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ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CARDIOVASCULAR COMPLAINTS AND ANXIETY DURING THE RUSSIAN-UKRAINIAN WAR: CASE SERIES 俄罗斯-乌克兰战争期间心血管疾病和焦虑患者的内皮功能障碍:病例系列
Pub Date : 2023-03-30 DOI: 10.31435/rsglobal_ws/30032023/7968
O. Savchenko, Y. Tyravska, V. Sobol, Yu.О. Moshkovska
Any war influences the mental and physical health of inhabitants of the country suffering from aggression. Anxiety is one of the mental disorders with increased prevalence during the war. A close relationship between anxiety and carbon dioxide concentration in the human body was revealed. There is no doubt about the pivotal role of the later in vascular tone control and the appropriate functioning of the endothelium. This paper presented case series of three female patients with similar complaints exacerbated after a stressful situation (bombing) in the period of the Russian-Ukrainian War. In addition to routine investigational methods (anamnesis taking, physical examination, electrocardiography, and transthoracic echocardiography at rest), Hamilton Anxiety Score and capnometry were used. The trend of drastically decreased end-tidal concentration of carbon dioxide and mild to severe anxiety levels was noticed. We consider there is a connection between the severity of anxiety and end-tidal concentration of carbon dioxide that indirectly reflects the possible endothelial dysfunction. Therefore, taking into consideration patho-mechanisms and pathology data, using differential pathogenetic methods of surgical invasion and computer monitoring of post-operative period we managed to decrease mortality in severecerebro-cranial traumas to 29-30% comparing to pre computer periods 36-38 % and comparing to data of other clinics 35-45%.
任何战争都会影响遭受侵略的国家居民的身心健康。焦虑是战争期间普遍存在的精神障碍之一。揭示了焦虑与人体内二氧化碳浓度之间的密切关系。毫无疑问,后者在血管张力控制和内皮细胞的正常功能中起着关键作用。本文介绍了三名女性患者的病例系列,她们在俄乌战争期间的应激情况(轰炸)后出现了类似的症状。除了常规的调查方法(记录记忆、体格检查、心电图和静息时经胸超声心动图)外,还使用汉密尔顿焦虑评分和血液计量法。注意到潮末二氧化碳浓度和轻度至重度焦虑水平急剧下降的趋势。我们认为焦虑的严重程度和潮汐末二氧化碳浓度之间存在联系,这间接反映了可能的内皮功能障碍。因此,考虑到病理机制和病理资料,采用手术侵袭的鉴别病理方法和术后计算机监测,我们成功地将重型颅脑损伤的死亡率降低到29-30%,而计算机前的死亡率为36- 38%,与其他诊所的数据相比为35-45%。
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引用次数: 0
МODERN NON-INVASIVE METHODS FOR TREATING PEYRONIE'S DISEASE Мodern治疗佩罗尼病的非侵入性方法
Pub Date : 2023-03-30 DOI: 10.31435/rsglobal_ws/30032023/7959
Georgi Tosev, Evgeniya Vladeva, Ivaylo Dimov
Summary: Peyronie's disease (PD) is a common disease in men that can lead to significant penile deformity and pain, erectile dysfunction, and mental health problems. So far, surgical correction with plaque removal offers the greatest likelihood of success during the stable phase of the disease. However, for men in the acute phase of PD or those with a milder deformity who choose to avoid surgery, conservative treatment methods are also available. New innovative methods are extracorporeal shock wave therapy (ESWT) and ultrasound therapy. Intralesional therapy with IFN-α2b, verapamil, and Clostridium histolyticum (CCH) collagenase can significantly reduce penile deviation (PD), but these results may not be clinically significant in men with more severe disease. Iontophoresis (EMDA, electromotive drug administration) of verapamil and cortisone have shown reductions in PD and penile pain.Penile traction therapy offers clinically significant improvement in penile length and curvature. It requires daily therapy lasting several hours. Oral therapies with substances such as L-arginine, L-citrulline, vitamin E and phosphodiesterase inhibitors are most helpful as part of a combination regimen rather than as monotherapy. Regenerative therapies with stem cells and platelet-rich plasma, as well as intralesional therapy with botulinum toxin (Botox) have not yet been well clinically studied and their possible application is currently taking place within the framework of clinical research. The combination of various oral, topical, intralesional therapies, extracorporeal shock wave therapy, ultrasound and traction therapies together with clinical psychosexual therapy if needed could provide a more effective treatment, which in turn could prevent or reduce the need for definitive reconstructive penile surgery. Materials and methods: For the purposes of the literature review, a systematic search was conducted for articles in German and English on non-invasive treatment methods for Peyronie's disease. The articles were selected according to their relevance to the given topic. The main findings were summarized and presented in tabular form.
