Pub Date : 2023-01-01DOI: 10.29090/psa.2023.02.22.332
Arloe ThankGod, I. Suleiman, T. Aremu
Pharmaceutical care of HIV infected persons on antiretroviral therapy is pertinent in optimal management to achieve viral suppression and improve immune status. The objective of the study was to assess pharmaceutical care services provided to HIV infected patients on antiretroviral therapy. A prospective, cross-sectional study was carried out among 217 pharmacists giving pharmaceutical care services to HIV positive patients in Rivers State, Nigeria. Data collection tool was a structured, pre-tested questionnaire used to assess pharmaceutical care services carried out by pharmacists. The data collected were analyzed using SPSS version 20 and Microsoft Excel. Most of the respondents were female (62.8%). More than half (59.9%) of the subjects involved in provision of pharmaceutical care to HIV infected patients were practicing in the hospital setting. Most respondents (77.8%) did not monitor for drug therapy problems (DTPs), while most (89.9%) did not document interventions to identified drug therapy problems. Majority of respondents (90.3%) established rapport with patients to improve adherence. Most respondents (72.5%) had regular supply of antiretroviral drugs in their health facility. Pharmaceutical care services rendered to HIV infected patients on antiretroviral therapy was sub-optimal. Identification of DTPs and respective interventions, involvement in general patient management, and documentation of activities were the most affected.
在抗逆转录病毒治疗中，HIV感染者的药学服务与优化管理有关，以实现病毒抑制和改善免疫状态。本研究的目的是评估向接受抗逆转录病毒治疗的艾滋病毒感染者提供的药学服务。一项前瞻性的横断面研究在217名药剂师中进行，这些药剂师为尼日利亚河流州的艾滋病毒阳性患者提供药物护理服务。数据收集工具是一份结构化的、预先测试的问卷，用于评估药剂师开展的药学服务。收集的数据使用SPSS version 20和Microsoft Excel进行分析。受访者中以女性居多(62.8%)。参与向艾滋病毒感染患者提供药学服务的受试者中，有一半以上(59.9%)在医院执业。大多数受访者(77.8%)没有监测药物治疗问题(dtp)，而大多数(89.9%)没有记录干预措施以确定药物治疗问题。大多数应答者(90.3%)与患者建立了良好的关系，以提高依从性。大多数答复者(72.5%)的卫生机构定期提供抗逆转录病毒药物。对接受抗逆转录病毒治疗的艾滋病毒感染者提供的药学服务不够理想。确定dtp和相应的干预措施、参与一般患者管理和记录活动受到的影响最大。
{"title":"Assessment of pharmaceutical care services provided to HIV infected patients on antiretroviral therapy in Rivers state, Nigeria","authors":"Arloe ThankGod, I. Suleiman, T. Aremu","doi":"10.29090/psa.2023.02.22.332","DOIUrl":"https://doi.org/10.29090/psa.2023.02.22.332","url":null,"abstract":"Pharmaceutical care of HIV infected persons on antiretroviral therapy is pertinent in optimal management to achieve viral suppression and improve immune status. The objective of the study was to assess pharmaceutical care services provided to HIV infected patients on antiretroviral therapy. A prospective, cross-sectional study was carried out among 217 pharmacists giving pharmaceutical care services to HIV positive patients in Rivers State, Nigeria. Data collection tool was a structured, pre-tested questionnaire used to assess pharmaceutical care services carried out by pharmacists. The data collected were analyzed using SPSS version 20 and Microsoft Excel. Most of the respondents were female (62.8%). More than half (59.9%) of the subjects involved in provision of pharmaceutical care to HIV infected patients were practicing in the hospital setting. Most respondents (77.8%) did not monitor for drug therapy problems (DTPs), while most (89.9%) did not document interventions to identified drug therapy problems. Majority of respondents (90.3%) established rapport with patients to improve adherence. Most respondents (72.5%) had regular supply of antiretroviral drugs in their health facility. Pharmaceutical care services rendered to HIV infected patients on antiretroviral therapy was sub-optimal. Identification of DTPs and respective interventions, involvement in general patient management, and documentation of activities were the most affected.