Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20230220020230
Abdul Qadeer
Abdul Qadeer1,2, Muhammad Avais1*, Abdul Wajid3, Muhammad Zahid Iqbal1, Hanif Ullah4, Asad Khan5, Sajid Ur Rahman2,6, Aqeel Javeed7 and Sher Zaman Safi8,9 1Department of Veterinary Medicine, University of Veterinary and Animal Sciences Lahore 2Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Affairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China 3Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan 4West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China, 5Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Chengdu 611130, China 6Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China 7Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore 8Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia 9Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad, Lahore, Pakistan Article Information Received 20 February 2023 Revised 25 May 2023 Accepted 16 June 2023 Available online 08 September 2023 (early access)
{"title":"Evaluation of In-Vitro and In-Vivo Efficacy of Hedera helix Extracts against Haemonchus contortus in Sheep","authors":"Abdul Qadeer","doi":"10.17582/journal.pjz/20230220020230","DOIUrl":"https://doi.org/10.17582/journal.pjz/20230220020230","url":null,"abstract":"Abdul Qadeer1,2, Muhammad Avais1*, Abdul Wajid3, Muhammad Zahid Iqbal1, Hanif Ullah4, Asad Khan5, Sajid Ur Rahman2,6, Aqeel Javeed7 and Sher Zaman Safi8,9 1Department of Veterinary Medicine, University of Veterinary and Animal Sciences Lahore 2Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Affairs, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China 3Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan 4West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China, 5Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Chengdu 611130, China 6Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China 7Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore 8Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia 9Interdisciplinary Research Center in Biomedical Materials, COMSATS University Islamabad, Lahore, Pakistan Article Information Received 20 February 2023 Revised 25 May 2023 Accepted 16 June 2023 Available online 08 September 2023 (early access)","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135355383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20230415100435
Nan Jiang
, RPL8, mTORC1, SREBP1 The fat content in yak milk is higher than that in dairy cows, but the molecular mechanisms responsible for milk fat synthesis in yaks are still unclear. This study examined the regulatory mechanism of milk fat synthesis in yak mammary epithelial cells (YMECs) by investigating the role of Ribosomal protein L8 (RPL8) in the mTORC1-SREBP1 signaling pathways. The results showed that over-expression or inhibition of RPL8 had a significant effect on triglyceride (TG) secretion, which also affected the sterol regulatory element-binding protein 1 (SREBP1) pathway. Similarly, the intervention of SREBP1 revealed that RPL8 promoted TG secretion through the SREBP1 pathway. Additionally, the study found that over-expression or inhibition of RPL8 regulated the signaling activity of the mammalian target of rapamycin complex 1 (mTORC1), which promoted the SREBP1 signaling pathway through mTORC1. Further examination by over-expressing or inhibiting SREBP1 or mTOR showed that mTOR promoted TG secretion through the mTORC1-SREBP1 signaling pathway. Moreover, YMECs treated with palmitic acid showed increased expression of RPL8, mTOR, and SREBP1, as well as increased TG secretion. Overall, the study’s findings provide insights into the underlying mechanisms of milk fat synthesis in yaks, and suggest that the RPL8 gene and mTORC1-SREBP1 signaling pathways could serve as potential genetic markers for milk fat synthesis in yak mammary glands.
{"title":"Uncovering the Role of Ribosomal Protein L8 in Milk Fat Synthesis Mechanisms in Yak Mammary Epithelial Cells","authors":"Nan Jiang","doi":"10.17582/journal.pjz/20230415100435","DOIUrl":"https://doi.org/10.17582/journal.pjz/20230415100435","url":null,"abstract":", RPL8, mTORC1, SREBP1 The fat content in yak milk is higher than that in dairy cows, but the molecular mechanisms responsible for milk fat synthesis in yaks are still unclear. This study examined the regulatory mechanism of milk fat synthesis in yak mammary epithelial cells (YMECs) by investigating the role of Ribosomal protein L8 (RPL8) in the mTORC1-SREBP1 signaling pathways. The results showed that over-expression or inhibition of RPL8 had a significant effect on triglyceride (TG) secretion, which also affected the sterol regulatory element-binding protein 1 (SREBP1) pathway. Similarly, the intervention of SREBP1 revealed that RPL8 promoted TG secretion through the SREBP1 pathway. Additionally, the study found that over-expression or inhibition of RPL8 regulated the signaling activity of the mammalian target of rapamycin complex 1 (mTORC1), which promoted the SREBP1 signaling pathway through mTORC1. Further examination by over-expressing or inhibiting SREBP1 or mTOR showed that mTOR promoted TG secretion through the mTORC1-SREBP1 signaling pathway. Moreover, YMECs treated with palmitic acid showed increased expression of RPL8, mTOR, and SREBP1, as well as increased TG secretion. Overall, the study’s findings provide insights into the underlying mechanisms of milk fat synthesis in yaks, and suggest that the RPL8 gene and mTORC1-SREBP1 signaling pathways could serve as potential genetic markers for milk fat synthesis in yak mammary glands.","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136208718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20230728161028
