Physiology & Behavior最新文献_第3页

Women have the power: When motor efficiency makes the difference in older individuals of the sardinian blue zone 女性拥有力量：当运动效率对撒丁岛蓝区老年人产生影响时。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-14 DOI: 10.1016/j.physbeh.2025.114811

Massimiliano Pau , Benedetta Brandas , Maria Chiara Fastame

This study was mainly aimed at exploring the effect of gender on the patterns of Physical Activty (PA) in older people living in an area of exceptional longevity, the so-called Sardinian Blue Zone. Furthermore, the study intended to investigate the nature of the relationships among PA metrics, cognitive measures, and age. One hundred and nine community-dwelling participants (M_age = 81.7 years old, SD = 8.1 years) completed a battery of cognitive tests (i.e., Mini-Mental State Examination and Trail Making Test) and were provided a wearable accelerometer to collect data for 7 consecutive days about amount and intensity of the performed PA on a daily basis. A series of Analyses of Covariance was conducted to examine the impact of gender on PA variables, whereas the global cognitive functioning measure was used as a covariate. Thus, it was found that women outperformed men in terms of a more active lifestyle, as indicated by the significantly reduced sedentary behavior and increased percentage of time spent in PA of moderate to vigorous intensity (MVPA). Moreover, significant associations were found among age, PA, and cognitive measures. Finally, global cognitive functioning was significantly associated with MVPA and overall accelerometric counts, as well as significant relationships were found between time spent in sedentary behavior and MVPA, accelerometric counts, speed of processing, and cognitive flexibility, respectively. Overall, these outcomes suggest that older individuals, especially women, exhibiting more preserved cognitive efficiency also reported superior levels of PA. Therefore, the promotion of a more active lifestyle is essential to achieve better functional and cognitive health in late adulthood.

这项研究的主要目的是探索性别对生活在所谓的撒丁岛蓝区特别长寿地区的老年人的体育活动模式（PA）的影响。此外，本研究旨在探讨PA指标、认知测量和年龄之间关系的本质。109名社区居民参与者（Mage = 81.7岁，SD = 8.1岁）完成了一系列认知测试（即迷你精神状态检查和轨迹测试），并提供了一个可穿戴加速度计，连续7天收集每天执行PA的数量和强度的数据。我们进行了一系列的协方差分析，以检验性别对PA变量的影响，而全球认知功能测量被用作协变量。因此，研究发现，在更积极的生活方式方面，女性的表现优于男性，这一点可以从久坐行为的显著减少和中强度到高强度运动（MVPA）的时间百分比的增加中看出。此外，发现年龄、PA和认知测量之间存在显著关联。最后，整体认知功能与MVPA和整体加速度计计数显著相关，并且发现久坐行为时间与MVPA、加速度计计数、处理速度和认知灵活性之间分别存在显著关系。总的来说，这些结果表明，老年人，尤其是女性，表现出更多的认知效率，也报告了更高水平的PA。因此，促进更积极的生活方式对于在成年后期实现更好的功能和认知健康至关重要。

{"title":"Women have the power: When motor efficiency makes the difference in older individuals of the sardinian blue zone","authors":"Massimiliano Pau , Benedetta Brandas , Maria Chiara Fastame","doi":"10.1016/j.physbeh.2025.114811","DOIUrl":"10.1016/j.physbeh.2025.114811","url":null,"abstract":"<div><div>This study was mainly aimed at exploring the effect of gender on the patterns of Physical Activty (PA) in older people living in an area of exceptional longevity, the so-called Sardinian Blue Zone. Furthermore, the study intended to investigate the nature of the relationships among PA metrics, cognitive measures, and age. One hundred and nine community-dwelling participants (M<sub>age</sub> = 81.7 years old, SD = 8.1 years) completed a battery of cognitive tests (i.e., Mini-Mental State Examination and Trail Making Test) and were provided a wearable accelerometer to collect data for 7 consecutive days about amount and intensity of the performed PA on a daily basis. A series of Analyses of Covariance was conducted to examine the impact of gender on PA variables, whereas the global cognitive functioning measure was used as a covariate. Thus, it was found that women outperformed men in terms of a more active lifestyle, as indicated by the significantly reduced sedentary behavior and increased percentage of time spent in PA of moderate to vigorous intensity (MVPA). Moreover, significant associations were found among age, PA, and cognitive measures. Finally, global cognitive functioning was significantly associated with MVPA and overall accelerometric counts, as well as significant relationships were found between time spent in sedentary behavior and MVPA, accelerometric counts, speed of processing, and cognitive flexibility, respectively. Overall, these outcomes suggest that older individuals, especially women, exhibiting more preserved cognitive efficiency also reported superior levels of PA. Therefore, the promotion of a more active lifestyle is essential to achieve better functional and cognitive health in late adulthood.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114811"},"PeriodicalIF":2.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal changes in psychological, physiological, and nutritional measures and predictors of success in Special Forces training 心理、生理和营养方面的纵向变化以及特种部队训练成功的预测因素。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-13 DOI: 10.1016/j.physbeh.2024.114790

Emily K. Farina , Jesse A. Stein , Lauren A. Thompson , Joseph J. Knapik , Stefan M. Pasiakos , James P. McClung , Harris R. Lieberman

The mentally and physically challenging 19–20 day, multi-stressor US Army Special Forces Assessment and Selection (SFAS) course selects soldiers for Army Special Forces (SF) training. If selected, candidates enroll for advanced training in the 2-year Special Forces Qualification Course (SFQC) to qualify for the SF. This longitudinal study examined physiological, psychological, and nutritional status of soldiers before (pre-SFAS) and after SFAS (post-SFAS), and post-SFQC, to identify predictors of graduation from SFQC. Fasting blood was collected from candidates (n =192) and assayed for physiological and nutritional biomarkers at all three times. Self-reported resilience and body composition assessed with skin-folds were assessed at all three time points. Self-reported Grit and diet quality assessed with food frequency questionnaire were assessed at pre-SFAS and post-SFAS. Physical performance was assessed by SFAS staff. Changes over time and predictors of SFQC graduation were assessed with linear mixed models and logistic regression. The three weeks of SFAS reduced fat mass and fat-free mass, and increased HPA-axis, inflammatory, and appetite markers. Post-SFQC neuropeptide-Y concentrations, fat mass, fat-free mass, diet quality, and resilience fell below pre-SFAS values. Testosterone, DHEA-S, brain-derived neurotropic factor, IL-6 and prolactin were elevated after SFQC. Odds of graduating SFQC increased when cortisol increased during SFAS. Reduced body mass, fat mass, and BMI at SFAS and higher physical performance during SFAS also increased odds of graduating SFQC. This study documented changes occurring over approximately 2-years of SF training. In addition, it identified physical performance, body composition, and biochemical predictors of success at U.S. Army Special Forces training.

