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Recent patents and a market overview on green or bio-based solvents for chromatographic analysis: a review. 用于色谱分析的绿色或生物基溶剂的最新专利和市场概述：综述。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-11-01 Epub Date: 2021-11-10 DOI: 10.4155/ppa-2021-0015
Abdul Muheem, Mohammed Asadullah Jahangir, Sanjula Baboota, Javed Ali

Green solvents (GS) in chromatography originate from green chemistry. Therefore, using GSs in liquid chromatographic analysis to separate drugs and chemicals is an emerging approach to reduce hazardous chemicals in nature. The Orbit Intelligence database was used to conduct a strategic patent search for peer-reviewed patents on GSs as a mobile phase for chromatographic analysis. This article reported numerous approaches for encouraging GSs such as ethanol, butanol, esters, polyethylene glycol, supercritical fluids and nonionic surfactants to analyze drugs or compounds. The main aim of this article is to explore the patented GSs for chromatographic analysis and forecasting of the GSs that encourage industries to shift from hazardous to GSs.

色谱法中的绿色溶剂（GS）源自绿色化学。因此，在液相色谱分析中使用 GS 分离药物和化学品是减少自然界中有害化学品的一种新兴方法。我们利用 Orbit Intelligence 数据库对有关 GS 作为色谱分析流动相的同行评议专利进行了战略性专利检索。这篇文章报道了许多鼓励使用乙醇、丁醇、酯类、聚乙二醇、超临界流体和非离子表面活性剂等 GSs 分析药物或化合物的方法。本文的主要目的是探讨用于色谱分析的专利 GS，并预测鼓励工业从危险品转向 GS 的 GS。
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引用次数: 0
Patent highlights April-May 2021. 专利亮点2021年4-5月。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-09-06 DOI: 10.4155/ppa-2021-0011
H. Mucke
A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.
与药物和医学研发相关的专利文献中值得注意的最新进展的快照。
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引用次数: 0
Vaccines and treatments for Zika virus infection: patent status, triumphs and challenges. 寨卡病毒感染的疫苗和治疗:专利现状、胜利和挑战。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-09-01 Epub Date: 2021-09-07 DOI: 10.4155/ppa-2021-0014
Sandro G Viveiros Rosa, Wilson C Santos
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引用次数: 1
Treating Dravet syndrome: a patent landscape. 治疗Dravet综合征:专利景观。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-09-01 Epub Date: 2021-09-07 DOI: 10.4155/ppa-2021-0020
Barbara Miziak, Stanislaw J Czuczwar
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引用次数: 0
A nontoxic ionic liquid composition for the delivery of biological macromolecular anions across the skin barrier. 一种无毒离子液体组合物，用于跨越皮肤屏障递送生物大分子阴离子。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-07-01 Epub Date: 2021-08-09 DOI: 10.4155/ppa-2021-0012
Neeraj Kumar, Balraj Saini, Rajwinder Kaur

The development of biocompatible ionic liquids is needed in order to explore their vastly underutilized pharmaceutical potential. US10912834 patent discloses ionic liquids comprising macromolecular biological anions and alkylated cations, which provides enhanced dermal delivery and cell internalization of the large biological anions. The studies of ex vivo permeation through excised pig skin indicated significantly higher skin penetration of percent dose and enhanced drug internalization was achieved using these ionic liquids. Although, the patent advances an infant field of biological macromolecule-based ionic liquids, the evaluation of these claimed ionic liquids relies only on the in vivo cytotoxicity data and ex vivo skin permeation behavior. Exhaustive studies, including dermatokinetic evaluation and long-term animal toxicity experiments, should be performed in order to unravel the potential of the aforementioned ionic liquids.

生物相容性离子液体的开发是开发其未充分利用的医药潜力的必要条件。US10912834专利公开了包含大分子生物阴离子和烷基化阳离子的离子液体，其提供了增强的大生物阴离子的皮肤递送和细胞内化。通过猪皮肤的离体渗透研究表明，使用这些离子液体可以显著提高百分之百剂量的皮肤渗透，并增强药物的内化。虽然，该专利推进了基于生物大分子的离子液体的婴儿领域，但对这些声称的离子液体的评估仅依赖于体内细胞毒性数据和体外皮肤渗透行为。为了揭示上述离子液体的潜力，应该进行详尽的研究，包括皮肤动力学评估和长期动物毒性实验。
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引用次数: 1
Patentability challenges associated with emerging pharmaceutical technologies. 与新兴制药技术相关的可专利性挑战。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-07-01 Epub Date: 2021-07-13 DOI: 10.4155/ppa-2021-0009
Srishti Aggarwal, Amrish Chandra

According to the recent patent filing trends, it has been observed that certain pharmaceutical technologies are more popular than others and are commonly referred to as emerging technologies. The emerging technologies in the pharmaceutical sector include artificial intelligence, big data and certain advanced biological therapies such as personalized medicine and stem cell therapy. These trends have various applications in the medicine and healthcare industry. Since these technologies are relatively new and each of them is very unique in its own way, current patent laws are inadequate to deal with the complex challenges associated with them. A brief analysis of the challenges associated with these emerging technologies and their applications is discussed in this paper.

根据最近的专利申请趋势，已经观察到某些制药技术比其他技术更受欢迎，通常被称为新兴技术。制药领域的新兴技术包括人工智能、大数据和某些先进的生物疗法，如个性化医疗和干细胞疗法。这些趋势在医药和保健行业有各种各样的应用。由于这些技术相对较新，每一项技术都有其独特之处，目前的专利法不足以应对与之相关的复杂挑战。本文简要分析了与这些新兴技术及其应用相关的挑战。
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引用次数: 2
5-HT4R modulators: a patent landscape. 5-HT4R调制器:专利景观。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-07-01 Epub Date: 2021-08-09 DOI: 10.4155/ppa-2021-0017
Patrick Dallemagne, Christophe Rochais
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引用次数: 3
Patents targeting cannabinoid receptor type 2 ligands: an interview with Uwe Grether. 以大麻素受体 2 型配体为目标的专利：采访 Uwe Grether。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-07-01 Epub Date: 2021-08-09 DOI: 10.4155/ppa-2021-0013
Uwe Grether
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引用次数: 0
Patent highlights February-March 2021. 2021 年 2 月至 3 月的专利要点。
IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Pharmaceutical patent analyst
Pub Date : 2021-07-01 Epub Date: 2021-07-07 DOI: 10.4155/ppa-2021-0010
Hermann Am Mucke

A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.

与制药和医疗研发相关的专利文献中值得关注的最新进展快照。
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引用次数: 0
Contemporary approaches to treat Naegleria fowleri: a patent overview. 当代治疗福氏奈格里氏杆菌的方法:专利概述。
IF 1.3 Q3 Pharmacology, Toxicology and Pharmaceutics
Pharmaceutical patent analyst
Pub Date : 2021-05-01 Epub Date: 2021-06-02 DOI: 10.4155/ppa-2020-0023
Ruqaiyyah Siddiqui, Naveed A Khan
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引用次数: 4
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