Pub Date : 2023-06-15DOI: 10.34215/1609-1175-2023-2-86-88
V. A. Atoian, M. F. Fadeev, A. S. Zolotov, E. Zinkova, B. Geltser
Nikolau syndrome is a rare post-injection complication with unclear etiology and pathogenesis, characterized by the development of acute local pain syndrome, localized erythematous rash, livedoid and hemorrhagic skin lesions with foci of ischemic necrosis. The paper presents a clinical case of Nikolau syndrome induced by intramuscular administration of diclofenac solution as an analgesic after hip replacement. The analysis of the causes, clinical picture and stages of treatment of post-injection complication was carried out.
{"title":"Post-injection necrosis of femoral soft tissues induced by diclofenac, nonsteroidal anti-inflammatory drug (clinical case)","authors":"V. A. Atoian, M. F. Fadeev, A. S. Zolotov, E. Zinkova, B. Geltser","doi":"10.34215/1609-1175-2023-2-86-88","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-86-88","url":null,"abstract":"Nikolau syndrome is a rare post-injection complication with unclear etiology and pathogenesis, characterized by the development of acute local pain syndrome, localized erythematous rash, livedoid and hemorrhagic skin lesions with foci of ischemic necrosis. The paper presents a clinical case of Nikolau syndrome induced by intramuscular administration of diclofenac solution as an analgesic after hip replacement. The analysis of the causes, clinical picture and stages of treatment of post-injection complication was carried out.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"117 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86438749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.34215/1609-1175-2023-2-98-100
S. Belov
To the 65th anniversary of the thoracic department of the Primorsky Regional Tuberculosis DispensaryThe paper reviews the main stages of the sixty-five-year history of the Thoracic Surgical Department of Primorsky Krai TB Dispensary. During this time, the department has handled all the difficulties of establishing the TB service, turning it to a platform for mastering new technologies in close cooperation with leading research institutions of Russia. Due to high professionalism and considerable efforts of managers, doctors and whole staff, the department is rapidly developing in the field of practical medical care and scientific work. All these historical chapters are inextricably interlinked with people whose respectful work and personal talents serve as an example for new generations of specialists.
{"title":"Development of tuberculosis surgical service in Primorsky krai","authors":"S. Belov","doi":"10.34215/1609-1175-2023-2-98-100","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-98-100","url":null,"abstract":"To the 65th anniversary of the thoracic department of the Primorsky Regional Tuberculosis DispensaryThe paper reviews the main stages of the sixty-five-year history of the Thoracic Surgical Department of Primorsky Krai TB Dispensary. During this time, the department has handled all the difficulties of establishing the TB service, turning it to a platform for mastering new technologies in close cooperation with leading research institutions of Russia. Due to high professionalism and considerable efforts of managers, doctors and whole staff, the department is rapidly developing in the field of practical medical care and scientific work. All these historical chapters are inextricably interlinked with people whose respectful work and personal talents serve as an example for new generations of specialists.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85433565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.34215/1609-1175-2023-2-94-97
O. Bykova, A. Nее, T. A. Shumatova, N. G. Prikhodchenko, Е. V. Sergeeva, O. V. Semeshina
This article presents a clinical case of diffuse large B-cell lymphoma in a teenager, who had laboratory and clinical signs of acute kidney injury in the onset of the disease. The presented case is characterized by the late manifestation of the disease in the absence of classical tumor markers. The diagnosis was verified only following a repeat spine MRI. This case may be relevant for pediatricians, pediatric oncologists and hematologists, pediatric nephrologists.
{"title":"Clinical case of renal manifestations in the onset of diffuse large B-cell lymphoma in a teenager","authors":"O. Bykova, A. Nее, T. A. Shumatova, N. G. Prikhodchenko, Е. V. Sergeeva, O. V. Semeshina","doi":"10.34215/1609-1175-2023-2-94-97","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-94-97","url":null,"abstract":"This article presents a clinical case of diffuse large B-cell lymphoma in a teenager, who had laboratory and clinical signs of acute kidney injury in the onset of the disease. The presented case is characterized by the late manifestation of the disease in the absence of classical tumor markers. The diagnosis was verified only following a repeat spine MRI. This case may be relevant for pediatricians, pediatric oncologists and hematologists, pediatric nephrologists.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"65 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87749026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.34215/1609-1175-2023-2-89-93
P. А. Griban, S. Terehov, K. V. Maystrovskiy, V. Usov, A. Polezhaev, V. V. Protopopov, S. Sotnichenko, V. A. Bogdanov
The present study involves an analysis of treatment results of the severe burn patients of the Burn Unit, Far Eastern District Medical Center in 2020–2022. The paper describes a clinical case of comprehensive intensive treatment of a patient with major burn injury (80% body surface area burned). The study indicates a vital importance of the fastest evacuation of severely burned patients to a special care unit and adequate intensive therapy to be carried out during transportation. This enables an invasive surgical approach to be adopted, including effective early removal of necrotic tissues, leading to a reduction in the number of complications and improvement of treatment outcomes. The recovery of patients with major burn injury highly correlates with total availability of medication and instruments, individual management of patients, and active rehabilitation measures.
