Pub Date : 2022-01-01DOI: 10.29090/psa.2022.01.21.077
Natchaporn Choochuen, Ampa Jimtaisong
Clitoria ternatea, commonly known as butterfly pea or blue pea, is an edible plant species belonging to the Fabaceae family. The plant has several therapeutic activities like a memory enhancer, antidepressant, antistress, sedative agent, anxiolytic and tranquilizing agent . The C. ternatea blue flower contains anthocyanins, which are mainly delphinidin-glucosides. The blue flowers of butterfly peas have good free radical scavenging activity and have potential as antioxidants. The flower is commonly used as a source of natural coloring agent for food and cosmetics and as a natural pH indicator in pharmaceutical industry. It has been reported that the butterfly pea flower fermentation solution can be added to cosmetic formula as a natural raw material of skin care products to improve moisture retention and had whitening effects. The application of crushed fresh butterfly pea flower (also known as Aunchan) directly on the eyebrows and scalp for the benefits of coloring and promoting hair growth is traditionally and commonly found in Thailand. The ability to promote hair growth may be related with its inhibition of the 5α-reductase enzyme activity. Clove (Eugenia caryophyllus) is an important medicinal plant that has been employed for centuries as food preservative and pain reliever. It is also claimed to be the rich source of phenolic antioxidants. Eugenol and eugenyl acetate, which are poorly water soluble
{"title":"Physical stability and subjective efficacy study of liposome loaded with Clitoria ternatea (butterfly pea) flower extract and Eugenia caryophyllus (clove) oil","authors":"Natchaporn Choochuen, Ampa Jimtaisong","doi":"10.29090/psa.2022.01.21.077","DOIUrl":"https://doi.org/10.29090/psa.2022.01.21.077","url":null,"abstract":"Clitoria ternatea, commonly known as butterfly pea or blue pea, is an edible plant species belonging to the Fabaceae family. The plant has several therapeutic activities like a memory enhancer, antidepressant, antistress, sedative agent, anxiolytic and tranquilizing agent . The C. ternatea blue flower contains anthocyanins, which are mainly delphinidin-glucosides. The blue flowers of butterfly peas have good free radical scavenging activity and have potential as antioxidants. The flower is commonly used as a source of natural coloring agent for food and cosmetics and as a natural pH indicator in pharmaceutical industry. It has been reported that the butterfly pea flower fermentation solution can be added to cosmetic formula as a natural raw material of skin care products to improve moisture retention and had whitening effects. The application of crushed fresh butterfly pea flower (also known as Aunchan) directly on the eyebrows and scalp for the benefits of coloring and promoting hair growth is traditionally and commonly found in Thailand. The ability to promote hair growth may be related with its inhibition of the 5α-reductase enzyme activity. Clove (Eugenia caryophyllus) is an important medicinal plant that has been employed for centuries as food preservative and pain reliever. It is also claimed to be the rich source of phenolic antioxidants. Eugenol and eugenyl acetate, which are poorly water soluble","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88295916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29090/psa.2022.01.21.104
Paktraporn Mekloy, K. Sakchaisri, W. Jiratchariyakul, S. Bunsupa
Momordica charantia L. (M. charantia), also known as bitter melon, belongs to the Cucurbitaceae family. M. charantia is cultivated in many regions globally, including Asia, South America, and Africa. It has many varieties and local names, including the Chinese variety (lai-pu-tao, ku-gua), Japanese variety (goya), Indian variety (karela), Vietnamese variety (la khoqua), and Thai variety (mara). Varieties differ substantially in the shape and bitterness of the fruit. However, they have the same scientific name as Momordica charantia L.. The plant has been widely used as herbal anti-aging medicine. Major pharmacological activities that have been