Dan Liao
The objective of this study was to further explore the influence of hypertension on blood lithium levels and its concentration to dose ratio (C/D) in patients with manic episodes. A total of 112 patients with manic episodes from the Wuhan Wudong Hospital between July 2021 and December 2022 were assigned into a control group (CG) and a hypertension group (HG). The patients’ blood lithium concentrations, blood lithium C/D ratios, antihypertensive medication use, Young Mania Rating Scale (YMRS) scores, adverse reactions (ARs), and other parameters were monitored and compared. The average blood lithium concentration in the CG was 0.78±0.27 mmol/L, and the average blood lithium C/D ratio was 0.91±0.43 mmol·L -1 ·g -1 ·d, which were remarkably inferior to those (0.89±0.20 mmol/L and 0.97±0.46 mmol·L - 1 ·g -1 ·d) in the HG. Further subgroup analysis based on antihypertensive medication revealed a drastic increase in blood lithium C/D ratio in the calcium channel blocker (CCB) subgroup. After the treatment, the YMRS score was 7.84±0.82 in the CG and 9.12±0.89 in the HG. The total number of ARs in the HG was superior to the CG, and the occurrence of ARs in both groups was concentrated within 3-15 days, accounting for 48.6% of all ARs. Patients in the HG had higher blood lithium concentrations, slower lithium metabolism, and a higher risk of ARs versus the CG. It was concluded that further investigation is warranted to explore the underlying mechanisms of these effects.
{"title":"Effect of Hypertension on Blood Lithium Level and its Concentration to Dose Ratio in Manic Episode Patients","authors":"Dan Liao","doi":"10.17582/journal.pjz/20230728161028","DOIUrl":"https://doi.org/10.17582/journal.pjz/20230728161028","url":null,"abstract":"The objective of this study was to further explore the influence of hypertension on blood lithium levels and its concentration to dose ratio (C/D) in patients with manic episodes. A total of 112 patients with manic episodes from the Wuhan Wudong Hospital between July 2021 and December 2022 were assigned into a control group (CG) and a hypertension group (HG). The patients’ blood lithium concentrations, blood lithium C/D ratios, antihypertensive medication use, Young Mania Rating Scale (YMRS) scores, adverse reactions (ARs), and other parameters were monitored and compared. The average blood lithium concentration in the CG was 0.78±0.27 mmol/L, and the average blood lithium C/D ratio was 0.91±0.43 mmol·L -1 ·g -1 ·d, which were remarkably inferior to those (0.89±0.20 mmol/L and 0.97±0.46 mmol·L - 1 ·g -1 ·d) in the HG. Further subgroup analysis based on antihypertensive medication revealed a drastic increase in blood lithium C/D ratio in the calcium channel blocker (CCB) subgroup. After the treatment, the YMRS score was 7.84±0.82 in the CG and 9.12±0.89 in the HG. The total number of ARs in the HG was superior to the CG, and the occurrence of ARs in both groups was concentrated within 3-15 days, accounting for 48.6% of all ARs. Patients in the HG had higher blood lithium concentrations, slower lithium metabolism, and a higher risk of ARs versus the CG. It was concluded that further investigation is warranted to explore the underlying mechanisms of these effects.","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136210037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20230105090129
Ahmed Guerfi
1Department of Agronomy, Faculty of Nature and Life Sciences, Chadli Bendjedid University of El Tarf, PO Box 73, El Tarf, 36000, Algeria. 2Department of Biology, Faculty of Nature and Life Sciences, Mohamed Cherif Messaadia University of Souk Ahras, PO Box 1553, Souk-Ahras, 41000, Algeria 3Department of Biology, Faculty of Nature and Life Sciences and Sciences of Earth and Universe, 08 May 1945 University of Guelma, Guelma, 24000, Algeria Article Information Received 05 January 2023 Revised 22 June 2023 Accepted 24 July 2023 Available online 09 October 2023 (early access)
{"title":"Breeding Bird Assemblages in Relation to Changing Forest Composition in North-Eastern Algeria: Zonation or Continuum?","authors":"Ahmed Guerfi","doi":"10.17582/journal.pjz/20230105090129","DOIUrl":"https://doi.org/10.17582/journal.pjz/20230105090129","url":null,"abstract":"1Department of Agronomy, Faculty of Nature and Life Sciences, Chadli Bendjedid University of El Tarf, PO Box 73, El Tarf, 36000, Algeria. 2Department of Biology, Faculty of Nature and Life Sciences, Mohamed Cherif Messaadia University of Souk Ahras, PO Box 1553, Souk-Ahras, 41000, Algeria 3Department of Biology, Faculty of Nature and Life Sciences and Sciences of Earth and Universe, 08 May 1945 University of Guelma, Guelma, 24000, Algeria Article Information Received 05 January 2023 Revised 22 June 2023 Accepted 24 July 2023 Available online 09 October 2023 (early access)","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136210038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20221010101012