在为期19-20天的精神和身体挑战中，美国陆军特种部队评估和选拔（SFAS）课程为陆军特种部队（SF）训练挑选士兵。如果被选中，候选人将参加为期两年的特种部队资格课程（SFQC）的高级培训，以获得特种部队的资格。本纵向研究考察了士兵在SFAS前、SFAS后和SFQC后的生理、心理和营养状况，以确定SFQC毕业的预测因素。从候选人（n =192）中采集空腹血，并在所有三次中检测生理和营养生物标志物。在所有三个时间点评估自我报告的恢复力和皮肤皱褶评估的身体成分。在sfas前和sfas后分别用食物频率问卷对自述砂砾和饮食质量进行评估。体能表现由SFAS工作人员评估。通过线性混合模型和逻辑回归评估SFQC毕业随时间的变化和预测因素。三周的SFAS减少了脂肪量和无脂肪量，增加了hpa轴、炎症和食欲指标。sfqc后的神经肽- y浓度、脂肪质量、无脂肪质量、饮食质量和恢复力都低于sfas前的值。SFQC后睾酮、DHEA-S、脑源性神经营养因子、IL-6、催乳素均升高。当SFAS期间皮质醇升高时，SFQC毕业的几率增加。SFAS期间降低的体重、脂肪量和BMI以及更高的身体表现也增加了SFQC毕业的几率。这项研究记录了大约2年的SF训练中发生的变化。此外，它还确定了美国陆军特种部队训练成功的物理性能、身体成分和生化预测指标。

{"title":"Longitudinal changes in psychological, physiological, and nutritional measures and predictors of success in Special Forces training","authors":"Emily K. Farina , Jesse A. Stein , Lauren A. Thompson , Joseph J. Knapik , Stefan M. Pasiakos , James P. McClung , Harris R. Lieberman","doi":"10.1016/j.physbeh.2024.114790","DOIUrl":"10.1016/j.physbeh.2024.114790","url":null,"abstract":"<div><div>The mentally and physically challenging 19–20 day, multi-stressor US Army Special Forces Assessment and Selection (SFAS) course selects soldiers for Army Special Forces (SF) training. If selected, candidates enroll for advanced training in the 2-year Special Forces Qualification Course (SFQC) to qualify for the SF. This longitudinal study examined physiological, psychological, and nutritional status of soldiers before (pre-SFAS) and after SFAS (post-SFAS), and post-SFQC, to identify predictors of graduation from SFQC. Fasting blood was collected from candidates (n =192) and assayed for physiological and nutritional biomarkers at all three times. Self-reported resilience and body composition assessed with skin-folds were assessed at all three time points. Self-reported Grit and diet quality assessed with food frequency questionnaire were assessed at pre-SFAS and post-SFAS. Physical performance was assessed by SFAS staff. Changes over time and predictors of SFQC graduation were assessed with linear mixed models and logistic regression. The three weeks of SFAS reduced fat mass and fat-free mass, and increased HPA-axis, inflammatory, and appetite markers. Post-SFQC neuropeptide-Y concentrations, fat mass, fat-free mass, diet quality, and resilience fell below pre-SFAS values. Testosterone, DHEA-S, brain-derived neurotropic factor, IL-6 and prolactin were elevated after SFQC. Odds of graduating SFQC increased when cortisol increased during SFAS. Reduced body mass, fat mass, and BMI at SFAS and higher physical performance during SFAS also increased odds of graduating SFQC. This study documented changes occurring over approximately 2-years of SF training. In addition, it identified physical performance, body composition, and biochemical predictors of success at U.S. Army Special Forces training.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114790"},"PeriodicalIF":2.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acupuncture relieves postoperative pain of mixed hemorrhoids through the P2X7/ERK axis in dorsal root ganglion 针刺通过背根神经节P2X7/ERK轴缓解混合痔术后疼痛。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-13 DOI: 10.1016/j.physbeh.2025.114806

Bin Chen , Tian Wang , Jie Gao , Yan Chen , Haijing Chang , Yi Shu , Yaling Zhang , Jiahuan Li , Weiqun Weng

Haemorrhoids are a common anorectal disease primarily treated through surgery, often leading to complications such as pain. The efficacy of acupuncture in relieving postoperative pain in mixed haemorrhoids has not been well-documented. This study included 90 patients undergoing haemorrhoid surgery and their Visual Analogue Score (VAS), inflammatory factor levels, Hamilton Depression Rating Scale (HAMD), and analgesic drug use were accessed. A rat incisional pain model was also constructed to monitor behavioral responses, with assessments including Sucrose Preference Test (SPT) and Open Field Test (OFT). The levels of ATP and proinflammatory cytokines in the dorsal root ganglion (DRG) were measured using luciferase assay and ELISA. We also examined P2×7 and ERK1/2 levels in DRG tissues of anal incisional pain rat model. In a Chronic Constriction Injury (CCI) rat model treated with BzATP, a potent agonist for P2×7 receptors, followed by acupuncture for 15 days, postoperative pain and behavioral responses were observed and assessed, alongside mechanistic studies of ATP and inflammatory factors in DRG tissues. Patients receiving acupuncture had significantly lower VAS scores, reduced levels of inflammatory factors, improved depression scores, and decreased analgesic drug use. In the animal model, acupuncture increased pain thresholds, improved behavioral responses, reduced ATP content and inflammatory factors, and modulated the P2×7/ERK axis. In the CCI model, BzATP increased P2×7 and ERK1/2 levels, pain sensitivity, and anxiety, which were mitigated by acupuncture. Our data suggest that acupuncture significantly alleviates postoperative pain following haemorrhoid surgery and modulates the pain response through the P2×7/ERK axis.