{"title":"Treatment of patients with major burn injury in the Burn Unit, Far Eastern District Medical Center of Federal Medical Biological Agency, Russia","authors":"P. А. Griban, S. Terehov, K. V. Maystrovskiy, V. Usov, A. Polezhaev, V. V. Protopopov, S. Sotnichenko, V. A. Bogdanov","doi":"10.34215/1609-1175-2023-2-89-93","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-89-93","url":null,"abstract":"The present study involves an analysis of treatment results of the severe burn patients of the Burn Unit, Far Eastern District Medical Center in 2020–2022. The paper describes a clinical case of comprehensive intensive treatment of a patient with major burn injury (80% body surface area burned). The study indicates a vital importance of the fastest evacuation of severely burned patients to a special care unit and adequate intensive therapy to be carried out during transportation. This enables an invasive surgical approach to be adopted, including effective early removal of necrotic tissues, leading to a reduction in the number of complications and improvement of treatment outcomes. The recovery of patients with major burn injury highly correlates with total availability of medication and instruments, individual management of patients, and active rehabilitation measures.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74621867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.34215/1609-1175-2023-2-81-85
N. Grachev, V. G. Rapovka
The paper presents a clinical case of endovascular treatment for a patient affected by acute myocardial infarction combined with acute ischemic stroke. The study emphasizes a role of early diagnosis of ischemic stroke in timely detection of cerebral embolism in large vessels during the postoperative period. Treatment strategy is analyzed along with the effectiveness of intravascular thrombectomy that significantly reduces mortality and disability of patients with acute cerebrovascular disease.
{"title":"А clinical case of endovascular treatment for myocardial infarction combined with ischemic stroke","authors":"N. Grachev, V. G. Rapovka","doi":"10.34215/1609-1175-2023-2-81-85","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-81-85","url":null,"abstract":"The paper presents a clinical case of endovascular treatment for a patient affected by acute myocardial infarction combined with acute ischemic stroke. The study emphasizes a role of early diagnosis of ischemic stroke in timely detection of cerebral embolism in large vessels during the postoperative period. Treatment strategy is analyzed along with the effectiveness of intravascular thrombectomy that significantly reduces mortality and disability of patients with acute cerebrovascular disease.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75386427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-41-47
T. A. Yunatskaya, D. V. Turchaninov, N. Vlasenko, E. Pavlinova, A. V. Brusentsova
Objective. To evaluate the actual diet of children with type I diabetes in order to develop recommendations for nutrition correction.Materials and methods. An observational study of actual diet of the case-control type was conducted in a group of children with type I diabetes mellitus (DM1; n=47) and a comparison group of conditionally healthy children living in Omsk Oblast (n=43). Actual nutrition was studied by analyzing the frequency of food consumption reported by parents in interviews.Results. The level of energy consumed with food in the group of children with DM1 accounted for 1929 kcal. It corresponded to physiological needs and was consistent with the comparison group. However, consumption of fats was higher than recommended, while that of carbohydrates was, on the contrary, lower. Energy from added sugars and saturated fats was at twice the recommended levels. Protein intake was adequate to physiological needs, but the proportion of animal proteins was greater in the group of children with diabetes. The author noted excessive consumption of fats and shortage of omega-3 fatty acids. The amount of carbohydrates in the diet of children with DM1 was lower than the physiological needs, but did not differ from the comparison group, the consumption of simple sugars was greater in children from the comparison group. There were no differences in consumption of minerals and vitamins, with the exception of vitamin A, which was greater in the diet of children with DM1. The amounts of vitamin A, D, beta-carotene, vitamin B9 and iodine were lower than recommended. An excess of sodium and phosphorus in the diet and calcium imbalance were also revealed.Conclusion. Nutrition of children with type I diabetes is considered to be improper. The nutrition imbalances are similar in both groups. When consumption of carbohydrates is insufficient, an excess of simple sugars is noted. Priority micronutrients for correction are vitamins A and D, folates, iodine.