observed in bitter melon include abortifacient, antidiabetic, antibacterial, antiviral, and antitumor. These characteristics have been correlated with the presence of phytochemicals, including saponins, alkaloids, triterpenes, steroids, and proteins. Several compounds have been isolated from all plant parts, such as momordicins, charantins, cucurbitins, and goyaglycosides. Charantins, a mixture of steroidal saponins found in the fruits of M. charantia exhibit hypoglycaemic activity. Many proteins and peptides which possess RNA N-glycosidase, DNase-like, antitumor, immunosuppressive, and antimicrobial activities have also been isolated, such as
苦瓜(Momordica charantia L.， M. charantia)，又名苦瓜，属于葫芦科。夏兰草在全球许多地区都有种植，包括亚洲、南美和非洲。它有许多品种和地方名称，包括中国品种(lai-pu-tao, ku-gua)，日本品种(goya)，印度品种(karela)，越南品种(la khoqua)和泰国品种(mara)。不同的品种在形状和苦味上有很大的不同。然而，它们与Momordica charantia L有着相同的学名。这种植物已被广泛用作抗衰老的草药。在苦瓜中观察到的主要药理作用包括堕胎、降糖、抗菌、抗病毒和抗肿瘤。这些特征与植物化学物质的存在有关，包括皂苷、生物碱、三萜、类固醇和蛋白质。一些化合物已经从所有的植物部位分离出来，如苦瓜素、香瓜素、葫芦素和山茱萸苷。Charantins是一种混合物，在charantia的果实中发现的甾体皂苷具有降血糖活性。许多具有RNA n -糖苷酶、核糖核酸样、抗肿瘤、免疫抑制和抗菌活性的蛋白质和肽也被分离出来，如
{"title":"Investigation of genes coding for anti-HIV proteins MAP30 and MRK29 from Thai bitter melon (Momordica charantia L.)","authors":"Paktraporn Mekloy, K. Sakchaisri, W. Jiratchariyakul, S. Bunsupa","doi":"10.29090/psa.2022.01.21.104","DOIUrl":"https://doi.org/10.29090/psa.2022.01.21.104","url":null,"abstract":"Momordica charantia L. (M. charantia), also known as bitter melon, belongs to the Cucurbitaceae family. M. charantia is cultivated in many regions globally, including Asia, South America, and Africa. It has many varieties and local names, including the Chinese variety (lai-pu-tao, ku-gua), Japanese variety (goya), Indian variety (karela), Vietnamese variety (la khoqua), and Thai variety (mara). Varieties differ substantially in the shape and bitterness of the fruit. However, they have the same scientific name as Momordica charantia L.. The plant has been widely used as herbal anti-aging medicine. Major pharmacological activities that have been observed in bitter melon include abortifacient, antidiabetic, antibacterial, antiviral, and antitumor. These characteristics have been correlated with the presence of phytochemicals, including saponins, alkaloids, triterpenes, steroids, and proteins. Several compounds have been isolated from all plant parts, such as momordicins, charantins, cucurbitins, and goyaglycosides. Charantins, a mixture of steroidal saponins found in the fruits of M. charantia exhibit hypoglycaemic activity. Many proteins and peptides which possess RNA N-glycosidase, DNase-like, antitumor, immunosuppressive, and antimicrobial activities have also been isolated, such as","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85680602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29090/psa.2022.02.21.133
M. Nimworapan, Sinwisuth Sutheechai, W. Wongcharoen, A. Phrommintikul, S. Eakanunkul
Edoxaban is available in 60 mg, 30 mg, and 15 mg unscored film-coated tablets. Tablet splitting may be an option to reduce medication costs and reduce the country’s budget. The objectives of this study were to determine the weight variation and the dissolution profile of the 60 mg edoxaban in split half-tablets using a pill splitter. Thirty edoxaban 60 mg tablets were cut into halves by a right-handed pharmacist. The weight variation of the whole and half tablets were compared. For the dissolution test, 6 whole tablets and 12 half-tablets were separately dissolved in three dissolution media. Sixty half-tablets of edoxaban had the expected half-tablet weight within the 75% to 125% range that fell within the proxy United States Pharmacopeia (USP). The mean total weight of the 1 st and 2 nd halves were not significantly different from the mean weight of the intact tablets ( p -value=0.216). The amount of drug release from the whole and half tablets in 0.1 N HCl medium was greater than 85% in 15 minutes which met the acceptance criteria for the dissolution test. Edoxaban tablets splitting had low variations in weight. Therefore, edoxaban tablets can be split into halves by a tablet cutter.