痔疮是一种常见的肛肠疾病，主要通过手术治疗，经常导致并发症，如疼痛。针刺在缓解混合性痔疮术后疼痛方面的疗效尚未得到充分证实。本研究包括90例痔疮手术患者的视觉模拟评分（VAS）、炎症因子水平、汉密尔顿抑郁评定量表（HAMD）和镇痛药物使用情况。建立大鼠切口疼痛模型，通过蔗糖偏好测试（SPT）和开放场测试（OFT）评估大鼠的行为反应。采用荧光素酶法和酶联免疫吸附法检测大鼠背根神经节（DRG） ATP和促炎细胞因子水平。我们还检测了肛门切口痛模型大鼠DRG组织中P2X7和ERK1/2的水平。在慢性收缩损伤（CCI）大鼠模型中，用P2X7受体的强效激动剂BzATP治疗，然后针灸15天，观察和评估术后疼痛和行为反应，同时研究ATP和炎症因子在DRG组织中的机制。接受针灸治疗的患者VAS评分明显降低，炎症因子水平降低，抑郁评分改善，镇痛药物使用减少。在动物模型中，针灸增加了疼痛阈值，改善了行为反应，降低了ATP含量和炎症因子，并调节了P2X7/ERK轴。在CCI模型中，BzATP增加P2X7和ERK1/2水平、疼痛敏感性和焦虑，针刺可减轻这些水平。我们的数据表明，针灸可以显著缓解痔疮手术后的疼痛，并通过P2X7/ERK轴调节疼痛反应。

{"title":"Acupuncture relieves postoperative pain of mixed hemorrhoids through the P2X7/ERK axis in dorsal root ganglion","authors":"Bin Chen , Tian Wang , Jie Gao , Yan Chen , Haijing Chang , Yi Shu , Yaling Zhang , Jiahuan Li , Weiqun Weng","doi":"10.1016/j.physbeh.2025.114806","DOIUrl":"10.1016/j.physbeh.2025.114806","url":null,"abstract":"<div><div>Haemorrhoids are a common anorectal disease primarily treated through surgery, often leading to complications such as pain. The efficacy of acupuncture in relieving postoperative pain in mixed haemorrhoids has not been well-documented. This study included 90 patients undergoing haemorrhoid surgery and their Visual Analogue Score (VAS), inflammatory factor levels, Hamilton Depression Rating Scale (HAMD), and analgesic drug use were accessed. A rat incisional pain model was also constructed to monitor behavioral responses, with assessments including Sucrose Preference Test (SPT) and Open Field Test (OFT). The levels of ATP and proinflammatory cytokines in the dorsal root ganglion (DRG) were measured using luciferase assay and ELISA. We also examined P2×7 and ERK1/2 levels in DRG tissues of anal incisional pain rat model. In a Chronic Constriction Injury (CCI) rat model treated with BzATP, a potent agonist for P2×7 receptors, followed by acupuncture for 15 days, postoperative pain and behavioral responses were observed and assessed, alongside mechanistic studies of ATP and inflammatory factors in DRG tissues. Patients receiving acupuncture had significantly lower VAS scores, reduced levels of inflammatory factors, improved depression scores, and decreased analgesic drug use. In the animal model, acupuncture increased pain thresholds, improved behavioral responses, reduced ATP content and inflammatory factors, and modulated the P2×7/ERK axis. In the CCI model, BzATP increased P2×7 and ERK1/2 levels, pain sensitivity, and anxiety, which were mitigated by acupuncture. Our data suggest that acupuncture significantly alleviates postoperative pain following haemorrhoid surgery and modulates the pain response through the P2×7/ERK axis.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114806"},"PeriodicalIF":2.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in motivation to take sucrose following abstinence and environmental enrichment in Long-Evans rats Long-Evans大鼠戒糖和环境富集后服用蔗糖动机的性别差异。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-10 DOI: 10.1016/j.physbeh.2025.114810

Jeffrey W. Grimm, Frances Sauter, Derek MacDougall, Emily Spaulding, Sarah Giadone, Kyra Stensgaard, Mason Hardy

There are clinically significant sex differences in addiction behaviors. We have previously reported robust sex differences in motivation to consume sucrose in adult Long-Evans rats. In the present study, motivation to consume 10 % sucrose was assessed with lever press responding (0.4 mL per reinforcement) on a progressive ratio (PR) schedule during daily 3-h sessions for 1 week following either overnight (acute) or 1 month (chronic) environmental enrichment (EE). Acute EE was provided immediately after initial training or after 29 days of abstinence. Males and females were segregated by sex throughout the study. Females responded to higher breakpoints during training and post-EE testing. In both sexes, there was an abstinence-dependent increase (incubation) of PR responding for sucrose in control subjects tested after 1 month vs. 1 day of abstinence. Both acute and chronic EE decreased subsequent breakpoints, but the persistence of the effect differed by sex and length of abstinence. For testing following 1 day of abstinence from sucrose, acute EE with males resulted in decreased breakpoints persisting 3 days. EE-induced reductions in breakpoints for females were not statistically significant. For testing starting after 29 days of abstinence from sucrose, acute EE with males resulted in decreased breakpoints persisting 3 days. Chronic EE with males decreased their breakpoints for 3 days but had no effect on responding by females. EE-induced reductions in breakpoints for females were not statistically significant. Sucrose consumption relative to body weight was reduced by EE for males similar to decreases in breakpoints. For females, acute (both early and late abstinence) and chronic EE also reduced sucrose consumption, but only on the first day of testing. These results replicate our previous findings of greater motivation to consume sucrose by females, demonstrate an incubation of PR responding for both sexes, and an overall more persistent anti-sucrose taking effect of EE with males.

在临床上，成瘾行为存在显著的性别差异。我们以前曾报道过成年龙-埃文斯大鼠在消耗蔗糖的动机上存在明显的性别差异。在本研究中，在连续1周的夜间（急性）或1个月（慢性）环境富集（EE）后，以渐进比率（PR）计划每天3小时的杠杆按压反应（每次强化0.4 mL）来评估消耗10%蔗糖的动机。急性情感表达是在初始训练后立即提供的，或在禁欲29天后提供的。在整个研究过程中，男性和女性按性别分开。女性在训练和情感表达后测试中有更高的断点。在两性中，对照受试者在禁欲1个月后与禁欲1天相比，对蔗糖的PR反应有戒断依赖性增加（潜伏期）。急性和慢性情感表达都降低了随后的断点，但效果的持久性因性别和禁欲时间长短而异。在禁食蔗糖1天后的测试中，男性急性EE导致断点下降持续3天。电子电气诱导的女性断点降低在统计学上不显著。在禁食29天后开始的测试中，男性急性EE导致断点下降持续3天。男性的慢性情感表达在3天内降低了他们的断点，但对女性的反应没有影响。电子电气诱导的女性断点降低在统计学上不显著。相对于体重的蔗糖消耗量被EE降低了，这与断点的降低相似。对于女性，急性（早期和晚期禁欲）和慢性EE也减少了蔗糖的消耗，但仅在测试的第一天。这些结果重复了我们之前的研究结果，即雌性更有动力消耗蔗糖，证明了两性都有PR反应的潜伏期，以及雄性EE总体上更持久的抗蔗糖作用。