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"515 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77857129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29090/psa.2023.03.23.477
Venkatesh Prasad S, P. Sudheer, Kannika Belludi Chandrashekhar Shetty
{"title":"Current advances in nose to brain drug delivery","authors":"Venkatesh Prasad S, P. Sudheer, Kannika Belludi Chandrashekhar Shetty","doi":"10.29090/psa.2023.03.23.477","DOIUrl":"https://doi.org/10.29090/psa.2023.03.23.477","url":null,"abstract":"","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85322205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29090/psa.2023.01.22.339
Zarni Myint, P. Lawanprasert, S. Puttipipatkhachorn, J. Leanpolchareanchai
{"title":"The use of hydrophilic carrier derived from eggshell and novel gel forming technique in a solid dispersion system","authors":"Zarni Myint, P. Lawanprasert, S. Puttipipatkhachorn, J. Leanpolchareanchai","doi":"10.29090/psa.2023.01.22.339","DOIUrl":"https://doi.org/10.29090/psa.2023.01.22.339","url":null,"abstract":"","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89365482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29090/psa.2023.01.22.309
Ngo Xuan Hoang, T. Vo, Van-Hai Hoang, T. K. Nguyen, J. Seo, Phuong-Thao Tran
{"title":"Design, synthesis, and evaluation of indoleamin-2,3-dioxygenase 1 inhibition activity of novel 5/6-amino indazole derivatives with amide template","authors":"Ngo Xuan Hoang, T. Vo, Van-Hai Hoang, T. K. Nguyen, J. Seo, Phuong-Thao Tran","doi":"10.29090/psa.2023.01.22.309","DOIUrl":"https://doi.org/10.29090/psa.2023.01.22.309","url":null,"abstract":"","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"275 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89207673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tagetes erecta L. (marigold) flowers were extracted to obtain crude ethanolic extract (MGE), water insoluble extract (MGP), as well as water soluble extract (MGW). All extracts were determined of total flavonoid content and antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa . The results suggested that MGP contained the highest amount of total flavonoids (29.48%w/w quercetin equivalent) with good activity against S. aureus (MIC 6.25 mg/mL and MBC 25.0 mg/mL). This extract was subjected to formulate the topical gels at the concentration of 1 and 2 times of MIC. The gel formulation containing 1.25%w/w MGP with the solvent mixture of propylene glycol and ethanol (1:1) showed good physical properties. Furthermore, it exhibited the most effective antibacterial activity against S. aureus by agar well diffusion method with the inhibition zone of 15.15±0.43 mm. Therefore, the extract of marigold flower could be formulated as topical gel for the treatment of skin infections.