依多沙班有60mg、30mg和15mg无刻痕薄膜包衣片剂。片剂拆分可能是降低药物成本和减少国家预算的一种选择。本研究的目的是测定60 mg艾多沙班半片剂的重量变化和溶出度。30片60毫克的依多沙班被一名右撇子药剂师切成两半。比较了整片和半片的重量变化情况。溶出度试验采用3种溶出介质分别溶出6片整片和12片半片。60半片依多沙班的预期半片重量在美国药典(USP)的75% - 125%范围内。第1、2半片剂的平均总重量与完整片剂的平均总重量无显著差异(p值=0.216)。在0.1 N HCl介质中，15 min内整片和半片的释药量均大于85%，符合溶出度试验验收标准。艾多沙班片剂分裂后重量变化较小。因此，依多沙班片剂可以用片剂切割器切成两半。
{"title":"Study of weight variation and dissolution of Edoxaban split tablets in pharmacy practice","authors":"M. Nimworapan, Sinwisuth Sutheechai, W. Wongcharoen, A. Phrommintikul, S. Eakanunkul","doi":"10.29090/psa.2022.02.21.133","DOIUrl":"https://doi.org/10.29090/psa.2022.02.21.133","url":null,"abstract":"Edoxaban is available in 60 mg, 30 mg, and 15 mg unscored film-coated tablets. Tablet splitting may be an option to reduce medication costs and reduce the country’s budget. The objectives of this study were to determine the weight variation and the dissolution profile of the 60 mg edoxaban in split half-tablets using a pill splitter. Thirty edoxaban 60 mg tablets were cut into halves by a right-handed pharmacist. The weight variation of the whole and half tablets were compared. For the dissolution test, 6 whole tablets and 12 half-tablets were separately dissolved in three dissolution media. Sixty half-tablets of edoxaban had the expected half-tablet weight within the 75% to 125% range that fell within the proxy United States Pharmacopeia (USP). The mean total weight of the 1 st and 2 nd halves were not significantly different from the mean weight of the intact tablets ( p -value=0.216). The amount of drug release from the whole and half tablets in 0.1 N HCl medium was greater than 85% in 15 minutes which met the acceptance criteria for the dissolution test. Edoxaban tablets splitting had low variations in weight. Therefore, edoxaban tablets can be split into halves by a tablet cutter.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"6 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86412580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29090/psa.2021.06.21.008
N. Worakajit, Penjai Thongnuanjan, Napason Chabang, Sirima Soodvilai, P. Tuchinda, S. Soodvilai
1 Research Center of Transporter Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand 2 Toxicology Graduate Program, Multidisciplinary Unit, Faculty of Science, Mahidol University, Bangkok, Thailand 3 School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok, Thailand 4 Department of Pharmaceutical Technology, Faculty of Pharmacy, Rangsit University, Pathumthani, Thailand 5 Excellent Center for Drug Discovery, Mahidol University, Bangkok, Thailand
{"title":"Pinostrobin attenuates colistin-induced apoptosis of human renal proximal tubular cells","authors":"N. Worakajit, Penjai Thongnuanjan, Napason Chabang, Sirima Soodvilai, P. Tuchinda, S. Soodvilai","doi":"10.29090/psa.2021.06.21.008","DOIUrl":"https://doi.org/10.29090/psa.2021.06.21.008","url":null,"abstract":"1 Research Center of Transporter Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand 2 Toxicology Graduate Program, Multidisciplinary Unit, Faculty of Science, Mahidol University, Bangkok, Thailand 3 School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok, Thailand 4 Department of Pharmaceutical Technology, Faculty of Pharmacy, Rangsit University, Pathumthani, Thailand 5 Excellent Center for Drug Discovery, Mahidol University, Bangkok, Thailand","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81422161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29090/psa.2021.05.20.077