摘要:佩罗尼氏病(PD)是一种男性常见病,可导致严重的阴茎畸形和疼痛、勃起功能障碍和精神健康问题。到目前为止,在疾病的稳定阶段,手术矫正与清除斑块提供了最大的成功可能性。然而,对于PD急性期或轻度畸形的男性,如果选择避免手术,也可以采用保守治疗方法。新的创新方法是体外冲击波治疗(ESWT)和超声治疗。病灶内应用IFN-α2b、维拉帕米和溶组织梭状芽胞杆菌(CCH)胶原酶治疗可显著降低阴茎偏离(PD),但这些结果在病情更严重的男性中可能没有临床意义。维拉帕米和可的松的离子电泳(EMDA,电动机给药)显示PD和阴茎疼痛的减少。阴茎牵引治疗可显著改善阴茎长度和弯曲度。它需要每天持续几个小时的治疗。口服药物如l -精氨酸、l -瓜氨酸、维生素E和磷酸二酯酶抑制剂作为联合治疗方案的一部分比单独治疗更有帮助。干细胞和富血小板血浆的再生疗法以及肉毒杆菌毒素(Botox)的病灶内治疗尚未得到很好的临床研究,它们的可能应用目前正在临床研究的框架内进行。各种口服、局部、病灶内治疗、体外冲击波治疗、超声和牵引治疗结合临床性心理治疗可以提供更有效的治疗,从而可以预防或减少对阴茎重建手术的需要。材料和方法:为了进行文献综述,我们系统检索了德文和英文的关于Peyronie病无创治疗方法的文章。这些文章是根据它们与给定主题的相关性挑选出来的。对主要研究结果进行了总结,并以表格形式提出。
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引用次数: 0
THE CONTENT OF PHENOLIC COMPOUNDS AND ANTIOXIDANT ACTIVITY OF THE BUTCHER’S BROOM PLANT (RUSCUS ACULEATUS L) 金雀花(ruscus aculeatus l)酚类化合物含量及抗氧化活性研究
Pub Date : 2023-03-30 DOI: 10.31435/rsglobal_ws/30032023/7960
Gabidzashvili Manana, Guleishvili Nino, Inga Bochoidze
The nature of medicinal products of plant origin is determined by the content of various active components, which makes it possible to use them as therapeutic excipients in traditional medicine. The objects of the research were the roots and the ground part of butcher’s broom wild-growing in Georgia, in the active phase of vegetation: root - in November, the ground part (stem and leaves) in May. The 70% and 40% ethanol alcoholic extracts from root and herbs were prepared, 26.6 - 60.4 mg/g of total phenols were found in all four extracts; the content of flavonoids was 9.2 - 21.2 mg/g and the antioxidant activity was evaluated by the DPPH method at 24.3 - 68.2%.