{"title":"Dietary patterns of preschool children with type I diabetes","authors":"T. A. Yunatskaya, D. V. Turchaninov, N. Vlasenko, E. Pavlinova, A. V. Brusentsova","doi":"10.34215/1609-1175-2023-2-41-47","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-41-47","url":null,"abstract":"Objective. To evaluate the actual diet of children with type I diabetes in order to develop recommendations for nutrition correction.Materials and methods. An observational study of actual diet of the case-control type was conducted in a group of children with type I diabetes mellitus (DM1; n=47) and a comparison group of conditionally healthy children living in Omsk Oblast (n=43). Actual nutrition was studied by analyzing the frequency of food consumption reported by parents in interviews.Results. The level of energy consumed with food in the group of children with DM1 accounted for 1929 kcal. It corresponded to physiological needs and was consistent with the comparison group. However, consumption of fats was higher than recommended, while that of carbohydrates was, on the contrary, lower. Energy from added sugars and saturated fats was at twice the recommended levels. Protein intake was adequate to physiological needs, but the proportion of animal proteins was greater in the group of children with diabetes. The author noted excessive consumption of fats and shortage of omega-3 fatty acids. The amount of carbohydrates in the diet of children with DM1 was lower than the physiological needs, but did not differ from the comparison group, the consumption of simple sugars was greater in children from the comparison group. There were no differences in consumption of minerals and vitamins, with the exception of vitamin A, which was greater in the diet of children with DM1. The amounts of vitamin A, D, beta-carotene, vitamin B9 and iodine were lower than recommended. An excess of sodium and phosphorus in the diet and calcium imbalance were also revealed.Conclusion. Nutrition of children with type I diabetes is considered to be improper. The nutrition imbalances are similar in both groups. When consumption of carbohydrates is insufficient, an excess of simple sugars is noted. Priority micronutrients for correction are vitamins A and D, folates, iodine.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85628062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-37-40
A. S. Shapovalov, S. Belov, A. Grigoryuk, N. A. Pushkina, N. A. Pimenov
Objective. To evaluate the effectiveness of CT-guided thoracic biopsy in the diagnosis of lung and mediastinal malignancies.Materials and methods. A retrospective analysis of 32 cases of CT-guided transthoracic biopsy was performed. Lung and mediastinal masses suspicious for malignancy with a size of more than 2.0 cm in the area available for manipulation were the indication for Cor-biopsy with additional examination of impression smears. A step-by-step procedure involved CT positioning of the object, marking by the radiation therapy program, and performing the procedure. The cytological and histological materials were evaluated and compared.Results. The analysis of manipulations performed in 32 patients with lung masses (75±7.7%) and mediastinal masses (25±7.7%) proved the technical effectiveness of the procedure, which lasted 37±9 minutes. The diagnosis was confirmed by cytological analysis of impression smears in 81.3±6.9% of cases, and using histological methods – in 71.9±8% (p>0.05). The agreement between the results obtained by both methods was 53.1±8.8%. Immunohistochemical analysis of the material was performed in 69.6±9.6% of patients. Procedural complications (pneumothorax and hemoptysis) were observed in 21.9±7.3% of patients. Cytological examination allowed the results of a planned histological and immunohistochemical analysis to be foreseen with a high degree of probability.Conclusion. CT-guided transthoracic puncture is a highly effective method of diagnosing lung and mediastinal malignancies, which allows their morphological characterization to be done in 81% of cases.
{"title":"Еffectiveness of ct-guided transthoracic biopsy","authors":"A. S. Shapovalov, S. Belov, A. Grigoryuk, N. A. Pushkina, N. A. Pimenov","doi":"10.34215/1609-1175-2023-2-37-40","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-37-40","url":null,"abstract":"Objective. To evaluate the effectiveness of CT-guided thoracic biopsy in the diagnosis of lung and mediastinal malignancies.Materials and methods. A retrospective analysis of 32 cases of CT-guided transthoracic biopsy was performed. Lung and mediastinal masses suspicious for malignancy with a size of more than 2.0 cm in the area available for manipulation were the indication for Cor-biopsy with additional examination of impression smears. A step-by-step procedure involved CT positioning of the object, marking by the radiation therapy program, and performing the procedure. The cytological and histological materials were evaluated and compared.Results. The analysis of manipulations performed in 32 patients with lung masses (75±7.7%) and mediastinal masses (25±7.7%) proved the technical effectiveness of the procedure, which lasted 37±9 minutes. The diagnosis was confirmed by cytological analysis of impression smears in 81.3±6.9% of cases, and using histological methods – in 71.9±8% (p>0.05). The agreement between the results obtained by both methods was 53.1±8.8%. Immunohistochemical analysis of the material was performed in 69.6±9.6% of patients. Procedural complications (pneumothorax and hemoptysis) were observed in 21.9±7.3% of patients. Cytological examination allowed the results of a planned histological and immunohistochemical analysis to be foreseen with a high degree of probability.Conclusion. CT-guided transthoracic puncture is a highly effective method of diagnosing lung and mediastinal malignancies, which allows their morphological characterization to be done in 81% of cases.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88194833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-15-19
K. Stegnii, Zh.A. Rakhmonov, R. Goncharuk, M. Krekoten, E. Dvoinikova, E. Morova, M. Dmitriev
The presacral, or pararectal, space is a potential site for the formation of various cysts and tumors, since it contains a variety of embryonic tissues. Magnetic resonance imaging is the principal method for the diagnosis of presacral cysts, and endoscopic ultrasonography is an auxiliary method. These masses are subject to surgical removal, even in cases of asymptomatic course. The paper presents the successful experience of treating 3 patients using various surgical approaches and describes their advantages and disadvantages.