{"title":"Sex differences in motivation to take sucrose following abstinence and environmental enrichment in Long-Evans rats","authors":"Jeffrey W. Grimm, Frances Sauter, Derek MacDougall, Emily Spaulding, Sarah Giadone, Kyra Stensgaard, Mason Hardy","doi":"10.1016/j.physbeh.2025.114810","DOIUrl":"10.1016/j.physbeh.2025.114810","url":null,"abstract":"<div><div>There are clinically significant sex differences in addiction behaviors. We have previously reported robust sex differences in motivation to consume sucrose in adult Long-Evans rats. In the present study, motivation to consume 10 % sucrose was assessed with lever press responding (0.4 mL per reinforcement) on a progressive ratio (PR) schedule during daily 3-h sessions for 1 week following either overnight (acute) or 1 month (chronic) environmental enrichment (EE). Acute EE was provided immediately after initial training or after 29 days of abstinence. Males and females were segregated by sex throughout the study. Females responded to higher breakpoints during training and post-EE testing. In both sexes, there was an abstinence-dependent increase (incubation) of PR responding for sucrose in control subjects tested after 1 month vs. 1 day of abstinence. Both acute and chronic EE decreased subsequent breakpoints, but the persistence of the effect differed by sex and length of abstinence. For testing following 1 day of abstinence from sucrose, acute EE with males resulted in decreased breakpoints persisting 3 days. EE-induced reductions in breakpoints for females were not statistically significant. For testing starting after 29 days of abstinence from sucrose, acute EE with males resulted in decreased breakpoints persisting 3 days. Chronic EE with males decreased their breakpoints for 3 days but had no effect on responding by females. EE-induced reductions in breakpoints for females were not statistically significant. Sucrose consumption relative to body weight was reduced by EE for males similar to decreases in breakpoints. For females, acute (both early and late abstinence) and chronic EE also reduced sucrose consumption, but only on the first day of testing. These results replicate our previous findings of greater motivation to consume sucrose by females, demonstrate an incubation of PR responding for both sexes, and an overall more persistent anti-sucrose taking effect of EE with males.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114810"},"PeriodicalIF":2.4,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nicotine dependence comorbid with depressive symptoms may limit immediate cognitive improvement following exercise 尼古丁依赖伴抑郁症状可能限制运动后认知能力的即刻改善。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-08 DOI: 10.1016/j.physbeh.2025.114809

Teri Kim , Jinwoo Han , Sechang Kwon

This study investigated how acute bouts of aerobic exercise versus yoga affect inhibitory control differently in smokers with nicotine dependence depending on the presence of depressive symptoms. Thirty adult smokers were equally divided into a depressed smoker group and a non-depressed smoker group based on their Beck Depression Inventory scores. Each participant underwent baseline measurements, a 30 min aerobic exercise session, and a 30 min yoga session on different days. Brainwaves were recorded at baseline and after exercise during the Go/No-Go task. Performance accuracy, response time, and event-related potential (ERP) N2 and P3 amplitudes and latencies were analyzed. The major findings showed that the non-depressed smoker group exhibited higher accuracy than the depressed smoker group after yoga, and the non-depressed smoker group's response time improved after aerobic exercise compared with baseline. The ERP analyses revealed that the depressed smoker group exhibited smaller N2 and P3 amplitudes and shorter P3 latencies than the non-depressed smoker group. The behavioral and electrophysiological data highlight a possible cognitive deficit among smokers with depressive symptoms due to comorbid depression and addiction. Aerobic exercise elicited a larger P3 amplitude than yoga, suggesting the importance of physical intensity in promoting the active engagement of neural networks associated with inhibitory control processes. These findings suggest that expecting cognitive enhancement through acute exercise in smokers with comorbid depression may be more challenging than that in general smokers.

这项研究调查了急性有氧运动与瑜伽对尼古丁依赖吸烟者的抑制性控制的影响，这取决于抑郁症状的存在。根据他们的贝克抑郁量表得分，将30名成年吸烟者平均分为抑郁吸烟者组和非抑郁吸烟者组。每位参与者在不同的日子进行了基线测量、30分钟的有氧运动和30分钟的瑜伽练习。在进行Go/No-Go任务时，在基线和运动后记录脑电波。分析表现准确性、反应时间、事件相关电位（ERP） N2和P3振幅和潜伏期。主要研究结果显示，非抑郁吸烟者组在瑜伽后的反应准确率高于抑郁吸烟者组，而非抑郁吸烟者组在有氧运动后的反应时间比基线有所提高。ERP分析显示，与非抑郁吸烟者组相比，抑郁吸烟者组表现出更大的N2和P3波幅和更短的P3潜伏期。行为学和电生理数据强调了伴有抑郁症状的吸烟者由于抑郁和成瘾的共病而可能存在认知缺陷。有氧运动比瑜伽引起更大的P3振幅，这表明体力强度在促进与抑制控制过程相关的神经网络的积极参与方面的重要性。这些研究结果表明，期望通过急性运动增强患有合并抑郁症的吸烟者的认知能力可能比普通吸烟者更具挑战性。

{"title":"Nicotine dependence comorbid with depressive symptoms may limit immediate cognitive improvement following exercise","authors":"Teri Kim , Jinwoo Han , Sechang Kwon","doi":"10.1016/j.physbeh.2025.114809","DOIUrl":"10.1016/j.physbeh.2025.114809","url":null,"abstract":"<div><div>This study investigated how acute bouts of aerobic exercise versus yoga affect inhibitory control differently in smokers with nicotine dependence depending on the presence of depressive symptoms. Thirty adult smokers were equally divided into a depressed smoker group and a non-depressed smoker group based on their Beck Depression Inventory scores. Each participant underwent baseline measurements, a 30 min aerobic exercise session, and a 30 min yoga session on different days. Brainwaves were recorded at baseline and after exercise during the Go/No-Go task. Performance accuracy, response time, and event-related potential (ERP) N2 and P3 amplitudes and latencies were analyzed. The major findings showed that the non-depressed smoker group exhibited higher accuracy than the depressed smoker group after yoga, and the non-depressed smoker group's response time improved after aerobic exercise compared with baseline. The ERP analyses revealed that the depressed smoker group exhibited smaller N2 and P3 amplitudes and shorter P3 latencies than the non-depressed smoker group. The behavioral and electrophysiological data highlight a possible cognitive deficit among smokers with depressive symptoms due to comorbid depression and addiction. Aerobic exercise elicited a larger P3 amplitude than yoga, suggesting the importance of physical intensity in promoting the active engagement of neural networks associated with inhibitory control processes. These findings suggest that expecting cognitive enhancement through acute exercise in smokers with comorbid depression may be more challenging than that in general smokers.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114809"},"PeriodicalIF":2.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of CTRP14/C1QL1 in motor coordination and learning across the lifespan CTRP14/C1QL1在运动协调和学习中的作用。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-04 DOI: 10.1016/j.physbeh.2025.114799