植物源性药材的性质是由各种活性成分的含量决定的,这使得它们有可能在传统医学中用作治疗辅料。研究的对象是生长在佐治亚州的野生肉鸡的根和地面部分,在植被的活跃阶段:根-在11月,地面部分(茎和叶)在5月。制备了70%和40%乙醇提取物,总酚含量均为26.6 ~ 60.4 mg/g;总黄酮含量为9.2 ~ 21.2 mg/g, DPPH法测定其抗氧化活性为24.3 ~ 68.2%。
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引用次数: 0
INVESTIGATION OF VIBRATION IN DIESEL-FUELED MOTOBLOCKS IN THE CASE OF SUPPLYING DIFFERENT TYPES OF FUEL MIXTURE 柴油马达块在不同类型混合燃料情况下的振动研究
Pub Date : 2023-03-30 DOI: 10.31435/rsglobal_ws/30032023/7976
M. Mamuladze, M. Lejava, F. Abuselidze
At present, where most of the soils of Georgia have a small contour, the demand for small-capacity technical means, in particular motoblocks, has increased. Motoblocks perform agricultural work for various purposes, where the work process is performed by the operator, who experiences various magnitudes of vibration, impact, noise, and in general, as a result of long-term work production, causes body damage, dynamic load, and respiratory diseases in people. In the scientific paper, the dependence on the vibration of different types of diesel fuel is investigated in the case of five different revolutions in the internal combustion engine. Studies have shown that fuel and engine speed are the only risk factors that contradict the ISO 5349-2(2004) international standard. The experience of four years of work studies showed that 10% of operators received various types of injuries as a result of working with motoblocks. Experiments also showed that the amount of vibration decreases when the number of revolutions of the engine increases, and in the case of using biodiesel fuel, the damage risk factor is 5-10%, and in the case of using conventional diesel, this indicator has gone up to 20%.
目前,格鲁吉亚大部分土壤的轮廓都很小,因此对小容量技术手段,特别是摩托车的需求增加了。摩托车为各种目的进行农业工作,其中工作过程由操作员进行,操作员经历不同程度的振动、冲击和噪音,并且由于长期工作生产,通常会导致人体损伤、动负荷和呼吸系统疾病。在这篇科学论文中,研究了内燃机在五种不同转数的情况下,不同类型的柴油对振动的依赖。研究表明,燃油和发动机转速是唯一与ISO 5349-2(2004)国际标准相矛盾的风险因素。四年的工作研究表明,10%的操作人员因使用马达座而受到各种类型的伤害。实验还表明,随着发动机转数的增加,振动量减小,在使用生物柴油燃料的情况下,损坏风险系数为5-10%,而在使用常规柴油的情况下,该指标已达到20%。
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引用次数: 0
RESEARCH OF THE POST-TRAUMATIC STRESS INFLUENCE ON THE RISK OF CARBOHYDRATE METABOLISM DISORDERS IN WOMEN – VETERANS 创伤后应激对女退伍军人碳水化合物代谢紊乱风险影响的研究
Pub Date : 2023-03-29 DOI: 10.31435/rsglobal_ws/30032023/7958
A. Serbeniuk
Research aim. to assess the impact of post-traumatic stress on the risk of carbohydrate metabolism disorders in concussed female veterans. Systematization of multidisciplinary analysis and obtained data on the impact of PTSD on the development and course of carbohydrate metabolism disorders. Material and methods. A comprehensive clinical and laboratory examination of women veterans with PTSD and women from the comparison group was carried out. Group I consisted of examination data of women who suffered contusion during combat operations with PTSD, group II – control one, consisted of healthy women. Complaints, obstetric – gynaecological and somatic history were studied in detail, anthropometric data, the state of carbohydrate metabolism, and mental health were assessed. Results and conclusions. The results of the conducted research show that the correction of carbohydrate metabolism disorders and treatment of pre-existing pathology caused by the influence of stress factors in combatants in order to preserve reproductive health is expedient and necessary.
研究的目标。评估创伤后应激对女退伍军人脑震荡后碳水化合物代谢紊乱风险的影响。对创伤后应激障碍对碳水化合物代谢紊乱的发展和过程的影响进行了系统化的多学科分析和获得的数据。材料和方法。对患PTSD的女退伍军人和对照组进行全面的临床和实验室检查。第一组为在战斗中遭受创伤后应激障碍挫伤的妇女的检查资料,第二组为对照组,由健康妇女组成。详细研究了患者的投诉、产科-妇科和躯体病史,评估了人体测量数据、碳水化合物代谢状态和心理健康。结果和结论。所进行的研究结果表明,为了保持生殖健康,纠正战斗人员因压力因素的影响而造成的碳水化合物代谢紊乱和治疗先前存在的病理是权宜之计和必要的。
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引用次数: 0
EFFECTIVENESS OF DAPAGLIFLOZIN IN PATIENTS WITH CHRONIC HEART FAILURE 达格列净治疗慢性心力衰竭的疗效
Pub Date : 2023-03-25 DOI: 10.31435/rsglobal_ws/30032023/7957
Лядова Т.І., Вовк К.В., Власенко О.О., Шерстюк Л.Л., Кратенко Г.С., Мартиненко М.В.