{"title":"Surgery of presacral cysts: case series analysis and literature review","authors":"K. Stegnii, Zh.A. Rakhmonov, R. Goncharuk, M. Krekoten, E. Dvoinikova, E. Morova, M. Dmitriev","doi":"10.34215/1609-1175-2023-2-15-19","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-15-19","url":null,"abstract":"The presacral, or pararectal, space is a potential site for the formation of various cysts and tumors, since it contains a variety of embryonic tissues. Magnetic resonance imaging is the principal method for the diagnosis of presacral cysts, and endoscopic ultrasonography is an auxiliary method. These masses are subject to surgical removal, even in cases of asymptomatic course. The paper presents the successful experience of treating 3 patients using various surgical approaches and describes their advantages and disadvantages.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75261119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-60-64
Y. Zharikov, R. Maslennikov, A. N. Gadzhiakhmedova, A. Aliyeva, V. Nikolenko, V. Ivashkin
Objective. To evaluate the nature of changes in body fat composition in cirrhotic patients of various somatotypes.Materials and methods. The data of 46 cirrhotic patients and 20 volunteers were analyzed. Anthropometric examination was carried out according to methodological requirements with assessing the body composition of patients by means of bioimpedance analysis using ABC-01 Medass system (NTC Medass, Russia). Somatotypes were determined according to the Heath–Carter method. Ranks for the somatotype scale were assigned as endomorphy scores increased. Spearman rank correlation was used to identify the relationships between the variables. Differences between continuous variables were determined using the Mann–Whitney test. Statistical analysis was performed using Statistica 10 (StatSoft Inc., USA).Results. Child–Pugh scores for men and women were 9 (7.3–11.8) and 7 (6–9), respectively. Body fat percentage (BFP) of cirrhotic patients accounted for 27.7% (23.3–33) in men and 41.2% (33.6–46.3) in women. In healthy volunteers, the BFP was 21.9% (13.9–26.3) in men and 32.7% (29.3–41.6) in women. Assessment of the relationships between liver cirrhosis severity and body fat was characterized by a correlation coefficient of r = -0.47528 (p-value < 0.001). A significant negative correlation was determined between the liver cirrhosis severity according to Child–Pugh scores and somatotypes (r = -0.30536, p = 0.03905).Conclusion. The results of this study emphasize the correlation between somatotypes and changes in BFP in patients with liver cirrhosis of various degrees of severity. The sum of Child–Pugh scores and endomorphic indicators demonstrated the inverse relationship, which must be taken into account when developing mathematical models of the personalized prognosis of liver cirrhosis.