Adyasha Sahu
{"title":"Carapace Length–Weight, Carapace Width–Weight Relationships and Relative Condition Factor of Four Portunid Crab Species of the Gulf of Mannar, Southeast Coast of India","authors":"Adyasha Sahu","doi":"10.17582/journal.pjz/20221010101012","DOIUrl":"https://doi.org/10.17582/journal.pjz/20221010101012","url":null,"abstract":"","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136306361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20210911090910
Bounthan Sounyvong
We examined the abundance of five small rodent species, the chestnut white-bellied rat ( Niviventer fulvescens ), red spiny rat ( Maxomys surifer ), long-tailed giant rat ( Leopoldamys sabanus ), house mouse ( Mus musculus ), and black rat ( Rattus rattus ), and the stand structure of primary and secondary forest stands resulting from two types of post-fire silvicultural management practices in the Phou Khao Khauy National Protected Area (PKKNPA), Lao PDR. Post-fire silvicultural practices contributed to dramatically converting the structure of forests. Coverage of overstory, midstory, and ground vegetation, number of tree stems, woody seedlings, snags, and volume of coarse woody debris all had significant differences among study sites. We captured 456 individual small rodents during the dry and rainy seasons. The mean number of small rodents captured in primary forests was significantly higher than that in two secondary forests. In addition, there were more rodents in burned rice field stands than in burned rubber plantation stands. The value of overstory to understory vegetation coverage and the volume of coarse woody debris were strongly associated with small-mammal abundance in the PKKNPA. Thus, post-fire silvicultural practices should take the differences in small rodent abundance as well as forest structure into account. Long-term experiments may help illuminate the potential effects of management strategies after forest fires in the Lao PDR.
{"title":"Small Mammal Abundance and Forest Structure Changes by Different Post-Fire Silviculural Practices in Phou Khao Khauy National Protected Area, Lao PDR","authors":"Bounthan Sounyvong","doi":"10.17582/journal.pjz/20210911090910","DOIUrl":"https://doi.org/10.17582/journal.pjz/20210911090910","url":null,"abstract":"We examined the abundance of five small rodent species, the chestnut white-bellied rat ( Niviventer fulvescens ), red spiny rat ( Maxomys surifer ), long-tailed giant rat ( Leopoldamys sabanus ), house mouse ( Mus musculus ), and black rat ( Rattus rattus ), and the stand structure of primary and secondary forest stands resulting from two types of post-fire silvicultural management practices in the Phou Khao Khauy National Protected Area (PKKNPA), Lao PDR. Post-fire silvicultural practices contributed to dramatically converting the structure of forests. Coverage of overstory, midstory, and ground vegetation, number of tree stems, woody seedlings, snags, and volume of coarse woody debris all had significant differences among study sites. We captured 456 individual small rodents during the dry and rainy seasons. The mean number of small rodents captured in primary forests was significantly higher than that in two secondary forests. In addition, there were more rodents in burned rice field stands than in burned rubber plantation stands. The value of overstory to understory vegetation coverage and the volume of coarse woody debris were strongly associated with small-mammal abundance in the PKKNPA. Thus, post-fire silvicultural practices should take the differences in small rodent abundance as well as forest structure into account. Long-term experiments may help illuminate the potential effects of management strategies after forest fires in the Lao PDR.","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67546175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20210320070322
J. Jaba
{"title":"Effect of different Sowing Windows on Major Insect Pests and Host Plant Resistance to Pod Borer, Helicoverpa armigera in Pigeonpea (Cajanus cajan (L.) Millsp.)","authors":"J. Jaba","doi":"10.17582/journal.pjz/20210320070322","DOIUrl":"https://doi.org/10.17582/journal.pjz/20210320070322","url":null,"abstract":"","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67537518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20221031021052
Xinyue Wang
Influenced by water pollution and flow
受水污染和水流影响
{"title":"Age and Growth of Triplophysa (Hedinichthys) yarkandensis (Day, 1877) in the Tarim River in Xinjiang, China","authors":"Xinyue Wang","doi":"10.17582/journal.pjz/20221031021052","DOIUrl":"https://doi.org/10.17582/journal.pjz/20221031021052","url":null,"abstract":"Influenced by water pollution and flow","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67569644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20221110081129