Fangluo Chen , Muzna Saqib , Chantelle E. Terrillion , Chloe Miranda , Dylan C. Sarver , Joseph Scafidi , G.William Wong

C1q/TNF-related protein 14 (CTRP14), also known as C1q-like 1 (C1QL1), is a synaptic protein predominantly expressed in the brain. It plays a critical role in the formation and maintenance of the climbing fiber-Purkinje cell synapses, ensuring that only one single winning climbing fiber from the inferior olivary neuron synapses with the proximal dendrites of Purkinje cells during the early postnatal period. Loss of CTRP14/C1QL1 results in incomplete elimination of supernumerary climbing fibers, leading to multiple persistent climbing fibers synapsing with the Purkinje cells. While this deficit impairs oculomotor learning in adult mice, the impact of CTRP14 deficiency on motor function throughout adulthood has not been examined. Here, we conduct behavioral tests on a constitutive Ctrp14 knockout (KO) mouse model to determine whether CTRP14 is required for motor learning and function in mice across the lifespan. We show that CTRP14 deficiency does not affect grip strength, nor sprint and endurance running, in young and old mice of either sex. We performed accelerated rotarod tests on mice at 6, 12, and 18 months old to assess motor coordination and learning. No significant differences were observed between WT and Ctrp14-KO mice of either sex across the lifespan. Lastly, we performed complex running wheel tests to detect latent motor deficits and found that aged Ctrp14-KO mice have intact motor skills. Despite some limitations of the study, our data suggest that CTRP14 is dispensable for gross motor skills, coordination, and learning throughout adulthood based on the specific tests performed.

C1q/ tnf相关蛋白14 (CTRP14)，也称为C1q样1 (C1QL1)，是一种主要在大脑中表达的突触蛋白。它在攀爬纤维-浦肯野细胞突触的形成和维持中起着至关重要的作用，确保在出生后早期浦肯野细胞近端树突的下橄榄神经元突触中只有一条攀爬纤维获胜。CTRP14/C1QL1的缺失导致多余的攀爬纤维不完全消除，导致多个持久的攀爬纤维与浦肯野细胞突触。虽然这种缺陷损害了成年小鼠的动眼肌学习，但尚未研究CTRP14缺陷对整个成年期运动功能的影响。在这里，我们对组成型Ctrp14敲除（KO）小鼠模型进行了行为测试，以确定Ctrp14在小鼠的整个生命周期中是否需要运动学习和功能。我们发现CTRP14缺乏不影响握力，也不影响短跑和耐力跑，无论是年轻的还是年老的雌雄老鼠。我们对6个月、12个月和18个月大的小鼠进行了加速旋转测试，以评估运动协调和学习能力。无论性别，WT和Ctrp14-KO小鼠在整个寿命期间均未观察到显著差异。最后，我们进行了复杂的跑步轮试验来检测潜在的运动缺陷，发现年老的Ctrp14-KO小鼠具有完整的运动技能。尽管该研究存在一些局限性，但我们的数据表明，基于所进行的具体测试，CTRP14对整个成年期的大肌肉运动技能、协调和学习是不可或缺的。

{"title":"Role of CTRP14/C1QL1 in motor coordination and learning across the lifespan","authors":"Fangluo Chen , Muzna Saqib , Chantelle E. Terrillion , Chloe Miranda , Dylan C. Sarver , Joseph Scafidi , G.William Wong","doi":"10.1016/j.physbeh.2025.114799","DOIUrl":"10.1016/j.physbeh.2025.114799","url":null,"abstract":"<div><div>C1q/TNF-related protein 14 (CTRP14), also known as C1q-like 1 (C1QL1), is a synaptic protein predominantly expressed in the brain. It plays a critical role in the formation and maintenance of the climbing fiber-Purkinje cell synapses, ensuring that only one single winning climbing fiber from the inferior olivary neuron synapses with the proximal dendrites of Purkinje cells during the early postnatal period. Loss of CTRP14/C1QL1 results in incomplete elimination of supernumerary climbing fibers, leading to multiple persistent climbing fibers synapsing with the Purkinje cells. While this deficit impairs oculomotor learning in adult mice, the impact of CTRP14 deficiency on motor function throughout adulthood has not been examined. Here, we conduct behavioral tests on a constitutive <em>Ctrp14</em> knockout (KO) mouse model to determine whether CTRP14 is required for motor learning and function in mice across the lifespan. We show that CTRP14 deficiency does not affect grip strength, nor sprint and endurance running, in young and old mice of either sex. We performed accelerated rotarod tests on mice at 6, 12, and 18 months old to assess motor coordination and learning. No significant differences were observed between WT and <em>Ctrp14</em>-KO mice of either sex across the lifespan. Lastly, we performed complex running wheel tests to detect latent motor deficits and found that aged <em>Ctrp14</em>-KO mice have intact motor skills. Despite some limitations of the study, our data suggest that CTRP14 is dispensable for gross motor skills, coordination, and learning throughout adulthood based on the specific tests performed.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114799"},"PeriodicalIF":2.4,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating how eating behavior shapes mental health: A cross-sectional study 调查饮食行为如何影响心理健康：一项横断面研究。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2025-01-02 DOI: 10.1016/j.physbeh.2024.114798

Öykü Peren Türk , Özgür Tosun , Selçuk Dağdelen , Zehra Buyuktuncer

This study aimed to examine the relationship between eating behavior, nutritional status and mental health. It is a cross-sectional study conducted on a sample of 360 healthy individuals aged 19–64 years. The General Health Questionnaire (GHQ-12) was used to evaluate mental health and the Three-Factor Eating Scale (TFEQ-R21) was used to assess eating behavior. The Healthy Eating Index-2015 (HEI-2015) score was calculated from participants' 24 h food recalls as an indicator of diet quality. The mean age of the participants was 26.0 ± 8.40 years, and 50.6 % were female. Multivariate logistic regression model was performed. A statistically significant relationship was found between the participants' GHQ-12 score and both their emotional eating and uncontrolled eating scores (p < 0.001 for each). It was determined that individuals who had high levels of emotional eating and uncontrolled eating behaviors, along with higher dietary protein and lipid intake, and lower intake of long-chain fatty acids, were at a higher risk of mental health deterioration, according to the established model (R2 = 0.214). Dietary energy and nutrient intakes such as niacin, vitamin B12, folic acid, phosphorus, iron, sodium and carotene, as well as diet quality and BMI were not associated with mental health according to the model in this study. Eating behavior is associated with mental well-being, and nutritional status may be one of the underlying factors contributing to this association.

