Physiology & Behavior最新文献

{"title":"Physiological costs of warning: Defensive hissing increases metabolic rate and evaporative water loss in a venomous snake","authors":"Nicolas Van Zele ,&nbsp;Thomas Nicot ,&nbsp;Thierry Lengagne ,&nbsp;Rémi Ksas ,&nbsp;Olivier Lourdais","doi":"10.1016/j.physbeh.2024.114708","DOIUrl":"10.1016/j.physbeh.2024.114708","url":null,"abstract":"<div><div>To minimize predation risk and the cost of confronting predators, prey have developed a range of defensive strategies and warning signals. Although advantageous, defensive warnings may also induce physiological and energy costs to the emitter. Ventilatory sounds (hissing) are the most distributed warning sound in vertebrates. Because they involve the respiratory apparatus, defensive hissing may substantially increase evaporative water loss. Herein, we examined the determinants of hissing as well as its physiological costs in a medium-sized venomous snake, the long-nosed viper (<em>Vipera ammodytes</em>). We first used a neutral arena and applied standardized stimulation to measure the occurrence and acoustic characteristics of warning hissing. Then, we used open-flow respirometry to quantify changes in respiratory gas exchanges (oxygen consumption and evaporative water loss) during defensive responses. We demonstrated that males are more likely to engage in sound warnings when stimulated. Expirations generated the strongest signals compared to inspiration but did not differ between sexes. We found that defensive hissing dramatically increased average metabolic rate and evaporative water loss during the 10-minute stimulation period, and this effect was more pronounced in males. Metabolic rates and evaporative water loss were closely related to the duration of hissing. Overall, our results indicate that respiratory-based warning sounds induce significant physiological costs and may alter water balance. The higher responsiveness in males than females likely reflects sexually selective pressure (higher mobility for mate acquisition) and enhanced risk exposure.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114708"},"PeriodicalIF":2.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of food stimuli presentation on restrained eater's food choice: An ERP study","authors":"Yong Liu ,&nbsp;Xuemeng Zhang ,&nbsp;Yazhi Pang ,&nbsp;Jia Zhao ,&nbsp;Jinfeng Han ,&nbsp;Yuanluo Jing ,&nbsp;Hong Chen","doi":"10.1016/j.physbeh.2024.114704","DOIUrl":"10.1016/j.physbeh.2024.114704","url":null,"abstract":"<div><div>Restrained eaters are individuals who consciously follow a limited food intake diet to lose or maintain body weight. With the rising numbers of obesity cases, retrained eating has became more prevalent as more people adopt it to cope with obesity. The dual conflict theory states that restrained eaters often encounter conflicting choices of food pleasure and weight management. The present study investigated the difference in food choice regarding different presentations of the weight management goal. The study hypothesized difference in successful and unsuccessful restrained eaters’ food choice when presented with the conflicting food/weight maintenance stimuli. A total of 49 college students participated in the study and the N2, P3 and LPP event-related potentials (ERPs) were investigated during a food choice task. Results showed that the reaction time in unsuccessful restrained eaters (UREs) were greater than successful restrained eaters (SREs). The ERP results showed that SREs exhibited smaller N2 and greater P3 amplitudes than UREs, however, we did not find a difference in LPP amplitudes between the two groups. The findings suggest that the UREs demonstrated greater sensitivity and smaller inhibition to food cues, while we do not have supports for a difference in motivational and emotional salience. This is the first study that investigated the food choice of SREs and UREs when faced with different presentations of conflicting goals, which enriches the theoretical model and provides neural correlates evidence for future studies.