Phuong-Thao Ho
1Laboratory of Ecology and Environmental Management, Science and Technology Advanced Institute, Van Lang University, Ho Chi Minh City, Vietnam 2Faculty of Applied Technology, School of Engineering and Technology, Van Lang University, Ho Chi Minh City, Vietnam 3Faculty of Chemistry-Biology-Environment, Pham Van Dong University, Quang Ngai City, 49000, Vietnam 4Biology Department, Hue University of Education, Hue University, 49000, Vietnam Article Information Received 10 November 2022 Revised 22 December 2022 Accepted 24 January 2023 Available online 22 May 2023 (early access)
{"title":"Morphological Description and Weight-Length Relationship of the Intertidal Sipuncula Siphonosoma australe (Keferstein, 1865) along the Central Coast of Vietnam","authors":"Phuong-Thao Ho","doi":"10.17582/journal.pjz/20221110081129","DOIUrl":"https://doi.org/10.17582/journal.pjz/20221110081129","url":null,"abstract":"1Laboratory of Ecology and Environmental Management, Science and Technology Advanced Institute, Van Lang University, Ho Chi Minh City, Vietnam 2Faculty of Applied Technology, School of Engineering and Technology, Van Lang University, Ho Chi Minh City, Vietnam 3Faculty of Chemistry-Biology-Environment, Pham Van Dong University, Quang Ngai City, 49000, Vietnam 4Biology Department, Hue University of Education, Hue University, 49000, Vietnam Article Information Received 10 November 2022 Revised 22 December 2022 Accepted 24 January 2023 Available online 22 May 2023 (early access)","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67570125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17582/journal.pjz/20221114101149
M. Uzair
The study aimed to explore the beneficial aspect of serratiopeptidase (proteolytic enzyme) combined with low profile antibiotic (Neomycin) in chickens against the E. coli infection at the finisher stage. Both in-vitro and in-vivo studies were carried out to evaluate the antimicrobial activities and potency of this combination. A total of one hundred and eighty day-old chicks were randomly allotted to 6 groups i.e. G1 (negative control), G2 (positive control), G3 (standard antibiotic neomycin only), SN-1 (Serratiopeptidase @40g/L+Neomycin@10mg/L), SN-2 (Serratiopeptidase @50mg/L+ Neomycin @20mg/L), and SN-3 (Serratiopeptidase @ 60mg/L+ Neomycin @30mg/L). Each group consisted of thirty birds with 5 replicates (6 birds/ replicate). On day 21, fresh inocula of E. coli (1x10 9 cfu ) were orally administered to all the groups except negative control. The results revealed that birds in SN-3 group showed significantly larger zone of inhibition, increased feed intake, weight gain and improved feed conversion ratio compared to standard and control groups. Moreover, reduced (p<0.05) mortality and morbidity index was found in SN-3 group among all the treated groups. It was concluded, that use of serratiopeptidase combination with neomycin has better impact on broiler chickens to enhance the antimicrobial effect of Neomycin against E. coli infection and to enhance production parameters.
{"title":"Enhanced Neomycin Antibiotic Properties Through Proteolytic Enzyme in Escherichia coli Induced Infection in Broiler Chicks","authors":"M. Uzair","doi":"10.17582/journal.pjz/20221114101149","DOIUrl":"https://doi.org/10.17582/journal.pjz/20221114101149","url":null,"abstract":"The study aimed to explore the beneficial aspect of serratiopeptidase (proteolytic enzyme) combined with low profile antibiotic (Neomycin) in chickens against the E. coli infection at the finisher stage. Both in-vitro and in-vivo studies were carried out to evaluate the antimicrobial activities and potency of this combination. A total of one hundred and eighty day-old chicks were randomly allotted to 6 groups i.e. G1 (negative control), G2 (positive control), G3 (standard antibiotic neomycin only), SN-1 (Serratiopeptidase @40g/L+Neomycin@10mg/L), SN-2 (Serratiopeptidase @50mg/L+ Neomycin @20mg/L), and SN-3 (Serratiopeptidase @ 60mg/L+ Neomycin @30mg/L). Each group consisted of thirty birds with 5 replicates (6 birds/ replicate). On day 21, fresh inocula of E. coli (1x10 9 cfu ) were orally administered to all the groups except negative control. The results revealed that birds in SN-3 group showed significantly larger zone of inhibition, increased feed intake, weight gain and improved feed conversion ratio compared to standard and control groups. Moreover, reduced (p<0.05) mortality and morbidity index was found in SN-3 group among all the treated groups. It was concluded, that use of serratiopeptidase combination with neomycin has better impact on broiler chickens to enhance the antimicrobial effect of Neomycin against E. coli infection and to enhance production parameters.","PeriodicalId":19975,"journal":{"name":"Pakistan Journal of Zoology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67570310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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