本研究旨在探讨饮食行为、营养状况和心理健康之间的关系。这是一项对360名年龄在19-64岁之间的健康个体进行的横断面研究。心理健康评估采用一般健康问卷（GHQ-12），饮食行为评估采用三因素进食量表（TFEQ-R21）。健康饮食指数-2015 （HEI-2015）得分是根据参与者24小时食品召回作为饮食质量指标计算的。参与者的平均年龄为26.0±8.40岁，女性占50.6%。采用多元logistic回归模型。研究发现，受试者的GHQ-12得分与情绪性进食和不受控制的进食得分之间存在显著的统计学关系（p < 0.001）。根据建立的模型（R2 = 0.214），确定具有高水平情绪化饮食和不受控制的饮食行为的个体，以及较高的饮食蛋白质和脂肪摄入量，以及较低的长链脂肪酸摄入量，心理健康恶化的风险更高。根据本研究的模型，膳食能量和营养摄入，如烟酸、维生素B12、叶酸、磷、铁、钠和胡萝卜素，以及饮食质量和BMI与心理健康无关。饮食行为与心理健康有关，营养状况可能是促成这种联系的潜在因素之一。

{"title":"Investigating how eating behavior shapes mental health: A cross-sectional study","authors":"Öykü Peren Türk , Özgür Tosun , Selçuk Dağdelen , Zehra Buyuktuncer","doi":"10.1016/j.physbeh.2024.114798","DOIUrl":"10.1016/j.physbeh.2024.114798","url":null,"abstract":"<div><div>This study aimed to examine the relationship between eating behavior, nutritional status and mental health. It is a cross-sectional study conducted on a sample of 360 healthy individuals aged 19–64 years. The General Health Questionnaire (GHQ-12) was used to evaluate mental health and the Three-Factor Eating Scale (TFEQ-R21) was used to assess eating behavior. The Healthy Eating Index-2015 (HEI-2015) score was calculated from participants' 24 h food recalls as an indicator of diet quality. The mean age of the participants was 26.0 ± 8.40 years, and 50.6 % were female. Multivariate logistic regression model was performed. A statistically significant relationship was found between the participants' GHQ-12 score and both their emotional eating and uncontrolled eating scores (<em>p</em> < 0.001 for each). It was determined that individuals who had high levels of emotional eating and uncontrolled eating behaviors, along with higher dietary protein and lipid intake, and lower intake of long-chain fatty acids, were at a higher risk of mental health deterioration, according to the established model (R2 = 0.214). Dietary energy and nutrient intakes such as niacin, vitamin B12, folic acid, phosphorus, iron, sodium and carotene, as well as diet quality and BMI were not associated with mental health according to the model in this study. Eating behavior is associated with mental well-being, and nutritional status may be one of the underlying factors contributing to this association.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114798"},"PeriodicalIF":2.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of high-intensity interval training on insulin resistance, oxidative stress, and muscle function in a PCOS rat model 高强度间歇训练对多囊卵巢综合征大鼠模型胰岛素抵抗、氧化应激和肌肉功能的影响

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2024-12-31 DOI: 10.1016/j.physbeh.2024.114794

Seda Koçak , Hasan Çalışkan , Göktuğ Ömercioğlu , Fırat Akat , Deniz Billur , İrem İnanç , Hakan Fıçıcılar , Metin Baştuğ

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders . This study aimed to investigate the effects of high-intensity interval training (HIIT) on insulin resistance, oxidative stress, soleus muscle function, and myokine levels in a PCOS rat model. Female rats were assigned to four groups: Control, PCOS, PCOS+Exercise, and Exercise (n=15 each). PCOS was induced by subcutaneous administration of dehydroepiandrosterone (DHEA) for 3 weeks, and exercise groups underwent HIIT for 12 weeks. Insulin resistance (HOMA-IR), serum oxidative stress markers, hormone levels (FSH, LH), soleus myokine expression, and muscle function were analyzed. Results showed that the PCOS group exhibited increased blood pressure and insulin resistance compared to controls, with a significant reduction in FSH and LH levels in the PCOS+Exercise group. Exercise improved insulin sensitivity and reduced insulin resistance in the PCOS+Exercise group. Serum oxidative stress markers did not differ significantly between groups. Soleus muscle IL-6 levels were significantly reduced in the PCOS+Exercise group. Histological analysis revealed a larger cross-sectional area of the soleus muscle in the PCOS+Exercise group compared to the PCOS group, suggesting improved muscle morphology. Furthermore, exercise improved the functional capacity of soleus muscles, as evidenced by weightlifting performance. These findings indicate that HIIT has beneficial effects on insulin resistance, reproductive hormone levels in PCOS. Exercise also shows potential in slowing oocyte loss and improving follicle health, highlighting its role as a therapeutic intervention for reproductive health in PCOS. This study suggests that HIIT could be a beneficial approach for managing PCOS, and further research is needed to better understand its underlying mechanisms and potential long-term benefits.

多囊卵巢综合征（PCOS）是最常见的内分泌代谢疾病之一。本研究旨在探讨高强度间歇训练（HIIT）对PCOS大鼠模型胰岛素抵抗、氧化应激、比目鱼肌功能和肌因子水平的影响。雌性大鼠分为对照组、PCOS组、PCOS+运动组和运动组，每组15只。皮下注射脱氢表雄酮（DHEA）诱导PCOS 3周，运动组进行HIIT 12周。分析胰岛素抵抗（HOMA-IR）、血清氧化应激标志物、激素水平（FSH、LH）、比目鱼肌因子表达和肌肉功能。结果显示，与对照组相比，PCOS组表现出血压和胰岛素抵抗升高，PCOS+运动组FSH和LH水平显著降低。运动改善了多囊卵巢综合征+运动组的胰岛素敏感性，降低了胰岛素抵抗。血清氧化应激指标各组间无显著差异。PCOS+运动组比目鱼肌IL-6水平显著降低。组织学分析显示，与PCOS组相比，PCOS+运动组比目鱼肌的横截面积更大，表明肌肉形态得到改善。此外，锻炼提高了比目鱼肌的功能能力，举重成绩证明了这一点。这些发现表明HIIT对多囊卵巢综合征患者的胰岛素抵抗和生殖激素水平有有益的影响。运动还显示出减缓卵母细胞损失和改善卵泡健康的潜力，突出了其作为多囊卵巢综合征生殖健康治疗干预的作用。本研究表明HIIT可能是治疗PCOS的有益方法，需要进一步研究以更好地了解其潜在机制和潜在的长期益处。