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114704"},"PeriodicalIF":2.4,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress-induced overeating behaviors explained from a (transitory) relief-learning perspective","authors":"Silvia Papalini","doi":"10.1016/j.physbeh.2024.114707","DOIUrl":"10.1016/j.physbeh.2024.114707","url":null,"abstract":"<div><div>People use various behaviors to cope with stressful events. These behaviors are mostly adaptive, as they allow a successful release of stress without impacting other aspects of life: How nice is it to have a break with a few spoons of that favorite ice cream during a hectic working day? However, when excessive consumption of high-sugar/salt ultra-processed food becomes the gateway to find relief from stress, eating loses this adaptive function and may escalate to binge eating, lead to obesity, and other medical conditions linked to overweight.</div><div>Several etiological models attempt to explain stress-induced eating and excessive overeating behaviors characterizing these clinical conditions. The popular Emotional Eating Theory proposes that stress-related (over-)eating, a major predictor of obesity and diagnosed binge eating disorders, develops based on negative reinforcement learning since food consumption regulates the negative affective state associated with stressful circumstances. Differently, the prominent Incentive Sensitization Theory explains overeating, binge eating disorders (including bulimia), and obesity in terms of excessive amplification of reward ‘wanting’, which is thought to emerge from overexposure to obesogenic (food)cues. The several studies oriented by these theories have paved the way to better understand stress-related (over-)eating and its clinical excesses. However, a deep mechanistic understanding of how and why stress-induced (over-)eating can <em>escalate</em> till clinical forms of overeating remain elusive. A well-funded connection of the mechanisms proposed by the Emotional Eating Theory and the Incentive Sensitization Theory might address this etiological open question. To avoid erroneous arguments, it is however essential to first address the internal theoretical and methodological shortcomings of each theory and connected studies. These shortcomings stem from conceptual fallacies and poorly implemented designs, which might partially explain the ‘high variability and low replicability’ problem of empirical findings. Next, the formulation of a new integrative model could provide fresh insight into the deep learning and biological mechanisms of this escalation. A successful formalization of this model could then create the much-needed impact in clinical and preventive research since excessive overeating is a behavior hard to change once established.</div><div>In this opinion paper, I propose to apply recent insights we gathered on the role of relief from the field of safety learning to stress (over-)eating. I will present a new relief-based model that, as a starting point, has the potential to connect the Emotional Eating Theory with the Incentive Sensitization Theory, setting the base for more integrative science.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114707"},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A performance-based mental workload identification method for special vehicle crews","authors":"Mingyang Guo,&nbsp;Peiyan Duan,&nbsp;Xiaoping Jin,&nbsp;Qingyang Huang,&nbsp;Yuning Wei","doi":"10.1016/j.physbeh.2024.114706","DOIUrl":"10.1016/j.physbeh.2024.114706","url":null,"abstract":"<div><div>Detecting the mental workload state of armored vehicle crews is of great significance for monitoring the driving state of the crew and improving comprehensive combat effectiveness. In this manuscript, we propose a performance-based mental workload identification method and carry out experimental validation to improve the accuracy of crew mental workload identification and realize the effective classification of mental workload. Based on the virtual simulation system of the special vehicle crew task, this manuscript selects 20 subjects for the mental workload experiment of special vehicle crews. The experiment collected NASA-TLX scale, EEG, eye-tracking data, and performance data. The results show that the mental workload of the crews fluctuates in the segmented tasks of complex operations in typical scenes of special vehicles. The method of determining mental workload using NASA-TLX generates label noise in classification, which is not suitable for special vehicle tasks. Performance-based mental workload identification method is able to recognize fluctuations in the crew's mental workload during segmented tasks. Performance-based and NASA-TXL-based methods were classified using linear discriminant analysis. The results show that the accuracy of the method based on performance is improved by 15.72 %. This manuscript found the NASA-TXL scale is not suitable for the complex tasks of special vehicles, and proposed a performance-based identification method that can help to categorize the mental workload states of special vehicle crews.