E. M. Khaing, Torsak Intaraphairot, Wichai Santimaleeworagu, Yaowalak Phorom, Tiraniti Chuenbarn, T. Phaechamud
1 Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 2 Department of Biopharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 3 Natural Bioactive and Material for Health Promotion and Drug Delivery System Group (NBM), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 4 Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 5 Office of Secretary, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
{"title":"Natural-resin in-situ-forming gels: Physicochemical characteristics and bioactivities","authors":"E. M. Khaing, Torsak Intaraphairot, Wichai Santimaleeworagu, Yaowalak Phorom, Tiraniti Chuenbarn, T. Phaechamud","doi":"10.29090/psa.2021.05.20.077","DOIUrl":"https://doi.org/10.29090/psa.2021.05.20.077","url":null,"abstract":"1 Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 2 Department of Biopharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 3 Natural Bioactive and Material for Health Promotion and Drug Delivery System Group (NBM), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 4 Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand 5 Office of Secretary, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85099307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29090/psa.2021.04.20.106
C. Soontornpas, P. Mootsikapun, Ratchadaporn Soontornpas
Clostridium difficile infection (CDI) is a common and serious nosocomial infection worldwide. It is also problem in our hospital, a medical school in Khon Kaen University. Rationale use of antimicrobial in the treatment of CDI is still being questionable. This study aimed to explore the characteristic and evaluate the treatment of CDI in our setting. This retrospective cohort study was performed in 168 CDI patients admitted at Srinagarind Hospital between October 2013 and September 2016. Patient medical records were reviewed for demographics, comorbidities, antimicrobial exposures, treatments and clinical outcomes. Antimicrobial therapy for CDI was then evaluated in accordance with the current CDI guideline. Most CDI patients aged over 50 years (72.6%) and 42.8% aged over 65 years. Common comorbidities in the patients were cardiovascular disease (47.6%), diabetes mellitus (27.4%), chronic kidney disease (20.8%), malignancy (16.7%), cerebrovascular disease (11.3%), chronic hepatitis (3.6%) and chronic obstructive pulmonary disease (2.4%). Patients who had taken antimicrobial during hospitalization prior to CDI diagnosis constituted 83.9% of total study population. Metronidazole, vancomycin and both were initial therapy in 83.9, 4.8 and 11.3% of CDI, respectively. Appropriateness of CDI treatment in all terms was 44% and recovery rate was 62% of assessable cases. Nine patients (5.4%) died during hospitalization. In conclusion, most patients had CDI risk factors including elderly, comorbidity, antimicrobial exposure, and prolonged hospital stay. Inappropriate CDI treatment was found in asymptomatic carriers or inappropriate treatment duration. Initial therapy with metronidazole should change to oral vancomycin which was the first-line therapy in the current guidelines.