{"title":"The impact of high-intensity interval training on insulin resistance, oxidative stress, and muscle function in a PCOS rat model","authors":"Seda Koçak , Hasan Çalışkan , Göktuğ Ömercioğlu , Fırat Akat , Deniz Billur , İrem İnanç , Hakan Fıçıcılar , Metin Baştuğ","doi":"10.1016/j.physbeh.2024.114794","DOIUrl":"10.1016/j.physbeh.2024.114794","url":null,"abstract":"<div><div>Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders . This study aimed to investigate the effects of high-intensity interval training (HIIT) on insulin resistance, oxidative stress, soleus muscle function, and myokine levels in a PCOS rat model. Female rats were assigned to four groups: Control, PCOS, PCOS+Exercise, and Exercise (<em>n</em>=15 each). PCOS was induced by subcutaneous administration of dehydroepiandrosterone (DHEA) for 3 weeks, and exercise groups underwent HIIT for 12 weeks. Insulin resistance (HOMA-IR), serum oxidative stress markers, hormone levels (FSH, LH), soleus myokine expression, and muscle function were analyzed. Results showed that the PCOS group exhibited increased blood pressure and insulin resistance compared to controls, with a significant reduction in FSH and LH levels in the PCOS+Exercise group. Exercise improved insulin sensitivity and reduced insulin resistance in the PCOS+Exercise group. Serum oxidative stress markers did not differ significantly between groups. Soleus muscle IL-6 levels were significantly reduced in the PCOS+Exercise group. Histological analysis revealed a larger cross-sectional area of the soleus muscle in the PCOS+Exercise group compared to the PCOS group, suggesting improved muscle morphology. Furthermore, exercise improved the functional capacity of soleus muscles, as evidenced by weightlifting performance. These findings indicate that HIIT has beneficial effects on insulin resistance, reproductive hormone levels in PCOS. Exercise also shows potential in slowing oocyte loss and improving follicle health, highlighting its role as a therapeutic intervention for reproductive health in PCOS. This study suggests that HIIT could be a beneficial approach for managing PCOS, and further research is needed to better understand its underlying mechanisms and potential long-term benefits.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114794"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression and loneliness in a volunteer sample of adults at a suicide prevention and fund-raising walk: A feasibility study 预防自杀和筹款步行中成人志愿者的抑郁和孤独：可行性研究：预防自杀步行中的抑郁和孤独。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2024-12-27 DOI: 10.1016/j.physbeh.2024.114797

Carol A. Janney , Jonathon Im , Sabrina Ma , Kathy Dollard

Background

Loneliness is recognized as a distinct psychological experience separate from depression. This feasibility study explored the prevalence and association of depression and loneliness among adults at a suicide prevention walk, a potentially high risk and vulnerable population for depression, loneliness and suicide.

Methods

Adults completed anonymous loneliness, depression, and physical activity surveys. Based on Patient Health Questionnaire-2 (PHQ-2), adults were classified as screening positive (3 to 6) or negative (0 to 2) for depression. T-tests determined if the revised UCLA Loneliness Score (ULS) differed by depression screening status.

Results

Of the 133 survey participants, 13% screened positive for depression. Positive screens were highest for males, aged 18–35, living alone with a less active lifestyle. Participants averaged 36.8 ± 10.4 on the ULS; 11 %(n = 13) and 5%(n=6) were classified as experiencing moderate and very high levels of loneliness, respectively. Loneliness was significantly greater for those who screened positive for depression (49±9) compared to those who screened negative (35 ± 9)(p < 0.001). ULS and PHQ-2 were positively correlated (r=0.70, p < 0.01). Active participants reported less loneliness than less active participants(p < 0.01).

Limitations

The findings may be biased due to the volunteer sample composed primarily of female Caucasians.

Conclusion

In a sample that may be at higher risk for depression due to suicide attempts or being suicide loss survivors, 13 % screened positive for depression. Loneliness scores were not elevated in this population compared to national estimates. Suicide awareness events may be an efficient and cost-effective public health measure for the screening and appropriate follow-up of physical activity, depression and loneliness.

背景：孤独被认为是一种不同于抑郁的独特的心理体验。本可行性研究探讨了参加自杀预防步行的成年人中抑郁和孤独的患病率及其相关性，这些成年人是抑郁、孤独和自杀的潜在高风险和易感人群。方法：成年人完成匿名孤独、抑郁和身体活动调查。根据患者健康问卷-2 (PHQ-2)，将成年人分为抑郁症筛查阳性（3至6）或阴性（0至2）。t检验确定修订后的UCLA孤独评分（ULS）是否因抑郁筛查状态而异。结果：在133名调查参与者中，13%的人患有抑郁症。阳性筛查在18-35岁、独居且生活方式不太活跃的男性中比例最高。受试者平均ULS为36.8±10.4；11%（n=13）和5%（n=6）分别被归类为经历中度和非常高水平的孤独。抑郁筛查呈阳性的人（49±9）的孤独感明显高于筛查呈阴性的人（35±9）(局限性：由于志愿者样本主要由女性白种人组成，研究结果可能存在偏差。结论：在一个可能因自杀未遂或自杀幸存者而患抑郁症风险较高的样本中，13%的人筛查出抑郁症阳性。与全国估计相比，这一人群的孤独感得分没有升高。自杀意识活动可能是一种有效且具有成本效益的公共卫生措施，用于筛查和适当跟踪身体活动、抑郁和孤独。