СHF is a chronic progressive disease. Today in the world there are approximately 64 million patients with CHF. The disease is associated with significant morbidity and mortality. CHF is the leading cause of hospital admissions among people over 65 years of age, placing a significant burden on the health care system and economic burden. Experts identify several main categories of heart failure, using the LVEF assessment as an indicator of heart contractility: heart failure with low EF (LVEF ≤ 40%), HF with moderately reduced EF (LVEF 41-49%) and HF with preserved EF (LVEF ≥ 50%). Approximately half of all patients with CHF have HFrEF or HFpEF, a population of patients for whom a limited set of therapeutic options are currently available. Тhanks to effect on prognosis and symptoms in patients  with CHF with low EF (LVEF ≤ 40%), a favorable safety profile and ease of use (reception 1 time / day and no dose titration necessary), dapagliflozin may be considered as an addition to the standard therapy to reduce the severity of symptoms, improve the prognosis of survival incidence and reduction in the number of future hospitalizations in connection with CHF.
СHF是一种慢性进行性疾病。今天,全世界约有6400万名瑞士法郎患者。该病的发病率和死亡率都很高。CHF是65岁以上人群住院的主要原因,给卫生保健系统和经济负担带来了重大负担。专家将LVEF评估作为心脏收缩力的指标,确定了心力衰竭的几个主要类别:心力衰竭低(LVEF≤40%)、心力衰竭中度降低(LVEF 41-49%)和心力衰竭保留(LVEF≥50%)。大约一半的CHF患者患有HFrEF或HFpEF,目前对这些患者的治疗选择有限。Тhanks对于低EF (LVEF≤40%)、良好的安全性和易用性(接受1次/天,无需剂量滴定)的CHF患者的预后和症状的影响,可以考虑将达格列净作为标准治疗的补充,以减轻症状的严重程度,改善生存发生率的预后,并减少与CHF相关的未来住院次数。
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引用次数: 0
ANTISTRESS ACTION OF PYRIDOXINE UNDER EXPERIMENTAL CONDITIONS 吡哆醇在实验条件下的抗应激作用
Pub Date : 2023-03-24 DOI: 10.31435/rsglobal_ws/30032023/7956
Лядова Т.І., Кратенко Г.С., Вовк К.В., Власенко О.О., Шерстюк Л.Л., Резніченко О.Г., Бєляєва Л.В.
Stress reaction in general the meaning of this term includes the entire set of standard, stereotypical, genetic fixed processes that take place at the cellular, tissue and system levels. Research on animals is of great importance in studying the problems of mental pathological conditions. Special attention in such studies, attention is paid to the behavior of animals that are on the border between normality and pathology. After all, understanding that how sick animals behave, on which are affected by stress, weighs a lot to understand how people behave in similar situations. The aim of the work is to investigate the anti-stress effect of pyridoxine and its effect on tryptophan metabolism in the central nervous system under conditions of experimental emotional stress. Pyridoxine, which is a coenzyme of many enzyme systems of tryptophan exchange, when administered under EC conditions, leads to a statistically significant, compared to the control, decrease in the level of tryptophan in all the studied structures of the brain: cortex, stem, cerebellum, and hypothalamus. At the same time, the level of serotonin in all structures reliably increases to control values, and in the cortex it even exceeds them.
一般来说,应激反应这个术语的含义包括在细胞、组织和系统水平上发生的一整套标准的、刻板的、遗传的固定过程。动物实验对研究精神病理问题具有重要意义。在这类研究中,特别关注的是处于正常和病理之间的动物的行为。毕竟,了解生病的动物是如何受到压力影响的,对于理解人类在类似情况下的行为是很重要的。本研究旨在探讨实验性情绪应激条件下吡哆醇的抗应激作用及其对中枢神经系统色氨酸代谢的影响。吡哆醇是许多色氨酸交换酶系统的辅酶,当在EC条件下给药时,与对照组相比,在所有研究的大脑结构(皮层、茎、小脑和下丘脑)中色氨酸水平的降低具有统计学意义。与此同时,所有结构中的血清素水平都可靠地增加到控制值,而皮层中的血清素水平甚至超过了控制值。
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引用次数: 0
POLYETHILEN CREEPING IN ELECTROLUTE’S AREA 聚乙烯在电解液区蔓延
Pub Date : 2023-03-16 DOI: 10.31435/rsglobal_ws/30032023/7948
Avtandil Porchkhidze
In this work is given, that polymer’s sorbed liquids quantity influences creeping deformation increase.