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"288 ","pages":"Article 114706"},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet","authors":"Tomoyuki Sasaki ,&nbsp;Mariko Sugiyama ,&nbsp;Mitsuhiro Kuno ,&nbsp;Takashi Miyata ,&nbsp;Tomoko Kobayashi ,&nbsp;Yoshinori Yasuda ,&nbsp;Takeshi Onoue ,&nbsp;Hiroshi Takagi ,&nbsp;Daisuke Hagiwara ,&nbsp;Shintaro Iwama ,&nbsp;Hidetaka Suga ,&nbsp;Ryoichi Banno ,&nbsp;Hiroshi Arima","doi":"10.1016/j.physbeh.2024.114703","DOIUrl":"10.1016/j.physbeh.2024.114703","url":null,"abstract":"<div><div>A high-fat diet (HFD) causes inflammation with an increase in microglial activity in the hypothalamic arcuate nucleus (ARC) and ventral tegmental area (VTA), resulting in insulin resistance in both regions. This leads to a deterioration in glucose and energy metabolism. The effect of voluntary exercise on HFD-induced inflammation in the central nervous system (CNS) remains unclear. To clarify the effects of voluntary exercise on the CNS, 8-week-old male C57BL6 mice were fed a chow diet (CHD) or HFD for 4 weeks; each group was further divided into running exercise (EX+) on a wheel and no exercise (EX-) groups. The expression of the inflammatory cytokine, tumor necrosis factor alpha (TNFα), in the ARC and VTA was significantly increased in the HFD/EX- group, with an increase of microglial activity noted, compared to the CHD/EX- group. The expression of TNFα was significantly suppressed, with a decrease of microglial activity, in the HFD/EX+ compared to HFD/EX- group. Insulin resistance in the ARC and VTA was improved with the suppression of TNFα expression. The HFD/EX- group showed significant weight gain and impaired glucose metabolism compared to the CHD/EX- group. The HFD/EX+ group showed an improvement in glucose and energy metabolism compared to the HFD/EX- group. In addition, voluntary wheel running suppressed HFD-induced inflammation in the ARC, with a decrease in microglial activity observed independently of weight changes. Our data suggest that voluntary exercise prevents obesity and improves glucose metabolism by suppressing inflammation in the ARC and VTA under HFD conditions.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114703"},"PeriodicalIF":2.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific behavioral, cardiac, and neuroendocrine responses to repeated witness social stress in adult rats","authors":"Margherita Barbetti,&nbsp;Andrea Sgoifo,&nbsp;Luca Carnevali","doi":"10.1016/j.physbeh.2024.114702","DOIUrl":"10.1016/j.physbeh.2024.114702","url":null,"abstract":"<div><div>In humans, sex disparities exist in the prevalence of social stress-related disorders, yet our understanding of the predisposing factors and underlying mechanisms is still elusive. Also at the preclinical level, the investigation of sex differences in social stress responses is limited. In this study, adult male and female wild-type Groningen rats were repeatedly exposed to witness social defeat stress (WS) to assess sex-specific behavioral, neuroendocrine, and cardiac responses to the same social stress paradigm. Male and female rats bore witness to an aggressive social defeat episode between two males for nine consecutive days or were exposed to a control (CTR) procedure. Stress-related parameters were assessed in correspondence to the first and last WS/CTR exposure and also during subsequent exposure to the stress context alone in the absence of social defeat. During WS, rats of both sexes displayed larger amounts of burying behavior and smaller amounts of rearing and grooming behaviors, but with a greater extent in female witnesses. Cardiac autonomic responses to WS were similar between the sexes, yet only females displayed higher plasma corticosterone levels after the first WS exposure compared to CTRs, and had a larger corticosterone increase than male witnesses upon repeated WS. Exposure to the stress context alone (i.e., without the presence of the aggressive resident rat) elicited greater amount of burying behavior and more pronounced and persistent tachycardic responses in females than males with a history of WS. Our findings suggest sex-disparities in the response of adult rats to WS at multiple behavioral, cardiac, and neuroendocrine levels, highlighting the utility of this social stress paradigm for investigating predisposing factors and pathophysiological mechanisms underlying sex-specific vulnerabilities to stress-related pathologies.