{"title":"Medication use evaluation for Clostridium difficile infection: a case of super tertiary care hospital in northeastern Thailand","authors":"C. Soontornpas, P. Mootsikapun, Ratchadaporn Soontornpas","doi":"10.29090/psa.2021.04.20.106","DOIUrl":"https://doi.org/10.29090/psa.2021.04.20.106","url":null,"abstract":"Clostridium difficile infection (CDI) is a common and serious nosocomial infection worldwide. It is also problem in our hospital, a medical school in Khon Kaen University. Rationale use of antimicrobial in the treatment of CDI is still being questionable. This study aimed to explore the characteristic and evaluate the treatment of CDI in our setting. This retrospective cohort study was performed in 168 CDI patients admitted at Srinagarind Hospital between October 2013 and September 2016. Patient medical records were reviewed for demographics, comorbidities, antimicrobial exposures, treatments and clinical outcomes. Antimicrobial therapy for CDI was then evaluated in accordance with the current CDI guideline. Most CDI patients aged over 50 years (72.6%) and 42.8% aged over 65 years. Common comorbidities in the patients were cardiovascular disease (47.6%), diabetes mellitus (27.4%), chronic kidney disease (20.8%), malignancy (16.7%), cerebrovascular disease (11.3%), chronic hepatitis (3.6%) and chronic obstructive pulmonary disease (2.4%). Patients who had taken antimicrobial during hospitalization prior to CDI diagnosis constituted 83.9% of total study population. Metronidazole, vancomycin and both were initial therapy in 83.9, 4.8 and 11.3% of CDI, respectively. Appropriateness of CDI treatment in all terms was 44% and recovery rate was 62% of assessable cases. Nine patients (5.4%) died during hospitalization. In conclusion, most patients had CDI risk factors including elderly, comorbidity, antimicrobial exposure, and prolonged hospital stay. Inappropriate CDI treatment was found in asymptomatic carriers or inappropriate treatment duration. Initial therapy with metronidazole should change to oral vancomycin which was the first-line therapy in the current guidelines.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77032916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29090/psa.2021.03.20.038
P. M. Nguyen, Linh V. Pham, K. Nguyen, Dat Tan Nguyen, Hanh Duong Nguyen, Nong Van Lai, B. Nguyen, Yen N Diep, Thang Nguyen
The effects of calcium and vitamin D supplementation on representative factors of bone health have been separately evaluated in different study populations worldwide, however, no data from solely one study population that comprehensively assess the supplementation outcomes on the skeletal system are available. We aimed to evaluate how calcium and vitamin D affect vitamin D level, bone mineral density (BMD), parathyroid hormone (PTH), and bone turnover markers as well as growth parameters in schoolchildren with abnormal vitamin D status and/or low BMD. An uncontrolled trial was carried out on 151 schoolchildren, aged 6-14, recruited from Can Tho City, Vietnam. The subjects were prescribed the combinations of calcium and vitamin D based on their age for a course of 6 months. After the intervention, the concentration of 25OHD was significantly improved (P < 0.001) and only 5.3% of the subjects were found to have an abnormal 25OHD level. Only 10.6%, compared with 66.89% before supplementation, had low BMD after the intervention (P < 0.05). The supplementation also increased weight and height and decreased P1NP. However, no significant changes were observed in β-CTx among boys and in PTH among the two genders. There was a negative correlation between vitamin D level and growth parameter, β-CTx. Linear regression analyses show a significant association between height, β-CTx level, and 25OHD level. In conclusion, the findings from our research provide a comprehensive assessment of various factors affected by calcium-vitamin D supplementation.
{"title":"Effectiveness of calcium - vitamin D supplementation on children with abnormal vitamin D status, low BMD, or both in Vietnam","authors":"P. M. Nguyen, Linh V. Pham, K. Nguyen, Dat Tan Nguyen, Hanh Duong Nguyen, Nong Van Lai, B. Nguyen, Yen N Diep, Thang Nguyen","doi":"10.29090/psa.2021.03.20.038","DOIUrl":"https://doi.org/10.29090/psa.2021.03.20.038","url":null,"abstract":"The effects of calcium and vitamin D supplementation on representative factors of bone health have been separately evaluated in different study populations worldwide, however, no data from solely one study population that comprehensively assess the supplementation outcomes on the skeletal system are available. We aimed to evaluate how calcium and vitamin D affect vitamin D level, bone mineral density (BMD), parathyroid hormone (PTH), and bone turnover markers as well as growth parameters in schoolchildren with abnormal vitamin D status and/or low BMD. An uncontrolled trial was carried out on 151 schoolchildren, aged 6-14, recruited from Can Tho City, Vietnam. The subjects were prescribed the combinations of calcium and vitamin D based on their age for a course of 6 months. After the intervention, the concentration of 25OHD was significantly improved (P < 0.001) and only 5.3% of the subjects were found to have an abnormal 25OHD level. Only 10.6%, compared with 66.89% before supplementation, had low BMD after the intervention (P < 0.05). The supplementation also increased weight and height and decreased P1NP. However, no significant changes were observed in β-CTx among boys and in PTH among the two genders. There was a negative correlation between vitamin D level and growth parameter, β-CTx. Linear regression analyses show a significant association between height, β-CTx level, and 25OHD level. In conclusion, the findings from our research provide a comprehensive assessment of various factors affected by calcium-vitamin D supplementation.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75967261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29090/psa.2021.04.20.075