{"title":"Сorrelation between somatotypes and body fat changes in patients with liver cirrhosis","authors":"Y. Zharikov, R. Maslennikov, A. N. Gadzhiakhmedova, A. Aliyeva, V. Nikolenko, V. Ivashkin","doi":"10.34215/1609-1175-2023-2-60-64","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-60-64","url":null,"abstract":"Objective. To evaluate the nature of changes in body fat composition in cirrhotic patients of various somatotypes.Materials and methods. The data of 46 cirrhotic patients and 20 volunteers were analyzed. Anthropometric examination was carried out according to methodological requirements with assessing the body composition of patients by means of bioimpedance analysis using ABC-01 Medass system (NTC Medass, Russia). Somatotypes were determined according to the Heath–Carter method. Ranks for the somatotype scale were assigned as endomorphy scores increased. Spearman rank correlation was used to identify the relationships between the variables. Differences between continuous variables were determined using the Mann–Whitney test. Statistical analysis was performed using Statistica 10 (StatSoft Inc., USA).Results. Child–Pugh scores for men and women were 9 (7.3–11.8) and 7 (6–9), respectively. Body fat percentage (BFP) of cirrhotic patients accounted for 27.7% (23.3–33) in men and 41.2% (33.6–46.3) in women. In healthy volunteers, the BFP was 21.9% (13.9–26.3) in men and 32.7% (29.3–41.6) in women. Assessment of the relationships between liver cirrhosis severity and body fat was characterized by a correlation coefficient of r = -0.47528 (p-value < 0.001). A significant negative correlation was determined between the liver cirrhosis severity according to Child–Pugh scores and somatotypes (r = -0.30536, p = 0.03905).Conclusion. The results of this study emphasize the correlation between somatotypes and changes in BFP in patients with liver cirrhosis of various degrees of severity. The sum of Child–Pugh scores and endomorphic indicators demonstrated the inverse relationship, which must be taken into account when developing mathematical models of the personalized prognosis of liver cirrhosis.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88904136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-14DOI: 10.34215/1609-1175-2023-2-48-53
T. A. Krivolutskaya, A. Makarov
Aim. To evaluate the potential for detecting of gene allelic polymorphism for chickenpox in adults.Materials and methods. The examination involved 201 conscripted soldiers of Caucasian race, aged between 18 and 24, who were born in and served in Zabaykalsky Krai. Determination of gene polymorphism was carried out via polymerase chain reaction. Genomic DNA was extracted from whole blood leukocytes using DNA-Express reagent. IBM SPSS Statistics 25.0 (International Business Machines Corporation, License No. Z125-3301-14, USA) was used for statistical processing of the results.Results. IL-10(G1082A) obtains the highest predictive value for chickenpox, while TLR9(T1237C) – the lowest. More commonly, chickenpox affects adults with IL-10(C819T), IL-10(G1082A) and TLR9(A2848G). TLR9(T1237C) is insignificant for chickenpox. TT and TC IL-10(G1082A), GA and AA TLR9(A2848G), AG and GG IL-10(C819T) are activators of chickenpox. AA IL-10(G1082A), CC IL-10(C819T), AA TLR9(A2848G) are chickenpox protectors. Android app was created for prognosis and early diagnosis of chickenpox in adults.Conclusion. Genes GA, AA IL-10(G1082A, and TT, CT IL-10(C819T), as well as AG, GG TLR9(A2848G) predispose to chickenpox, and gene AA TLR9(A2848G) reduces the probability of developing the disease. Considering that, the main prognostic markers for chickenpox in adults are polymorphisms of genes IL-10(G1082A), TLR9(A2848G), IL-10(C819T), the developed diagnostic model allows for the prediction and early diagnosis of the disease.
{"title":"Prediction of chickenpox in adults","authors":"T. A. Krivolutskaya, A. Makarov","doi":"10.34215/1609-1175-2023-2-48-53","DOIUrl":"https://doi.org/10.34215/1609-1175-2023-2-48-53","url":null,"abstract":"Aim. To evaluate the potential for detecting of gene allelic polymorphism for chickenpox in adults.Materials and methods. The examination involved 201 conscripted soldiers of Caucasian race, aged between 18 and 24, who were born in and served in Zabaykalsky Krai. Determination of gene polymorphism was carried out via polymerase chain reaction. Genomic DNA was extracted from whole blood leukocytes using DNA-Express reagent. IBM SPSS Statistics 25.0 (International Business Machines Corporation, License No. Z125-3301-14, USA) was used for statistical processing of the results.Results. IL-10(G1082A) obtains the highest predictive value for chickenpox, while TLR9(T1237C) – the lowest. More commonly, chickenpox affects adults with IL-10(C819T), IL-10(G1082A) and TLR9(A2848G). TLR9(T1237C) is insignificant for chickenpox. TT and TC IL-10(G1082A), GA and AA TLR9(A2848G), AG and GG IL-10(C819T) are activators of chickenpox. AA IL-10(G1082A), CC IL-10(C819T), AA TLR9(A2848G) are chickenpox protectors. Android app was created for prognosis and early diagnosis of chickenpox in adults.Conclusion. Genes GA, AA IL-10(G1082A, and TT, CT IL-10(C819T), as well as AG, GG TLR9(A2848G) predispose to chickenpox, and gene AA TLR9(A2848G) reduces the probability of developing the disease. Considering that, the main prognostic markers for chickenpox in adults are polymorphisms of genes IL-10(G1082A), TLR9(A2848G), IL-10(C819T), the developed diagnostic model allows for the prediction and early diagnosis of the disease.","PeriodicalId":19705,"journal":{"name":"Pacific Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84675588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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