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114702"},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of long-term exposure to high-altitude on episodic memory: The moderating role of daytime dysfunction","authors":"Getong Tao ,&nbsp;Hailin Ma ,&nbsp;Yanjie Su","doi":"10.1016/j.physbeh.2024.114700","DOIUrl":"10.1016/j.physbeh.2024.114700","url":null,"abstract":"<div><div>Chronic exposure to high-altitude hypoxic environments may influence short-term memory and working memory. However, its impact on long-term memory, specifically episodic memory, remains understudied. In this study, we systematically investigated the effects of long-term exposure to high altitude (3650 m) on episodic memory, including item memory and source memory. Moreover, we examined the moderating role of daytime dysfunction on the relationship between altitude and episodic memory. In total, 97 participants were enrolled in the study: 49 were from the high-altitude (HA) group, comprising those born and raised in low altitude (LA) areas (&lt; 500 m) and had migrated to HA for 2∼3 years after turning 18; and 48 were from the LA group, who had never lived at high altitudes. Episodic memory was evaluated using a what-when-where task, whereas daytime dysfunction was measured by the Pittsburgh Sleep Quality Index. For item memory, hit rate and correct rejection rate were significantly lower in the HA group relative to the LA group. For source binding memory, the performance in what-where binding and what-when-where binding were decreased in the HA group, but the what-when binding did not differ between the two groups. Furthermore, the effects of altitude on hit rate, what-where binding, and what-when-where binding were significantly pronounced in individuals with higher levels of daytime dysfunction. These findings suggest that long-term exposure to high-altitude hypoxic environments influences episodic memory performance, including item recognition and source-binding memory. Specifically, spatial source memory is affected by high-altitude exposure, whereas temporal source memory remains unaffected. Moreover, these results highlight the importance of considering sleep quality, especially good daytime function, in maintaining optimal episodic memory function following chronic exposure to high altitudes.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114700"},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced voluntary wheel running behaviour in Kiss1r knockout mice","authors":"Raj Patel ,&nbsp;Aaron Gomes ,&nbsp;Shane K Maloney,&nbsp;Jeremy T Smith","doi":"10.1016/j.physbeh.2024.114701","DOIUrl":"10.1016/j.physbeh.2024.114701","url":null,"abstract":"<div><div>Kisspeptin and its receptor, Kiss1r, are novel players in the central balance of energy intake and expenditure. Recent evidence also indicates that kisspeptin signalling is important in thermoregulation and generation of the circadian rhythm. We used global Kiss1r knockout mice (<em>Kiss1r</em> KO), which are hypogonadal and develop obesity, to determine the impact of kisspeptin on circadian related behaviour. Voluntary wheel running was examined in <em>Kiss1r</em> KO and wild-type (WT) mice, using gonad intact and gonadectomised (GDX) mice to account for the effects of kisspeptin on gonadal sex steroids. Intact male and female <em>Kiss1r</em> KO mice covered only 10% and 30% of the distance travelled each day by their respective WT controls. In all mice, most of the running activity occurred during the dark phase. GDX WT mice ran significantly less during dark periods than the intact WT. GDX <em>Kiss1r</em> KO male mice ran significantly less than the GDX WT male mice, but the decrease was attenuated compared to intact mice. There was no difference between the female GDX <em>Kiss1r</em> KO and GDX WT. In contrast to the obese phenotype that develops in <em>Kiss1r</em> KO mice, body mass at the end of the study was significantly lower in the GDX <em>Kiss1r</em> KO than it was in the GDX WT mice. The difference in wheel running activity was not associated with any histological change in WAT, BAT, or muscle diameter. No difference in immunohistochemistry expression was seen in lateral hypothalamic orexin neurons or dopamine neurons in the ventral tegmental area / substantia nigra. We observed increased Iba1 expression (activation of microglia) in the arcuate nucleus of male <em>Kiss1r</em> KO mice. Overall, the circadian locomotor activity in male <em>Kiss1r</em> KO mice appears dependant on kisspeptin signalling and the obese phenotype does not develop in <em>Kiss1r</em> KO mice when they engage in voluntary activity.