpulmonary thermodilution methods. The technicalities of ultrasound examination of the abovementioned parameters are considered.
本文综述了危重病人血管内容量状态和器官灌注的超声监测。特别是,方法来确定液体反应性使用多普勒估计的血流外周动脉进行了讨论。通过与肺前和经肺热稀释法得到的参数进行比较,证实了这些参数的可靠性和准确性。考虑了超声检查上述参数的技术问题。
{"title":"Evaluation of organ perfusion and intravascular volume status by ultrasound","authors":"M. Zozulya, A. Lenkin","doi":"10.34215/1609-1175-2023-1-27-34","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-1-27-34","url":null,"abstract":"This review article is devoted to ultrasound monitoring of intravascular volume status and organ perfusion in critically ill patients. In particular, approaches to determination of fluid responsiveness using Doppler-estimated blood flow in peripheral arteries are discussed. The reliability and accuracy of these parameters are substantiated by their comparison with the parameters obtained by prepulmonary and transpulmonary thermodilution methods. The technicalities of ultrasound examination of the abovementioned parameters are considered.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74585564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paragonimus westermani ichunensis: evolution of parasitological situation 长春卫氏并殖吸虫:寄生情况的演变
Pub Date : 2023-04-13 DOI: 10.34215/1609-1175-2023-1-5-10
A. Popov, V. Besprozvannykh, G. Sukhanova, V. Ivanis, S. L. Kolpakov
The paper presents an analysis of parasitological situation with paragonimiasis in Primorsky Krai over the past 30 years. In the early 1990s regular medical checkups detected paragonimiasis in 1–6% of the inhabitants of the region. Since 1996, the situation in the south of the Russian Far East has changed dramatically. Within 1–2 years, the crayfish population decreased significantly in watercourses from southern Primorye up to the Amur basin. Therefore, the incidence of the disease in population of the region has decreased to zero level since 2000. From 2014 the number of crayfish in watercourses of Primorsky Krai started growing. In 2019 the first patient with larval paragonimiasis was reported. The paper reviews the experience of the Regional Clinical Hospital of Vladivostok in treatment of 368 patients with larval paragonimiasis for the period from 1967 to 1996. On average, the disease manifested itself in 1–4 weeks from the moment of infection. The diagnosis was confirmed in 97.9% of cases via serological method. The praziquantel treatment of patients with larval paragonimiasis resulted in a cure rate of 89%. The disease duration ranged from 1–2 to 10 or more years.
本文对滨海边疆区近30年来肺吸虫病的病原学情况进行了分析。20世纪90年代初,定期体检发现该地区1-6%的居民患有肺吸虫病。1996年以来,俄罗斯远东地区南部的局势发生了巨大变化。在1-2年内,从滨海边疆区南部到阿穆尔河流域的水道中小龙虾的数量显著减少。因此,自2000年以来,该地区人口中的该病发病率已降至零水平。从2014年开始,滨海边疆区水道中的小龙虾数量开始增长。2019年报告了第一例幼虫吸虫病患者。本文回顾了符拉迪沃斯托克地区临床医院在1967年至1996年期间治疗368例幼虫吸虫病的经验。平均而言,该病在感染后1-4周内表现出来。血清学方法确诊率为97.9%。吡喹酮治疗幼虫吸虫病的治愈率为89%。病程1-2年至10年或更长。
{"title":"Paragonimus westermani ichunensis: evolution of parasitological situation","authors":"A. Popov, V. Besprozvannykh, G. Sukhanova, V. Ivanis, S. L. Kolpakov","doi":"10.34215/1609-1175-2023-1-5-10","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-1-5-10","url":null,"abstract":"The paper presents an analysis of parasitological situation with paragonimiasis in Primorsky Krai over the past 30 years. In the early 1990s regular medical checkups detected paragonimiasis in 1–6% of the inhabitants of the region. Since 1996, the situation in the south of the Russian Far East has changed dramatically. Within 1–2 years, the crayfish population decreased significantly in watercourses from southern Primorye up to the Amur basin. Therefore, the incidence of the disease in population of the region has decreased to zero level since 2000. From 2014 the number of crayfish in watercourses of Primorsky Krai started growing. In 2019 the first patient with larval paragonimiasis was reported. The paper reviews the experience of the Regional Clinical Hospital of Vladivostok in treatment of 368 patients with larval paragonimiasis for the period from 1967 to 1996. On average, the disease manifested itself in 1–4 weeks from the moment of infection. The diagnosis was confirmed in 97.9% of cases via serological method. The praziquantel treatment of patients with larval paragonimiasis resulted in a cure rate of 89%. The disease duration ranged from 1–2 to 10 or more years.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86624238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactive technologies in the clinical training of future pediatricians 互动技术在未来儿科医生临床培训中的应用
Pub Date : 2023-01-18 DOI: 10.34215/1609-1175-2022-4-108-111
N. G. Sadova, E. Krukovich, L. E. Matienko, I. D. Mostovaya
A review study of interactive educational technologies as part of the educational process and their role in the clinical training of future pediatricians was carried out. The research was focused on the use of interactive technologies (on the example of role play) in teaching pediatrics students to ensure the formation of their professional competencies. Role play is a situational or demonstration technique applied to develop practical and communicative skills. This technique can be used to transform knowledge into skills most effectively by simulating real experiences that may arise in professional practice. Such simulationbased learning allows trainees to experience some concept or idea by acting it out in front of peer students, or by watching others. Role play is useful for developing communicative and decision-making skills. The effectiveness of interactive teaching methods is determined by the joint activity of the teacher and the students. In this context, education is seen as the formation of new goals and personal attitudes, while personal development is seen as the formation of personal capacity for independent activity and self-management.