{"title":"Formulation of topical gel containing Tagetes erecta L. floral extract and its antibacterial activity","authors":"Papangkorn Meetong, Pattarapol Ananchaiphatthana, Chawalinee Asawahame, Phurit Thanarangsarit, Aranya Jutiviboonsuk","doi":"10.29090/psa.2023.02.22.369","DOIUrl":"https://doi.org/10.29090/psa.2023.02.22.369","url":null,"abstract":"Tagetes erecta L. (marigold) flowers were extracted to obtain crude ethanolic extract (MGE), water insoluble extract (MGP), as well as water soluble extract (MGW). All extracts were determined of total flavonoid content and antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa . The results suggested that MGP contained the highest amount of total flavonoids (29.48%w/w quercetin equivalent) with good activity against S. aureus (MIC 6.25 mg/mL and MBC 25.0 mg/mL). This extract was subjected to formulate the topical gels at the concentration of 1 and 2 times of MIC. The gel formulation containing 1.25%w/w MGP with the solvent mixture of propylene glycol and ethanol (1:1) showed good physical properties. Furthermore, it exhibited the most effective antibacterial activity against S. aureus by agar well diffusion method with the inhibition zone of 15.15±0.43 mm. Therefore, the extract of marigold flower could be formulated as topical gel for the treatment of skin infections.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83692149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29090/psa.2023.03.23.245
A. M. A. Alridha, D. Kadhim, A. Alkhazrajy
Steroid-resistant nephrotic syndrome (SRNS) is a leading cause of end-stage renal disease in children, with an increasing number of cases. Polymorphisms in the MDR-1 gene were reported to contribute to SRNS development, but with varying results among different ethnicities. Thus, we investigated the association of the MDR-1 rs1128503 (C1236T) and rs1045642 (C3435T) polymorphisms with steroid responsiveness in Iraqi children with idiopathic nephrotic syndrome (INS). This case-control study was conducted at the Babylon Hospital for Maternity and Pediatrics. Children with SRNS (n=32) and steroid-sensitive nephrotic syndrome (SSNS; n=32) were genotyped via the polymerase chain reaction-restriction fragment length polymorphism. The genotypes were subjected to association testing and haplotype analysis. The C1236T TT genotype was associated with a higher risk of developing SRNS compared to the CC and TC genotypes (odds ratio [OR]=10.33, 95% confidence interval [95% CI]=1.208-88.362; p -value=0.026; recessive model). The combination of the two TT genotypes of C1236T and C3435T variants was significantly more frequent ( p -value=0.029) in SRNS (88.9%) than in SSNS (11.1%). The haplotype analysis showed no association between the C1236T and C3435T haplotypes and steroid responsiveness, but the TC haplotype was associated with an age at onset of ≥8 years ( p -value=0.0028). In conclusion, this study revealed that children who have the MRD-1 C1236T TT genotype alone or combined with the C3435T TT genotype may be at increased risk of developing SRNS and in need of other therapeutic strategies. Additional research is required to identify other genetic contributions to steroid responsiveness and further understand their
{"title":"Association of the rs1128503 and rs1045642 polymorphisms in the MDR-1 gene with steroid responsiveness in Iraqi children with idiopathic nephrotic syndrome","authors":"A. M. A. Alridha, D. Kadhim, A. Alkhazrajy","doi":"10.29090/psa.2023.03.23.245","DOIUrl":"https://doi.org/10.29090/psa.2023.03.23.245","url":null,"abstract":"Steroid-resistant nephrotic syndrome (SRNS) is a leading cause of end-stage renal disease in children, with an increasing number of cases. Polymorphisms in the MDR-1 gene were reported to contribute to SRNS development, but with varying results among different ethnicities. Thus, we investigated the association of the MDR-1 rs1128503 (C1236T) and rs1045642 (C3435T) polymorphisms with steroid responsiveness in Iraqi children with idiopathic nephrotic syndrome (INS). This case-control study was conducted at the Babylon Hospital for Maternity and Pediatrics. Children with SRNS (n=32) and steroid-sensitive nephrotic syndrome (SSNS; n=32) were genotyped via the polymerase chain reaction-restriction fragment length polymorphism. The genotypes were subjected to association testing and haplotype analysis. The C1236T TT genotype was associated with a higher risk of developing SRNS compared to the CC and TC genotypes (odds ratio [OR]=10.33, 95% confidence interval [95% CI]=1.208-88.362; p -value=0.026; recessive model). The combination of the two TT genotypes of C1236T and C3435T variants was significantly more frequent ( p -value=0.029) in SRNS (88.9%) than in SSNS (11.1%). The haplotype analysis showed no association between the C1236T and C3435T haplotypes and steroid responsiveness, but the TC haplotype was associated with an age at onset of ≥8 years ( p -value=0.0028). In conclusion, this study revealed that children who have the MRD-1 C1236T TT genotype alone or combined with the C3435T TT genotype may be at increased risk of developing SRNS and in need of other therapeutic strategies. Additional research is required to identify other genetic contributions to steroid responsiveness and further understand their","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81028195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29090/psa.2023.01.22.340
Muhammad Shidiq Rukman, Ayu Nala El Muna Haerussana
{"title":"The effect of different sweeteners on the free radical scavenging activities, alcohol contents, sugar reductions, and hedonic properties of green tea kombucha","authors":"Muhammad Shidiq Rukman, Ayu Nala El Muna Haerussana","doi":"10.29090/psa.2023.01.22.340","DOIUrl":"https://doi.org/10.29090/psa.2023.01.22.340","url":null,"abstract":"","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75133932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29090/psa.2023.01.22.304
Naga Raju Kandukoori, Deepika B, Kiranmai Mandava
{"title":"Study on consequences for interaction of myricetin with canagliflozin: A special attention to pharmacokinetics and pharmacodynamics of drug","authors":"Naga Raju Kandukoori, Deepika B, Kiranmai Mandava","doi":"10.29090/psa.2023.01.22.304","DOIUrl":"https://doi.org/10.29090/psa.2023.01.22.304","url":null,"abstract":"","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86366265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29090/psa.2022.02.21.156
John Paul Matthew Guzman, Sheila Mantaring, E. Panerio
Amylase and protease are two of the most commonly used enzymes in the pharmaceutical industry. Particularly, Bacillus spp. is widely regarded as a “factory” of these enzymes. In this study, a total of 40 isolates were collected from four soil samples from different metropolitan sites namely, near Chemicals and Energy Division (CED), and National Metrology Laboratory (NML) oil tankers parking lot inside the Department of Science and Technology (DOST) Compound in Taguig City, and two metropolitan-volcanic sites in Clark Freeport Zone, Pampanga (CRK1, CRK2). Of these, 33 isolates were deemed putative Bacillus spp. via phenotypic assays and were screened for the production of amylase and protease. Results showed that 26 of the screened isolates were able to produce protease and 12 were positive for amylase production. Molecular identification revealed that the enzyme-producing isolates were Bacillus spp., B. cereus, B. aryabhattai, B. amyloliquefaciens, B. firmus , B. velezensis , and Fictibacillus sp. No isolate was able to produce amylase alone. These results show the potential of Bacillus spp. from metropolitan soil as sources of pharmaceutically-important enzymes.
{"title":"Screening for production of amylase and protease by locally-isolated Bacillus spp. from soil collected in Taguig City and Clark Freeport Zone, Philippines","authors":"John Paul Matthew Guzman, Sheila Mantaring, E. Panerio","doi":"10.29090/psa.2022.02.21.156","DOIUrl":"https://doi.org/10.29090/psa.2022.02.21.156","url":null,"abstract":"Amylase and protease are two of the most commonly used enzymes in the pharmaceutical industry. Particularly, Bacillus spp. is widely regarded as a “factory” of these enzymes. In this study, a total of 40 isolates were collected from four soil samples from different metropolitan sites namely, near Chemicals and Energy Division (CED), and National Metrology Laboratory (NML) oil tankers parking lot inside the Department of Science and Technology (DOST) Compound in Taguig City, and two metropolitan-volcanic sites in Clark Freeport Zone, Pampanga (CRK1, CRK2). Of these, 33 isolates were deemed putative Bacillus spp. via phenotypic assays and were screened for the production of amylase and protease. Results showed that 26 of the screened isolates were able to produce protease and 12 were positive for amylase production. Molecular identification revealed that the enzyme-producing isolates were Bacillus spp., B. cereus, B. aryabhattai, B. amyloliquefaciens, B. firmus , B. velezensis , and Fictibacillus sp. No isolate was able to produce amylase alone. These results show the potential of Bacillus spp. from metropolitan soil as sources of pharmaceutically-important enzymes.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73496852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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