{"title":"Depression and loneliness in a volunteer sample of adults at a suicide prevention and fund-raising walk: A feasibility study","authors":"Carol A. Janney , Jonathon Im , Sabrina Ma , Kathy Dollard","doi":"10.1016/j.physbeh.2024.114797","DOIUrl":"10.1016/j.physbeh.2024.114797","url":null,"abstract":"<div><h3>Background</h3><div>Loneliness is recognized as a distinct psychological experience separate from depression. This feasibility study explored the prevalence and association of depression and loneliness among adults at a suicide prevention walk, a potentially high risk and vulnerable population for depression, loneliness and suicide.</div></div><div><h3>Methods</h3><div>Adults completed anonymous loneliness, depression, and physical activity surveys. Based on Patient Health Questionnaire-2 (PHQ-2), adults were classified as screening positive (3 to 6) or negative (0 to 2) for depression. T-tests determined if the revised UCLA Loneliness Score (ULS) differed by depression screening status.</div></div><div><h3>Results</h3><div>Of the 133 survey participants, 13% screened positive for depression. Positive screens were highest for males, aged 18–35, living alone with a less active lifestyle. Participants averaged 36.8 ± 10.4 on the ULS; 11 %(n = 13) and 5%(n=6) were classified as experiencing moderate and very high levels of loneliness, respectively. Loneliness was significantly greater for those who screened positive for depression (49±9) compared to those who screened negative (35 ± 9)(<em>p</em> < 0.001). ULS and PHQ-2 were positively correlated (r=0.70, <em>p</em> < 0.01). Active participants reported less loneliness than less active participants(<em>p</em> < 0.01).</div></div><div><h3>Limitations</h3><div>The findings may be biased due to the volunteer sample composed primarily of female Caucasians.</div></div><div><h3>Conclusion</h3><div>In a sample that may be at higher risk for depression due to suicide attempts or being suicide loss survivors, 13 % screened positive for depression. Loneliness scores were not elevated in this population compared to national estimates. Suicide awareness events may be an efficient and cost-effective public health measure for the screening and appropriate follow-up of physical activity, depression and loneliness.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"292 ","pages":"Article 114797"},"PeriodicalIF":2.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sedentary behaviors negatively related to depressive symptoms in college students: The roles of type and duration of sedentary behaviors 久坐行为与大学生抑郁症状负相关：久坐行为类型和持续时间的作用。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior

Pub Date : 2024-12-26 DOI: 10.1016/j.physbeh.2024.114796

Zehan Xia , Teck Cheng Tan , Yiting Liu , Jiaxin Zheng , Zhongbin Li , Qian Gu , Tao Huang

Objective

This study aimed to examine the associations of different types and duration with sedentary behaviors and depressive symptoms among college students.

Methods

A cross-sectional study was conducted at a university in Shanghai, China, utilizing convenience sampling to recruit 3,190 participants (mean age 20.06 ± 1.23 years). Sedentary behaviors were self-reported using a structured questionnaire detailing the average daily time spent in different types of sedentary behaviors. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CESD-10). Linear regression models were conducted to analyze the associations between sedentary behaviors and depressive symptoms with adjustment for relevant covariates.

Results

Recreational screen-based sedentary behaviors were significantly associated with higher depressive symptom scores on both weekdays (B = 0.523, 95 % CI= 0.409 to 0.637, p < 0.001) and weekends (B = 0.313, 95 % CI= 0.221 to 0.406, p < 0.001). Study-related sedentary behaviors showed no significant association on weekdays (p > 0.05), but were significantly associated with depressive symptoms on weekends (B = 0.084, 95 % CI= 0.017 to 0.151, p < 0.05). Other types of sedentary behaviors (e.g., commuting and eating) also showed a positive association with depression scores on both weekdays and weekends (p < 0.05). Longer durations of recreational screen-based and study-related sedentary behaviors were associated with higher depressive symptom scores (both p < 0.05).

Conclusion

The study suggests that the associations between sedentary behaviors and depressive symptoms vary by the type and context of sedentary behavior. Additionally, the duration of each sedentary behavior bout is a significant influencing factor.

目的：探讨不同类型和持续时间的久坐行为与大学生抑郁症状的关系。方法：采用横断面研究方法，在上海某大学采用方便抽样方法，共招募3190名参与者（平均年龄20.06±1.23岁）。久坐行为是通过一份结构化的问卷来报告的，详细记录了不同类型的久坐行为的平均每日时间。使用流行病学研究中心抑郁量表（CESD-10）评估抑郁症状。采用线性回归模型分析久坐行为与抑郁症状之间的关系，并校正相关协变量。结果：以娱乐屏幕为基础的久坐行为在工作日与较高的抑郁症状得分显著相关（B= 0.523, 95% CI= 0.409 ~ 0.637, p0.05），但在周末与抑郁症状显著相关（B= 0.084, 95% CI= 0.017 ~ 0.151, p）。结论：研究表明，久坐行为与抑郁症状的相关性因久坐行为的类型和环境而异。此外，每次久坐行为的持续时间也是一个重要的影响因素。

{"title":"Sedentary behaviors negatively related to depressive symptoms in college students: The roles of type and duration of sedentary behaviors","authors":"Zehan Xia , Teck Cheng Tan , Yiting Liu , Jiaxin Zheng , Zhongbin Li , Qian Gu , Tao Huang","doi":"10.1016/j.physbeh.2024.114796","DOIUrl":"10.1016/j.physbeh.2024.114796","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to examine the associations of different types and duration with sedentary behaviors and depressive symptoms among college students.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at a university in Shanghai, China, utilizing convenience sampling to recruit 3,190 participants (mean age 20.06 ± 1.23 years). Sedentary behaviors were self-reported using a structured questionnaire detailing the average daily time spent in different types of sedentary behaviors. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CESD-10). Linear regression models were conducted to analyze the associations between sedentary behaviors and depressive symptoms with adjustment for relevant covariates.</div></div><div><h3>Results</h3><div>Recreational screen-based sedentary behaviors were significantly associated with higher depressive symptom scores on both weekdays (B = 0.523, 95 % CI= 0.409 to 0.637, <em>p</em> < 0.001) and weekends (B = 0.313, 95 % CI= 0.221 to 0.406, <em>p</em> < 0.001). Study-related sedentary behaviors showed no significant association on weekdays (<em>p</em> > 0.05), but were significantly associated with depressive symptoms on weekends (B = 0.084, 95 % CI= 0.017 to 0.151, <em>p</em> < 0.05). Other types of sedentary behaviors (e.g., commuting and eating) also showed a positive association with depression scores on both weekdays and weekends (<em>p</em> < 0.05). Longer durations of recreational screen-based and study-related sedentary behaviors were associated with higher depressive symptom scores (both <em>p</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>The study suggests that the associations between sedentary behaviors and depressive symptoms vary by the type and context of sedentary behavior. Additionally, the duration of each sedentary behavior bout is a significant influencing factor.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"291 ","pages":"Article 114796"},"PeriodicalIF":2.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0