S. A. Kristina, Nada Salsabila, Y. Yulianto, G. Fortwengel
Lack of knowledge regarding antibiotics use has been widely identified as a main reason for inappropriate antibiotics use which leads to antibiotic resistance phenomenon. This study aimed to evaluate the effects of pharmacist-initiated educational intervention on promoting appropriate use of antibiotics and reducing self-medication with antibiotics. A pre and post intervention study using two validated self-administered questionnaires was performed in Yogyakarta province. A-two hour session of course and case discussion was delivered as method of intervention. Pharmacy customers attended Gema Cermat program were invited conveniently to complete both of pre- and post-educational questionnaires. Descriptive presentation was conducted to show scores on questions. Knowledge scores were categorized as poor, adequate and high. Of 268 respondents, 34.22% respondents had poor level of knowledge before receiving educational intervention, but this number decreased into 12.21% after post-interventional phase. Another 28.23% respondents had adequate level of knowledge before and then elevated into 38.28% after receiving education about appropriate use of antibiotics. Pre-education, 37.43% participants had a high level of knowledge about antibiotics use and resistance, whereas after education the number became slightly higher (49.25%). A vast majority of respondents (75.24%) became more aware about appropriate antibiotics practice after receiving educational inter- vention. Overall, didactic educational intervention imposed higher knowledge and better practice regarding antibiotics use (p < 0.05). This study showed that using didactical education intervention towards antibiotics use and resistance can be an initial strategy that led to substantial improvement of appropriate antibiotics use. Further systemic interventions to educate people should be performed and evaluated in order to promote the appropriate use of antibiotics.
{"title":"Effect of didactic educational intervention on improving knowledge of antibiotics use and resistance in Yogyakarta Community","authors":"S. A. Kristina, Nada Salsabila, Y. Yulianto, G. Fortwengel","doi":"10.29090/psa.2021.04.20.075","DOIUrl":"https://doi.org/10.29090/psa.2021.04.20.075","url":null,"abstract":"Lack of knowledge regarding antibiotics use has been widely identified as a main reason for inappropriate antibiotics use which leads to antibiotic resistance phenomenon. This study aimed to evaluate the effects of pharmacist-initiated educational intervention on promoting appropriate use of antibiotics and reducing self-medication with antibiotics. A pre and post intervention study using two validated self-administered questionnaires was performed in Yogyakarta province. A-two hour session of course and case discussion was delivered as method of intervention. Pharmacy customers attended Gema Cermat program were invited conveniently to complete both of pre- and post-educational questionnaires. Descriptive presentation was conducted to show scores on questions. Knowledge scores were categorized as poor, adequate and high. Of 268 respondents, 34.22% respondents had poor level of knowledge before receiving educational intervention, but this number decreased into 12.21% after post-interventional phase. Another 28.23% respondents had adequate level of knowledge before and then elevated into 38.28% after receiving education about appropriate use of antibiotics. Pre-education, 37.43% participants had a high level of knowledge about antibiotics use and resistance, whereas after education the number became slightly higher (49.25%). A vast majority of respondents (75.24%) became more aware about appropriate antibiotics practice after receiving educational inter- vention. Overall, didactic educational intervention imposed higher knowledge and better practice regarding antibiotics use (p < 0.05). This study showed that using didactical education intervention towards antibiotics use and resistance can be an initial strategy that led to substantial improvement of appropriate antibiotics use. Further systemic interventions to educate people should be performed and evaluated in order to promote the appropriate use of antibiotics.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87076591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29090/PSA.2021.02.19.148
B. Kuswandi, Arimbi S Kartika, Nia Kristiningrum, D. K. Pratoko, Indah Purnama Sary
Simple, rapid, and low-cost dipstick test has been fabricated for the detection of dexamethasone adulteration in traditional herbal medicine (Jamu) for the joint-pain killer. The dipstick test has been constructed by immobilization of FeCl3 and K3[Fe(CN)6] in cellulose acetate film as a sensing film toward dexamethasone. The sensing film changes its color from green to blue in the presence of dexamethasone. It has response time at 10 mins and good linearity in the range 0.5-75 μg/ml of dexamethasone with correlation coefficient (r) of 0.9997, with the detection limit, was 0.422 μg/ml. The dipstick tests have been successfully used for the detection of dexamethasone adulteration in jamu for the joint-pain killer, and the result demonstrated in good correlation with the UV spectrophotometry method. Thus, the dipstick test is simple, rapid, and low-cost; it can be used as an alternative method for the detection of dexamethasone adulteration in traditional herbal medicine.