本文给出了聚合物的吸液量对蠕变变形的影响。
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引用次数: 0
THERMODYNAMIC BASIS OF INTERACTION OF THERMAL MACHINES WITH THE ENVIRONMENT AND ENERGY LOSSES OF THE FILLING PROCESS 热机与环境相互作用的热力学基础和灌装过程的能量损失
Pub Date : 2023-03-11 DOI: 10.31435/rsglobal_ws/30032023/7946
G. Purtskhvanidze, Mikheil Lejava, Zaza Shubladze, Giorgi Nogaideli
The principle of work of the thermal car assumes its interaction with environment according to thermodynamics laws. All real processes owing to a friction, heat exchange at a final difference of temperatures and limitation of time of their course are irreversible. As irreversibility measure entropy serves. The paper considers the peculiarities of the transformation of thermal energy, taking into account entropy. A theoretical analysis of the efficiency of work performance (exergy) is given. The equations of thermal and exergic balance of thermal engines are presented, taking into account the impact on the environment. The main parameters characterizing the loss of efficiency of the charge air during the period of filling the cylinder are determined and calculated: the filling factor and the loss of pump strokes. The calculated value of pumping losses allows, with sufficient for calculating the gas exchange of engines and especially for calculating the operation of pumping passages, to determine the amount of loss in the efficiency of air pre-compressed in the pressurization unit.
热车的做功原理根据热力学定律假定其与环境的相互作用。由于摩擦、最终温差下的热交换和过程的时间限制而产生的一切实际过程都是不可逆的。作为不可逆性度量,熵起作用。本文在考虑熵的情况下,考虑了热能转换的特殊性。对工作性能(火用)的效率进行了理论分析。在考虑对环境影响的情况下,给出了热机的热平衡方程和火用平衡方程。确定并计算了充装气在充装气缸期间效率损失的主要参数:充装系数和泵冲程损失。抽气损失的计算值足以计算发动机的气体交换,特别是计算抽气通道的运行情况,从而确定增压装置内预压缩空气效率的损失量。
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引用次数: 0
IN TEA PICKING MACHINES, THE PROSPECT OF USING A NEW CUTTING MACHINE 在采茶机方面,采用新型切割机的前景广阔
Pub Date : 2023-02-18 DOI: 10.31435/rsglobal_ws/30032023/7944
M. Mamuladze
Tea represents the economy's main field in agriculture and plays a crucial role in growing and cultivation, proper performance and operation of machine technologies. In the areas where small peasant farms and cooperatives have been formed, and operation of heavy-duty machines is inappropriate, the labor costs should be decreased. Therefore, analysis of machines, which allow high tea leaf plucking quality without destroying the inefficient and unnecessary shoots should be refined and become technically perfect. In this scientific research presents interaction of bearing-less cutting machines with a rubber finger with the stem as a working cutting device, this gives opportunities of a lossless and high tea leaf harvesting quality in the small contoured sloped areas by using machines, based on light-duty engines
茶叶是农业经济的主要领域,在种植栽培、机械技术的合理性能和操作中起着至关重要的作用。在已经形成小农农场和合作社,不适宜操作重型机械的地区,应降低人工成本。因此,在不破坏低效和不必要的嫩枝的情况下,能够提高茶叶采摘质量的机器分析应该得到改进,并在技术上达到完美。在这项科学研究中,展示了带有橡胶手指的无轴承切割机与茎作为工作切割装置的相互作用,这使得使用基于轻型发动机的机器在小轮廓倾斜区域获得无损和高质量的茶叶收获机会
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引用次数: 0
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Pharmacy World & Science
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