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114701"},"PeriodicalIF":2.4,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The regulatory effect of the anterior cingulate cortex on helping behavior in juvenile social isolation model mice","authors":"Yue Jin ,&nbsp;Da Song ,&nbsp;Zhenzhen Quan ,&nbsp;Junjun Ni ,&nbsp;Hong Qing","doi":"10.1016/j.physbeh.2024.114698","DOIUrl":"10.1016/j.physbeh.2024.114698","url":null,"abstract":"<div><div>Social isolation during adolescence negatively impacts the development of adult social behaviors. However, the exact link between social experiences during adolescence and social behaviors in adulthood is not fully understood. In the present study, we investigated how isolation during juvenility affects harm avoidance behavior in a mouse model of juvenile social isolation. We found that mice subjected to social isolation as juveniles display atypical harm avoidance behaviors and that neurons in the anterior cingulate cortex are involved in these abnormal behaviors. Furthermore, we discovered that the chemogenetic activation of anterior cingulate cortex pyramidal neurons can rescue impaired harm-avoidance behaviors in these mice. Our findings provide valuable insights into the potential mechanisms underlying the impact of social experiences on behavior and brain function. Understanding how social isolation during crucial developmental periods can lead to alterations in behavior opens up new avenues for exploring therapeutic interventions for neuropsychiatric disorders characterized by impaired prosocial behaviors.</div></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114698"},"PeriodicalIF":2.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of double neonatal stress on female rat sexual behaviour","authors":"Marcos Rochedo Ferraz,&nbsp;Jéssica Santos Guimarães,&nbsp;Vittoria Ugenti Monteiro,&nbsp;Larissa Nascimento Santos ,&nbsp;Jéssica Sertório Casimiro e Silva,&nbsp;Elaine de Sousa Barbosa,&nbsp;Stephen de Sousa da Silva","doi":"10.1016/j.physbeh.2024.114692","DOIUrl":"10.1016/j.physbeh.2024.114692","url":null,"abstract":"<div><p>Neonatal stress affects psychological and physiological development and may be associated with affective disorders. The aim was to examine the effects of double neonatal stress (DNS) – a combination of limited bedding and nesting (LBN) and repeated maternal separation (MS) – on the oestrous cycle and sexual behaviour of adult female rats. LBN was achieved by removing part of the wood shavings from the boxes. In the control group, each box was lined with 100 g of wood shavings, while in the experimental group there were only 10 g of wood shavings. MS was performed from P1 (P0 = day of birth) to P15. At P90, the sexual response of females in oestrus was evaluated. Statistical analysis was performed using two-way analysis of variance followed by Tukey's test. The size and profile of the oestrous cycle and the sexual behaviour of female rats submitted to the DNS were considered, as well as the influence of female behaviour on the sexual response of male rats. Female rats submitted to DNS showed a reduction in the lordosis quotient, suggesting a reduction in female receptivity. These rats also showed a reduction in the number of hops and darts, the number of ear wiggles, and the genital exploration time rate, suggesting a reduction in proceptivity. The males that interacted with the females of the DNS group showed a reduction in intromission ratio. Experimental model that mimics neonatal factors that affect adult female sexual response will allow more effective interventions to prevent and treat such changes. In addition, analysis of the female sexual response makes it possible to assess the general state of health and quality of life. In female rats, DNS exerted inhibitory effects on sexual behaviour. LBN was probably the most important factor. In conclusion, combating childhood poverty can be a key measure to prevent problems in the sex life of adults and improve overall health.</p></div>","PeriodicalId":20201,"journal":{"name":"Physiology & Behavior","volume":"287 ","pages":"Article 114692"},"PeriodicalIF":2.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}