{"title":"Simple and rapid dipstick test for detection of dexamethasone adulteration in traditional herbal medicines","authors":"B. Kuswandi, Arimbi S Kartika, Nia Kristiningrum, D. K. Pratoko, Indah Purnama Sary","doi":"10.29090/PSA.2021.02.19.148","DOIUrl":"https://doi.org/10.29090/PSA.2021.02.19.148","url":null,"abstract":"Simple, rapid, and low-cost dipstick test has been fabricated for the detection of dexamethasone adulteration in traditional herbal medicine (Jamu) for the joint-pain killer. The dipstick test has been constructed by immobilization of FeCl3 and K3[Fe(CN)6] in cellulose acetate film as a sensing film toward dexamethasone. The sensing film changes its color from green to blue in the presence of dexamethasone. It has response time at 10 mins and good linearity in the range 0.5-75 μg/ml of dexamethasone with correlation coefficient (r) of 0.9997, with the detection limit, was 0.422 μg/ml. The dipstick tests have been successfully used for the detection of dexamethasone adulteration in jamu for the joint-pain killer, and the result demonstrated in good correlation with the UV spectrophotometry method. Thus, the dipstick test is simple, rapid, and low-cost; it can be used as an alternative method for the detection of dexamethasone adulteration in traditional herbal medicine.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89345794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.29090/PSA.2021.02.19.034
Ragil Setia Dianingati, A. Riewpaiboon
281 articles were excluded regarding the selection criteria. Then, 51 articles were screened on the full articles. Finally 18 articles were included in this systematic review (Figure 1). Quality indicators Description 4. Has a unit cost analysis method of this study been stated? To check whether the unit cost analysis method of the study has been clearly stated or not (can be average, micro-costing, RVU, or RCC). 5. Did this study mention indirect cost allocation method? The indirect cost allocation method can be direct method, step-down method, double distribution method, and simultaneous method. 6. Was this study stated the year of the cost value? Year of cost value means what year cost had
{"title":"Unit cost analysis of medical service in asia: A systematic review","authors":"Ragil Setia Dianingati, A. Riewpaiboon","doi":"10.29090/PSA.2021.02.19.034","DOIUrl":"https://doi.org/10.29090/PSA.2021.02.19.034","url":null,"abstract":"281 articles were excluded regarding the selection criteria. Then, 51 articles were screened on the full articles. Finally 18 articles were included in this systematic review (Figure 1). Quality indicators Description 4. Has a unit cost analysis method of this study been stated? To check whether the unit cost analysis method of the study has been clearly stated or not (can be average, micro-costing, RVU, or RCC). 5. Did this study mention indirect cost allocation method? The indirect cost allocation method can be direct method, step-down method, double distribution method, and simultaneous method. 6. Was this study stated the year of the cost value? Year of cost value means what year cost had","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"19 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80594054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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