对交互式教育技术作为教育过程的一部分及其在未来儿科医生临床培训中的作用进行了回顾研究。本研究以互动技术(以角色扮演为例)在儿科学教学中运用,以确保学生专业能力的形成。角色扮演是一种情境或示范技巧,用于发展实践和沟通技巧。这种技术可以通过模拟专业实践中可能出现的真实经验来最有效地将知识转化为技能。这种基于模拟的学习允许受训者通过在同龄人面前表演或观察其他人来体验一些概念或想法。角色扮演有助于培养沟通和决策能力。互动式教学方法的有效性取决于教师和学生的共同活动。在这种背景下,教育被视为新的目标和个人态度的形成,而个人发展被视为个人独立活动和自我管理能力的形成。
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引用次数: 0
Tuberculosis screening and early diagnostics in adolescents in Primorsky Krai 滨海边疆区青少年结核病筛查和早期诊断
Pub Date : 2023-01-18 DOI: 10.34215/1609-1175-2022-4-104-107
L. N. Motanova, P. E. Kalashnikov
Aim. To define the objectives of phthisiatric service with respect to organizing screening for tuberculosis infection (TB) and early diagnostics among adolescents in Primorsky Krai.Material and Methods. The data of epidemiological monitoring conducted by the Primorsky Regional TB Dispensary in 1994–2021 were analyzed. The TB incidence, clinical structure of newly-diagnosed cases, phases of the tuberculosis process, as well as the presence of bacterial excretion were assessed. At a level of 0.95, the statistical hypothesis of equal shares was tested under an alternative hypothesis.Results. The implementation of mass immunodiagnostics using the recombinant tuberculosis allergen (TBA) by medical organizations, which are joint into a unified medical network, improves screening efficiency of TB among adolescents. This is confirmed by a decreased TB incidence rate and improved clinical structure of newly-diagnosed cases. The prevalence of secondary TB forms in the clinical structure of newly-diagnosed cases in adolescents justifies the importance of annual fluorographic examination. Annual RTA testing and fluorographic examination of the chest in adolescents once every six months should be a priority anti-tuberculosis measure.Conclusions. TB in adolescents remains to be a serious phthisiological problem. An effective system of screening and early detection of TB in adolescents should include mass immunodiagnostics and, with an interval of six months, fluorographic examination of the chest.
的目标。确定在滨海边疆区组织青少年结核病感染筛查和早期诊断方面的肺结核服务目标。材料和方法。对滨海边疆区结核病诊疗所1994-2021年流行病学监测数据进行分析。评估了结核病发病率、新诊断病例的临床结构、结核病进程的各个阶段以及细菌排泄的存在。在0.95的水平上,在可选假设下检验相等份额的统计假设。医疗机构联合形成统一的医疗网络,采用重组结核过敏原(TBA)进行大规模免疫诊断,提高了青少年结核病筛查效率。结核病发病率的下降和新诊断病例的临床结构的改善证实了这一点。在青少年新诊断病例的临床结构中继发结核形式的流行证明了每年进行x线检查的重要性。青少年应优先进行年度RTA检测和6个月1次胸部x线检查。青少年结核病仍然是一个严重的生理问题。青少年结核病筛查和早期发现的有效系统应包括大规模免疫诊断和间隔6个月的胸部x线检查。
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引用次数: 0
Experience and efficiency of outreach diagnostics for glaucoma patients in Komsomolsk-on-Amur 阿穆尔河畔共青城青光眼患者外展诊断的经验和效率
Pub Date : 2023-01-18 DOI: 10.34215/1609-1175-2022-4-99-103
A. Marchenko, N. V. Samokhvalov, Т. G. Gasendych, S. Y. Vysotskaya, E. Stepanova
The efficiency of outreach diagnostics was assessed in 273 patients suffering from various forms glaucoma aged from 27 to 80 years. Following the developed algorithm, a set of instrumental and diagnostic tests was carried out to select 153 patients for surgical treatment and 64 patients for laser treatment. Necessary adjustments were made to the regimens of antihypertensive treatment for most patients, and recommendations were given. All glaucoma patients selected for surgical and laser treatment received timely and qualified assistance from specialists of the Khabarovsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, which allowed the course of the disease to be stabilized and visual functions to be preserved. As a result, outreach consultations for patients with various forms of glaucoma showed their high efficiency. More than 60% of the examined patients were referred for surgical and laser treatment, 20% of patients were offered a corrected hypotensive regimen. Along with examining patients, outreach consultations provide methodological assistance for local ophthalmologists concerning the development of professional competencies in managing such patients. Due to a lack of ophthalmological services in regional polyclinical departments, the organization of outreach consultations for glaucoma patients is justified in terms of reducing cases of glaucoma progression and loss of visual functions.
本文对273例27 ~ 80岁的青光眼患者进行了外展诊断。根据开发的算法,进行了一套仪器和诊断测试,选择153例患者进行手术治疗,64例患者进行激光治疗。对大多数患者的降压治疗方案进行了必要的调整,并给出了建议。所有选择接受手术和激光治疗的青光眼患者都得到了S.费奥多罗夫眼科显微外科联邦国立机构哈巴罗夫斯克分院专家及时和合格的协助,从而稳定了病程并保留了视觉功能。结果,对各种形式青光眼患者的外展会诊显示出较高的效率。超过60%的患者接受了手术和激光治疗,20%的患者接受了正确的降压方案。在检查病人的同时,外展会诊为本地眼科医生提供方法上的协助,以发展他们管理这类病人的专业能力。由于地区多临床科室缺乏眼科服务,为青光眼患者组织外展会诊是合理的,可以减少青光眼进展和视力丧失的病例。
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引用次数: 0
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Pacific Medical Journal
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